Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease

Neurobiology of Disease

Volumn 24, Issue 2, 2006, Pages 280-285

  Kishikawa, Shotaro ^a   Li, Jian Liang ^b   Gillis, Tammy ^a   Hakky, Michael M ^a   Warby, Simon ^c   Hayden, Michael ^c,d   MacDonald, Marcy E ^a,d   Myers, Richard H ^b   Gusella, James F ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Huntington's Disease Society of America Coalition for the Cure Team 5: Huntingtin Normal Function   (United States)

Author keywords

Age at onset; Brain derived neurotrophic factor (BDNF); Functional polymorphism; Genetic modifier; Huntington's disease (HD)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; HUNTINGTON CHOREA; INTRON; MAJOR CLINICAL STUDY; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA MUTATIONAL ANALYSIS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETIC TESTING; GENOTYPE; HAPLOTYPES; HUNTINGTON DISEASE; INTRONS; METHIONINE; POLYMORPHISM, SINGLE NUCLEOTIDE; TRINUCLEOTIDE REPEAT EXPANSION; VALINE;

EID: 33749988016     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.07.008     Document Type: Article

References (44)

1. Alberch J., Lo'pez M., Badenas C., Carrasco J.L., Mila M., Munoz E., and Canals J.M. Association between BDNF Val66Met polymorphism and age at onset in Huntington disease. Neurology 65 (2005) 964-965
2. Bedard A., Gravel C., and Parent A. Chemical characterization of newly generated neurons in the striatum of adult primates. Exp. Brain Res. 170 (2006) 501-512
3. Bueller J.A., Aftab M., Sen S., Gomez-Hassen D., Burmeister M., and Zubieta J.K. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol. Psychiatry 59 (2006) 812-815
4. Chattopadhyay B., Ghosh S., Gangopadhyay P.K., Das S.K., Roy T., Sinha K.K., Jha D.K., Mukherjee S.C., Chakraborty A., Singhal B.S., Bhattacharya A.K., and Bhattacharyya N.P. Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India. Neurosci. Lett. 345 (2003) 93-96
5. Chen Z.Y., Patel P.D., Sant G., Meng C.X., Teng K.K., Hempstead B.L., and Lee F.S. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J. Neurosci. 24 (2004) 4401-4411
6. Cheng C.Y., Hong C.J., Yu Y.W., Chen T.J., Wu H.C., and Tsai S.J. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res. Mol. Brain Res. 140 (2005) 86-90
7. Desai P., Nebes R., DeKosky S.T., and Kamboh M.I. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci. Lett. 379 (2005) 229-234
8. Di Maria, E., Marasco, A., Tartari, M., Ciotti, P., Abbruzzese, G., Novelli, G., Bellone, E., Cattaneo, E., Mandich, P., in press. No evidence of association between BDNF gene variants and age at onset in Huntington's disease. Neurobiol. Dis.
9. Djoussé' L., Knowlton B., Hayden M., Almqvist E.W., Brinkman R., Ross C., Margolis R., Rosenblatt A., Durr A., Dode C., Morrison P.J., Novelletto A., Frontali M., Trent R.J., McCusker E., Gomez-Tortosa E., Mayo D., Jones R., Zanko A., Nance M., Abramson R., Suchowersky O., Paulsen J., Harrison M., Yang Q., Cupples L.A., Gusella J.F., MacDonald M.E., and Myers R.H. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am. J. Med. Genet., A 119 (2003) 279-282
10. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., Lu B., and Weinberger D.R. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
11. Gauthier L.R., Charrin B.C., Borrell-Pages M., Dompierre J.P., Rangone H., Cordelieres F.P., De Mey J., MacDonald M.E., Lessmann V., Humbert S., and Saudou F. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118 (2004) 127-138
12. Gusella J.F., and MacDonald M.E. Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nat. Rev., Neurosci. 1 (2000) 0.109-0.115
13. Gusella J., and MacDonald M.E. No post-genetics era in human disease research. Nat. Rev., Genet. 3 (2002) 72-79
14. Hariri A.R., Goldberg T.E., Mattay V.S., Kolachana B.S., Callicott J.H., Egan M.F., and Weinberger D.R. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J. Neurosci. 23 (2003) 6690-6694
