-
1
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
Huntington's Disease Collaborative Research Group
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
4
-
-
0027432418
-
Widespread expression of the human and rat Huntington's disease gene in brain and nonneuronal tissues
-
(1993)
Nat. Genet
, vol.5
, pp. 259-265
-
-
Strong, T.V.1
Tagle, D.A.2
Valdes, J.M.3
Elmer, L.W.4
Boehm, K.5
Swaroop, M.6
Kaatz, K.7
Collins, F.S.8
Albin, R.L.9
-
5
-
-
0029034511
-
Widespread expression of Huntington's disease gene (IT15) protein product
-
(1995)
Neuron
, vol.14
, pp. 1065-1074
-
-
Sharp, A.H.1
Loev, S.J.2
Schilling, G.3
Li, S.H.4
Li, X.J.5
Bao, J.6
Wagster, M.V.7
Kotzuk, J.A.8
Steiner, J.P.9
Lo, A.10
-
6
-
-
0028891145
-
Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals
-
(1995)
Ann. Neurol
, vol.37
, pp. 218-230
-
-
Landwehrmeyer, G.B.1
McNeil, S.M.2
Dure, L.S.3
Ge, P.4
Aizawa, H.5
Huang, Q.6
Ambrose, C.M.7
Duyao, M.P.8
Bird, E.D.9
Bonilla, E.10
-
8
-
-
0033614776
-
Polyglutamine pathogenesis
-
(1999)
Philos. Trans. R. Soc. Lond. B Biol. Sci
, vol.354
, pp. 1005-1011
-
-
Ross, C.A.1
Wood, J.D.2
Schilling, G.3
Peters, M.F.4
Nucifora, F.C.J.5
Cooper, J.K.6
Sharp, A.H.7
Margolis, R.L.8
Borchelt, D.R.9
-
9
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
-
10
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
(1998)
J. Biol. Chem
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hackam, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
-
11
-
-
0033081766
-
Mutant huntingtin expression in clonal striatal cells: Dissociation of inclusion formation and neuronal survival by caspase inhibition
-
(1999)
J. Neurosci
, vol.19
, pp. 964-973
-
-
Kim, M.1
Lee, H.S.2
LaForet, G.3
McIntyre, C.4
Martin, E.J.5
Chang, P.6
Kim, T.W.7
Williams, M.8
Reddy, P.H.9
Tagle, D.10
-
13
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.H.7
Aronin, N.8
DiFiglia, M.9
-
15
-
-
0033560924
-
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
-
(1999)
J. Neurosci
, vol.19
, pp. 3248-3257
-
-
Carter, R.J.1
Lione, L.A.2
Humby, T.3
Mangiarini, L.4
Mahal, A.5
Bates, G.P.6
Dunnett, S.B.7
Morton, A.J.8
-
16
-
-
0034234519
-
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
-
(2000)
J. Neurosci
, vol.20
, pp. 5115-5123
-
-
Murphy, K.P.1
Carter, R.J.2
Lione, L.A.3
Mangiarini, L.4
Mahal, A.5
Bates, G.P.6
Dunnett, S.B.7
Morton, A.J.8
-
18
-
-
0033119123
-
Nuclear and neuropil aggregates in Huntington's disease: Relationship to neuropathology
-
(1999)
J. Neurosci
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.A.1
Li, S.H.2
Yi, H.3
Mulroy, J.S.4
Kuemmerle, S.5
Jones, R.6
Rye, D.7
Ferrante, R.J.8
Hersch, S.M.9
Li, X.J.10
-
22
-
-
0032919205
-
Formation of polyglutamine inclusions in non-CNS tissue
-
(1999)
Hum. Mol. Genet
, vol.8
, pp. 813-822
-
-
Sathasivam, K.1
Hobbs, C.2
Turmaine, M.3
Mangiarini, L.4
Mahal, A.5
Bertaux, F.6
Wanker, E.E.7
Doherty, P.8
Davies, S.W.9
Bates, G.P.10
-
25
-
-
0034702030
-
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 1259-1271
-
-
Luthi-Carter, R.1
Strand, A.2
Peters, N.L.3
Solano, S.M.4
Hollingsworth, Z.R.5
Menon, A.S.6
Frey, A.S.7
Spektor, B.S.8
Penney, E.B.9
Schilling, G.10
-
26
-
-
12944263711
-
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6763-6768
-
-
Steffan, J.S.1
Kazantsev, A.2
Spasic-Boskovic, O.3
Greenwald, M.4
Zhu, Y.Z.5
Gohler, H.6
Wanker, E.E.7
Bates, G.P.8
Housman, D.E.9
Thompson, L.M.10
-
27
-
-
0034285017
-
CREB-binding protein sequestration by expanded polyglutamine
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 2197-2202
-
-
McCampbell, A.1
Taylor, J.P.2
Taye, A.A.3
Robitschek, J.4
Li, M.5
Walcott, J.6
Merry, D.7
Chai, Y.8
Paulson, H.9
Sobue, G.10
-
28
-
-
0035937523
-
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
-
(2001)
Science
, vol.291
, pp. 2423-2428
-
-
Nucifora F.C., Jr.1
Sasaki, M.2
Peters, M.F.3
Huang, H.4
Cooper, J.K.5
