The "Nonamyloidogenic" p3 fragment (amyloid β17-42) is a major constituent of down's syndrome cerebellar preamyloid

Journal of Biological Chemistry

Volumn 271, Issue 52, 1996, Pages 33623-33631

  Lalowski, Maciej ^a   Golabek, Adam ^a   Lemere, Cynthia A ^b   Selkoe, Dennis J ^b   Wisniewski, Henryk M ^c   Beavis, Ronald C ^a   Frangione, Bias ^a   Wisniewski, Thomas ^a,d  

^a NEW YORK UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN P3, HUMAN; AMYLOID BETA-PROTEIN P3, HUMAN; THIAZOLE DERIVATIVE; THIOFLAVINE;

ADULT; ARTICLE; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; DOWN SYNDROME; GENE INSERTION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LEPTOMENINX; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYMPTOMATOLOGY; ALZHEIMER DISEASE; BRAIN; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PATHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOWN SYNDROME; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUOROMETRY; HUMANS; MASS SPECTROMETRY; THIAZOLES;

EID: 0030300022     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.52.33623     Document Type: Article

References (86)

1. Wisniewaki, T., Ghiso, J., and Frangione, B. (1994) Neurobiol. Aging 15, 143-152
2. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10, 373-403
3. Wisniewski, H. M., Wegiel, J., and Popovitch, E. R. (1994) Dev. Brain Dysfunct. 7, 330-339
4. Giaccone, G., Tagliavini, F., Linoli, G., Bouras, C., Frigerior, L., Frangione, B., and Bugiani, O. (1939) Neurosci. Lett. 97, 232-238
5. Mann, D. M. (1989) Neurobiol. Aging 10, 397-399
6. Motte, J. and Williams, R. S. (1989) Acta Neuropathol. 77, 535-546
7. Yamaguchi, H., Hirai, S., Morimatsu, M., Shoji, M., and Harigaya, Y. (1988) Acta Neuropathol. 77, 113-119
8. Tagliavini, F., Giaccone, G., Frangione, B., and Bugiani, O. (1988) Neurosci. Lett. 93, 191-196
9. Wisniewski, H. M., Bancher, C., Barcikowska, M., Wen, G. Y., and Currie, J. (1989) Acta Neuropathol. 78, 337-347
10. Yamazaki, T., Yamaguchi, H., Okamoto, K., and Hirai, S. (1991) Acta Neuropathol. 81, 640-545
11. Yamaguchi, H., Nakazato, Y., Shoji, M., Takatama, M., and Hirai, S. (1991) Acta Neuropathol. 82, 13-20
12. Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks-Nelson, H., and Antis, P. (1993) Ann. Neurol. 34, 566-573
13. Davies, P., Duyckaerts, C., Beyreuther, K., Masters, C. L., Peitte, F., and Hauw, J. J. (1988) Neurology 38, 1688-1693
14. Delaere, P., Duyckaerts, C., Beyreuther, K., Masters, C. L., Peitte, F., and Hauw, J. J. (1990) Neurosci. Lett. 116, 87-93
15. Kida, E., Choi-Miura, N. H., and Wisniewski, K. E. (1995) Brain Res. 685, 211-216
16. Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., and Selkoe, D. J. (1996) Neurobiol. Dis. 3, 16-32
17. Wisniewski, H. M., Wegiel, J., and Kotula, L. (1996) Neuropathol. Appl. Neurobiol. 22, 3-11
18. Kosik, K. S., and Coleman, P. (1992) Neurobiol. Aging 13, 535-627
19. Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., and Cotman, C. W. (1993) J. Neurosci. 13, 1676-1687
20. Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I., Becker, G. W., Brems, D. N., and Li, W. Y. (1994) Mol. Pharmacol. 45, 373-379
21. Ueda, K., Fukui, Y., and Kageyama, H. (1994) Brain Res. 639, 240-244
22. Lorenzo, A., and Yankner, B. A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12243-12247
23. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
24. Selkoe, D. J., Abraham, C. R., Podlisny, M. B., and Duffy, L. K. (1986) J. Neurochem. 46, 1820-1834
25. Mori, H., Takio, K., Ogawara, M., and Selkoe, D. J. (1992) J. Biol. Chem. 267, 17082-17086
26. Miller, D. L., Papayannopoulos, I. A., Styles, J., Bobin, S. A., Lin, Y. Y., Biemann, K., and Iqbal, K. (1993) Arch. Biochem. Biophys. 301, 41-52
27. Roher, A. E., Lowenson, J. D., Clarke, S., Wolkow, C., Wang, R., Cotter, R. J., Rearson, I. M., Zurcher-Neely, H. A., Heinrikson, R. L., Ball, M. J., and Greenburg, B. D. (1993) J. Biol. Chem. 268, 3072-3083
28. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
29. Gorevic, P. D., Goni, F., Pons-Estel, B., Alvarez, F., Peress, N. S., and Frangione, B. (1986) J. Neuropathol. Exp. Neurl. 45, 647-664
30. Joachim, C. L., Dufly, L. K., Morris, J. H., and Selkoe, D. J. (1988) Brain Res. 474, 100-111
31. Prelli, F., Castano, E. M., Glenner, G. G., and Frangione, B. (1988) J. Neurochem. 51, 648-651
32. Roher, A. E., Lowenson, J. D., Clarke, S., Woods, A. S., Cotter, R. J., Gowing, E., Bail, and MJ. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10836-10840
33. Gowing, E., Roher, A. E., Woods, A. S., Cotter, R. J., Chaney, M., Little, S. P., Ball, and MJ. (1994) J. Biol. Chem. 269, 10987-10990
34. Wisniewski, T., Lalowski, M., Bobik, M., Russell, M., Strosznajder, J., and Frangione, B. (1996) Biochem. J. 313, 576-580
35. Cummings, B. J., Su, J. H., Cotman, C. W., White, R., and Russell, M. J. (1993) Neurobiol. Aging 14, 547-560
36. Wisniewski, H. M., Wegiel, J., Morys, J., Baucher, C., Soltysiak, Z., and Kim, K. S. (1990) in Alzheimer's Disease: Epidemiology, Neuropathology, Neurochemistry and Clinics (Maurer, K., Rieder, D., and Beckman, H. eds) pp. 151-168, Springer-Verlag, Berlin
37. Kida, E., Wisniewski, K. E., and Wisniewski, H. M. (1995) Neurosci. Lett. 193, 105-108
38. Kim, K. S., Miller, D. L., Sapienza, V. J., Chen, C. M. J., Bai, C., Grundke-Iqbal, I., Currie, J., and Wisniewski, H. M. (1988) Neurosci. Res. Commun. 2, 121-130
39. Tabaton, M., Nunzi, M. G., Xue, R., Usiak, M., Autilio-Gambetti, L., and Gambetti, P. (1994) Biochem. Biophys. Res. Commun. 200, 1598-1603
40. Teller, J. K., Russo, C., DeBusk, L. M., Angelini, G., Zaccheo, D., Dagna-Bricarelli, F., Scartezzini, P., Bertolini, S., Mann, D. M. A., Tabaton, M., and Gambetti, P. (1996) Nat. Med. 2, 93-95
41. Beavis, R. C. (1996) J. Am. Soc. Mass Spectrom. 7, 107-11342.
42. Hillenkamp, F., Karas, M., Beavis, R. C., and Chait, B. T. (1991) Anal. Chem. 63, 1193A-1203A
43. Cohen, S. L., and Chait, B. T. (1996) Anal. Chem. 68, 31-37
44. Yamaguchi, H., Sugihara, S., Isahiguro, K., Takatama, A., and Hirai, S. (1995) Amyloid 2, 7-16
45. Naiki, H., Higuchi, K., Nakakuki, K., and Takeda, T. (1991) Lab. Invest. 65, 104-110
46. LeVine, H. (1993) Protein Sci. 2, 404-410
47. Wisniewski, T., Castafio, E. M., Golabek, A. A., Vogel, T., and Frangione, B. (1994) Am. J. Pathol. 145, 1030-1035
48. Iwateubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., and Ihara, Y. (1994) Neuron 13, 45-53
49. Yang, F., Mak, K., Vinters, H. V., Frautschy, S. A., and Cole, G. M. (1994) Neuroreport 5, 2117-2120
50. Saldo, T. C., Iwatsubo, T., Mann, D. M., Shimada, H., Ihara, Y., and Kawashima, S. (1995) Neuron 14, 457-466
51. Pike, C. J., Overman, M. J., and Cotman, C. W. (1995) J. Biol. Chem. 270, 23895-23898
52. Iwatsubo, T., Mann, D. M., Odaka, A., Suzuki, N., and Ihara, Y. (1995) Ann. Neurol 37, 294-299
53. Checler, F. (1995) J. Neurochem. 65, 1431-1444
54. Younkin, S. G. (1995) Ann. Neurol. 37, 287-288
55. Jarrett, J. T., Berger, E. P., and Lansbury, P. T., Jr. (1993) Biochem. 32, 4693-4697
56. Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L., and Beyreuther, K. (1991) J. Mol. Biol. 218, 149-163
