Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

European Journal of Neuroscience

Volumn 23, Issue 3, 2006, Pages 649-658

  Ginés, Silvia ^a   Bosch, Miquel ^a   Marco, Sonia ^a   Gavaldà, Núria ^a   Díaz Hernández, Miguel ^b   Lucas, José J ^b   Canals, Josep M ^a   Alberch, Jordi ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Huntingtin; Huntington's disease brain; Neurodegenerative disease; Neuroprotection; Neurotrophic factor; Striatum

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN PROTEIN; HUNTINGTIN; MUTANT PROTEIN; POLYGLUTAMINE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN; BRAIN LEVEL; CAUDATE NUCLEUS; CONTROLLED STUDY; DISEASE MODEL; EXON; FEMALE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; KNOCKOUT MOUSE; MALE; MOTOR CORTEX; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION; TRANSGENIC MOUSE;

ADULT; AGED; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXONS; GENE EXPRESSION REGULATION; HUMANS; HUNTINGTON DISEASE; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; POSTMORTEM CHANGES; RECEPTOR, TRKB; RNA, MESSENGER;

EID: 33644956205     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.04590.x     Document Type: Article

References (52)

1. Agerman K. Hjerling-Leffler J. Blanchard MP. Scarfone E. Canlon B. Nosrat C. Ernfors P. 2003 BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development Development 130 1479 1491
2. Alberch J. Perez-Navarro E. Canals JM. 2002 Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease Brain ResBull 57 817 822
3. Alberch J. Perez-Navarro E. Canals JM. 2004 Neurotrophic factors in Huntington's disease ProgBrain Res 146 195 229
4. Allen SJ. Wilcock GK. Dawbarn D. 1999 Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease BiochemBiophysResCommun 264 648 651
5. Canals JM. Marco S. Checa N. Michels A. Perez-Navarro E. Arenas E. Alberch J. 1998 Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease NeurobiolDis 5 357 364
6. Canals JM. Checa N. Marco S. Michels A. Perez-Navarro E. Alberch J. 1999 The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum Brain ResMolBrain Res 69 242 248
7. Canals JM. Checa N. Marco S. Akerud P. Michels A. Perez-Navarro E. Tolosa E. Arenas E. Alberch J. 2001 Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area JNeurosci 21 117 124
8. Canals JM. Pineda JR. Torres-Peraza JF. Bosch M. Martin-Ibanez R. Munoz MT. Mengod G. Ernfors P. Alberch J. 2004 Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease JNeurosci 24 7727 7739
9. Checa N. Canals JM. Alberch J. 2000 Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections ExpNeurol 165 118 124
10. Checa N. Canals JM. Gratacos E. Alberch J. 2001 TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia ExpNeurol 172 282 292
11. Chiang MC. Lee YC. Huang CL. Chern Y. 2005 cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues JBiolChem 280 14 331 14 340
12. Connor B. Young D. Lawlor P. Gai W. Waldvogel H. Faull RLM. Dragunow M. 1996 Trk receptor alterations in Alzheimer's disease MolBrain Res 42 1 17
13. Connor B. Young D. Yan Q. Faull RLM. Synek B. Dragunow M. 1997 Brain-derived neurotrophic factor is reduced in Alzheimer's disease MolBrain Res 49 71 81
14. Deogracias R. Espliguero G. Iglesias T. Rodriguez-Pena A. 2004 Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons MolCell Neurosci 26 470 480
15. Diaz-Hernandez Moreno-Herrero F. Gomez-Ramos P. Moran MA. Ferrer I. Baro AM. Avila J. Hernandez F. Lucas JJ. 2004 Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain JNeurosci 24 42 9361 9371
16. DiFiglia M. 1997 Clinical genetics, II. Huntington's disease: from the gene to pathophysiology AmJPsychiat 154 1046
17. Dragunow M. Hughes P. Mason-Parker SE. Lawlor P. Abraham WC. 1997 TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation MolBrain Res 46 274 280
18. Ferrer I. Marin C. Rey MJ. Ribalta T. Goutan E. Blanco R. Tolosa E. Marti E. 1999 BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies JNeuropatholExpNeurol 58 729 739
19. Ferrer I. Goutan E. Marin C. Rey MJ. Ribalta T. 2000 Brain-derived neurotrophic factor in Huntington disease Brain Res 866 257 261
20. Freeman AY. Soghomonian JJ. Pierce RC. 2003 Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine Neuroscience 117 147 156
21. Gauthier LR. Charrin BC. Borrell-Pages M. Dompierre JP. Rangone H. Cordelieres FP. De Mey J. MacDonald ME. Lessmann V. Humbert S. Saudou F. 2004 Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules Cell 118 127 138
22. Gines S. Seong IS. Fossale E. Ivanova E. Trettel F. Gusella JF. Wheeler VC. Persichetti F. MacDonald ME. 2003 Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice HumMolGenet 12 497 508
23. Giordano M. Takashima H. Herranz A. Poltorak M. Séller HM. Marone M. Freed WJ. 1993 Immortalized GABAergic cell lines derived from rat striatum using a temperature-sensitive allele of the SV40 large T antigen ExpNeurol 124 95 400
24. Huntington's Disease Collaborative Research Group 1993 A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosome Cell 72 971 983
25. Kazantsev A. Preisinger E. Dranovsky A. Goldgaber D. Housman D. 1999 Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells ProcNatl AcadSciUSA 96 11 404 11 409
26. Klein R. Conway D. Parada LF. Barbacid M. 1990 The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain Cell 61 647 656
27. Klein R. Nanduri V. Jing SA. Lamballe F. Tapley P. Bryant S. Cordon-Cardo C. Jones KR. Reichardt LF. Barbacid M. 1991 The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 Cell 66 395 403
28. Kokaia Z. Metsis M. Kokaia M. Elmer E. Lindvall O. 1995 Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins Neuroreport 6 769 772
29. Laprade N. Soghomonian JJ. 1997 Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons Brain ResMolBrain Res 48 333 345
30. Lindvall O. Ernfors P. Bengzon J. Kokaia Z. Smith ML. Siesjo BK. Persson H. 1992 Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma ProcNatl AcadSciUSA 89 648 652
31. Luthi-Carter R. Strand A. Peters NL. Solano SM. Hollingsworth ZR. Menon AS. Frey AS. Spektor BS. Penney EB. Schilling G. Ross CA. Borchelt DR. Tapscott SJ. Young AB. Cha JH. Olson JM. 2000 Decreased expression of striatal signaling genes in a mouse model of Huntington's disease HumMolGenet 9 1259 1271
32. Macdonald V. Halliday G. 2002 Pyramidal cell loss in motor cortices in Huntington's disease NeurobiolDis 10 378 386 q14
33. Mangiarini L. Sathasivam K. Seller M. Cozens B. Harper A. Hetherington C. Lawton M. Trottier Y. Lehrach H. Davies SW. Bates GP. 1996 Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice Cell 87 493 506
34. Merlio JP. Ernfors P. Jaber M. Persson H. 1992 Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system Neuroscience 51 513 532
35. Miyashita T. Tabuchi A. Fukuchi M. Hara D. Kisukeda T. Shimohata T. Tsuji S. Tsuda M. 2005 Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons BiochemBiophysResCommun 333 1241 1248
36. Perez-Navarro E. Alberch J. Neveu I. Arenas E. 1999 Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo Neuroscience 91 1257 1264
37. Perez-Navarro E. Canudas AM. Akerund P. Alberch J. Arenas E. 2000 Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease JNeurochem 75 2190 2199
38. Pineda JR. Canals JM. Bosch M. Adell A. Mengod G. Artigas F. Ernfors P. Alberch J. 2005 Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease JNeurochem 93 5 1057 1068
39. Savaskan E. Muller-Spahn F. Olivieri G. Bruttel S. Otten U. Rosenberg C. Hulette C. Hock C. 2000 Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease EurNeurol 44 172 180
40. Sommerfeld MT. Schweigreiter R. Barde YA. Hoppe E. 2000 Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB JBiolChem 275 12 8982 8990
41. Soontornniyomkij V. Wang G. Pittman CA. Hamilton RL. Wiley CA. Achim CL. 1999 Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease Acta Neuropathol(Berl) 98 345 348
42. Sugars KL. Brown R. Cook LJ. Swartz J. Rubinsztein DC. 2004 Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis JBiolChem 279 4988 4999
43. Takeda A. Onodera H. Sugimoto A. Kogure K. Obinata M. Shibahara S. 1993 Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia Neuroscience 55 23 31
44. Q111 striatal cells HumMolGenet 9 2799 2809
45. Vonsattel JP. DiFiglia M. 1998 Huntington disease JNeuropatholExpNeurol 57 369 384
46. Vonsattel JP. Myers RH. Stevens TJ. Ferrante RJ. Bird ED. Richardson EP. Jr. 1985 Neuropathological classification of Huntington's disease JNeuropatholExpNeurol 44 559 577
47. Wheeler VC. Auerbach W. White JK. Srinidhi J. Auerbach A. Ryan A. Duyao MP. Vrbanac V. Weaver M. Gusella JF. Joyner AL. MacDonald ME. 1999 Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse HumMolGenet 8 115 122
48. Wheeler VC. White JK. Gutekunst CA. Vrbanac V. Weaver M. Li XJ. Li SH. Yi H. Vonsattel JP. Gusella JF. Hersch S. Auerbach W. Joyner AL. MacDonald ME. 2000 Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice HumMolGenet 9 503 513
49. Wheeler VC. Gutekunst CA. Vrbanac V. Lebel LA. Schilling G. Hersch S. Friedlander RM. Gusella JF. Vonsattel JP. Borchelt DR. MacDonald ME. 2002 Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice HumMolGenet 11 633 640
50. Wyttenbach A. Swartz J. Kita H. Thykjaer T. Carmichael J. Bradley J. Brown R. Maxwell M. Schapira A. Orntoft TF. Kato K. Rubinsztein DC. 2001 Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease HumMolGenet 10 1829 1845
51. Yamamoto A. Lucas JJ. Hen R. 2000 Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease Cell 101 57 66
52. Zuccato C. Ciammola A. Rigamonti D. Leavitt BR. Goffredo D. Conti L. MacDonald ME. Friedlander RM. Silani V. Hayden MR. Timmusk T. Sipione S. Cattaneo E. 2001 Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 493 498