-
1
-
-
70549106846
-
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
-
Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci 12(12):1567–1576
-
(2009)
Nat Neurosci
, vol.12
, Issue.12
, pp. 1567-1576
-
-
Abramov, E.1
Dolev, I.2
Fogel, H.3
Ciccotosto, G.D.4
Ruff, E.5
Slutsky, I.6
-
2
-
-
0028963635
-
Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro
-
Allinquant B, Hantraye P, Mailleux P, Moya K, Bouillot C, Prochiantz A (1995) Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro. J Cell Biol 128(5):919–927
-
(1995)
J Cell Biol
, vol.128
, Issue.5
, pp. 919-927
-
-
Allinquant, B.1
Hantraye, P.2
Mailleux, P.3
Moya, K.4
Bouillot, C.5
Prochiantz, A.6
-
3
-
-
0242330374
-
ADAMs family members as amyloid precursor protein alpha-secretases
-
Allinson TM, Parkin ET, Turner AJ, Hooper NM (2003) ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 74(3):342–352
-
(2003)
J Neurosci Res
, vol.74
, Issue.3
, pp. 342-352
-
-
Allinson, T.M.1
Parkin, E.T.2
Turner, A.J.3
Hooper, N.M.4
-
4
-
-
0030974261
-
Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation
-
Almkvist O, Basun H, Wagner SL, Rowe BA, Wahlund LO, Lannfelt L (1997) Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Arch Neurol 54(5):641–644
-
(1997)
Arch Neurol
, vol.54
, Issue.5
, pp. 641-644
-
-
Almkvist, O.1
Basun, H.2
Wagner, S.L.3
Rowe, B.A.4
Wahlund, L.O.5
Lannfelt, L.6
-
5
-
-
0032768748
-
Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits
-
Anderson JJ, Holtz G, Baskin PP, Wang R, Mazzarelli L, Wagner SL, Menzaghi F (1999) Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. Neuroscience 93(4):1409–1420
-
(1999)
Neuroscience
, vol.93
, Issue.4
, pp. 1409-1420
-
-
Anderson, J.J.1
Holtz, G.2
Baskin, P.P.3
Wang, R.4
Mazzarelli, L.5
Wagner, S.L.6
Menzaghi, F.7
-
6
-
-
0026318496
-
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture
-
Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J (1991) Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochem Biophys Res Commun 181(1):265–271
-
(1991)
Biochem Biophys Res Commun
, vol.181
, Issue.1
, pp. 265-271
-
-
Araki, W.1
Kitaguchi, N.2
Tokushima, Y.3
Ishii, K.4
Aratake, H.5
Shimohama, S.6
Nakamura, S.7
Kimura, J.8
-
7
-
-
0033617522
-
Notch signaling: cell fate control and signal integration in development
-
Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284(5415):770–776
-
(1999)
Science
, vol.284
, Issue.5415
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
8
-
-
84900126183
-
Mechanisms of microglial activation by amyloid precursor protein and its proteolytic fragments
-
Lane TE, Carson M, Bergmann C, Wyss-Coray T, (eds), Springer, New York
-
Austin SA, Combs CK (2008) Mechanisms of microglial activation by amyloid precursor protein and its proteolytic fragments. In: Lane TE, Carson M, Bergmann C, Wyss-Coray T (eds) Central nervous system diseases and inflammation, 2008th edn. Springer, New York, pp 13–32
-
(2008)
Central nervous system diseases and inflammation
, pp. 13-32
-
-
Austin, S.A.1
Combs, C.K.2
-
9
-
-
0037067655
-
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
-
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110(1):55–67
-
(2002)
Cell
, vol.110
, Issue.1
, pp. 55-67
-
-
Baek, S.H.1
Ohgi, K.A.2
Rose, D.W.3
Koo, E.H.4
Glass, C.K.5
Rosenfeld, M.G.6
-
10
-
-
79952903577
-
A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function
-
Barbagallo AP, Wang Z, Zheng H, D’Adamio L (2011) A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem 286(11):8717–8721
-
(2011)
J Biol Chem
, vol.286
, Issue.11
, pp. 8717-8721
-
-
Barbagallo, A.P.1
Wang, Z.2
Zheng, H.3
D’Adamio, L.4
-
11
-
-
78649496201
-
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo
-
Barbagallo AP, Weldon R, Tamayev R, Zhou D, Giliberto L, Foreman O, D’Adamio L (2010) Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One 5(11):e15503
-
(2010)
PLoS One
, vol.5
, Issue.11
, pp. e15503
-
-
Barbagallo, A.P.1
Weldon, R.2
Tamayev, R.3
Zhou, D.4
Giliberto, L.5
Foreman, O.6
D’Adamio, L.7
-
12
-
-
0030610645
-
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein
-
Barger SW, Harmon AD (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388(6645):878–881
-
(1997)
E. Nature
, vol.388
, Issue.6645
, pp. 878-881
-
-
Barger, S.W.1
Harmon, A.D.2
-
13
-
-
0032146775
-
Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
-
Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan CE (1998) Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J Neurosci 18(15):5869–5880
-
(1998)
J Neurosci
, vol.18
, Issue.15
, pp. 5869-5880
-
-
Barnes, N.Y.1
Li, L.2
Yoshikawa, K.3
Schwartz, L.M.4
Oppenheim, R.W.5
Milligan, C.E.6
-
14
-
-
84901613223
-
Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease
-
Bayer TA, Wirths O (2014) Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease. Acta Neuropathol 127(6):787–801
-
(2014)
Acta Neuropathol
, vol.127
, Issue.6
, pp. 787-801
-
-
Bayer, T.A.1
Wirths, O.2
-
15
-
-
0033586449
-
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
-
Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL (1999) Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Mol Brain Res 66(1–2):150–162
-
(1999)
Mol Brain Res
, vol.66
, Issue.1-2
, pp. 150-162
-
-
Berger-Sweeney, J.1
McPhie, D.L.2
Arters, J.A.3
Greenan, J.4
Oster-Granite, M.L.5
Neve, R.L.6
-
16
-
-
79960809092
-
Neuronal activity regulates the regional vulnerability to amyloid-beta deposition
-
Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM (2011) Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat Neurosci 14(6):750–756
-
(2011)
Nat Neurosci
, vol.14
, Issue.6
, pp. 750-756
-
-
Bero, A.W.1
Yan, P.2
Roh, J.H.3
Cirrito, J.R.4
Stewart, F.R.5
Raichle, M.E.6
Lee, J.M.7
Holtzman, D.M.8
-
17
-
-
0035652138
-
A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo
-
Bertrand E, Brouillet E, Caille I, Bouillot C, Cole GM, Prochiantz A, Allinquant B (2001) A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo. Mol Cell Neurosci 18(5):503–511
-
(2001)
Mol Cell Neurosci
, vol.18
, Issue.5
, pp. 503-511
-
-
Bertrand, E.1
Brouillet, E.2
Caille, I.3
Bouillot, C.4
Cole, G.M.5
Prochiantz, A.6
Allinquant, B.7
-
18
-
-
77249092998
-
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density
-
Boon WC, van den Buuse M, Wegener N, Martin S, Chua HK, Bush AI, Masters CL, Adlard PA, Li QX (2010) Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density. Behav Brain Res 209(1):27–35
-
(2010)
Behav Brain Res
, vol.209
, Issue.1
, pp. 27-35
-
-
Boon, W.C.1
van den Buuse, M.2
Wegener, N.3
Martin, S.4
Chua, H.K.5
Bush, A.I.6
Masters, C.L.7
Adlard, P.A.8
Li, Q.X.9
-
19
-
-
67749139805
-
Neurodegeneration in Alzheimer’s disease: caspases and synaptic element interdependence
-
Bredesen DE (2009) Neurodegeneration in Alzheimer’s disease: caspases and synaptic element interdependence. Mol Neurodegener 4:27
-
(2009)
Mol Neurodegener
, vol.4
, pp. 27
-
-
Bredesen, D.E.1
-
20
-
-
78650662312
-
Importance of the caspase cleavage site in amyloid-beta protein precursor
-
Bredesen DE, John V, Galvan V (2010) Importance of the caspase cleavage site in amyloid-beta protein precursor. J Alzheimers Dis 22(1):57–63