57. Suzuki, N., Cheung, T. T., Cai, T. T., Cai, X.-D., Odaka, A., Otvoa, L., Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264,1336-1340
58. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., and Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
59. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shafler, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1992) Science 258, 126-129
60. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
61. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D. J., Lieberburg, I., and Schenk, D. B. (1992) Nature 359, 325-327
62. Tjernberg, L. O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A. R., Thyberg, J., Terenius, L., and Nordstedt, C. (1996) J. Biol. Chem. 271, 8545-8548
63. Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L., and Beyreuther, K. (1992) J. Mol. Biol. 228, 1-14
64. Soto, C., Castaño, E. M., Frangione, B., and Inestrosa, N. C. (1995) J. Biol. Chem. 270, 3063-3067
65. Wisniewski, T., Ghiso, J., and Frangione, B. (1991) Biochem. Biophys. Res. Commun. 178, 1247-1254
66. Clements, A., Walsh, D. M., Williams, C. H., and Allsop, D. (1993) Neurosci. Lett. 161,17-20
67. Timmers, W. F., Tagliavini, F., Haan, J., and Frangione, B. (1990) Neurosci. Lett. 118, 223-226
68. Mann, D. M. A., Iwatsubo, T., Ihara, Y., Cairns, N. J., Lantos, P. L., Bogdanovic, N., Lannfelt, L., Winblad, B., Maat-Schieman, M. L. C., and Rossor, M. N. (1996) Am. J. Pathol. 148, 1257-1266
69. Castano, E. M., Prelli, F., Soto, C., Beavis, R., Matsubara, E. Shoji, M., and Frangione, B. (1996) J. Biol. Chem. 271, 32185-32191
70. Higgins, L. S., Murphy, G. M., Forno, L. S., Catalano, R., and Cordell, B. (1996) Am. J. Pathol. 149, 585-596
71. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagoplan, S., Johnson-Wood, K., Kan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B., and Zhao, J. (1995) Nature 373, 523-527
72. Morris, J. C., Storandt, M., McKeel, D. W., Jr., Rubin, E. H., Price, J. L., Grant, E. A., and Berg, L. (1996) Neurology 46, 707-719
73. Dyrks, T., Dyrks, E., Hartmann, T., Masters, C., and Beyreuther, K. (1992) J. Biol. Chem. 267, 18210-18217
74. Tomiyama, T., Asano, S., Furiya, Y., Shirasawa, T., Endo, N., and Mori, H. (1994) J. Biol. Chem. 269, 10205-10208
75. Yankner, B. A. (1996) Neuron 16, 921-932
76. Wisniewski, T., and Frangione, B. (1996) Acta Neurobiol. Exp. 56, 267-279
77. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
78. Wisniewski, T., Lalowski, M., Golabek, A. A., Vogel, T., and Frangione, B. (1995) Lancet 345, 956-958
79. Naslund, J., Thyberg, J., Tjernberg, L. O., Wernstedt, C., Karlström, A. R., Bogdanovic, N., Gandy, S. E., Lannfelt, L., Terenius, L., and Nordstedt, C. (1995) Neuron 15, 219-228
80. Ma, J., Yee, A., Brewer, H. B., Jr., Das, S., and Potter, H. (1994) Nature 372, 92-94
81. Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., and Lansbury, P. T., Jr. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 763-767
82. Wisniewski, T., Palha, J. A., Ghiso, J., and Frangione, B. (1995)Lancet 346, 1366
83. Snow, A. D., Willner, J., and Kisilevsky, R. (1987) Lab. Invest. 56, 120-124
84. Wisniewski, T., Lalowski, M., Baumann, M., Rauvala, H., Raulo, E., Nolo, R., and Frangione, B. (1996) Neuroreport 7, 667-671
85. Abraham, C. R., Selkoe, D. J., and Potter, H. (1988) Cell 52, 487-501
86. Bush, A. I., Pettingell, W. H., Multhaup, G., de Paradis, M., Vonsattel, J. P., Gusella, J. F., Beyreuther, K., Masters, C. L., and Tanzi, R. E. (1994) Science 265, 1464-1467