Mouse and rat BDNF gene structure and expression revisited

Journal of Neuroscience Research

Volumn 85, Issue 3, 2007, Pages 525-535

  Aid, Tamara ^a   Kazantseva, Anna ^a   Piirsoo, Marko ^a   Palm, Kaia ^a   Timmusk, Tõnis ^a  

^a TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

Author keywords

BDNF; Calcium; DNA methylation; Exon; Histone deacetylation; Kainic acid; Promoter

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM ION; DNA; HISTONE; MESSENGER RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; EXON; GENE CONTROL; GENE EXPRESSION; GENE STRUCTURE; GENETIC TRANSCRIPTION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; RNA SPLICING;

ANIMALS; BASE SEQUENCE; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA METHYLATION; EXONS; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RATS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 33847250395     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21139     Document Type: Article

References (71)

1. Ballas N, Mandel G. 2005. The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 15:500-506.
2. Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. 2005. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121:645-657.
3. Baranova A, Hammarsund M, Ivanov D, Skoblov M, Sangfelt O, Corcoran M, Borodina T, Makeeva N, Pestova A, Tyazhelova T, et al. 2003. Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species-and human-specific antisense transcript RFP2OS. Gene 321:103-112.
4. Bibel M, Barde YA. 2000. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14:2919-2937.
5. Binder DK. 2004. The role of BDNF in epilepsy and other diseases of the mature nervous system. Adv Exp Med Biol 548:34-56.
6. Binder DK, Scharfman HE. 2004. Brain-derived neurotrophic factor. Growth Factors 22:123-131.
7. Bishop JF, Mueller GP, Mouradian MM. 1994. Alternate 5′ exons in the rat brain-derived neurotrophic factor gene: differential patterns of expression across brain regions. Brain Res Mol Brain Res 26:225-232.
8. Bolanos CA, Nestler EJ. 2004. Neurotrophic mechanisms in drug addiction. Neuromol Med 5:69-83.
9. Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, Gottgens B, Buckley NJ. 2004. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A 101:10458-10463.
10. Castren E. 2004. Neurotrophins as mediators of drug effects on mood, addiction, neuroprotection. Mol Neurobiol 29:289-302.
11. Cattaneo E, Zuccato C, Tartari M. 2005. Normal huntingtin function: an alternative approach to Huntington's disease. Nat Rev Neurosci 6:919-930.
12. Chao MV. 2003. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
13. Chao MV, Rajagopal R, Lee FS. 2006. Neurotrophin signalling in health and disease. Clin Sci 110:167-173.
14. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, Greenberg ME. 2003a. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302:885-889.
15. 2+-responsive transcription in neurons. J Neurosci 23:2572-2581.
16. Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Altshuller YM, Frohman MA, Kraner SD, Mandel G. 1995. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957.
17. Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S. 1997. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci 17:295-2313.
18. Cotman CW, Berchtold NC. 2002. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 25:295-301.
19. Dechant G, Barde YA. 2002. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 5:1131-1136.
20. Ernfors P, Wetmore C, Olson L, Persson H. 1990. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511-526.
21. Farhadi HF, Mowla SJ, Petrecca K, Morris SJ, Seidah NG, Murphy RA. 2000. Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. J Neurosci 20:4059-4068.
22. Ghosh A, Carnahan J, Greenberg ME. 1994. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263:1618-1623.
23. Hashimoto K, Shimizu E, Iyo M. 2004. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 45:104-114.
24. Hayes VY, Towner MD, Isackson PJ. 1997. Organization, sequence and functional analysis of a mouse BDNF promoter. Brain Res Mol Brain Res 45:189-198.
25. Heinrich G, Pagtakhan CJ. 2004. Both 5′ and 3′ flanks regulate Zebrafish brain-derived neurotrophic factor gene expression. BMC Neurosci 5:19.
26. Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA. 1990. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341.
27. Hohn A, Leibrock J, Bailey K, Barde YA. 1990. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341.
28. Hsieh J, Gage FH. 2004. Epigenetic control of neural stem cell fate. Curr Opin Genet Dev 14:461-469.
29. Kaplan DR, Miller FD. 2000. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10:381-391.
30. Kawamoto Y, Nakamura S, Nakano S, Oka N, Akiguchi I. 1996. Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain. Neuroscience 74:1209-1226.
31. Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, Laplant Q, Sasaki TS, Whistler KN, et al. 2005. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314.
32. Lavorgna G, Dahary D, Lehner B, Sorek R, Sanderson CM, Casari G. 2004. In search of antisense. Trends Biochem Sci 29:88-94.
33. Lee R, Kermani P, Teng KK, Hempstead BL. 2001. Regulation of cell survival by secreted proneurotrophins. Science 294:1945-1948.
