Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex

Neuroscience

Volumn 93, Issue 4, 1999, Pages 1491-1506

  Croll, S D ^a   Suri, C ^a   Compton, D L ^a   Simmons, M V ^a   Yancopoulos, G D ^a   Lindsay, R M ^a   Wiegand, S J ^a   Rudge, J S ^a   Scharfman, H E ^b,c  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b HELEN HAYES HOSPITAL   (United States)

^c Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

Entorhinal cortex; Epilepsy; Hippocampus; Long term potentiation; Neurotrophin; Passive avoidance

Indexed keywords

BETA ACTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; KAINIC ACID; MESSENGER RNA;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DENTATE GYRUS; DISEASE SEVERITY; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; HISTOLOGY; HOT PLATE TEST; IN SITU HYBRIDIZATION; LEARNING DISORDER; LIMBIC SYSTEM; LOCOMOTION; LONG TERM POTENTIATION; MAZE TEST; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; NORTHERN BLOTTING; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEIZURE; SOUTHERN BLOTTING; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BLOTTING, NORTHERN; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENTATE GYRUS; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION; HEAT; IN SITU HYBRIDIZATION; KAINIC ACID; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; PAIN THRESHOLD; RNA, MESSENGER; SWIMMING; TRANSGENES;

EID: 0032765275     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00296-1     Document Type: Article

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