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Volumn 2, Issue 1, 2009, Pages

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCINEURIN; HUNTINGTIN; SERINE; TACROLIMUS; HUNTINGTON PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PHOSPHOSERINE; POLYGLUTAMINE;

EID: 72949098095     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-2-33     Document Type: Article
Times cited : (57)

References (50)
  • 1
    • 33751282353 scopus 로고    scopus 로고
    • Huntington's disease: From huntingtin function and dysfunction to therapeutic strategies
    • 10.1007/s00018-006-6242-0. 17041811
    • Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. M Borrell-Pages D Zala S Humbert F Saudou, Cell Mol Life Sci 2006 63 2642 2660 10.1007/s00018-006-6242-0 17041811
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2642-2660
    • Borrell-Pages, M.1    Zala, D.2    Humbert, S.3    Saudou, F.4
  • 2
    • 52049085768 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: From huntingtin functions to potential treatments
    • 10.1097/WCO.0b013e328304b692. 18607213
    • Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments. E Roze F Saudou J Caboche, Curr Opin Neurol 2008 21 497 503 10.1097/WCO.0b013e328304b692 18607213
    • (2008) Curr Opin Neurol , vol.21 , pp. 497-503
    • Roze, E.1    Saudou, F.2    Caboche, J.3
  • 5
    • 1542267796 scopus 로고    scopus 로고
    • Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    • 10.1073/pnas.0400243101. 14978262
    • Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. WC Lee M Yoshihara JT Littleton, Proc Natl Acad Sci USA 2004 101 3224 3229 10.1073/pnas.0400243101 14978262
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3224-3229
    • Lee, W.C.1    Yoshihara, M.2    Littleton, J.T.3
  • 8
    • 0032519646 scopus 로고    scopus 로고
    • Interaction of huntingtin-associated protein with dynactin P150Glued
    • 9454836
    • Interaction of huntingtin-associated protein with dynactin P150Glued. SH Li CA Gutekunst SM Hersch XJ Li, J Neurosci 1998 18 1261 1269 9454836
    • (1998) J Neurosci , vol.18 , pp. 1261-1269
    • Li, S.H.1    Gutekunst, C.A.2    Hersch, S.M.3    Li, X.J.4
  • 10
    • 34547193908 scopus 로고    scopus 로고
    • Huntingtin facilitates dynein/dynactin-mediated vesicle transport
    • 10.1073/pnas.0610628104. 17548833
    • Huntingtin facilitates dynein/dynactin-mediated vesicle transport. JP Caviston JL Ross SM Antony M Tokito EL Holzbaur, Proc Natl Acad Sci USA 2007 104 10045 10050 10.1073/pnas.0610628104 17548833
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10045-10050
    • Caviston, J.P.1    Ross, J.L.2    Antony, S.M.3    Tokito, M.4    Holzbaur, E.L.5
  • 11
    • 33645642673 scopus 로고    scopus 로고
    • Interaction of Huntingtin-associated protein-1 with kinesin light chain: Implications in intracellular trafficking in neurons
    • 10.1074/jbc.M509806200. 16339760
    • Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. JR McGuire J Rong SH Li XJ Li, J Biol Chem 2006 281 3552 3559 10.1074/jbc.M509806200 16339760
    • (2006) J Biol Chem , vol.281 , pp. 3552-3559
    • McGuire, J.R.1    Rong, J.2    Li, S.H.3    Li, X.J.4
  • 12
    • 49149112606 scopus 로고    scopus 로고
    • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
    • 10.1038/emboj.2008.133. 18615096
    • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. E Colin D Zala G Liot H Rangone M Borrell-Pages XJ Li F Saudou S Humbert, Embo J 2008 27 2124 2134 10.1038/emboj.2008.133 18615096
    • (2008) Embo J , vol.27 , pp. 2124-2134
    • Colin, E.1    Zala, D.2    Liot, G.3    Rangone, H.4    Borrell-Pages, M.5    Li, X.J.6    Saudou, F.7    Humbert, S.8
  • 13
