Cystamine inhibits caspase activity: Implications for the treatment of polyglutamine disorders

Journal of Biological Chemistry

Volumn 278, Issue 6, 2003, Pages 3825-3830

  Lesort, Mathieu ^a   Lee, Matthew ^b   Tucholski, Janusz ^b   Johnson, Gail V W ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELLS; TISSUE;

PRO-APOPTOTIC AGENTS;

ENZYME INHIBITION;

ANTIOXIDANT; CASPASE; CASPASE 3; CYSTAMINE; GLUTATHIONE; MUTANT PROTEIN; POLYGLUTAMINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RECOMBINANT ENZYME; THIOL; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CYSTEINE PROTEINASE INHIBITOR; HYDROGEN PEROXIDE; PEPTIDE;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL LEVEL; CELL LINE; CELL LYSATE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IC 50; IN VITRO STUDY; MITOCHONDRION; NERVE CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SURVIVAL RATE; WILD TYPE; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM;

CASPASE 3; CASPASES; CYSTAMINE; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; HUMANS; HUNTINGTON DISEASE; HYDROGEN PEROXIDE; PEPTIDES; TUMOR CELLS, CULTURED;

EID: 0037423204     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205812200     Document Type: Article

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