34. Lipovich L, Vanisri RR, Kong SL, Lin CY, Liu E. 2006. Primate-specific endogenous cis-antisense transcription in the human 5q31 protocadherin gene cluster. J Mol Evol 62:73-88.
35. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR. 2005. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, assessments of associations with substance abuse and Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 134:93-103.
36. Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, Uhl GR. 2006. Rodent BDNF genes, novel promoters, novel splice variants, regulation by cocaine. Brain Res 1067:1-12.
37. Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG. 2002. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298:1747-1752.
38. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. 2003. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302:890-893.
39. 2+-dependent gene expression. Crit Rev Neurobiol 16:43-49.
40. Metsis M, Timmusk T, Arenas E, Persson H. 1993. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc Natl Acad Sci U S A 90:8802-8806.
41. Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, Nagatsu T. 1999. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci Lett 270.
42. Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA. 2001. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276:12660-12666.
43. Murer MG, Yan Q, Raisman-Vozari R. 2001. Brain-derived neurotrophic factor in the control human brain and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63:71-124.
44. Palm K, Belluardo N, Metsis M, Timmusk T. 1998. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci 18:1280-1296.
45. Parain K, Murer MG, Yan Q, Faucheux B, Agid Y, Hirsch E, Raisman-Vozari R. 1999. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 10:557-561.
46. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW. 1991. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7:695-702.
47. Russo-Neustadt AA, Chen MJ. 2005. Brain-derived neurotrophic factor and antidepressant activity. Curr Pharm Des 11:1495-1510.
48. Sathanoori M, Dias BG, Nair AR, Banerjee SB, Tole S, Vaidya VA. 2004. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, in response to kainate administration. Brain Res Mol Brain Res 130:170-177.
49. Schoenherr CJ, Anderson DJ. 1995. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267:1360-1363.
50. Shieh PB, Ghosh A. 1999. Molecular mechanisms underlying activity-dependent regulation of BDNF expression. J Neurobiol 41:127-134.
51. Shieh PB, Hu SC, Bobb K, Timmusk T, Ghosh A. 1998. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20:727-740.
52. Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M. 2002. Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J Biol Chem 277:35920-35931.
53. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709-726.
54. Tao X, West AE, Chen WG, Corfas G, Greenberg ME. 2002. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33:383-395.
55. Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, et al. 2005. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455-5463.
56. Teng KK, Hempstead BL. 2004. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci 61:35-48.
57. Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, Persson H. 1993. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10:475-489.
58. Timmusk T, Lendahl U, Funakoshi H, Arenas E, Persson H, Metsis M. 1995. Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice. J Cell Biol 128:185-199.
59. Timmusk T, Palm K, Lendahl U, Metsis M. 1999. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J Biol Chem 274:1078-1084.
60. Tsankova NM, Kumar A, Nestler EJ. 2004. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci 24:5603-5610.
61. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. 2006. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9:519-525.
62. Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller L. 2002. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 9:224-237.
63. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME. 2001. Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A 98:11024-11031.
64. NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8:1069-1077.
65. Wood IC, Belyaev ND, Bruce AW, Jones C, Mistry M, Roopra A, Buckley NJ. 2003. Interaction of the repressor element 1-silencing transcription factor (REST) with target genes. J Mol Biol 334:863-874.
66. Yamada K, Mizuno M, Nabeshima T. 2002. Role for brain-derived neurotrophic factor in learning and memory. Life Sci 70:735-744.
67. Yan Q, Rosenfeld RD, Matheson CR, Hawkins N, Lopez OT, Bennett L, Welcher AA. 1997. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience 78:431-448.
68. Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D. 1990. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545-3550.
69. Zafra F, Castren E, Thoenen H, Lindholm D. 1991. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc Natl Acad Sci U S A 88:10037-10041.
70. Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, et al. 2001. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293:493-498.
71. Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, et al. 2003. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35:76-83.