-
(2010)
J Alzheimers Dis
, vol.22
, Issue.1
, pp. 57-63
-
-
Bredesen, D.E.1
John, V.2
Galvan, V.3
-
21
-
-
23944444806
-
Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory
-
Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, Sheline YI, Klunk WE, Mathis CA, Morris JC, Mintun MA (2005) Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 25(34):7709–7717
-
(2005)
J Neurosci
, vol.25
, Issue.34
, pp. 7709-7717
-
-
Buckner, R.L.1
Snyder, A.Z.2
Shannon, B.J.3
LaRossa, G.4
Sachs, R.5
Fotenos, A.F.6
Sheline, Y.I.7
Klunk, W.E.8
Mathis, C.A.9
Morris, J.C.10
Mintun, M.A.11
-
22
-
-
0035816661
-
A transcriptionally (correction of transcriptively) active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Sudhof TC (2001) A transcriptionally (correction of transcriptively) active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293(5527):115–120
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
23
-
-
0041632362
-
App gene dosage modulates endosomal abnormalities of Alzheimer’s disease in a segmental trisomy 16 mouse model of down syndrome
-
Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA (2003) App gene dosage modulates endosomal abnormalities of Alzheimer’s disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23(17):6788–6792
-
(2003)
J Neurosci
, vol.23
, Issue.17
, pp. 6788-6792
-
-
Cataldo, A.M.1
Petanceska, S.2
Peterhoff, C.M.3
Terio, N.B.4
Epstein, C.J.5
Villar, A.6
Carlson, E.J.7
Staufenbiel, M.8
Nixon, R.A.9
-
24
-
-
84655176404
-
Functions of Abeta, sAPPalpha and sAPPbeta : similarities and differences
-
Chasseigneaux S, Allinquant B (2012) Functions of Abeta, sAPPalpha and sAPPbeta: similarities and differences. J Neurochem 120(Suppl 1):99–108
-
(2012)
J Neurochem
, vol.120
, pp. 99-108
-
-
Chasseigneaux, S.1
Allinquant, B.2
-
25
-
-
60849095497
-
Abeta40 promotes neuronal cell fate in neural progenitor cells
-
Chen Y, Dong C (2009) Abeta40 promotes neuronal cell fate in neural progenitor cells. Cell Death Differ 16(3):386–394
-
(2009)
Cell Death Differ
, vol.16
, Issue.3
, pp. 386-394
-
-
Chen, Y.1
Dong, C.2
-
26
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58(1):42–51
-
(2008)
Neuron
, vol.58
, Issue.1
, pp. 42-51
-
-
Cirrito, J.R.1
Kang, J.E.2
Lee, J.3
Stewart, F.R.4
Verges, D.K.5
Silverio, L.M.6
Bu, G.7
Mennerick, S.8
Holtzman, D.M.9
-
27
-
-
0034839287
-
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
-
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B (2001) The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem 78(5):1168–1178
-
(2001)
J Neurochem
, vol.78
, Issue.5
, pp. 1168-1178
-
-
Cupers, P.1
Orlans, I.2
Craessaerts, K.3
Annaert, W.4
De Strooper, B.5
-
28
-
-
78649757007
-
APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells
-
De Chiara G, Marcocci ME, Civitelli L, Argnani R, Piacentini R, Ripoli C, Manservigi R, Grassi C, Garaci E, Palamara AT (2010) APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells. PLoS One 5(11):e13989
-
(2010)
PLoS One
, vol.5
, Issue.11
, pp. e13989
-
-
De Chiara, G.1
Marcocci, M.E.2
Civitelli, L.3
Argnani, R.4
Piacentini, R.5
Ripoli, C.6
Manservigi, R.7
Grassi, C.8
Garaci, E.9
Palamara, A.T.10
-
29
-
-
44449159903
-
P3 peptide, a truncated form of A beta devoid of synaptotoxic effect, does not assemble into soluble oligomers
-
Dulin F, Leveille F, Ortega JB, Mornon JP, Buisson A, Callebaut I, Colloc’h N (2008) P3 peptide, a truncated form of A beta devoid of synaptotoxic effect, does not assemble into soluble oligomers. FEBS Lett 582(13):1865–1870
-
(2008)
FEBS Lett
, vol.582
, Issue.13
, pp. 1865-1870
-
-
Dulin, F.1
Leveille, F.2
Ortega, J.B.3
Mornon, J.P.4
Buisson, A.5
Callebaut, I.6
Colloc’h, N.7
-
30
-
-
0029923244
-
Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the beta-amyloid precursor protein
-
Fraser SP, Suh YH, Chong YH, Djamgoz MB (1996) Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the beta-amyloid precursor protein. J Neurochem 66(5):2034–2040
-
(1996)
J Neurochem
, vol.66
, Issue.5
, pp. 2034-2040
-
-
Fraser, S.P.1
Suh, Y.H.2
Chong, Y.H.3
Djamgoz, M.B.4
-
31
-
-
8944228919
-
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice
-
Fukuchi K, Ho L, Younkin SG, Kunkel DD, Ogburn CE, LeBoeuf RC, Furlong CE, Deeb SS, Nochlin D, Wegiel J, Wisniewski HM, Martin GM (1996) High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice. Am J Pathol 149(1):219–227
-
(1996)
Am J Pathol
, vol.149
, Issue.1
, pp. 219-227
-
-
Fukuchi, K.1
Ho, L.2
Younkin, S.G.3
Kunkel, D.D.4
Ogburn, C.E.5
LeBoeuf, R.C.6
Furlong, C.E.7
Deeb, S.S.8
Nochlin, D.9
Wegiel, J.10
Wisniewski, H.M.11
Martin, G.M.12
-
32
-
-
0028111578
-
Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells
-
Fukuchi KI, Kunkel DD, Schwartzkroin PA, Kamino K, Ogburn CE, Furlong CE, Martin GM (1994) Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells. Exp Neurol 127(2):253–264
-
(1994)
Exp Neurol
, vol.127
, Issue.2
, pp. 253-264
-
-
Fukuchi, K.I.1
Kunkel, D.D.2
Schwartzkroin, P.A.3
Kamino, K.4
Ogburn, C.E.5
Furlong, C.E.6
Martin, G.M.7
-
33
-
-
0029841562
-
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain
-
Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP (1996) Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem 67(5):1882–1896
-
(1996)
J Neurochem
, vol.67
, Issue.5
, pp. 1882-1896
-
-
Furukawa, K.1
Sopher, B.L.2
Rydel, R.E.3
Begley, J.G.4
Pham, D.G.5
Martin, G.M.6
Fox, M.7
Mattson, M.P.8
-
34
-
-
0036064748
-
Caspase cleavage of members of the amyloid precursor family of proteins
-
Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE (2002) Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem 82(2):283–294
-
(2002)
J Neurochem
, vol.82
, Issue.2
, pp. 283-294
-
-
Galvan, V.1
Chen, S.2
Lu, D.3
Logvinova, A.4
Goldsmith, P.5
Koo, E.H.6
Bredesen, D.E.7
-
35
-
-
33646480747
-
Reversal of Alzheimer’s-like pathology and behavior in human APP transgenic mice by mutation of Asp664
-
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE (2006) Reversal of Alzheimer’s-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci 103(18):7130–7135
-
(2006)
Proc Natl Acad Sci
, vol.103
, Issue.18
, pp. 7130-7135
-
-
Galvan, V.1
Gorostiza, O.F.2
Banwait, S.3
Ataie, M.4
Logvinova, A.V.5
Sitaraman, S.6
Carlson, E.7
Sagi, S.A.8
Chevallier, N.9
Jin, K.10
Greenberg, D.A.11
Bredesen, D.E.12
-
36
-
-
43849090364
-
Long-term prevention of Alzheimer’s disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664
-
Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE (2008) Long-term prevention of Alzheimer’s disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res 191(2):246–255
-
(2008)
Behav Brain Res
, vol.191
, Issue.2
, pp. 246-255
-
-
Galvan, V.1
Zhang, J.2
Gorostiza, O.F.3
Banwait, S.4
Huang, W.5
Ataie, M.6
Tang, H.7
Bredesen, D.E.8
-
37
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer’s amyloid-beta precursor protein and amyloidogenic A beta peptide formation
-
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW (1999) Involvement of caspases in proteolytic cleavage of Alzheimer’s amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 97(3):395–406
-
(1999)
Cell
, vol.97
, Issue.3
, pp. 395-406
-
-
Gervais, F.G.1
Xu, D.2
Robertson, G.S.3
Vaillancourt, J.P.4
Zhu, Y.5
Huang, J.6
LeBlanc, A.7
Smith, D.8
Rigby, M.9
Shearman, M.S.10
Clarke, E.E.11
Zheng, H.12
Van Der Ploeg, L.H.13
Ruffolo, S.C.14
Thornberry, N.A.15
Xanthoudakis, S.16
Zamboni, R.J.17
Roy, S.18
Nicholson, D.W.19
-
38
-
-
80053633517
-
Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice
-
Ghosal K, Pimplikar SW (2011) Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice. Neurobiol Aging 32(12):2321–2329
-
(2011)
Neurobiol Aging
, vol.32
, Issue.12
, pp. 2321-2329
-
-
Ghosal, K.1
Pimplikar, S.W.2
-
39
-
-
70450235497
-
Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain
-
Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW (2009) Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci 106(43):18367–18372
-
(2009)
Proc Natl Acad Sci
, vol.106
, Issue.43
, pp. 18367-18372
-
-
Ghosal, K.1
Vogt, D.L.2
Liang, M.3
Shen, Y.4
Lamb, B.T.5
Pimplikar, S.W.6
-
40
-
-
77955408755
-
Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer’s disease-like traits in vivo
-
Giliberto L, d’Abramo C, Acker CM, Davies P, D’Adamio L (2010) Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer’s disease-like traits in vivo. PLoS One 5(7):e11609
-
(2010)
PLoS One
, vol.5
, Issue.7
, pp. e11609
-
-
Giliberto, L.1
d’Abramo, C.2
Acker, C.M.3
Davies, P.4
D’Adamio, L.5
-
41
-
-
52049112089
-
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a “regulated” transcriptional role
-
Giliberto L, Zhou D, Weldon R, Tamagno E, De Luca P, Tabaton M, D’Adamio L (2008) Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a “regulated” transcriptional role. Mol Neurodegener 3:12
-
(2008)
Mol Neurodegener
, vol.3
, pp. 12
-
-
Giliberto, L.1
Zhou, D.2
Weldon, R.3
Tamagno, E.4
De Luca, P.5
Tabaton, M.6
D’Adamio, L.7
-
42
-
-
0028179341
-
Chemical characterization of A beta 17–42 peptide, a component of diffuse amyloid deposits of Alzheimer disease
-
Gowing E, Roher AE, Woods AS, Cotter RJ, Chaney M, Little SP, Ball MJ (1994) Chemical characterization of A beta 17–42 peptide, a component of diffuse amyloid deposits of Alzheimer disease. J Biol Chem 269(15):10987–10990
-
(1994)
J Biol Chem
, vol.269
, Issue.15
, pp. 10987-10990
-
-
Gowing, E.1
Roher, A.E.2
Woods, A.S.3
Cotter, R.J.4
Chaney, M.5
Little, S.P.6
Ball, M.J.7
-
43
-
-
84855483701
-
APP physiological and pathophysiological functions: insights from animal models
-
Guo Q, Wang Z, Li H, Wiese M, Zheng H (2012) APP physiological and pathophysiological functions: insights from animal models. Cell Res 22(1):78–89
-
(2012)
Cell Res
, vol.22
, Issue.1
, pp. 78-89
-
-
Guo, Q.1
Wang, Z.2
Li, H.3
Wiese, M.4
Zheng, H.5
-
44
-
-
0242442605
-
Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation
-
Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A (2003) Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res 63(21):7032–7037
-
(2003)
Cancer Res
, vol.63
, Issue.21
, pp. 7032-7037
-
-
Hansel, D.E.1
Rahman, A.2
Wehner, S.3
Herzog, V.4
Yeo, C.J.5
Maitra, A.6
-
45
-
-
0032876784
-
Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons
-
Harada J, Sugimoto M (1999) Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons. Brain Res 842(2):311–323
-
(1999)
Brain Res
, vol.842
, Issue.2
, pp. 311-323
-
-
Harada, J.1
Sugimoto, M.2
-
46
-
-
0026597063
-
Alzheimer’s disease: the amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256(5054):184–185
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
47
-
-
74849103981
-
Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer’s disease are independent of caspase cleavage of the amyloid precursor protein
-
Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L (2010) Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer’s disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci 30(1):372–381
-
(2010)
J Neurosci
, vol.30
, Issue.1
, pp. 372-381
-
-
Harris, J.A.1
Devidze, N.2
Halabisky, B.3
Lo, I.4
Thwin, M.T.5
Yu, G.Q.6
Bredesen, D.E.7
Masliah, E.8
Mucke, L.9
-
48
-
-
65549119787
-
Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production
-
Hoey SE, Williams RJ, Perkinton MS (2009) Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. J Neurosci 29(14):4442–4460
-
(2009)
J Neurosci
, vol.29
, Issue.14
, pp. 4442-4460
-
-
Hoey, S.E.1
Williams, R.J.2
Perkinton, M.S.3
-
49
-
-
33846923049
-
APL-1, a caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability
-
Hornsten A, Lieberthal J, Fadia S, Malins R, Ha L, Xu X, Daigle I, Markowitz M, O’Connor G, Plasterk R, Li C (2007) APL-1, a caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci 104(6):1971–1976
-
(2007)
Proc Natl Acad Sci
, vol.104
, Issue.6
, pp. 1971-1976
-
-
Hornsten, A.1
Lieberthal, J.2
Fadia, S.3
Malins, R.4
Ha, L.5
Xu, X.6
Daigle, I.7
Markowitz, M.8
O’Connor, G.9
Plasterk, R.10
Li, C.11
-
50
-
-
84879707418
-
A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death
-
Hu Y, Lee X, Shao Z, Apicco D, Huang G, Gong BJ, Pepinsky RB, Mi S (2013) A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death. Cell Death Dis 4:e579
-
(2013)
Cell Death Dis
, vol.e579
, pp. 4
-
-
Hu, Y.1
Lee, X.2
Shao, Z.3
Apicco, D.4
Huang, G.5
Gong, B.J.6
Pepinsky, R.B.7
Mi, S.8
-
51
-
-
0026047558
-
Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung
-
Itoh H, Kataoka H, Koita H, Nabeshima K, Inoue T, Kangawa K, Koono M (1991) Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung. Int J Cancer 49(3):436–443
-
(1991)
Int J Cancer
, vol.49
, Issue.3
, pp. 436-443
-
-
Itoh, H.1
Kataoka, H.2
Koita, H.3
Nabeshima, K.4
Inoue, T.5
Kangawa, K.6
Koono, M.7
-
52
-
-
0032433258
-
Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis
-
Ivins KJ, Bui ET, Cotman CW (1998) Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiol Dis 5(5):365–378
-
(1998)
Neurobiol Dis
, vol.5
, Issue.5
, pp. 365-378
-
-
Ivins, K.J.1
Bui, E.T.2
Cotman, C.W.3
-
53
-
-
0029849644
-
Full-length amyloid-beta [1-42(43)] and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques
-
Iwatsubo T, Saido TC, Mann DM, Lee VM, Trojanowski JQ (1996) Full-length amyloid-beta [1-42(43)] and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. Am J Pathol 149(6):1823–1830
-
(1996)
Am J Pathol
, vol.149
, Issue.6
, pp. 1823-1830
-
-
Iwatsubo, T.1
Saido, T.C.2
Mann, D.M.3
Lee, V.M.4
Trojanowski, J.Q.5
-
54
-
-
70450219526
-
-
Jager S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU (2009) alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem 111(6):1369–1382
-
Jager S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU (2009) alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem 111(6):1369–1382
-
-
-
-
55
-
-
0031740915
-
Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis
-
Jin LW, Hearn MG, Ogburn CE, Dang N, Nochlin D, Ladiges WC, Martin GM (1998) Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis. Am J Pathol 153(6):1679–1686
-
(1998)
Am J Pathol
, vol.153
, Issue.6
, pp. 1679-1686
-
-
Jin, L.W.1
Hearn, M.G.2
Ogburn, C.E.3
Dang, N.4
Nochlin, D.5
Ladiges, W.C.6
Martin, G.M.7
-