Yamada, M.6
Takahashi, H.7
Tsuji, S.8
Troncoso, J.9
Dawson, V.L.10
-
29
-
-
0033818112
-
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
-
(2000)
Nat. Genet
, vol.26
, pp. 29-36
-
-
Shimohata, T.1
Nakajima, T.2
Yamada, M.3
Uchida, C.4
Onodera, O.5
Naruse, S.6
Kimura, T.7
Koide, R.8
Nozaki, K.9
Sano, Y.10
-
30
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsev, A.7
Schmidt, E.8
Zhu, Y.Z.9
Greenwald, M.10
-
31
-
-
0035880474
-
Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 1829-1845
-
-
Wyttenbach, A.1
Swartz, J.2
Kita, H.3
Thykjaer, T.4
Carmichael, J.5
Bradley, J.6
Brown, R.7
Maxwell, M.8
Schapira, A.9
Orntoft, T.F.10
-
32
-
-
0037150687
-
Sp1 and TAFII130 transcriptional activity disrupted in early huntington's disease
-
(2002)
Science
, vol.296
, pp. 2238-2243
-
-
Dunah, A.W.1
Jeong, H.2
Griffin, A.3
Kim, Y.M.4
Standaert, D.G.5
Hersch, S.M.6
Mouradian, M.M.7
Young, A.B.8
Tanese, N.9
Krainc, D.10
-
34
-
-
0035805255
-
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
-
(2001)
Science
, vol.292
, pp. 929-934
-
-
Ideker, T.1
Thorsson, V.2
Ranish, J.A.3
Christmas, R.4
Buhler, J.5
Bumgarner, R.6
Goodlett, D.R.7
Aebersold, R.8
Hood, L.9
-
36
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington's disease
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
Ren, S.7
Li, X.J.8
Albin, R.L.9
Detloff, P.J.10
-
38
-
-
0037101837
-
Polyglutamine and transcription: Gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 1927-1937
-
-
Luthi-Carter, R.1
Strand, A.D.2
Hanson, S.A.3
Kooperberg, C.4
Schilling, G.5
La Spada, A.R.6
Merry, D.7
Young, A.B.8
Ross, C.A.9
Borchelt, D.R.10
Olson, J.M.11
-
39
-
-
0037101838
-
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 1939-1951
-
-
Chan, E.Y.W.1
Luthi-Carter, R.2
Strand, A.3
Solano, S.M.4
Hanson, S.A.5
Kooperberg, C.6
Chase, K.O.7
Young, A.B.8
Leavitt, B.R.9
Cha, J.-H.J.10
-
41
-
-
0037101839
-
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 1953-1965
-
-
Sipione, S.1
Rigamonti, D.2
Valenza, M.3
Zuccato, C.4
Conti, L.5
Pritchard, J.6
Kooperberg, C.7
Olson, J.8
Cattaneo, E.9
-
42
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
43
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
45
-
-
0032833981
-
Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
-
(1999)
Hum. Mol. Genet
, vol.8
, pp. 1647-1655
-
-
Boutell, J.M.1
Thomas, P.2
Neal, J.W.3
Weston, V.J.4
Duce, J.5
Harper, P.S.6
Jones, A.L.7
-
50
-
-
0035909321
-
Huntington's disease. Exploiting expression
-
691 and
-
(2001)
Nature
, vol.413
, pp. 693-694
-
-
Bates, G.P.1
-
52
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
Ciammola, A.2
Rigamonti, D.3
Leavitt, B.R.4
Goffredo, D.5
Conti, L.6
MacDonald, M.E.7
Friedlander, R.M.8
Silani, V.9
Hayden, M.R.10
-
54
-
-
0034307476
-
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
-
(2000)
J. Neurosci
, vol.20
, pp. 7268-7278
-
-
Kegel, K.B.1
Kim, M.2
Sapp, E.3
McIntyre, C.4
Castano, J.G.5
Aronin, N.6
DiFiglia, M.7
-
55
-
-
0034703869
-
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
-
(2000)
Hum. Mol. Genet
, vol.9
, pp. 2799-2809
-
-
Trettel, F.1
Rigamonti, D.2
Hilditch-Maguire, P.3
Wheeler, V.C.4
Sharp, A.H.5
Persichetti, F.6
Cattaneo, E.7
MacDonald, M.E.8
-
56
-
-
0033587128
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
-
(1999)
Nature
, vol.399
, pp. 263-267
-
-
Ona, V.O.1
Li, M.2
Vonsattel, J.P.3
Andrews, L.J.4
Khan, S.Q.5
Chung, W.M.6
Frey, A.S.7
Menon, A.S.8
Li, X.J.9
Stieg, P.E.10
-
59
-
-
0032568517
-
Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6480-6485
-
-
Cha, J.H.1
Kosinski, C.M.2
Kerner, J.A.3
Alsdorf, S.A.4
Mangiarini, L.5
Davies, S.W.6
Penney, J.B.7
Bates, G.P.8
Young, A.B.9
-
60
-
-
0034081681
-
The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
-
(2000)
Neuroscience
, vol.97
, pp. 505-519
-
-
Glass, M.1
Dragunow, M.2
Faull, R.L.3
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