Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury

Journal of Molecular Neuroscience

Volumn 16, Issue 1, 2001, Pages 1-12

  Duan, W ^a   Lee, J ^a   Guo, Z ^a   Mattson, M P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Apoptosis; BDNF; Caloric restriction; Cerebral cortex; Epileptic seizures; Glutamate

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CALORIC RESTRICTION; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; DIET RESTRICTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIFESPAN; MALE; NERVE CELL PLASTICITY; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SEIZURE; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; ANTIBODIES; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CEREBRAL CORTEX; EPILEPSY; FOOD DEPRIVATION; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; NEOSTRIATUM; NERVE GROWTH FACTOR; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

ANIMALIA; RODENTIA;

EID: 0035030699     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:16:1:1     Document Type: Article

References (51)

1. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain
2. Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer
3. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemispheric communication
4. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults
5. Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex
6. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults
7. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
8. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease
9. Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of mouse
10. Caloric restriction increases the expression of heat shock protein in the gut
11. Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression
12. Requirement for BDNF in activity-dependent survival of cortical neurons
13. Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats
14. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a presenilin-1 mutation
15. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
16. Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1
17. Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma
18. Dietary restriction: Effects on radial maze learning and lipofuscin pigment deposition in the hippocampus and frontal cortex
19. Dietary restriction benefits learning and motor performance of aged mice
20. Role of brain-derived neurotrophic factor and presynaptic proteins in passive avoidance learning in day-old domestic chicks
21. A role for BDNF in the late-phase of hippocampal long-term potentiation
22. Influence of caloric intake on experimental carcinogenesis: A review
23. Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats
24. Early induction of mRNA for calbindin-D28k and BDNF but not NT-3 in rat hippocampus after kainic acid treatment
25. 2-deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Involvement of stress proteins
26. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
27. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma
28. Programmed cell life: Anti-apoptotic signaling and therapeutic strategies for neurodegenerative disorders
29. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
30. Increased transcription of the astrocyte gene GFAP during middle age is attenuated by food restriction: Implications for the role of oxidative stress
31. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
32. Exercise and brain neurotrophins
33. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
34. Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
35. Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia
36. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective
37. Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP
38. In situ hybridization approaches to the study of the nervous system
39. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: Selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway
40. Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits
41. Oxidative stress, caloric restriction, and aging
42. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
43. The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes
44. Effect of intermittent feeding on thermoregulatory abilities of young and aged C57BL/6J mice
45. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells
46. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced parkinsonism in monkeys
47. The beneficial effects of dietary restriction: Reduced oxidative damage and enhanced apoptosis
48. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
49. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
50. Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism
51. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation