Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Journal of Neuroscience

Volumn 24, Issue 9, 2004, Pages 2270-2276

  Spires, Tara L ^a,b   Grote, Helen E ^a   Varshney, Neelash K ^a   Cordery, Patricia M ^a   Van Dellen, Anton ^a   Blakemore, Colin ^a   Hannan, Anthony J ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

BDNF; DARPP 32; Environmental enrichment; Huntington's disease; NGF; R6 1; Transgenic mouse model

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN PROTEIN; DOPAMINE; NERVE GROWTH FACTOR; PHOSPHOPROTEIN DARPP 32;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; ENVIRONMENT; HIPPOCAMPUS; HUNTINGTON CHOREA; MOLECULAR BIOLOGY; MOTOR ACTIVITY; MOUSE; NEOSTRIATUM; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; SYMPTOM; TRANSGENE; TRANSGENIC MOUSE; WEIGHT REDUCTION; WESTERN BLOTTING;

AGE FACTORS; ANIMALS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; ENVIRONMENT; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; MOVEMENT DISORDERS; NEOSTRIATUM; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGAN SIZE; PHOSPHOPROTEINS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 1542286877     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1658-03.2004     Document Type: Article

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