56
-
-
0028136865
-
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension
-
Jin LW, Ninomiya H, Roch JM, Schubert D, Masliah E, Otero DA, Saitoh T (1994) Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J Neurosci 14(9):5461–5470
-
(1994)
J Neurosci
, vol.14
, Issue.9
, pp. 5461-5470
-
-
Jin, L.W.1
Ninomiya, H.2
Roch, J.M.3
Schubert, D.4
Masliah, E.5
Otero, D.A.6
Saitoh, T.7
-
57
-
-
84899851998
-
A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer’s disease-related pathophysiology in murine models
-
Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM (2014) A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer’s disease-related pathophysiology in murine models. J Neurosci 34(19):6425–6437
-
(2014)
J Neurosci
, vol.34
, Issue.19
, pp. 6425-6437
-
-
Kallop, D.Y.1
Meilandt, W.J.2
Gogineni, A.3
Easley-Neal, C.4
Wu, T.5
Jubb, A.M.6
Yaylaoglu, M.7
Shamloo, M.8
Tessier-Lavigne, M.9
Scearce-Levie, K.10
Weimer, R.M.11
-
58
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37(6):925–937
-
(2003)
Neuron
, vol.37
, Issue.6
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
59
-
-
0026443727
-
Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain
-
Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegon M, Cotman C, Vaught JL, Neve RL (1992) Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci 89(22):10857–10861
-
(1992)
Proc Natl Acad Sci
, vol.89
, Issue.22
, pp. 10857-10861
-
-
Kammesheidt, A.1
Boyce, F.M.2
Spanoyannis, A.F.3
Cummings, B.J.4
Ortegon, M.5
Cotman, C.6
Vaught, J.L.7
Neve, R.L.8
-
60
-
-
33845324145
-
C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression
-
Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, Suh YH (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J 17(13):1951–1953
-
(2003)
FASEB J
, vol.17
, Issue.13
, pp. 1951-1953
-
-
Kim, H.S.1
Kim, E.M.2
Lee, J.P.3
Park, C.H.4
Kim, S.5
Seo, J.H.6
Chang, K.A.7
Yu, E.8
Jeong, S.J.9
Chong, Y.H.10
Suh, Y.H.11
-
61
-
-
0033580084
-
C-terminal fragment of Alzheimer’s amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SH cell
-
Kim HS, Lee JH, Suh YH (1999) C-terminal fragment of Alzheimer’s amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SH cell. Neuroreport 10(1):113–116
-
(1999)
Neuroreport
, vol.10
, Issue.1
, pp. 113-116
-
-
Kim, H.S.1
Lee, J.H.2
Suh, Y.H.3
-
62
-
-
0035955693
-
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
-
Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276(43):40288–40292
-
(2001)
J Biol Chem
, vol.276
, Issue.43
, pp. 40288-40292
-
-
Kimberly, W.T.1
Zheng, J.B.2
Guenette, S.Y.3
Selkoe, D.J.4
-
63
-
-
0037047434
-
The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells
-
Kinoshita A, Whelan CM, Berezovska O, Hyman BT (2002) The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem 277(32):28530–28536
-
(2002)
J Biol Chem
, vol.277
, Issue.32
, pp. 28530-28536
-
-
Kinoshita, A.1
Whelan, C.M.2
Berezovska, O.3
Hyman, B.T.4
-
64
-
-
0027288860
-
Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth
-
Koo EH, Park L, Selkoe DJ (1993) Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proc Natl Acad Sci 90(10):4748–4752
-
(1993)
Proc Natl Acad Sci
, vol.90
, Issue.10
, pp. 4748-4752
-
-
Koo, E.H.1
Park, L.2
Selkoe, D.J.3
-
65
-
-
79957919528
-
Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer’s disease
-
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wullner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J (2011) Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer’s disease. EMBO J 30(11):2255–2265
-
(2011)
EMBO J
, vol.30
, Issue.11
, pp. 2255-2265
-
-
Kumar, S.1
Rezaei-Ghaleh, N.2
Terwel, D.3
Thal, D.R.4
Richard, M.5
Hoch, M.6
Mc Donald, J.M.7
Wullner, U.8
Glebov, K.9
Heneka, M.T.10
Walsh, D.M.11
Zweckstetter, M.12
Walter, J.13
-
66
-
-
80052410564
-
Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation
-
Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, Konig S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT (2011) Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833–844
-
(2011)
Neuron
, vol.71
, Issue.5
, pp. 833-844
-
-
Kummer, M.P.1
Hermes, M.2
Delekarte, A.3
Hammerschmidt, T.4
Kumar, S.5
Terwel, D.6
Walter, J.7
Pape, H.C.8
Konig, S.9
Roeber, S.10
Jessen, F.11
Klockgether, T.12
Korte, M.13
Heneka, M.T.14
-
67
-
-
33846633336
-
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease
-
Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer’s disease. J Neurosci 27(4):796–807
-
(2007)
J Neurosci
, vol.27
, Issue.4
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
68
-
-
0030300022
-
The “nonamyloidogenic” p3 fragment (amyloid beta17-42) is a major constituent of Down’s syndrome cerebellar preamyloid
-
Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T (1996) The “nonamyloidogenic” p3 fragment (amyloid beta17-42) is a major constituent of Down’s syndrome cerebellar preamyloid. J Biol Chem 271(52):33623–33631
-
(1996)
J Biol Chem
, vol.271
, Issue.52
, pp. 33623-33631
-
-
Lalowski, M.1
Golabek, A.2
Lemere, C.A.3
Selkoe, D.J.4
Wisniewski, H.M.5
Beavis, R.C.6
Frangione, B.7
Wisniewski, T.8
-
69
-
-
0028982840
-
Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer’s disease
-
Lannfelt L, Basun H, Wahlund LO, Rowe BA, Wagner SL (1995) Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer’s disease. Nat Med 1(8):829–832
-
(1995)
Nat Med
, vol.1
, Issue.8
, pp. 829-832
-
-
Lannfelt, L.1
Basun, H.2
Wahlund, L.O.3
Rowe, B.A.4
Wagner, S.L.5
-
70
-
-
0033551738
-
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease
-
LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J (1999) Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease. J Biol Chem 274(33):23426–23436
-
(1999)
J Biol Chem
, vol.274
, Issue.33
, pp. 23426-23436
-
-
LeBlanc, A.1
Liu, H.2
Goodyer, C.3
Bergeron, C.4
Hammond, J.5
-
71
-
-
84864464317
-
Cross-linking of cell surface amyloid precursor protein leads to increased beta-amyloid peptide production in hippocampal neurons: implications for Alzheimer’s disease
-
Lefort R, Pozueta J, Shelanski M (2012) Cross-linking of cell surface amyloid precursor protein leads to increased beta-amyloid peptide production in hippocampal neurons: implications for Alzheimer’s disease. J Neurosci 32(31):10674–10685
-
(2012)
J Neurosci
, vol.32
, Issue.31
, pp. 10674-10685
-
-
Lefort, R.1
Pozueta, J.2
Shelanski, M.3
-
72
-
-
0033051445
-
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer’s disease precursor protein in the hippocampus of aged transgenic mice
-
Li QX, Maynard C, Cappai R, McLean CA, Cherny RA, Lynch T, Culvenor JG, Trevaskis J, Tanner JE, Bailey KA, Czech C, Bush AI, Beyreuther K, Masters CL (1999) Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer’s disease precursor protein in the hippocampus of aged transgenic mice. J Neurochem 72(6):2479–2487
-
(1999)
J Neurochem
, vol.72
, Issue.6
, pp. 2479-2487
-
-
Li, Q.X.1
Maynard, C.2
Cappai, R.3
McLean, C.A.4
Cherny, R.A.5
Lynch, T.6
Culvenor, J.G.7
Trevaskis, J.8
Tanner, J.E.9
Bailey, K.A.10
Czech, C.11
Bush, A.I.12
Beyreuther, K.13
Masters, C.L.14
-
73
-
-
0034107524
-