    • 57049184027 scopus 로고    scopus 로고
    • Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons
    • 10.1093/hmg/ddn281. 18772195
    • Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. D Zala E Colin H Rangone G Liot S Humbert F Saudou, Hum Mol Genet 2008 17 24 3837 46 10.1093/hmg/ddn281 18772195
    • (2008) Hum Mol Genet , vol.17 , Issue.24 , pp. 3837-46
    • Zala, D.1    Colin, E.2    Rangone, H.3    Liot, G.4    Humbert, S.5    Saudou, F.6
  • 14
    • 0036083379 scopus 로고    scopus 로고
    • The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
    • 10.1016/S1534-5807(02)00188-0. 12062094
    • The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. S Humbert EA Bryson FP Cordelieres NC Connors SR Datta S Finkbeiner ME Greenberg F Saudou, Dev Cell 2002 2 831 837 10.1016/S1534-5807(02)00188-0 12062094
    • (2002) Dev Cell , vol.2 , pp. 831-837
    • Humbert, S.1    Bryson, E.A.2    Cordelieres, F.P.3    Connors, N.C.4    Datta, S.R.5    Finkbeiner, S.6    Greenberg, M.E.7    Saudou, F.8
  • 15
    • 32544432052 scopus 로고    scopus 로고
    • Inhibition of calcineurin by FK506 protects against polyglutamine- huntingtin toxicity through an increase of huntingtin phosphorylation at S421
    • 10.1523/JNEUROSCI.3706-05.2006. 16452687
    • Inhibition of calcineurin by FK506 protects against polyglutamine- huntingtin toxicity through an increase of huntingtin phosphorylation at S421. R Pardo E Colin E Regulier P Aebischer N Deglon S Humbert F Saudou, J Neurosci 2006 26 1635 1645 10.1523/JNEUROSCI.3706-05.2006 16452687
    • (2006) J Neurosci , vol.26 , pp. 1635-1645
    • Pardo, R.1    Colin, E.2    Regulier, E.3    Aebischer, P.4    Deglon, N.5    Humbert, S.6    Saudou, F.7
  • 16
    • 0346993604 scopus 로고    scopus 로고
    • Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice
    • 10.1016/j.expneurol.2003.09.002. 14697316
    • Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. D Zala JC Bensadoun L Pereira de Almeida BR Leavitt CA Gutekunst P Aebischer MR Hayden N Deglon, Exp Neurol 2004 185 26 35 10.1016/j.expneurol.2003.09.002 14697316
    • (2004) Exp Neurol , vol.185 , pp. 26-35
    • Zala, D.1    Bensadoun, J.C.2    Pereira De Almeida, L.3    Leavitt, B.R.4    Gutekunst, C.A.5    Aebischer, P.6    Hayden, M.R.7    Deglon, N.8
  • 17
    • 20444448900 scopus 로고    scopus 로고
    • Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
    • 10.1093/hmg/ddi165. 15843398
    • Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. SC Warby EY Chan M Metzler L Gan RR Singaraja SF Crocker HA Robertson MR Hayden, Hum Mol Genet 2005 14 1569 1577 10.1093/hmg/ddi165 15843398
    • (2005) Hum Mol Genet , vol.14 , pp. 1569-1577
    • Warby, S.C.1    Chan, E.Y.2    Metzler, M.3    Gan, L.4    Singaraja, R.R.5    Crocker, S.F.6    Robertson, H.A.7    Hayden, M.R.8
  • 19
    • 43549092044 scopus 로고    scopus 로고
    • Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells
    • 10.1111/j.1471-4159.2008.05252.x. 18221365
    • Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells. X Xifro JM Garcia-Martinez D Del Toro J Alberch E Perez-Navarro, J Neurochem 2008 105 1596 1612 10.1111/j.1471-4159.2008.05252.x 18221365
    • (2008) J Neurochem , vol.105 , pp. 1596-1612
    • Xifro, X.1    Garcia-Martinez, J.M.2    Del Toro, D.3    Alberch, J.4    Perez-Navarro, E.5
  • 20
    • 66449104770 scopus 로고    scopus 로고
    • Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro
    • 10.1074/jbc.M900639200. 19270310
    • Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. G Ermak KJ Hench KT Chang S Sachdev KJ Davies, J Biol Chem 2009 284 11845 11853 10.1074/jbc. M900639200 19270310
    • (2009) J Biol Chem , vol.284 , pp. 11845-11853
