App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of Down syndrome

Journal of Neuroscience

Volumn 23, Issue 17, 2003, Pages 6788-6792

  Cataldo, Anne M ^a,b,c   Petanceska, Suzana ^c   Peterhoff, Corrinne M ^c   Terio, Nicole B ^c   Epstein, Charles J ^d   Villar, Angela ^d   Carlson, Elaine J ^e   Staufenbiel, Matthias ^f   Nixon, Ralph A ^c,g  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

^g NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Basal forebrain neurons; Down syndrome; Endocytic pathway; Endosomes; Ts1Cje; Ts65Dn

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BIOCHEMICAL MARKER; EARLY ENDOSOMAL ANTIGEN 1; RAB PROTEIN; RABAPTIN 5; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APP GENE; ARTICLE; BRAIN ATROPHY; CHROMOSOME 16; CONTROLLED STUDY; DOWN SYNDROME; ENDOCYTOSIS; ENDOSOME; FEMALE; FOREBRAIN; GENE; GENE DELETION; GENE DOSAGE; GENE OVEREXPRESSION; MALE; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRISOMY 16;

EID: 0041632362     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-17-06788.2003     Document Type: Article

References (27)

1. Allore R, O'Hanlon D, Price R, Neilson K, Willard HF, Cox DR, Marks A, Dunn RJ (1988) Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. Science 239:1311-1313.
2. Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, Zerial M (1992) The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70:715-728.
3. Busciglio J, Yankner BA (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378:776-779.
4. Cataldo AM, Barnett JL, Pieroni C, Nixon RA (1997) Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J Neurosci 17:6142-6151.
5. Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000a) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157:277-286.
6. Cataldo AM, Nixon RA, Troncoso J, Durham R, Buxbaum J, Epstein C, Carlson E, Peterhoff C (2000b) Endocytic alterations in human preclinical Alzheimer's disease and a trisomic mouse model of Down syndrome: implications for β-amyloidogenesis. Neurobiol Aging 21:293.
7. Cataldo AM, Rebeck GW, Ghetti B, Hulette C, Lippa C, van Broeckhoven C, van Duijn C, Cras P, Bogdanovic N, Bird T, Peterhoff CM, Nixon RA (2001) Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Ann Neurol 50:661-665.
8. Cooper J, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JK, Carlson EJ, Epstein CJ, Mobley WC (2001) Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci USA 98:10439-10444.
9. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
10. Davisson MT, Schmidt C,Akeson EC (1990) Segmental trisomy of murine chromosome 16: new model system for studying Down syndrome. Prog Clin Biol Res 360:263-280.
11. Gournier H, Stenmark H, Rybin V, Lippe R, Zerial M (1998) Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J 17:1930-1940.
12. Grbovic OM, Mathews PM, Schmidt SD, Nixon RA, Cataldo AM (2002) Rab5 Overexpressionin a cell model of AD-related endocytic abnormalities influences processing of βAPP. Neurobiol Aging 23:S 13:50.
13. Griffin WST, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86:7611-7615.
14. Griffin WST, Sheng JG, McKenzie LE, Royston MC, Gentleman SM, Brumback RA, Cork LC, Del Bigio MR, Roberts GW, Mrak RE (1998) Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis. Neurobiol Aging 19:401-405.
15. Holcomb L, Gordon M, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsaio K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1:97-100.
16. Holtzman DM, Santucci D, Kilbridge J, Chua-Couzons J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sung Y, Carlson E, Alleva E, Epstein CJ, Mobley WC (1996) Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci USA 93:13333-13338.
17. Huse JT, Pijak DS, Leslie GJ, Lee VM-Y, Doms RW (2000) Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J Biol Chem 275:33729-33737.
18. Motonaga K, Itoh M, Becker LE, Goto Y, Takashima S (2002) Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome. Neurosci Lett 326:64-66.
19. Reeves RH, Irving N, Moran T, Wohn A, Kitt C, Sisodia SS, Schmidt C, Bronson R, Davisson M (1995) A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet 11:177-184.
20. Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT (1998) Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci USA 95:6256-6261.
21. Sheng JG, MrakRE, Griffin WST (1997) Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages. J Neuropathol Exp Neurol 56:285-290.
22. Stenmark H, Vitale G, Ullrich O, Zerial M (1995) Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell 83:423-432.
23. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94:13287-13292.
24. van der Sluijs P, Hull M, Webster P, Male P, Goud B, Mellman I (1992) The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 70:729-740.
25. Vassar R, Bennett BD, Babu-Khan S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
26. Wenk GL, Willard LB (1998) The neural mechanisms underlying cholinergic cell death within the basal forebrain. Int J Dev Neurosci 16:729-735.
27. Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJS, Hopkins R, Smith DW, Heavens RP, Dawson DW, Boyce S, Connor MW, Stevens KA, Slunt HH, Sisodia SS, Chen HY, Van der Ploeg LHT (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531.