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
-
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE (2000) A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 6(4):397–404
-
(2000)
Nat Med
, vol.6
, Issue.4
, pp. 397-404
-
-
Lu, D.C.1
Rabizadeh, S.2
Chandra, S.3
Shayya, R.F.4
Ellerby, L.M.5
Ye, X.6
Salvesen, G.S.7
Koo, E.H.8
Bredesen, D.E.9
-
74
-
-
0345602771
-
Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes
-
Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH (2003) Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol 54(6):781–789
-
(2003)
Ann Neurol
, vol.54
, Issue.6
, pp. 781-789
-
-
Lu, D.C.1
Shaked, G.M.2
Masliah, E.3
Bredesen, D.E.4
Koo, E.H.5
-
75
-
-
0142179222
-
Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity
-
Lu DC, Soriano S, Bredesen DE, Koo EH (2003) Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem 87(3):733–741
-
(2003)
J Neurochem
, vol.87
, Issue.3
, pp. 733-741
-
-
Lu, D.C.1
Soriano, S.2
Bredesen, D.E.3
Koo, E.H.4
-
76
-
-
27744547991
-
SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain
-
Madeira A, Pommet JM, Prochiantz A, Allinquant B (2005) SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. FASEB J 19(13):1905–1907
-
(2005)
FASEB J
, vol.19
, Issue.13
, pp. 1905-1907
-
-
Madeira, A.1
Pommet, J.M.2
Prochiantz, A.3
Allinquant, B.4
-
77
-
-
84884184688
-
Death receptor 6 regulates adult experience-dependent cortical plasticity
-
Marik SA, Olsen O, Tessier-Lavigne M, Gilbert CD (2013) Death receptor 6 regulates adult experience-dependent cortical plasticity. J Neurosci 33(38):14998–15003
-
(2013)
J Neurosci
, vol.33
, Issue.38
, pp. 14998-15003
-
-
Marik, S.A.1
Olsen, O.2
Tessier-Lavigne, M.3
Gilbert, C.D.4
-
78
-
-
0028322171
-
The toxic effect of Alzheimer amyloid protein precursor overexpressed in the neuroblastoma cell line NB-1 on neurite outgrowth
-
Maruyama K, Kumagae Y, Saito Y, Yamao-Harigaya W, Usami M, Ishiura S, Kawashima S, Obata K (1994) The toxic effect of Alzheimer amyloid protein precursor overexpressed in the neuroblastoma cell line NB-1 on neurite outgrowth. Gerontology 40(Suppl 2):57–64
-
(1994)
Gerontology
, vol.40
, pp. 57-64
-
-
Maruyama, K.1
Kumagae, Y.2
Saito, Y.3
Yamao-Harigaya, W.4
Usami, M.5
Ishiura, S.6
Kawashima, S.7
Obata, K.8
-
79
-
-
84884714222
-
A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein
-
Matrone C (2013) A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein. Bioessays 35(10):847–852
-
(2013)
Bioessays
, vol.35
, Issue.10
, pp. 847-852
-
-
Matrone, C.1
-
80
-
-
84869164516
-
Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance
-
Matrone C, Luvisetto S, La Rosa LR, Tamayev R, Pignataro A, Canu N, Yang L, Barbagallo AP, Biundo F, Lombino F, Zheng H, Ammassari-Teule M, D’Adamio L (2012) Tyr682 in the Abeta-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell 11(6):1084–1093
-
(2012)
Aging Cell
, vol.11
, Issue.6
, pp. 1084-1093
-
-
Matrone, C.1
Luvisetto, S.2
La Rosa, L.R.3
Tamayev, R.4
Pignataro, A.5
Canu, N.6
Yang, L.7
Barbagallo, A.P.8
Biundo, F.9
Lombino, F.10
Zheng, H.11
Ammassari-Teule, M.12
D’Adamio, L.13
-
81
-
-
40549088942
-
The FE65 proteins and Alzheimer’s disease
-
McLoughlin DM, Miller CC (2008) The FE65 proteins and Alzheimer’s disease. J Neurosci Res 86(4):744–754
-
(2008)
J Neurosci Res
, vol.86
, Issue.4
, pp. 744-754
-
-
McLoughlin, D.M.1
Miller, C.C.2
-
82
-
-
0035900875
-
-
McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL (2001) beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations. Mol Brain Res 97(1):103–113
-
McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL (2001) beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations. Mol Brain Res 97(1):103–113
-
-
-
-
83
-
-
0032514633
-
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice
-
Meziane H, Dodart JC, Mathis C, Little S, Clemens J, Paul SM, Ungerer A (1998) Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. Proc Natl Acad Sci 95(21):12683–12688
-
(1998)
Proc Natl Acad Sci
, vol.95
, Issue.21
, pp. 12683-12688
-
-
Meziane, H.1
Dodart, J.C.2
Mathis, C.3
Little, S.4
Clemens, J.5
Paul, S.M.6
Ungerer, A.7
-
84
-
-
84976219233
-
Elimination of APP caspase cleavage site D664 attenuates Aβ-mediated synaptic depression
-
Midthune B, Maruyama H, Malinow R, Koo EH (2011) Elimination of APP caspase cleavage site D664 attenuates Aβ-mediated synaptic depression. Alzheimer’s Dementia 7(4):S588
-
(2011)
Alzheimer’s Dementia
, vol.7
, Issue.4
, pp. S588
-
-
Midthune, B.1
Maruyama, H.2
Malinow, R.3
Koo, E.H.4
-
85
-
-
1842633450
-
The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by A beta and acts as a cognitive enhancer
-
Mileusnic R, Lancashire CL, Rose SP (2004) The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by A beta and acts as a cognitive enhancer. Eur J Neurosci 19(7):1933–1938
-
(2004)
Eur J Neurosci
, vol.19
, Issue.7
, pp. 1933-1938
-
-
Mileusnic, R.1
Lancashire, C.L.2
Rose, S.P.3
-
86
-
-
0027970897
-
Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice
-
Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR (1994) Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 666(2):151–167
-
(1994)
Brain Res
, vol.666
, Issue.2
, pp. 151-167
-
-
Mucke, L.1
Masliah, E.2
Johnson, W.B.3
Ruppe, M.D.4
Alford, M.5
Rockenstein, E.M.6
Forss-Petter, S.7
Pietropaolo, M.8
Mallory, M.9
Abraham, C.R.10
-
87
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L (2000) High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20(11):4050–4058
-
(2000)
J Neurosci
, vol.20
, Issue.11
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
88
-
-
48349085043
-
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer’s disease
-
Muller T, Meyer HE, Egensperger R, Marcus K (2008) The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer’s disease. Prog Neurobiol 85(4):393–406
-
(2008)
Prog Neurobiol
, vol.85
, Issue.4
, pp. 393-406
-
-
Muller, T.1
Meyer, H.E.2
Egensperger, R.3
Marcus, K.4
-
89
-
-
70149102204
-
Amyloid beta protein: abeta40 inhibits Abeta42 oligomerization
-
Murray MM, Bernstein SL, Nyugen V, Condron MM, Teplow DB, Bowers MT (2009) Amyloid beta protein: abeta40 inhibits Abeta42 oligomerization. J Am Chem Soc 131(18):6316–6317
-
(2009)
J Am Chem Soc
, vol.131
, Issue.18
, pp. 6316-6317
-
-
Murray, M.M.1
Bernstein, S.L.2
Nyugen, V.3
Condron, M.M.4
Teplow, D.B.5
Bowers, M.T.6
-
90
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98–103
-
(2000)
Nature
, vol.403
, Issue.6765
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yankner, B.A.6
Yuan, J.7
-
91
-
-
0030978998
-
Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
-
Nalbantoglu J, Tirado-Santiago G, Lahsaini A, Poirier J, Goncalves O, Verge G, Momoli F, Welner SA, Massicotte G, Julien JP, Shapiro ML (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387(6632):500–505
-
(1997)
Nature
, vol.387
, Issue.6632
, pp. 500-505
-
-
Nalbantoglu, J.1
Tirado-Santiago, G.2
Lahsaini, A.3
Poirier, J.4
Goncalves, O.5
Verge, G.6
Momoli, F.7
Welner, S.A.8
Massicotte, G.9
Julien, J.P.10
Shapiro, M.L.11
-
92
-
-
0029888942
-
Transgenic mice expressing APP-C100 in the brain