    • Ermak, G.1    Hench, K.J.2    Chang, K.T.3    Sachdev, S.4    Davies, K.J.5
  • 21
    • 0033200022 scopus 로고    scopus 로고
    • Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain
    • 10.1002/(SICI)1097-4547(19990901)57:5<651::AID-JNR7>3.0.CO;2-G. 10462689
    • Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain. C Sola JM Tusell J Serratosa, J Neurosci Res 1999 57 651 662 10.1002/(SICI)1097-4547(19990901)57:5<651::AID-JNR7>3.0. CO;2-G 10462689
    • (1999) J Neurosci Res , vol.57 , pp. 651-662
    • Sola, C.1    Tusell, J.M.2    Serratosa, J.3
  • 22
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • 11015619
    • Calcineurin: form and function. F Rusnak P Mertz, Physiol Rev 2000 80 1483 1521 11015619
    • (2000) Physiol Rev , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 23
    • 0036171986 scopus 로고    scopus 로고
    • Calcineurin as a multifunctional regulator
    • 11754729
    • Calcineurin as a multifunctional regulator. F Shibasaki U Hallin H Uchino, J Biochem 2002 131 1 15 11754729
    • (2002) J Biochem , vol.131 , pp. 1-15
    • Shibasaki, F.1    Hallin, U.2    Uchino, H.3
  • 24
    • 34548233496 scopus 로고    scopus 로고
    • Calcineurin: A central controller of signalling in eukaryotes
    • 10.1038/sj.embor.7400133. 15060569
    • Calcineurin: a central controller of signalling in eukaryotes. J Aramburu J Heitman GR Crabtree, EMBO Rep 2004 5 343 348 10.1038/sj.embor.7400133 15060569
    • (2004) EMBO Rep , vol.5 , pp. 343-348
    • Aramburu, J.1    Heitman, J.2    Crabtree, G.R.3
  • 25
    • 0037237668 scopus 로고    scopus 로고
    • The role of modulatory calcineurin-interacting proteins in calcineurin signaling
    • 10.1016/S1050-1738(02)00188-3. 12554096
    • The role of modulatory calcineurin-interacting proteins in calcineurin signaling. BA Rothermel RB Vega RS Williams, Trends Cardiovasc Med 2003 13 15 21 10.1016/S1050-1738(02)00188-3 12554096
    • (2003) Trends Cardiovasc Med , vol.13 , pp. 15-21
    • Rothermel, B.A.1    Vega, R.B.2    Williams, R.S.3
  • 26
    • 0034708825 scopus 로고    scopus 로고
    • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
    • 10.1074/jbc.275.12.8719. 10722714
    • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. B Rothermel RB Vega J Yang H Wu R Bassel-Duby RS Williams, J Biol Chem 2000 275 8719 8725 10.1074/jbc.275.12.8719 10722714
    • (2000) J Biol Chem , vol.275 , pp. 8719-8725
    • Rothermel, B.1    Vega, R.B.2    Yang, J.3    Wu, H.4    Bassel-Duby, R.5    Williams, R.S.6
  • 27
    • 0037109035 scopus 로고    scopus 로고
    • Novel human ZAKI-4 isoforms: Hormonal and tissue-specific regulation and function as calcineurin inhibitors
    • 10.1042/BJ20011797. 12102656
    • Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. X Cao F Kambe T Miyazaki D Sarkar S Ohmori H Seo, Biochem J 2002 367 459 466 10.1042/BJ20011797 12102656
    • (2002) Biochem J , vol.367 , pp. 459-466
    • Cao, X.1    Kambe, F.2    Miyazaki, T.3    Sarkar, D.4    Ohmori, S.5    Seo, H.6
  • 28
    • 0343192437 scopus 로고    scopus 로고
    • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans
    • 10.1093/emboj/19.14.3618. 10899116
    • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. J Gorlach DS Fox NS Cutler GM Cox JR Perfect J Heitman, EMBO J 2000 19 3618 3629 10.1093/emboj/19.14.3618 10899116
    • (2000) EMBO J , vol.19 , pp. 3618-3629
    • Gorlach, J.1    Fox, D.S.2    Cutler, N.S.3    Cox, G.M.4    Perfect, J.R.5    Heitman, J.6
  • 29
    • 0034234963 scopus 로고    scopus 로고
    • A conserved family of calcineurin regulators
    • 10887154
    • A conserved family of calcineurin regulators. TJ Kingsbury KW Cunningham, Genes Dev 2000 14 1595 1604 10887154
