Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery

Pharmacological Research

Volumn 52, Issue 2, 2005, Pages 133-139

  Zuccato, Chiara ^a   Liber, Daniel ^a   Ramos, Catarina ^a   Tarditi, Alessia ^a   Rigamonti, Dorotea ^a   Tartari, Marzia ^a   Valenza, Marta ^a   Cattaneo, Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

BDNF; Huntingtin; R6 2 mice

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; EXON; GENE MUTATION; HUNTINGTON CHOREA; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION;

ALTERNATIVE SPLICING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; RNA, MESSENGER;

EID: 20444456571     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.01.001     Document Type: Article

References (41)

1. A. Reiner, R.L. Albin, K.D. Anderson, C.J. D'Amato, J.B. Penney, and A.B. Young Differential loss of striatal projection neurons in Huntington disease Proc Natl Acad Sci USA 85 15 1988 5733 5737
2. The Huntington's Disease Collaborative Research Group Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 6 1993 971 983
3. S. Sipione, and E. Cattaneo Modeling Huntington's disease in cells, flies, and mice Mol Neurobiol 23 1 2001 21 51
4. Goffredo D, Rigamonti D, Zuccato C, Tartari M, Valenza M, Cattaneo E. Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's disease. Pharmacol Res, in press.
5. E. Cattaneo, D. Rigamonti, D. Goffredo, C. Zuccato, F. Squitieri, and S. Sipione Loss of normal huntingtin function: new developments in Huntington's disease research Trends Neurosci 24 3 2001 182 188
6. C. Zuccato, A. Ciammola, D. Rigamonti, B.R. Leavitt, D. Goffredo, and L. Conti Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 5529 2001 493 498
7. F.R. Fusco, Q. Chen, W.J. Lamoreaux, G. Figueredo-Cardenas, Y. Jiao, and J.A. Coffman Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease J Neurosci 19 4 1999 1189 1202
8. F.R. Fusco, C. Zuccato, M. Tartari, A. Martorana, Z. De March, and C. Giampa Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain Eur J Neurosci 18 5 2003 1093 1102
9. L.R. Gauthier, B.C. Charrin, M. Borrell-Pages, J.P. Dompierre, H. Rangone, and F.P. Cordelieres Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules Cell 118 1 2004 127 138
10. T. Timmusk, K. Palm, M. Metsis, T. Reintam, V. Paalme, and M. Saarma Multiple promoters direct tissue-specific expression of the rat BDNF gene Neuron 10 3 1993 475 489
11. T. Timmusk, U. Lendahl, H. Funakoshi, E. Arenas, H. Persson, and M. Metsis Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice J Cell Biol 128 1/2 1995 185 199
12. M. Metsis, T. Timmusk, E. Arenas, and H. Persson Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation Proc Natl Acad Sci USA 90 19 1993 8802 8806
13. L. Mangiarini, K. Sathasivam, M. Seller, B. Cozens, A. Harper, and C. Hetherington Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice Cell 87 3 1996 493 506
14. L.A. Lione, R.J. Carter, M.J. Hunt, G.P. Bates, A.J. Morton, and S.B. Dunnett Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation J Neurosci 19 23 1999 10428 10437
15. C. Zuccato, M. Tartari, A. Crotti, D. Goffredo, M. Valenza, and L. Conti Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes Nat Genet 35 1 2003 76 83
16. I. Ferrer, E. Goutan, C. Marin, M.J. Rey, and T. Ribalta Brain-derived neurotrophic factor in Huntington disease Brain Res 866 1/2 2000 257 261
17. S. Gines, I.S. Seong, E. Fossale, E. Ivanova, F. Trettel, and J.F. Gusella Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice Hum Mol Genet 12 5 2003 497 508
18. G. Marsicano, S. Goodenough, K. Monory, H. Hermann, M. Eder, and A. Cannich CB1 cannabinoid receptors and on-demand defense against excitotoxicity Science 302 5642 2003 84 88
19. Z.C. Baquet, J.A. Gorski, and K.R. Jones Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor J Neurosci 24 17 2004 4250 4258
