Genetic analysis reveals that Amyloid Precursor Protein and Death Receptor 6 function in the same pathway to control axonal pruning independent of β-secretase

Journal of Neuroscience

Volumn 34, Issue 19, 2014, Pages 6438-6447

  Olsen, Olav ^a   Kallop, Dara Y ^b   McLaughlin, Todd ^c   Huntwork Rodriguez, Sarah ^b   Wu, Zhuhao ^a   Duggan, Cynthia D ^a   Simon, David J ^a   Lu, Yanmei ^b   Easley Neal, Courtney ^b   Takeda, Kentaro ^b   Hass, Philip E ^b   Jaworski, Alexander ^a   O'Leary, Dennis D M ^c   Weimer, Robby M ^b   Tessier Lavigne, Marc ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b GENENTECH INC   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Degeneration; Pruning

Indexed keywords

ALKALINE PHOSPHATASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CASPASE; DEATH RECEPTOR; DEATH RECEPTOR 6; NERVE GROWTH FACTOR; POLYHISTIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AXONAL PRUNING; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GENETIC ANALYSIS; GENOTYPE; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MOUSE; NERVE FIBER DEGENERATION; NERVE FIBER GROWTH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; WESTERN BLOTTING;

DEGENERATION; PRUNING;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; CELL COUNT; CELLS, CULTURED; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; NERVE DEGENERATION; PROTEIN BINDING; RECEPTORS, TUMOR NECROSIS FACTOR; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION;

EID: 84899888552     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3522-13.2014     Document Type: Article

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