메뉴 건너뛰기




Volumn 27, Issue 15, 2008, Pages 2124-2134

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Author keywords

APP; BDNF; Dynactin; Dynein; Kinesin 1

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DYNACTIN; HUNTINGTIN; KINESIN 1;

EID: 49149112606     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.133     Document Type: Article
Times cited : (281)

References (42)
  • 3
    • 0024805885 scopus 로고
    • Changes in microtubule polarity orientation during the development of hippocampal neurons in culture
    • Baas PW, Black MM, Banker GA (1989) Changes in microtubule polarity orientation during the development of hippocampal neurons in culture. J Cell Biol 109: 3085-3094
    • (1989) J Cell Biol , vol.109 , pp. 3085-3094
    • Baas, P.W.1    Black, M.M.2    Banker, G.A.3
  • 4
    • 2442506955 scopus 로고    scopus 로고
    • Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
    • Baquet ZC, Gorski JA, Jones KR (2004) Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci 24: 4250-4258
    • (2004) J Neurosci , vol.24 , pp. 4250-4258
    • Baquet, Z.C.1    Gorski, J.A.2    Jones, K.R.3
  • 6
    • 33751282353 scopus 로고    scopus 로고
    • Huntington's disease: From huntingtin function and dysfunction to therapeutic strategies
    • Borrell-Pages M, Zala D, Humbert S, Saudou F (2006) Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. Cell Mol Life Sci 63: 2642-2660
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2642-2660
    • Borrell-Pages, M.1    Zala, D.2    Humbert, S.3    Saudou, F.4
  • 7
    • 0025021497 scopus 로고
    • A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm
    • Brady ST, Pfister KK, Bloom GS (1990) A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm. Proc Natl Acad Sci USA 87: 1061-1065
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1061-1065
    • Brady, S.T.1    Pfister, K.K.2    Bloom, G.S.3
  • 8
    • 0030727535 scopus 로고    scopus 로고
    • Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution
    • Burkhardt JK, Echeverri CJ, Nilsson T, Vallee RB (1997) Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J Cell Biol 139: 469-484
    • (1997) J Cell Biol , vol.139 , pp. 469-484
    • Burkhardt, J.K.1    Echeverri, C.J.2    Nilsson, T.3    Vallee, R.B.4
  • 11
    • 34047175919 scopus 로고    scopus 로고
    • Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
    • Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, Humbert S, Saudou F (2007) Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27: 3571-3583
    • (2007) J Neurosci , vol.27 , pp. 3571-3583
    • Dompierre, J.P.1    Godin, J.D.2    Charrin, B.C.3    Cordelieres, F.P.4    King, S.J.5    Humbert, S.6    Saudou, F.7
  • 12
    • 0034710696 scopus 로고    scopus 로고
    • A mutant of the motor protein kinesin that moves in both directions on microtubules
    • Endow SA, Higuchi H (2000) A mutant of the motor protein kinesin that moves in both directions on microtubules. Nature 406: 913-916
    • (2000) Nature , vol.406 , pp. 913-916
    • Endow, S.A.1    Higuchi, H.2
  • 15
    • 33646768127 scopus 로고    scopus 로고
    • Axonal transport of mitochondria requires Milton to recruit kinesin heavy chain and is light chain independent
    • Glater EE, Megeath LJ, Stowers RS, Schwarz TL (2006) Axonal transport of mitochondria requires Milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol 173: 545-557
    • (2006) J Cell Biol , vol.173 , pp. 545-557
    • Glater, E.E.1    Megeath, L.J.2    Stowers, R.S.3    Schwarz, T.L.4
  • 16
    • 0141503438 scopus 로고    scopus 로고
    • A determinant for directionality of organelle transport in Drosophila embryos
    • Gross SP, Guo Y, Martinez JE, Welte MA (2003) A determinant for directionality of organelle transport in Drosophila embryos. Curr Biol 13: 1660-1668
    • (2003) Curr Biol , vol.13 , pp. 1660-1668
    • Gross, S.P.1    Guo, Y.2    Martinez, J.E.3    Welte, M.A.4
  • 19
    • 30544452263 scopus 로고    scopus 로고
    • The axonal transport of mitochondria
    • Hollenbeck PJ, Saxton WM (2005) The axonal transport of mitochondria. J Cell Sci 118: 5411-5419
    • (2005) J Cell Sci , vol.118 , pp. 5411-5419
    • Hollenbeck, P.J.1    Saxton, W.M.2
  • 20
    • 0031947483 scopus 로고    scopus 로고
    • The role of the dynactin complex in intracellular motility
    • Holleran EA, Karki S, Holzbaur ELF (1998) The role of the dynactin complex in intracellular motility. Int Rev Cytol 182: 69-109
    • (1998) Int Rev Cytol , vol.182 , pp. 69-109
    • Holleran, E.A.1    Karki, S.2    Holzbaur, E.L.F.3
  • 22
    • 0034075589 scopus 로고    scopus 로고
    • Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons
    • Kaether C, Skehel P, Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11: 1213-1224
    • (2000) Mol Biol Cell , vol.11 , pp. 1213-1224
    • Kaether, C.1    Skehel, P.2    Dotti, C.G.3
  • 24
    • 20344382542 scopus 로고    scopus 로고
    • Kinesin and dynein move a peroxisome in vivo: A tug-of-war or coordinated movement?
    • Kural C, Kim H, Syed S, Goshima G, Gelfand VI, Selvin PR (2005) Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Science 308: 1469-1472