15. Harris S.E., Fox H., Wright A.F., Hayward C., Starr J.M., Whalley L.J., and Deary I.J. The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Mol. Psychiatry 11 (2006) 505-513
16. Horvath S., Xu X., Lake S.L., Silverman E.K., Weiss S.T., and Laird N.M. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet. Epidemiol. 26 (2004) 61-69
17. Hwang J.P., Tsai S.J., Hong C.J., Yang C.H., Lirng J.F., and Yang Y.M. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol. Aging (2005) (2005 Dec 9; electronic publication ahead of print)
18. Ivkovic S., and Ehrlich M.E. Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro. J. Neurosci. 19 (1999) 5409-5419
19. Karamohamed S., Latourelle J.C., Racette B.A., Perlmutter J.S., Wooten G.F., Lew M., Klein C., Shill H., Golbe L.I., Mark M.H., Guttman M., Nicholson G., Wilk J.B., Saint-Hilaire M., DeStefano A.L., Prakash R., Tobin S., Williamson J., Suchowersky O., Labell N., Growdon B.N., Singer C., Watts R., Goldwurm S., Pezzoli G., Baker K.B., Giroux M.L., Pramstaller P.P., Burn D.J., Chinnery P., Sherman S., Vieregge P., Litvan I., Gusella J.F., Myers R.H., and Parsian A. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD study. Neurology 65 (2005) 1823-1825
20. Kleim J.A., Chan S., Pringle E., Schallert K., Procaccio V., Jimenez R., and Cramer S.C. BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nat. Neurosci. 9 (2006) 735-737
21. Kunugi H., Ueki A., Otsuka M., Isse K., Hirasawa H., Kato N., Nabika T., Kobayashi S., and Nanko S. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol. Psychiatry 6 (2001) 83-86
22. Li J.L., Hayden M.R., Almqvist E.W., Brinkman R.R., Durr A., Dode C., Morrison P.J., Suchowersky O., Ross C.A., Margolis R.L., Rosenblatt A., Gomez-Tortosa E., Cabrero D.M., Novelletto A., Frontali M., Nance M., Trent R.J., McCusker E., Jones R., Paulsen J.S., Harrison M., Zanko A., Abramson R.K., Russ A.L., Knowlton B., Djousse L., Mysore J.S., Tariot S., Gusella M.F., Wheeler V.C., Atwood L.D., Cupples L.A., Saint-Hilaire M., Cha J.H., Hersch S.M., Koroshetz W.J., Gusella J.F., MacDonald M.E., and Myers R.H. A genome scan for modifiers of age at onset in Huntington disease: the HD MAPS study. Am. J. Hum. Genet. 73 (2003) 682-687
23. Liu Q.-R., Walther D., Drgon T., Polesskaya O., Lesnick T.G., Strain K.J., de Andrade M., Bower J.H., Maraganore D.M., and Uhl G.R. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's disease. Am. J. Med. Genet., B Neuropsychiatr. Genet. 134B (2005) 93-103
24. Lohoff F.W., Sander T., Ferraro T.N., Dahl J.P., Gallinat J., and Berrettini W.H. Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am. J. Med. Genet., B Neuropsychiatr. Genet. 139 (2005) 51-53
25. MacDonald M.E., Vonsattel J.P., Srinidhi J., Couropmitree N.N., Cupples L.A., Bird E.D., Gusella J.F., and Myers R.H. Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. Neurology 53 (1999) 1330-1332
26. Metzger S., Bauer P., Tomiuk J., Laccone F., Didonato S., Gellera C., Soliveri P., Lange H.W., Weirich-Schwaiger H., Wenning G.K., Melegh B., Havasi V., Baliko L., Wieczorek S., Arning L., Zaremba J., Sulek A., Hoffman-Zacharska D., Basak A.N., Ersoy N., Zidovska J., Kebrdlova V., Pandolfo M., Ribai P., Kadasi L., Kvasnicova M., Weber B.H., Kreuz F., Dose M., Stuhrmann M., and Riess O. The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington's disease. Neurogenetics 7 (2006) 27-30
27. Nakao N., Brundin P., Funa K., Lindvall O., and Odin P. Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro. Brain Res. Dev. Brain Res. 90 (1995) 92-101
28. Naze P., Vuillaume I., Destee A., Pasquier F., and Sablonniere B. Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease. Neurosci. Lett. 328 (2002) 1-4
29. Nemoto K., Ohnishi T., Mori T., Moriguchi Y., Hashimoto R., Asada T., and Kunugi H. The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neurosci. Lett. 397 (2006) 25-29
30. Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., and Kennedy J.L. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am. J. Hum. Genet. 71 (2002) 651-655
31. Neves-Pereira M., Cheung J.K., Pasdar A., Zhang F., Breen G., Yates P., Sinclair M., Crombie C., Walker N., and St Clair D.M. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol. Psychiatry 10 (2005) 208-212
32. Numata S., Ueno S., Iga J., Yamauchi K., Hongwei S., Ohta K., Kinouchi S., Shibuya-Tayoshi S., Tayoshi S., Aono M., Kameoka N., Sumitani S., Tomotake M., Kaneda Y., Taniguchi T., Ishimoto Y., and Ohmori T. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci. Lett. 401 (2006) 1-5
33. Olin D., MacMurray J., and Comings D.E. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci. Lett. 381 (2005) 275-278
34. Oroszi G., Lapteva L., Davis E., Yarboro C.H., Weickert T., Roebuck T., Bleiberg J., Rosenstein D., Pao M., Lipsky P.E., Goldman D., Lipsky R.H., and Illei G.G. The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus (SLE). Ann. Rheum. Dis. (2006) (2006 Apr 10; Epub ahead of print)
35. Rosenblatt A., Liang K.Y., Zhou H., Abbott M.H., Gourley L.M., Margolis R.L., Brandt J., and Ross C.A. The association of CAG repeat length with clinical progression in Huntington disease. Neurology 66 (2006) 1016-1020
36. Rubinsztein D.C., Leggo J., Chiano M., Dodge A., Norbury G., Rosser E., and Craufurd D. Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 3872-3876
37. Strauss J., Barr C.L., George C.J., Delvin B., Vetro A., Kiss E., Baji I., King N., Shaikh S., Lanktree M., Kovacs M., and Kennedy J.L. Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample. Mol. Psychiatry 10 (2005) 861-867
38. Szeszko P.R., Lipsky R., Mentschel C., Robinson D., Gunduz-Bruce H., Sevy S., Ashtari M., Napolitano B., Bilder R.M., Kane J.M., Goldman D., and Malhotra A.K. Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol. Psychiatry 10 (2005) 631-636
39. Tsai S.J., Hong C.J., Liu H.C., Liu T.Y., and Liou Y.J. The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population. Dement. Geriatr. Cogn. Disord. 21 (2006) 139-143
40. Ventimiglia R., Mather P.E., Jones B.E., and Lindsay R.M. The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur. J. Neurosci. 7 (1995) 213-222
41. Wexler N.S., Lorimer J., Porter J., Gomez F., Moskowitz C., Shackell E., Marder K., Penchaszadeh G., Roberts S.A., Gayan J., Brocklebank D., Cherny S.S., Cardon L.R., Gray J., Dlouhy S.R., Wiktorski S., Hodes M.E., Conneally P.M., Penney J.B., Gusella J., Cha J.H., Irizarry M., Rosas D., Hersch S., Hollingsworth Z., MacDonald M., Young A.B., Andresen J.M., Housman D.E., De Young M.M., Bonilla E., Stillings T., Negrette A., Snodgrass S.R., Martinez-Jaurrieta M.D., Ramos-Arroyo M.A., Bickham J., Ramos J.S., Marshall F., Shoulson I., Rey G.J., Feigin A., Arnheim N., Acevedo-Cruz A., Acosta L., Alvir J., Fischbeck K., Thompson L.M., Young A., Dure L., O'Brien C.J., Paulsen J., Brickman A., Krch D., Peery S., Hogarth P., Higgins D.S., and Landwehrmeyer B. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3498-3503
42. Zhang H., Ozbay F., Lappalainen J., Kranzler H.R., van Dyck C.H., Charney D.S., Price L.H., Southwick S., Yang B.Z., Rasmussen A., and Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am. J. Med. Genet. B Neuropyschiatr. Genet. 141 (2006) 387-393
43. Zuccato C., Ciammola A., Rigamonti D., Leavitt B.R., Goffredo D., Conti L., MacDonald M.E., Friedlander R.M., Silani V., Hayden M.R., Timmusk T., Sipione S., and Cattaneo E. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293 (2001) 493-498
44. Zuccato C., Tartari M., Crotti A., Goffredo D., Valenza M., Conti L., Cataudella T., Leavitt B.R., Hayden M.R., Timmusk T., Rigamonti D., and Cattaneo E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35 (2003) 76-83