Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of β-amyloid precursor protein in mice

Journal of Neurochemistry

Volumn 71, Issue 2, 1998, Pages 875-878

  Song, D K ^a   Won, M H ^a   Jung, J S ^a   Lee, J C ^a   Kang, T C ^b   Suh, H W ^a   Huh, S O ^a   Paek, S H ^a   Kim, Y H ^a   Kim, S H ^b   Suh, Y H ^b  

^a Hallym University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Carboxyl terminal fragment; Neuronal degeneration; Reactive gliosis; Step through passive avoidance task; Amyloid precursor protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GLIOSIS; HIPPOCAMPUS; MOUSE; NEOCORTEX; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031724004     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71020875.x     Document Type: Article

References (21)

1. Caputo C. B., Sobel I. R., Scott C. W., Brunner W. F., Barth P. T., and Blowers D. P. (1992) Association of the carboxy-terminus of beta-amyloid protein precursor with Alzheimer paired helical filaments. Biochem. Biophys. Res. Commun. 185, 1034-1040.
2. Chong Y. H., Jung J. M., Choi W., Park C. W., Choi K. S., and Suh Y.-H. (1994) Bacterial expression, purification of full length and carboxy terminal fragment of Alzheimer amyloid precursor protein and their proteolytic processing by thrombin. Life Sci. 54, 1259-1268.
3. Cullen W. K., Suh Y.-H., Anwyl R., and Rowan M. J. (1997) Block of late-phase long-term potentiation in rat hippocampus in vivo by β-amyloid precursor protein fragments. Neuroreport 8, 3213-3217.
4. Duffy P. E., Rapport M., and Graf L. (1980) Glial fibrillary acidic protein and Alzheimer-type senile dementia. Neurology 30, 778-782.
5. Fraser S. P., Suh Y.-H., Chong Y. H., and Djamgoz M. B. A. (1996) Membrane currents induced by Xenopus oocytes by the C-terminal fragment of the β-amyloid precursor protein. J. Neurochem. 66, 2034-2040.
6. Fraser S. P., Suh Y.-H., and Djamgoz M. B. A. (1997) Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments. Trends Neurosci. 20, 67-72.
7. Fukuchi K., Kamino K., Deeb S. S., Furlong C. E., Sundstrom J. A., Smith A. C., and Martin G. M. (1992) Expression of a carboxyterminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity. Mol. Brain Res. 16, 37-46.
8. Kammesheidt A., Boyce F. M., Spanoyannis A. F., Cummings B. J., Ortegon M., Cotman C., Vaught J. L., and Neve R. L. (1992) Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxy-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA 89, 10857-10861.
9. Kim S.-H. and Suh Y.-H. (1996) Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer's amyloid precursor protein. J. Neurochem. 67, 1172-1182.
10. Laursen S. E. and Belknap J. K. (1986) Intracerebroventricular injections in mice. Some methodological refinements. J. Pharmacol. Methods 16, 355-357.
11. Nalbantoglu J., Tirado-Santiago G., Lahsaini A., Poirier J., Goncalves O., Verge G., Momoli F., Weiner S. A., Massicotte G., Julien J.-P., and Shapiro M. L. (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387, 500-505.
12. Neve R. L., Kammesheidt A., and Hohmann C. F. (1992) Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc. Natl. Acad. Sci. USA 89, 3448-3452.
13. Oster-Granite M. L., McPhie D. L., Greenan J., and Neve R. L. (1996) Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J. Neurosci. 16, 6732-6741.
14. Pike C. J., Cummings B. J., and Cotman C. W. (1995) Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Exp. Neural. 132, 172-179.
15. Potter H. (1992) The involvement of astrocytes and an acute phase response in the amyloid deposition of Alzheimer's disease. Prog. Brain Res. 94, 447-458.
16. Selkoe D. J. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
17. Selkoe D. J., Podlisny M. B., Joachim C. L., Vickers E. A., Lee G., Fritz L. C., and Oltersdorf T. (1988) Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. Natl. Acad. Sci. USA 85, 7341-7345.
18. Suh Y.-H. (1997) An etiological role of amyloidogenic carboxyl-terminal fragments of the β-amyloid precursor protein in Alzheimer's disease. J. Neurochem. 68, 1781-1791.
19. Tamaoka A., Kalaria R. N., Lieberburg I., and Selkoe D. J. (1992) Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proc. Natl. Acad. Sci. USA 89, 1345-1349.
20. Wisniewski H. M. and Wegiel J. (1991) Spatial relationships between astrocytes and classical plaque components. Neurobiol. Aging 12, 593-600.
21. Yankner B. A., Dawes L. R., Fisher S., Villa-Komaroff L., Oster-Granite M. L., and Neve R. L. (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420.