Transport of brain-derived neurotrophic factor across the blood-brain barrier

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1553-1561

  Pan, Weihong ^a,b   Banks, William A ^c   Fasold, Melita B ^a   Bluth, Jonathan ^a   Kastin, Abba J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Brain derived neurotrophic factor; Regeneration; Spinal cord

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IODINE 125;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; GEL ELECTROPHORESIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NERVE DEGENERATION; NERVE FIBER REGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAPILLARIES; CEREBROVASCULAR CIRCULATION; HUMANS; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; KINETICS; MALE; MICE; MICE, INBRED ICR; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TIME FACTORS;

EID: 0032404127     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00141-5     Document Type: Article

References (24)

1. Banks W.A., Broadwell R.D. Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments. J. Neurochem. 62:1994;2404-2419.
2. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human interleukin (IL) α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259:1991;988-996.
3. Banks W.A., Kastin A.J., Broadwell R.D. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation. 2:1995;241-248.
4. Banks, W.A., Fasold, M.B., Kastin, A.J., 1997. Measurement of efflux rates from brain to blood. In: Irvine, G.B., Williams, C.H. (Eds.), Methods in Molecular Biology, Neuropeptide Protocols. Humana Press, Totowa, NJ, pp. 353-360.
5. Blasberg R.G., Fenstermacher J.D., Patlak C.S. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J. Cereb. Blood Flow Metab. 3:1983;8-32.
6. Davson, H., Segal, M.B., 1996. Special aspects of the blood-brain barrier. In: Davson, H. (Ed.), Physiology of the CSF and Blood-brain Barriers. CRC Press, Boca Raton, FL, pp. 303-458.
7. Egleton R.D., Davis T.P. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides. 18:1997;1431-1439.
8. Gutierrez E.G., Banks W.A., Kastin A.J. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47:1993;169-176.
9. Lindsay R.M., Altar C.A., Cedarbaum J.M., Hyman C., Wiegand S.J. The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease. Exp. Neurol. 124:1993;103-118.
10. Louvel E., Hugon J., Doble A. Therapeutic advances in amyotrophic lateral sclerosis. Trends Pharm. Sci. 18:1997;196-203.
11. Narhi L.O., Rosenfeld R., Talvenheimo J., Prestrelski S.J., Arakawa T., Lary J.W., Kolvenbach C.G., Hecht R., Boone T., Miller J.A., Yphantis D.A. Comparison of the biophysical characteristics of human brain-derived neurotrophic factor, neurotrophin-3, and nerve growth factor. J. Biol. Chem. 268:1993;13309-13317.
12. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain and blood-spinal cord barriers to interferons. J. Neuroimmunol. 76:1997;105-111.
13. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain/spinal cord barrier to neurotrophins. Brain Res. 788:1998;87-94.
14. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3:1983;1-7.
15. Phillips H.S., Hains J.M., Armanini M., Laramee G.R., Johnson S.A., Winslow J.W. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. 7:1991;695-702.
16. Poduslo J.F., Curran G.L. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Mol. Brain Res. 36:1996;280-286.
17. Poduslo J.F., Curran G.L., Gill J.S., Haggard J.J. Putrescine-modified NGF: bioactivity, pharmacokinetics, blood-brain/nerve barrier permeability, and nervous system biodistribution. Soc. Neurosci. Abstr. 23:1997;308.
18. Radziejewski C., Robinson R.C., DiStefano P.S., Taylor J.W. Dimeric structure and conformational stability of brain-derived neurotrophic factor and neurotrophin-3. Biochemistry. 31:1992;4431-4436.
19. Sakane T., Pardridge W.M. Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity. Pharm. Res. 14:1997;1085-1091.
20. Schabitz W.-R., Schwab S., Spranger M., Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17:1997;500-506.
21. Triguero D., Buciak J., Pardridge W.M. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. Neurochem. 54:1990;1882-1888.
22. Xu X.M., Guénard V., Kleitman N., Aebischer P., Bunge M.B. A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp. Neurol. 134:1995;261-272.
23. Ye J.-H., Houle J.D. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp. Neurol. 143:1997;70-81.
24. Zlokovic B.V., Begley D.J., Djuricic B., Mitrovic D.M. Measurement of solute transport across the blood-brain barrier in the perfused guinea-pig brain: method and application to N-methyl-α-aminoisobutyric acid. J. Neurochem. 46:1986;1444-1451.