-
Neve RL, Boyce FM, McPhie DL, Greenan J, Oster-Granite ML (1996) Transgenic mice expressing APP-C100 in the brain. Neurobiol Aging 17(2):191–203
-
(1996)
Neurobiol Aging
, vol.17
, Issue.2
, pp. 191-203
-
-
Neve, R.L.1
Boyce, F.M.2
McPhie, D.L.3
Greenan, J.4
Oster-Granite, M.L.5
-
93
-
-
0026568638
-
Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo
-
Neve RL, Kammesheidt A, Hohmann CF (1992) Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc Natl Acad Sci 89(8):3448–3452
-
(1992)
Proc Natl Acad Sci
, vol.89
, Issue.8
, pp. 3448-3452
-
-
Neve, R.L.1
Kammesheidt, A.2
Hohmann, C.F.3
-
94
-
-
84958089397
-
-
Neuroscience Meeting Planner, Society for Neuroscience, San Diego. Online
-
Nhan HS, Midthune B, Zhang C, Tyan SH, Malinow R, Koo EH (2013) Benefits of the APP caspase cleavage site mutation at position D664 include attenuation of Aβ-induced post-synaptic AMPAR/NMDAR-mediated currents and attenuation of Aβ-induced spine loss in knock-in animals. Program No. 429.16. 2013 Neuroscience Meeting Planner, Society for Neuroscience, San Diego. Online
-
(2013)
(2013) Benefits of the APP caspase cleavage site mutation at position D664 include attenuation of Aβ-induced post-synaptic AMPAR/NMDAR-mediated currents and attenuation of Aβ-induced spine loss in knock-in animals. Program No. 429.16
-
-
Nhan, H.S.1
Midthune, B.2
Zhang, C.3
Tyan, S.H.4
Malinow, R.5
Koo, E.H.6
-
95
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O’Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981–989
-
(2009)
Nature
, vol.457
, Issue.7232
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O’Leary, D.D.3
Tessier-Lavigne, M.4
-
96
-
-
0032053984
-
Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
-
Nishimura I, Uetsuki T, Dani SU, Ohsawa Y, Saito I, Okamura H, Uchiyama Y, Yoshikawa K (1998) Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J Neurosci 18(7):2387–2398
-
(1998)
J Neurosci
, vol.18
, Issue.7
, pp. 2387-2398
-
-
Nishimura, I.1
Uetsuki, T.2
Dani, S.U.3
Ohsawa, Y.4
Saito, I.5
Okamura, H.6
Uchiyama, Y.7
Yoshikawa, K.8
-
97
-
-
84899888552
-
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase
-
Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O’Leary DD, Weimer RM, Tessier-Lavigne M (2014) Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase. J Neurosci 34(19):6438–6447
-
(2014)
J Neurosci
, vol.34
, Issue.19
, pp. 6438-6447
-
-
Olsen, O.1
Kallop, D.Y.2
McLaughlin, T.3
Huntwork-Rodriguez, S.4
Wu, Z.5
Duggan, C.D.6
Simon, D.J.7
Lu, Y.8
Easley-Neal, C.9
Takeda, K.10
Hass, P.E.11
Jaworski, A.12
O’Leary, D.D.13
Weimer, R.M.14
Tessier-Lavigne, M.15
-
98
-
-
33750357041
-
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis
-
Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A (2006) The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Commun 351(1):57–63
-
(2006)
Biochem Biophys Res Commun
, vol.351
, Issue.1
, pp. 57-63
-
-
Ozaki, T.1
Li, Y.2
Kikuchi, H.3
Tomita, T.4
Iwatsubo, T.5
Nakagawara, A.6
-
99
-
-
69249212154
-
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein
-
Park SA, Shaked GM, Bredesen DE, Koo EH (2009) Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun 388(2):450–455
-
(2009)
Biochem Biophys Res Commun
, vol.388
, Issue.2
, pp. 450-455
-
-
Park, S.A.1
Shaked, G.M.2
Bredesen, D.E.3
Koo, E.H.4
-
100
-
-
0034488295
-
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer’s amyloid beta protein precursor
-
Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D’Adamio L (2000) Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer’s amyloid beta protein precursor. J Alzheimers Dis 2(3–4):289–301
-
(2000)
J Alzheimers Dis
, vol.2
, Issue.3-4
, pp. 289-301
-
-
Passer, B.1
Pellegrini, L.2
Russo, C.3
Siegel, R.M.4
Lenardo, M.J.5
Schettini, G.6
Bachmann, M.7
Tabaton, M.8
D’Adamio, L.9
-
101
-
-
0033597884
-
Alternative, non-secretase processing of Alzheimer’s beta-amyloid precursor protein during apoptosis by caspase-6 and -8
-
Pellegrini L, Passer BJ, Tabaton M, Ganjei JK, D’Adamio L (1999) Alternative, non-secretase processing of Alzheimer’s beta-amyloid precursor protein during apoptosis by caspase-6 and -8. J Biol Chem 274(30):21011–21016
-
(1999)
J Biol Chem
, vol.274
, Issue.30
, pp. 21011-21016
-
-
Pellegrini, L.1
Passer, B.J.2
Tabaton, M.3
Ganjei, J.K.4
D’Adamio, L.5
-
102
-
-
77952547699
-
Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
-
Portelius E, Brinkmalm G, Tran A, Andreasson U, Zetterberg H, Westman-Brinkmalm A, Blennow K, Ohrfelt A (2010) Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid. Exp Neurol 223(2):351–358
-
(2010)
Exp Neurol
, vol.223
, Issue.2
, pp. 351-358
-
-
Portelius, E.1
Brinkmalm, G.2
Tran, A.3
Andreasson, U.4
Zetterberg, H.5
Westman-Brinkmalm, A.6
Blennow, K.7
Ohrfelt, A.8
-
103
-
-
42149165496
-
A closer look at alpha-secretase
-
Postina R (2008) A closer look at alpha-secretase. Curr Alzheimer Res 5(2):179–186
-
(2008)
Curr Alzheimer Res
, vol.5
, Issue.2
, pp. 179-186
-
-
Postina, R.1
-
104
-
-
0031939059
-
Molecular mapping of Alzheimer-type dementia in down’s syndrome
-
Prasher VP, Farrer MJ, Kessling AM, Fisher EM, West RJ, Barber PC, Butler AC (1998) Molecular mapping of Alzheimer-type dementia in down’s syndrome. Ann Neurol 43(3):380–383
-
(1998)
Ann Neurol
, vol.43
, Issue.3
, pp. 380-383
-
-
Prasher, V.P.1
Farrer, M.J.2
Kessling, A.M.3
Fisher, E.M.4
West, R.J.5
Barber, P.C.6
Butler, A.C.7
-
105
-
-
0035379571
-
Effects of carboxyl-terminal fragment of Alzheimer’s amyloid precursor protein and amyloid beta-peptide on the production of cytokines and nitric oxide in glial cells
-
Rah JC, Kim HS, Kim SS, Bach JH, Kim YS, Park CH, Seo JH, Jeong SJ, Suh YH (2001) Effects of carboxyl-terminal fragment of Alzheimer’s amyloid precursor protein and amyloid beta-peptide on the production of cytokines and nitric oxide in glial cells. FASEB J 15(8):1463–1465
-
(2001)
FASEB J
, vol.15
, Issue.8
, pp. 1463-1465
-
-
Rah, J.C.1
Kim, H.S.2
Kim, S.S.3
Bach, J.H.4
Kim, Y.S.5
Park, C.H.6
Seo, J.H.7
Jeong, S.J.8
Suh, Y.H.9
-
106
-
-
3142564315
-
Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP
-
Recuero M, Serrano E, Bullido MJ, Valdivieso F (2004) Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP. FEBS Lett 570(1–3):114–118
-
(2004)
FEBS Lett
, vol.570
, Issue.1-3
, pp. 114-118
-
-
Recuero, M.1
Serrano, E.2
Bullido, M.J.3
Valdivieso, F.4
-
107
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27(29):7817–7826
-
(2007)
J Neurosci
, vol.27
, Issue.29
, pp. 7817-7826
-
-
Ring, S.1
Weyer, S.W.2
Kilian, S.B.3
Waldron, E.4
Pietrzik, C.U.5
Filippov, M.A.6
Herms, J.7
Buchholz, C.8
Eckman, C.B.9
Korte, M.10
Wolfer, D.P.11
Muller, U.C.12
-
108
-
-
0028071334
-
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor
-
Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci 91(16):7450–7454
-
(1994)
Proc Natl Acad Sci
, vol.91
, Issue.16
, pp. 7450-7454
-
-
Roch, J.M.1
Masliah, E.2
Roch-Levecq, A.C.3
Sundsmo, M.P.4
Otero, D.A.5
Veinbergs, I.6
Saitoh, T.7
-
109
-
-
0032945805
-
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
-
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6(4):327–331
-
(1999)
Nat Struct Biol
, vol.6
, Issue.4
, pp. 327-331
-
-
Rossjohn, J.1
Cappai, R.2
Feil, S.C.3
Henry, A.4
McKinstry, W.J.5
Galatis, D.6
Hesse, L.7
Multhaup, G.8
Beyreuther, K.9
Masters, C.L.10
Parker, M.W.11
-
110
-
-
29444442794
-
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
-
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24–26
-
(2006)
Nat Genet
, vol.38
, Issue.1
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
Le Meur, N.4
Laquerriere, A.5
Vital, A.6
Dumanchin, C.7
Feuillette, S.8
Brice, A.9
Vercelletto, M.10
Dubas, F.11
Frebourg, T.12
Campion, D.13
-
111
-
-
0344405773
-
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
-
Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C (2003) No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiol Dis 12(2):110–120
-
(2003)
Neurobiol Dis
, vol.12
, Issue.2
, pp. 110-120
-
-
Rutten, B.P.1
Wirths, O.2
Van de Berg, W.D.3
Lichtenthaler, S.F.4
Vehoff, J.5
Steinbusch, H.W.6
Korr, H.7
Beyreuther, K.8
Multhaup, G.9
Bayer, T.A.10
Schmitz, C.11
-
112
-
-
27544442991
-
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
-
Ryan KA, Pimplikar SW (2005) Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol 171(2):327–335
-
(2005)
J Cell Biol
, vol.171
, Issue.2
, pp. 327-335
-
-
Ryan, K.A.1
Pimplikar, S.W.2
-
113
-
-
33845898816
-
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP
-
Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF (2006) Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci 26(52):13428–13436
-
(2006)
J Neurosci
, vol.26
, Issue.52
, pp. 13428-13436
-
-
Saganich, M.J.1
Schroeder, B.E.2
Galvan, V.3
Bredesen, D.E.4
Koo, E.H.5
Heinemann, S.F.6
-
114
-
-
0024395366
-
Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts
-
Saitoh T, Sundsmo M, Roch JM, Kimura N, Cole G, Schubert D, Oltersdorf T, Schenk DB (1989) Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58(4):615–622
-
(1989)
Cell
, vol.58
, Issue.4
, pp. 615-622
-
-
Saitoh, T.1
Sundsmo, M.2
Roch, J.M.3
Kimura, N.4
Cole, G.5
Schubert, D.6
Oltersdorf, T.7
Schenk, D.B.8
-
115
-
-
33745512851
-
Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration
-
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC (2006) Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29–42
-
(2006)
Neuron
, vol.51
, Issue.1
, pp. 29-42
-
-
Salehi, A.1
Delcroix, J.D.2
Belichenko, P.V.3
Zhan, K.4
Wu, C.5
Valletta, J.S.6
Takimoto-Kimura, R.7
Kleschevnikov, A.M.8
Sambamurti, K.9
Chung, P.P.10
Xia, W.11
Villar, A.12
Campbell, W.A.13
Kulnane, L.S.14
Nixon, R.A.15
Lamb, B.T.16
Epstein, C.J.17
Stokin, G.B.18
Goldstein, L.S.19
Mobley, W.C.20
more..
-
116
-
-
0030754865
-
Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor
-
Sato M, Kawarabayashi T, Shoji M, Kobayashi T, Tada N, Matsubara E, Hirai S (1997) Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor. Dement Geriatr Cogn Disord 8(5):296–307
-
(1997)
Dement Geriatr Cogn Disord
, vol.8
, Issue.5
, pp. 296-307
-
-
Sato, M.1
Kawarabayashi, T.2
Shoji, M.3
Kobayashi, T.4
Tada, N.5
Matsubara, E.6
Hirai, S.7
-
117
-
-
0041589353
-
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49–99 of beta-amyloid precursor protein
-
Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y (2003) Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49–99 of beta-amyloid precursor protein. J Biol Chem 278(27):24294–24301
-
(2003)
J Biol Chem
, vol.278
, Issue.27
, pp. 24294-24301
-
-
Sato, T.1
Dohmae, N.2
Qi, Y.3
Kakuda, N.4
Misonou, H.5
Mitsumori, R.6
Maruyama, H.7
Koo, E.H.8
Haass, C.9
Takio, K.10
Morishima-Kawashima, M.11
Ishiura, S.12
Ihara, Y.13
-
118
-
-
33749617597
-
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)
-
Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU (2006) On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry 45(41):12393–12399
-
(2006)
Biochemistry
, vol.45
, Issue.41
, pp. 12393-12399
-
-
Schilling, S.1
Lauber, T.2
Schaupp, M.3
Manhart, S.4
Scheel, E.5
Bohm, G.6
Demuth, H.U.7
-
119
-
-
0027421474
-
The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
-
Schubert D, Behl C (1993) The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Res 629(2):275–282
-
(1993)
Brain Res
, vol.629
, Issue.2
, pp. 275-282
-
-
Schubert, D.1
Behl, C.2
-
120
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27(11):2866–2875
-
(2007)
J Neurosci
, vol.27
, Issue.11
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
121
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat Med 14(8):837–842
-
(2008)
Nat Med
, vol.14
, Issue.8
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
122
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402(6761):537–540
-
(1999)
Nature
, vol.402
, Issue.6761
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McConlogue, L.26
John, V.27
more..
-
123
-
-
0028213567
-
A heparin-binding domain in the amyloid protein precursor of Alzheimer’s disease is involved in the regulation of neurite outgrowth
-
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL (1994) A heparin-binding domain in the amyloid protein precursor of Alzheimer’s disease is involved in the regulation of neurite outgrowth. J Neurosci 14(4):2117–2127
-
(1994)
J Neurosci
, vol.14
, Issue.4
, pp. 2117-2127
-
-
Small, D.H.1
Nurcombe, V.2
Reed, G.3
Clarris, H.4
Moir, R.5
Beyreuther, K.6
Masters, C.L.7
-
124
-
-
0028168596
-
Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury
-
Smith-Swintosky VL, Pettigrew LC, Craddock SD, Culwell AR, Rydel RE, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury. J Neurochem 63(2):781–784
-
(1994)
J Neurochem
, vol.63
, Issue.2
, pp. 781-784
-
-
Smith-Swintosky, V.L.1
Pettigrew, L.C.2
Craddock, S.D.3
Culwell, A.R.4
Rydel, R.E.5
Mattson, M.P.6
-
125
-
-
0031724004
-
Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice
-
Song DK, Won MH, Jung JS, Lee JC, Kang TC, Suh HW, Huh SO, Paek SH, Kim YH, Kim SH, Suh YH (1998) Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice. J Neurochem 71(2):875–878
-
(1998)
J Neurochem
, vol.71
, Issue.2
, pp. 875-878
-
-
Song, D.K.1
Won, M.H.2
Jung, J.S.3
Lee, J.C.4
Kang, T.C.5
Suh, H.W.6
Huh, S.O.7
Paek, S.H.8
Kim, Y.H.9
Kim, S.H.10
Suh, Y.H.11
-
126
-
-
84901036009
-
The intersection of amyloid beta and tau at synapses in Alzheimer’s disease
-
Spires-Jones TL, Hyman BT (2014) The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron 82(4):756–771
-
(2014)
Neuron
, vol.82
, Issue.4
, pp. 756-771
-
-
Spires-Jones, T.L.1
Hyman, B.T.2
-
127
-
-
3142552456
-
Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on cytochrome oxidase activity in skeletal muscle and brain
-
Strazielle C, Dumont M, Fukuchi K, Lalonde R (2004) Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on cytochrome oxidase activity in skeletal muscle and brain. J Chem Neuroanat 27(4):237–246
-
(2004)
J Chem Neuroanat
, vol.27
, Issue.4
, pp. 237-246
-
-
Strazielle, C.1
Dumont, M.2
Fukuchi, K.3
Lalonde, R.4
-
128
-
-
0035085610
-
Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo
-
Szczepanik AM, Rampe D, Ringheim GE (2001) Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo. J Neurochem 77(1):304–317
