Increased Expression and Processing of the Alzheimer Amyloid Precursor Protein in Pancreatic Cancer May Influence Cellular Proliferation

Cancer Research

Volumn 63, Issue 21, 2003, Pages 7032-7037

  Hansel, Donna E ^a,c   Rahman, Ayman ^a   Wehner, Sven ^b   Herzog, Volker ^b   Yeo, Charles J ^a   Maitra, Anirban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; CELL MOTILITY; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; CELL DIVISION; CELL LINE, TUMOR; CYTOSOL; HUMANS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0242442605     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Yoshikai, S., Sasaki, H., Doh-ura, K., Furuya, H., and Sakaki, Y. Genomic organization of the human amyloid β-protein precursor gene. Gene (Amst.), 87: 257-263, 1990.
2. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., and Ward, P. J. Cleavage of amyloid β peptide during constitutive processing of its precursor. Science (Wash. DC), 248: 1122-1124, 1990.
3. Sisodia, S. S., Koo, E. H., Beyreuther, K. Unterbeck, A., and Price, D. L. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (Wash. DC), 248: 492-495, 1990.
4. Hoffmann, J., Twiesselmann, C., Kummer, M. P., Romagnoli, P., and Herzog, V. A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. Eur. J. Cell Biol., 79: 905-914, 2000.
5. Graebert, K. S., Lemansky, P., Kehle, T., and Herzog, V. Localization and regulated release of Alzheimer amyloid precursor-like protein in thyrocytes. Lab. Investig., 72: 513-523, 1995.
6. Sandbrink, R., Masters, C. L., and Beyreuther. K. β A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. J. Biol. Chem., 269: 1510-1517, 1994.
7. Schmitz, A., Tikkanen, R., Kirfel, G., and Herzog, V. The biological role of the Alzheimer amyloid precursor protein in epithelial cells. Histochem. Cell Biol., 117: 171-180, 2002.
8. Ouyang, H., Mou, L., Luk, C., Liu, N., Karaskova, J., Squire, J., and Tsao, M. S. Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am. J. Pathol., 157: 1623-1631, 2000.
9. Esler, W. P., and Wolfe, M. S. A portrait of Alzheimer secretases: new features and familiar faces. Science (Wash. DC), 293: 1449-1454, 2001.
10. Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C. L., and Beyreuther, K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell, 57: 115-126, 1989.
11. Hoffmann, J., Pietrzik, C. U., Kummer, M. P., Twiesselmann, C., Bauer, C., and Herzog, V. Binding and selective detection of the secretory N-terminal domain of the Alzheimer amyloid precursor protein on cell surfaces. J. Histochem. Cytochem., 47: 373-382, 1999.
12. Sabo, S. L., Ikin, A. F., Buxbaum, J. D., and Greengard, P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J. Cell Biol., 153: 1403-1414, 2001.
13. Ohsawa, I., Takamura, C., Morimoto, T., Ishiguro, M., and Kohsaka, S. Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur. J. Neurosci., 11: 1907-1913, 1999.
14. Nishimura, I., Takazaki, R., Kuwako, K., Enokido, Y., and Yoshikawa, K. Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons. Exp. Cell Res., 286: 241-251, 2003.
15. Ge, Y. W., and Lahiri, D. K. Regulation of promoter activity of the APP gene by cytokines and growth factors: implications in Alzheimer's disease. Ann. N. Y. Acad. Sci., 973: 463-467, 2002.
16. Popp, G. M., Graebert, K. S., Pietrzik, C. U., Rosentreter, S. M., Lemansky, P., and Herzog, V. Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of β-amyloid precursor-like proteins. Endocrinology, 137: 1975-1983, 1996.
17. Jin, L. W., Ninomiya, H., Roch, J. M., Schubert, D., Masliah, E., Otero, D. A., and Saitoh, T. Peptides containing the RERMS sequence of amyloid β/A4 protein precursor bind cell surface and promote neurite extension. J. Neurosci., 14: 5461-5470, 1994.
18. Ishiguro, M., Ohsawa, I., Takamura, C., Morimoto, T., and Kohsaka, S. Secreted form of β-amyloid precursor protein activates protein kinase C and phospholipase Cγ1 in cultured embryonic rat neocortical cells. Brain Res. Mol. Brain Res., 53: 24-32, 1998.
19. Cheng, G., Yu, Z., Zhou, D., and Mattson, M. P. Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp. Neurol., 175: 407-414, 2002.
20. Luo, J. J., Wallace, M. S., Hawver, D. B., Kusiak, J. W., and Wallace, W. C. Characterization of the neurotrophic interaction between nerve growth factor and secreted α-amyloid precursor protein. J. Neurosci. Res., 63: 410-420, 2001.
21. Mook-Jung, I., and Saitoh, T. Amyloid precursor protein activates phosphotyrosine signaling pathway. Neurosci. Lett., 235: 1-4, 1997.
22. Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., and Suzuki, T. Interaction of Alzheimer's β-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J. Biol. Chem., 277: 20070-20078, 2002.
23. Chen, Y., McPhie, D. L., Hirschberg, J., and Neve, R. L. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J. Biol. Chem., 275: 8929-8935, 2000.
24. Davis, R. J. Signal transduction by the JNK group of MAP kinases. Cell, 103: 239-252, 2000.
25. Hoorens, A., Lemoine, N. R., McLellan, E., Morohoshi, T., Kamisawa, T., Heitz, P. U., Stamm, B., Ruschoff, J., Wiedenmann, B., and Kloppel, G. Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am. J. Pathol., 143: 685-698, 1993.