Transgenic mice expressing APP-C100 in the brain

Neurobiology of Aging

Volumn 17, Issue 2, 1996, Pages 191-203

  Neve, Rachael L ^a   Boyce, Frederick M ^b   McPhie, Donna L ^a   Greenan, Jane ^c   Oster Granite, Mary Lou ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; APP C100; Mouse brain

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOREACTIVITY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ULTRASTRUCTURE;

EID: 0029888942     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)02074-8     Document Type: Article

References (44)

1. Benowitz, L. I.; Rodriguez, W.; Paskevich, P.; Mufson, E. J.; Schenk, D.; Neve, R. L. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp. Neurol. 106:237-250; 1989.
2. Boyce, F. M.; Beggs, A. H.; Feener, C.; Kunkel, L. M. Dystrophin is transcribed in brain from a distant upstream promoter. Proc. Natl. Acad. Sci. USA 88:276-1280; 1991.
3. Cataldo, A. M.; Nixon, R. A. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc. Natl. Acad .Sci. USA 87:3861-3865; 1990.
4. Cummings, B. J.; Su, J. H.; Geddes, J. W.; Van Nostrand, W. E.; Wagner, S. L.; Cunningham, D. D.; Cotman, C. W. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 48:763-777; 1992.
5. Davies, P. Alz-50 as a reagent to assess animal models of Alzheimer's disease. Neurobiol. Aging 13:613-614; 1992.
6. DeKosky, S. T.; Scheff, S. W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann. Neurol. 27:457-464; 1990.
7. Flood, J. F.; Morley, J. E.; Roberts, E. Amnestic effects in mice of four synthetic peptides homologous to amyloid protein from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 88:3363-3366; 1991.
8. Frautschy, S. A.; Baird, A.; Cole, G. M. Effects of injected Alzheimer β-amyloid cores in rat brain. Proc. Natl. Acad. Sci. USA 88:8362-8366; 1991.
9. Frautschy, S. A.; Cole, G. M.; Baird, A. Phagocytosis and deposition of vascular β-amyloid in rat brains injected with Alzheimer β-amyloid. Am. J. Pathol. 140:1389-1399; 1992.
10. Fukuchi, K.; Kamino, K.; Deeb, S. S.; Smith, A. C.; Dang, T.; Martin, G. M. Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Commun. 182:165-173; 1992.
11. Fukuchi, K.; Sopher, B.; Furlong, C. E.; Smith, A. C.; Dang, N. T.; Martin, G. M. Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein. Neurosci. Lett. 154:145-148; 1993.
12. Fukuchi, K.; Kunkel, D. D.; Schwartzkroin, P. A.; Kamino, K.; Ogburn, C. E.; Furlong, C. E.; Martin, G. M. Overexpression of a C-terminal portion of the β-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells. Exp. Neurol. 127:253-264; 1994.
13. Games, D.; Adams, D.; Alessandrini, R.; Barbour, R.; Berthelette, P.; Blackwell, C.; Carr, T.; et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527; 1995.
14. Hamos, J. E.; DeGennaro, L. J.; Drachman, D. A.; Hamos J. E.; DeGennaro L. J.; Drachman DA. Synaptic loss in Alzheimer's disease and other dementias. Neurology 39:355-361; 1989.
15. Kammesheidt, A.; Boyce, F. M.; Spanoyannis, A. F.; Cummings, B. J.; Ortegon, M.; Cotman, C. W.; Vaught, J. L.; Neve, R. L. Amyloid deposition and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA 89:10857-10861; 1992.
16. Kosik, K. S.; Coleman, P. Is β-amyloid neurotoxic? Neurobiol. Aging 13:535-630; 1992.
17. Kowall, N. W.; Beal, M. F.; Busciglio, J.; Duffy, L. K.; Yankner, B. A. An in vivo model for the neurodegenerative effects of amyloid and protection by substance P. Proc. Natl. Acad. Sci. USA 88:7247-7251; 1991.
18. Kozlowski, M. R.; Spanoyannis, A. F.; Manly, S. P.; Fidel, S. A.; Neve, R. L. The neurotoxic carboxyterminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding. J. Neurosci. 12:1679-1687; 1992.
19. LaFerla, F. M.; Tinkle, B. T.; Bieberich, C. J.; Haudenschild, C. C.; Jay, G. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:21-29; 1995.
20. Lee, V. M.-Y.; Valin, B. J.; Otvos, L.; Trojanowski, J. Q. A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science 251:675-678; 1991.
21. Liberini, P.; Piccardo, P.; Cuello, A. C. Alz-50 immunoreactivity in the central nervous system of adult rat and primate. Neurosci. Lett. 151:200-204; 1993.