-
(2001)
J Neurochem
, vol.77
, Issue.1
, pp. 304-317
-
-
Szczepanik, A.M.1
Rampe, D.2
Ringheim, G.E.3
-
129
-
-
58249094850
-
Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth
-
Takayama K, Tsutsumi S, Suzuki T, Horie-Inoue K, Ikeda K, Kaneshiro K, Fujimura T, Kumagai J, Urano T, Sakaki Y, Shirahige K, Sasano H, Takahashi S, Kitamura T, Ouchi Y, Aburatani H, Inoue S (2009) Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth. Cancer Res 69(1):137–142
-
(2009)
Cancer Res
, vol.69
, Issue.1
, pp. 137-142
-
-
Takayama, K.1
Tsutsumi, S.2
Suzuki, T.3
Horie-Inoue, K.4
Ikeda, K.5
Kaneshiro, K.6
Fujimura, T.7
Kumagai, J.8
Urano, T.9
Sakaki, Y.10
Shirahige, K.11
Sasano, H.12
Takahashi, S.13
Kitamura, T.14
Ouchi, Y.15
Aburatani, H.16
Inoue, S.17
-
130
-
-
78049349176
-
Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer’s disease transgenic mice
-
Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, Gouras GK (2010) Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer’s disease transgenic mice. J Neurosci 30(43):14299–14304
-
(2010)
J Neurosci
, vol.30
, Issue.43
, pp. 14299-14304
-
-
Tampellini, D.1
Capetillo-Zarate, E.2
Dumont, M.3
Huang, Z.4
Yu, F.5
Lin, M.T.6
Gouras, G.K.7
-
131
-
-
47149092572
-
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
-
Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC (2008) Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis 31(2):250–260
-
(2008)
Neurobiol Dis
, vol.31
, Issue.2
, pp. 250-260
-
-
Taylor, C.J.1
Ireland, D.R.2
Ballagh, I.3
Bourne, K.4
Marechal, N.M.5
Turner, P.R.6
Bilkey, D.K.7
Tate, W.P.8
Abraham, W.C.9
-
132
-
-
27944496889
-
Apolipoprotein
-
Thal DR, Capetillo-Zarate E, Schultz C, Rub U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E (2005) Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol 110(5):459–471
-
(2005)
E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol
, vol.110
, Issue.5
, pp. 459-471
-
-
Thal, D.R.1
Capetillo-Zarate, E.2
Schultz, C.3
Rub, U.4
Saido, T.C.5
Yamaguchi, H.6
Haass, C.7
Griffin, W.S.8
Del Tredici, K.9
Braak, H.10
Ghebremedhin, E.11
-
133
-
-
33745263255
-
Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
-
Thornton E, Vink R, Blumbergs PC, Van Den Heuvel C (2006) Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats. Brain Res 1094(1):38–46
-
(2006)
Brain Res
, vol.1094
, Issue.1
, pp. 38-46
-
-
Thornton, E.1
Vink, R.2
Blumbergs, P.C.3
Van Den Heuvel, C.4
-
134
-
-
0034652232
-
Caspase-2 mediates neuronal cell death induced by beta-amyloid
-
Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML (2000) Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci 20(4):1386–1392
-
(2000)
J Neurosci
, vol.20
, Issue.4
, pp. 1386-1392
-
-
Troy, C.M.1
Rabacchi, S.A.2
Friedman, W.J.3
Frappier, T.F.4
Brown, K.5
Shelanski, M.L.6
-
135
-
-
0033566644
-
Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein
-
Uetsuki T, Takemoto K, Nishimura I, Okamoto M, Niinobe M, Momoi T, Miura M, Yoshikawa K (1999) Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein. J Neurosci 19(16):6955–6964
-
(1999)
J Neurosci
, vol.19
, Issue.16
, pp. 6955-6964
-
-
Uetsuki, T.1
Takemoto, K.2
Nishimura, I.3
Okamoto, M.4
Niinobe, M.5
Momoi, T.6
Miura, M.7
Yoshikawa, K.8
-
136
-
-
84863224213
-
Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments
-
Vella LJ, Cappai R (2012) Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments. FASEB J 26(7):2930–2940
-
(2012)
FASEB J
, vol.26
, Issue.7
, pp. 2930-2940
-
-
Vella, L.J.1
Cappai, R.2
-
137
-
-
79960133399
-
Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain
-
Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW (2011) Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging 32(9):1725–1729
-
(2011)
Neurobiol Aging
, vol.32
, Issue.9
, pp. 1725-1729
-
-
Vogt, D.L.1
Thomas, D.2
Galvan, V.3
Bredesen, D.E.4
Lamb, B.T.5
Pimplikar, S.W.6
-
138
-
-
34248190279
-
A beta oligomers—a decade of discovery
-
Walsh DM, Selkoe DJ (2007) A beta oligomers—a decade of discovery. J Neurochem 101(5):1172–1184
-
(2007)
J Neurochem
, vol.101
, Issue.5
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
139
-
-
0036707528
-
Abeta 17–42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis
-
Wei W, Norton DD, Wang X, Kusiak JW (2002) Abeta 17–42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain 125(Pt 9):2036–2043
-
(2002)
Brain
, vol.125
, pp. 2036-2043
-
-
Wei, W.1
Norton, D.D.2
Wang, X.3
Kusiak, J.W.4
-
140
-
-
0033605252
-
Proteolytic processing of the Alzheimer’s disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
-
Weidemann A, Paliga K, Durrwang U, Reinhard FB, Schuckert O, Evin G, Masters CL (1999) Proteolytic processing of the Alzheimer’s disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J Biol Chem 274(9):5823–5829
-
(1999)
J Biol Chem
, vol.274
, Issue.9
, pp. 5823-5829
-
-
Weidemann, A.1
Paliga, K.2
Durrwang, U.3
Reinhard, F.B.4
Schuckert, O.5
Evin, G.6
Masters, C.L.7
-
141
-
-
0024543836
-
Amyloid beta protein enhances the survival of hippocampal neurons in vitro
-
Whitson JS, Selkoe DJ, Cotman CW (1989) Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science 243(4897):1488–1490
-
(1989)
Science
, vol.243
, Issue.4897
, pp. 1488-1490
-
-
Whitson, J.S.1
Selkoe, D.J.2
Cotman, C.W.3
-
142
-
-
63649138195
-
-
Wolfe MS (2009) gamma-Secretase in biology and medicine. Semin Cell Dev Biol 20(2):219–224
-
Wolfe MS (2009) gamma-Secretase in biology and medicine. Semin Cell Dev Biol 20(2):219–224
-
-
-
-
143
-
-
0024472693
-
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease
-
Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease. Science 245(4916):417–420
-
(1989)
Science
, vol.245
, Issue.4916
, pp. 417-420
-
-
Yankner, B.A.1
Dawes, L.R.2
Fisher, S.3
Villa-Komaroff, L.4
Oster-Granite, M.L.5
Neve, R.L.6
-
144
-
-
0024990330
-
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides
-
Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250(4978):279–282
-
(1990)
Science
, vol.250
, Issue.4978
, pp. 279-282
-
-
Yankner, B.A.1
Duffy, L.K.2
Kirschner, D.A.3
-
145
-
-
0026779680
-
Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
-
Yoshikawa K, Aizawa T, Hayashi Y (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359(6390):64–67
-
(1992)
Nature
, vol.359
, Issue.6390
, pp. 64-67
-
-
Yoshikawa, K.1
Aizawa, T.2
Hayashi, Y.3
-
146
-
-
79955128215
-
Biology and pathophysiology of the amyloid precursor protein
-
Zheng H, Koo EH (2011) Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener 6(1):27
-
(2011)
Mol Neurodegener
, vol.6
, Issue.1
, pp. 27
-
-
Zheng, H.1
Koo, E.H.2
-
147
-
-
80051726275
-
The roles of amyloid precursor protein (APP) in neurogenesis: implications to pathogenesis and therapy of Alzheimer disease
-
Zhou ZD, Chan CH, Ma QH, Xu XH, Xiao ZC, Tan EK (2011) The roles of amyloid precursor protein (APP) in neurogenesis: implications to pathogenesis and therapy of Alzheimer disease. Cell Adhes Migr 5(4):280–292
-
(2011)
Cell Adhes Migr
, vol.5
, Issue.4
, pp. 280-292
-
-
Zhou, Z.D.1
Chan, C.H.2
Ma, Q.H.3
Xu, X.H.4
Xiao, Z.C.5
Tan, E.K.6
|