20. R.J. Carter, L.A. Lione, T. Humby, L. Mangiarini, A. Mahal, and G.P. Bates Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation J Neurosci 19 8 1999 3248 3257
21. K. Schmidtke, H. Manner, R. Kaufmann, and H. Schmolck Cognitive procedural learning in patients with fronto-striatal lesions Learn Mem 9 6 2002 419 429
22. Y. Zhang, M. Li, M. Drozda, M. Chen, S. Ren, and R.O. Mejia Sanchez Depletion of wild-type huntingtin in mouse models of neurologic diseases J Neurochem 87 1 2003 101 106
23. J.S. Steffan, A. Kazantsev, O. Spasic-Boskovic, M. Greenwald, Y.Z. Zhu, and H. Gohler The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription Proc Natl Acad Sci USA 97 12 2000 6763 6768
24. F.C. Nucifora Jr., M. Sasaki, M.F. Peters, H. Huang, J.K. Cooper, and M. Yamada Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity Science 291 5512 2001 2423 2428
25. F. Saudou, S. Finkbeiner, D. Devys, and M.E. Greenberg Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions Cell 95 1 1998 55 66
26. E. Perez-Navarro, A.M. Canudas, P. Akerund, J. Alberch, and E. Arenas Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease J Neurochem 75 5 2000 2190 2199
27. J. Alberch, E. Perez-Navarro, and J.M. Canals Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease Brain Res Bull 57 6 2002 817 822
28. A.P. Kells, D.M. Fong, M. Dragunow, M.J. During, D. Young, and B. Connor AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease Mol Ther 9 5 2004 682 688
29. J.M. Canals, J.R. Pineda, J.F. Torres-Peraza, M. Bosch, R. Martin-Ibanez, and M.T. Munoz Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease J Neurosci 24 35 2004 7727 7739
30. S.S. Gill, N.K. Patel, G.R. Hotton, K. O'Sullivan, R. McCarter, and M. Bunnage Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease Nat Med 9 5 2003 589 595
31. D. Zala, J.C. Bensadoun, L. Pereira de Almeida, B.R. Leavitt, C.A. Gutekunst, and P. Aebischer Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice Exp Neurol 185 1 2004 26 35
32. Zuccato C, Conti L, Reitano E, Tartari M, Cattaneo E. The function of the neuronal proteins Shc and huntingtin in stem cells and neurons and their pharmacological exploitation for human diseases. Ann N Y Acad Sci, in press.
33. P. Aebischer, M. Schluep, N. Deglon, J.M. Joseph, L. Hirt, and B. Heyd Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients Nat Med 2 6 1996 696 699
34. R.D. Penn, J.S. Kroin, M.M. York, and J.M. Cedarbaum Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial) Neurosurgery 40 1 1997 99 100 94-9; discussion
35. G. Ochs, R.D. Penn, M. York, R. Giess, M. Beck, and J. Tonn A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis Amyotroph Lateral Scler Other Motor Neuron Disord 1 3 2000 201 206
36. A.C. Bachoud-Levi, N. Deglon, J.P. Nguyen, J. Bloch, C. Bourdet, and L. Winkel Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF Hum Gene Ther 11 12 2000 1723 1729
37. J. Bloch, A.C. Bachoud-Levi, N. Deglon, J.P. Lefaucheur, L. Winkel, and S. Palfi Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study Hum Gene Ther 15 10 2004 968 975
38. J.A. Chong, J. Tapia-Ramirez, S. Kim, J.J. Toledo-Aral, Y. Zheng, and M.C. Boutros REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons Cell 80 6 1995 949 957
39. C.J. Schoenherr, and D.J. Anderson The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes Science 267 5202 1995 1360 1363
40. C.J. Schoenherr, A.J. Paquette, and D.J. Anderson Identification of potential target genes for the neuron-restrictive silencer factor Proc Natl Acad Sci USA 93 18 1996 9881 9886
41. J.K. Ryu, J. Kim, S.J. Cho, K. Hatori, A. Nagai, and H.B. Choi Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease Neurobiol Dis 16 1 2004 68 77