    • (2005) Science , vol.308 , pp. 1469-1472
    • Kural, C.1    Kim, H.2    Syed, S.3    Goshima, G.4    Gelfand, V.I.5    Selvin, P.R.6
  • 25
    • 0032519646 scopus 로고    scopus 로고
    • Interaction of huntingtin-associated protein with dynactin P150Glued
    • Li SH, Gutekunst CA, Hersch SM, Li XJ (1998) Interaction of huntingtin-associated protein with dynactin P150Glued. J Neurosci 18: 1261-1269
    • (1998) J Neurosci , vol.18 , pp. 1261-1269
    • Li, S.H.1    Gutekunst, C.A.2    Hersch, S.M.3    Li, X.J.4
  • 27
    • 2342640469 scopus 로고    scopus 로고
    • A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity
    • Ligon LA, Tokito M, Finklestein JM, Grossman FE, Holzbaur EL (2004) A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J Biol Chem 279: 19201-19208
    • (2004) J Biol Chem , vol.279 , pp. 19201-19208
    • Ligon, L.A.1    Tokito, M.2    Finklestein, J.M.3    Grossman, F.E.4    Holzbaur, E.L.5
  • 28
    • 0032741064 scopus 로고    scopus 로고
    • Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport
    • Martin M, Iyadurai SJ, Gassman A, Gindhart Jr JG, Hays TS, Saxton WM (1999) Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol Biol Cell 10: 3717-3728
    • (1999) Mol Biol Cell , vol.10 , pp. 3717-3728
    • Martin, M.1    Iyadurai, S.J.2    Gassman, A.3    Gindhart Jr, J.G.4    Hays, T.S.5    Saxton, W.M.6
  • 29
    • 0034657922 scopus 로고    scopus 로고
    • Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth
    • Martinez-Arca S, Alberts P, Zahraoui A, Louvard D, Galli T (2000) Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth. J Cell Biol 149: 889-900
    • (2000) J Cell Biol , vol.149 , pp. 889-900
    • Martinez-Arca, S.1    Alberts, P.2    Zahraoui, A.3    Louvard, D.4    Galli, T.5
  • 30
    • 33645642673 scopus 로고    scopus 로고
    • Interaction of Huntingtin-associated protein-1 with kinesin light chain: Implications in intracellular trafficking in neurons
    • McGuire JR, Rong J, Li SH, Li XJ (2006) Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem 281: 3552-3559
    • (2006) J Biol Chem , vol.281 , pp. 3552-3559
    • McGuire, J.R.1    Rong, J.2    Li, S.H.3    Li, X.J.4
  • 31
    • 32644434386 scopus 로고    scopus 로고
    • Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease
    • Pal A, Severin F, Lommer B, Shevchenko A, Zerial M (2006) Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol 172: 605-618
    • (2006) J Cell Biol , vol.172 , pp. 605-618
    • Pal, A.1    Severin, F.2    Lommer, B.3    Shevchenko, A.4    Zerial, M.5
  • 32
    • 32544432052 scopus 로고    scopus 로고
    • Inhibition of calcineurin by FK506 protects against polyglutamine- huntingtin toxicity through an increase of huntingtin phosphorylation at S421
    • Pardo R, Colin E, Regulier E, Aebischer P, Deglon N, Humbert S, Saudou F (2006) Inhibition of calcineurin by FK506 protects against polyglutamine- huntingtin toxicity through an increase of huntingtin phosphorylation at S421. J Neurosci 26: 1635-1645
    • (2006) J Neurosci , vol.26 , pp. 1635-1645
    • Pardo, R.1    Colin, E.2    Regulier, E.3    Aebischer, P.4    Deglon, N.5    Humbert, S.6    Saudou, F.7
  • 33
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou F, Finkbeiner S, Devys D, Greenberg ME (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95: 55-66
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 35
    • 0023754370 scopus 로고
    • The role of kinesin and other soluble factors in organelle movement along microtubules
    • Schroer TA, Schnapp BJ, Reese TS, Sheetz MP (1988) The role of kinesin and other soluble factors in organelle movement along microtubules. J Cell Biol 107: 1785-1792
    • (1988) J Cell Biol , vol.107 , pp. 1785-1792
    • Schroer, T.A.1    Schnapp, B.J.2    Reese, T.S.3    Sheetz, M.P.4
  • 37
    • 17144365137 scopus 로고    scopus 로고
    • Neurotrophins: A ticket to ride for BDNF
    • Thomas K, Davies A (2005) Neurotrophins: a ticket to ride for BDNF. Curr Biol 15: R262-R264
    • (2005) Curr Biol , vol.15
    • Thomas, K.1    Davies, A.2
  • 38
    • 0037459061 scopus 로고    scopus 로고
    • The molecular motor toolbox for intracellular transport
    • Vale RD (2003) The molecular motor toolbox for intracellular transport. Cell 112: 467-480
    • (2003) Cell , vol.112 , pp. 467-480
    • Vale, R.D.1
  • 40
    • 3142642871 scopus 로고    scopus 로고
    • Bidirectional transport along microtubules
    • Welte MA (2004) Bidirectional transport along microtubules. Curr Biol 14: R525-R537
    • (2004) Curr Biol , vol.14
    • Welte, M.A.1
  • 41
    • 0032548920 scopus 로고    scopus 로고
    • Developmental regulation of vesicle transport in Drosophila embryos: Forces and kinetics
    • Welte MA, Gross SP, Postner M, Block SM, Wieschaus EF (1998) Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics. Cell 92: 547-557
    • (1998) Cell , vol.92 , pp. 547-557
    • Welte, M.A.1    Gross, S.P.2    Postner, M.3    Block, S.M.4    Wieschaus, E.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.