    • (2000) Genes Dev , vol.14 , pp. 1595-1604
    • Kingsbury, T.J.1    Cunningham, K.W.2
  • 31
    • 0042970735 scopus 로고    scopus 로고
    • FK506 and its analogs - Therapeutic potential for neurological disorders
    • 10.2174/1568007033482878. 12769796
    • FK506 and its analogs - therapeutic potential for neurological disorders. A Klettner T Herdegen, Curr Drug Targets CNS Neurol Disord 2003 2 153 162 10.2174/1568007033482878 12769796
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 153-162
    • Klettner, A.1    Herdegen, T.2
  • 32
    • 1542395816 scopus 로고    scopus 로고
    • Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases
    • 10.2174/1568007033482652. 14683462
    • Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases. K Pong MM Zaleska, Curr Drug Targets CNS Neurol Disord 2003 2 349 356 10.2174/1568007033482652 14683462
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 349-356
    • Pong, K.1    Zaleska, M.M.2
  • 33
    • 34047175919 scopus 로고    scopus 로고
    • Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
    • 10.1523/JNEUROSCI.0037-07.2007. 17392473
    • Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. JP Dompierre JD Godin BC Charrin FP Cordelieres SJ King S Humbert F Saudou, J Neurosci 2007 27 3571 3583 10.1523/JNEUROSCI.0037-07.2007 17392473
    • (2007) J Neurosci , vol.27 , pp. 3571-3583
    • Dompierre, J.P.1    Godin, J.D.2    Charrin, B.C.3    Cordelieres, F.P.4    King, S.J.5    Humbert, S.6    Saudou, F.7
  • 34
    • 0028170809 scopus 로고
    • Protein serine/threonine phosphatases - New avenues for cell regulation
    • 10.1146/annurev.cb.10.110194.000415. 7888183
    • Protein serine/threonine phosphatases - new avenues for cell regulation. S Shenolikar, Annu Rev Cell Biol 1994 10 55 86 10.1146/annurev.cb.10.110194. 000415 7888183
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 55-86
    • Shenolikar, S.1
  • 36
    • 2442506955 scopus 로고    scopus 로고
    • Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
    • 10.1523/JNEUROSCI.3920-03.2004. 15115821
    • Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. ZC Baquet JA Gorski KR Jones, J Neurosci 2004 24 4250 4258 10.1523/JNEUROSCI.3920- 03.2004 15115821
    • (2004) J Neurosci , vol.24 , pp. 4250-4258
    • Baquet, Z.C.1    Gorski, J.A.2    Jones, K.R.3
  • 38
    • 0031004888 scopus 로고    scopus 로고
    • Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: Evidence for anterograde axonal transport
    • 9065491
    • Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. JM Conner JC Lauterborn Q Yan CM Gall S Varon, J Neurosci 1997 17 2295 2313 9065491
    • (1997) J Neurosci , vol.17 , pp. 2295-2313
    • Conner, J.M.1    Lauterborn, J.C.2    Yan, Q.3    Gall, C.M.4    Varon, S.5
  • 39
    • 20144379127 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    • 10.1111/j.1471-4159.2005.03047.x. 15934928
    • Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease. JR Pineda JM Canals M Bosch A Adell G Mengod F Artigas P Ernfors J Alberch, J Neurochem 2005 93 1057 1068 10.1111/j.1471-4159.2005.03047.x 15934928
    • (2005) J Neurochem , vol.93 , pp. 1057-1068
    • Pineda, J.R.1    Canals, J.M.2    Bosch, M.3    Adell, A.4    Mengod, G.5    Artigas, F.6    Ernfors, P.7    Alberch, J.8
  • 41
    • 0027937489 scopus 로고
    • Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
    • 10.1038/371336a0. 7522303
    • Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. J Sharkey SP Butcher, Nature 1994 371 336 339 10.1038/371336a0 7522303
    • (1994) Nature , vol.371 , pp. 336-339
    • Sharkey, J.1    Butcher, S.P.2
  • 42
    • 0036403825 scopus 로고    scopus 로고
    • Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition
    • 10.1006/nbdi.2002.0514. 12270685
    • Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. H Uchino R Minamikawa-Tachino T Kristian G Perkins M Narazaki BK Siesjo F Shibasaki, Neurobiol Dis 2002 10 219 233 10.1006/nbdi.2002.0514 12270685
    • (2002) Neurobiol Dis , vol.10 , pp. 219-233
    • Uchino, H.1    Minamikawa-Tachino, R.2    Kristian, T.3    Perkins, G.4    Narazaki, M.5    Siesjo, B.K.6    Shibasaki, F.7
  • 43
    • 0035882151 scopus 로고    scopus 로고
    • Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia
    • 10.1016/S0306-4522(01)00225-1. 11516824
    • Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia. K Miyata N Omori H Uchino T Yamaguchi A Isshiki F Shibasaki, Neuroscience 2001 105 571 578 10.1016/S0306-4522(01)00225-1 11516824
    • (2001) Neuroscience , vol.105 , pp. 571-578
    • Miyata, K.1    Omori, N.2    Uchino, H.3    Yamaguchi, T.4    Isshiki, A.5    Shibasaki, F.6
  • 44
    • 61849142791 scopus 로고    scopus 로고
    • Calcium signaling and neurodegenerative diseases
    • 10.1016/j.molmed.2009.01.001. 19230774
    • Calcium signaling and neurodegenerative diseases. I Bezprozvanny, Trends Mol Med 2009 15 89 100 10.1016/j.molmed.2009.01.001 19230774
    • (2009) Trends Mol Med , vol.15 , pp. 89-100
    • Bezprozvanny, I.1
  • 46
    • 0037775906 scopus 로고    scopus 로고
    • Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: Implications for Huntington's disease
    • 12832525
    • Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease. N Bizat JM Hermel F Boyer C Jacquard C Creminon S Ouary C Escartin P Hantraye S Kajewski E Brouillet, J Neurosci 2003 23 5020 5030 12832525
    • (2003) J Neurosci , vol.23 , pp. 5020-5030
    • Bizat, N.1    Hermel, J.M.2    Boyer, F.3    Jacquard, C.4    Creminon, C.5    Ouary, S.6    Escartin, C.7    Hantraye, P.8    Kajewski, S.9    Brouillet, E.10
  • 47
    • 0037096376 scopus 로고    scopus 로고
    • Calpain activation in Huntington's disease
    • 12077181
    • Calpain activation in Huntington's disease. J Gafni LM Ellerby, J Neurosci 2002 22 4842 4849 12077181
    • (2002) J Neurosci , vol.22 , pp. 4842-4849
    • Gafni, J.1    Ellerby, L.M.2
  • 48
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • 10.1016/S0092-8674(00)81782-1. 9778247
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. F Saudou S Finkbeiner D Devys ME Greenberg, Cell 1998 95 55 66 10.1016/S0092-8674(00)81782-1 9778247
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 49
    • 0029055601 scopus 로고
    • Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
    • 10.1038/ng0595-104. 7647777
    • Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Y Trottier D Devys G Imbert F Saudou I An Y Lutz C Weber Y Agid EC Hirsch JL Mandel, Nat Genet 1995 10 104 110 10.1038/ng0595-104 7647777
    • (1995) Nat Genet , vol.10 , pp. 104-110
    • Trottier, Y.1    Devys, D.2    Imbert, G.3    Saudou, F.4    An, I.5    Lutz, Y.6    Weber, C.7    Agid, Y.8    Hirsch, E.C.9    Mandel, J.L.10
  • 50
    • 0034163497 scopus 로고    scopus 로고
    • Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock- in mice
    • 10.1093/hmg/9.4.503. 10699173
    • Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock- in mice. VC Wheeler JK White CA Gutekunst V Vrbanac M Weaver XJ Li SH Li H Yi JP Vonsattel JF Gusella, et al. Hum Mol Genet 2000 9 503 513 10.1093/hmg/9.4.503 10699173
    • (2000) Hum Mol Genet , vol.9 , pp. 503-513
    • Wheeler, V.C.1    White, J.K.2    Gutekunst, C.A.3    Vrbanac, V.4    Weaver, M.5    Li, X.J.6    Li, S.H.7    Yi, H.8    Vonsattel, J.P.9    Gusella, J.F.10


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