22. Loo, D. T.; Copani, A.; Pike, C. J.; Whittemore, E. R.; Walencewicz, A. J.; Cotman. C. W. Is β-amyloid neurotoxic? Proc. Natl. Acad. Sci. USA 90:7951-7955; 1993.
23. Mann, D. M. A.; Yates, P. O. The quantitative assessment of lipofuscin pigment, cytoplasmic RNA and nucleolar volume in senile dementia. Neuropathol. Appl. Neurobiol. 4:129-135; 1974.
24. Martin, L. J.; Pardo, C. A.; Cork, L. C.; Price, D. L. Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am. J. Pathol. 145:1358-1381; 1994.
25. Martin, T. L.; Felsenstein, K. M.; Baetge, E. E. Cells transfected with amyloid precursor protein DNA fragment AB-1 produce medium toxic to differentiated PC12 cells. Soc. Neurosci. Abstr. 17:1072; 1991.
26. Maruyama, K.; Terakado, K.; Usami, M.; Yoshikawa, K. Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 347:566-569; 1990.
27. Mullan, M.; Crawford, F. Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16:398-403; 1993.
28. Neve, R. L.; Finch, E. A.; Dawes, L. R. Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1:669-677; 1988.
29. Neve, R. L.; Kammesheidt, A.; Hohmann, C. F. Brain transplants of cells expressing the carboxyterminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc. Natl. Acad. Sci. USA 89:3448-3452; 1992.
30. Neve, R. L.; Boyce F. M. In: Perez-Polo, J. R., ed. Paradigms of Neural Injury Construction and analysis of transgenic mice expressing amyloidogenic fragments of the Alzheimer amyloid protein precursor. Methods Neurosci. (in press).
31. Nitta, A.; Itoh, A.; Hasegawa, T.; Nabeshima, T. β-Amyloid protein-induced Alzheimer's disease animal model. Neurosci. Lett. 170:63-66; 1994.
32. Oster-Granite, M. L.; Greenan, J.; Neve, R. L. Structural alterations in the brains of mice transgenic for the carboxy terminal portion of the amyloid precursor protein gene. Soc. Neurosci. Abstr. 18:730; 1992.
33. Prickett, K. S.; Amberg, D. C.; Hopp, T. P. A calcium-dependent antibody for identification and purification of recombinant proteins. Biotechniques 7:580-589; 1989.
34. Quon, D.; Wang, Y.; Catalano, R.; Scardina, J. M.; Murakami, K.; Cordell, B. Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352:239-241; 1991.
35. Rye, D. B.; Leverenz, J.; Greenberg, S. G.; Davies, P.; Saper, C. B. The distribution of Alz-50 immunoreactivity in the normal human brain. Neuroscience 56:109-127; 1993.
36. Schmechel, D. E.; Saunders, A. M.; Strittmatter, W. J.; Crain, B. J.; Hulette, C. M.; Joo, S. H.; Pericak-Vance, M. A.; Goldgaber, D.; Roses, A. D. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:9649-9653; 1993.
37. Snow, A. D.; Sekiguchi, R.; Nochlin, D.; Fraser, P.; Kimata, K.; Mizutani, A.; Arai, M.; Schreier, W. A.; Morgan, D. G. An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron 12:219-234; 1994.
38. Suzuki, N.; Cheung, T. T.; Cai, X.-D.; Odaka, A.; Otvos, L., Jr.; Eckman, C.; Golde, T. E.; Younkin, S. G. An increased percentage of long amyloid protein secreted by familial amyloid protein precursor (APP717) mutants. Science 264:1336-1340; 1994.
39. Terry, R. D.; Masliah, E.; Salmon, D. P.; Butters, N.; DeTeresa , R.; Hill, R.; Hansen, L. A.; Katzman, R. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:572-580; 1991.
40. van de Nes, J. A. P.; Sluiter, A. A.; Pool, C. W.; Kamphorst, W.; Ravid, R.; Swaaab, D. F. The monoclonal antibody Alz-50, used to reveal cytoskeletal changes in Alzheimer's disease, also reacts with a large subpopulation of somatostatin neurons in the normal human hypothalamus and adjoining areas. Brain Res. 655:97-109; 1994.
41. Wolf, D.; Quon, D.; Wang, Y.; Cordell, B. Identification and characterization of C-terminal fragments of the β-amyloid precursor produced in cell culture. EMBO J. 9:2079-2084; 1990.
42. Wolozin, B. L.; Pruchnicki, A.; Dickson, D. W.; Davies, P. A neuronal antigen in the brains of Alzheimer patients. Science 232:8-650; 1986.
43. Yankner, B. A.; Dawes, L. R.; Fisher, S.; Villa-Komaroff, L.; Oster-Granite, M. L.; Neve, R. L. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245:417-420; 1989.
44. Yoshikawa, K.; Aizawa, T.; Hayashi, Y. Degeneration in vitro of postmitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359:64-67; 1992.