A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo

Molecular and Cellular Neuroscience

Volumn 18, Issue 5, 2001, Pages 503-511

  Bertrand, Eric ^a   Brouillet, Emmanuel ^a   Caillé, Isabelle ^a   Bouillot, Colette ^a   Cole, Greg M ^b   Prochiantz, Alain ^a   Allinquant, Bernadette ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3; CASPASE 6; CASPASE 8; DNA FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONTROLLED STUDY; DNA CLEAVAGE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SENILE PLAQUE;

ANIMALIA;

EID: 0035652138     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2001.1030     Document Type: Article

References (37)

1. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
2. Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain
3. The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction
4. Trojan peptides: The penetratin system for intracellular delivery
5. The third helix of the Antennapedia homeodomain translocates through biological membranes
6. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation
7. G protein βg complex-mediated apoptosis by familial Alzheimer's disease mutant of APP
8. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: Involvement of calcium and oxyradicals
9. Polarized sorting of β-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
10. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor protein
11. Carboxy-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
12. In vitro control of neuronal polarity by glycosaminoglycans
13. Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells
14. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain
15. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
16. APP carboxy-terminal fragment without Aβ domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons
17. A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
18. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic animals
19. Impaired leaning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
20. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go
21. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
22. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein
23. Alternative, non-secretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8
24. Translating cell biology into therapeutic advances in Alzheimer's disease
25. Requirement for presenilin-dependent cleavage of Notch and other transmembrane proteins
26. Caspase-2 mediates neuronal cell death induced by β-amyloid
27. Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein
28. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
29. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/Inhibitor of caspase-activated DNase inactivation
30. Participation of Presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
31. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis
32. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer disease-associated mutants of APP
33. Antibody to caspasecleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease
34. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
35. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
36. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells
37. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein