Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Journal of Neuroscience

Volumn 24, Issue 18, 2004, Pages 4401-4411

  Chen, Zhe Yu ^a,b   Patel, Paresh D ^c   Sant, Gayatree ^a   Meng, Chui Xiang ^b   Teng, Kenneth K ^a   Hempstead, Barbara L ^a   Lee, Francis S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Brain derived neurotrophic factor; Intracellular trafficking; Polymorphism; Prodomain; Proneurotrophin; Regulated secretion

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DIMER; HETERODIMER; METHIONINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BDNF GENE; BDNF MET GENE; BDNF VAL GENE; BRAIN CELL; BRAIN DEVELOPMENT; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DIMERIZATION; DISEASE PREDISPOSITION; GENE; GENE EXPRESSION PROFILING; HETEROZYGOSITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MEMORY DISORDER; MENTAL DISEASE; MOUSE; NEUROLOGIC DISEASE; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; SECRETORY GRANULE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CEREBRAL CORTEX; COS CELLS; DIMERIZATION; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; MICE; MUSCLE, SMOOTH, VASCULAR; MUTATION; NERVE GROWTH FACTOR; NEURONS; NEUROSECRETORY SYSTEMS; PC12 CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RATS; TRANSFECTION;

EID: 2342550552     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0348-04.2004     Document Type: Article

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