-
1
-
-
0024347713
-
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
-
Aghajanian GK, Rasmussen K (1989) Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse 3:331-338.
-
(1989)
Synapse
, vol.3
, pp. 331-338
-
-
Aghajanian, G.K.1
Rasmussen, K.2
-
2
-
-
0035829390
-
Measuring normal and pathological anxiety-like behaviour in mice: A review
-
Belzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125:141-149.
-
(2001)
Behav Brain Res
, vol.125
, pp. 141-149
-
-
Belzung, C.1
Griebel, G.2
-
3
-
-
0033586449
-
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
-
Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL (1999) Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Mol Brain Res 66:150 -162.
-
(1999)
Mol Brain Res
, vol.66
, pp. 150-162
-
-
Berger-Sweeney, J.1
McPhie, D.L.2
Arters, J.A.3
Greenan, J.4
Oster-Granite, M.L.5
Neve, R.L.6
-
4
-
-
0035652138
-
A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo
-
Bertrand E, Brouillet E, Caillé I, Bouillot C, Cole GM, Prochiantz A, Allinquant B (2001) A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo. Mol Cell Neurosci 18:503-511.
-
(2001)
Mol Cell Neurosci
, vol.18
, pp. 503-511
-
-
Bertrand, E.1
Brouillet, E.2
Caillé, I.3
Bouillot, C.4
Cole, G.M.5
Prochiantz, A.6
Allinquant, B.7
-
6
-
-
67749139805
-
Neurodegeneration in Alzheimer's disease: Caspases and synaptic element interdependence
-
Bredesen DE (2009) Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener 4:27.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 27
-
-
Bredesen, D.E.1
-
7
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276.
-
(1999)
Nat Neurosci
, vol.2
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
Cooper-Blacketer, D.4
Marshall, V.J.5
Irizarry, M.6
Younkin, L.7
Good, M.A.8
Bliss, T.V.9
Hyman, B.T.10
Younkin, S.G.11
Hsiao, K.K.12
-
8
-
-
34548258322
-
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
-
Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L (2007) Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 282:23818 -23828.
-
(2007)
J Biol Chem
, vol.282
, pp. 23818-23828
-
-
Cheng, I.H.1
Scearce-Levie, K.2
Legleiter, J.3
Palop, J.J.4
Gerstein, H.5
Bien-Ly, N.6
Puoliväli, J.7
Lesné, S.8
Ashe, K.H.9
Muchowski, P.J.10
Mucke, L.11
-
9
-
-
2442711560
-
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
-
Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L (2004) Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 24:4692- 4697.
-
(2004)
J Neurosci
, vol.24
, pp. 4692-4697
-
-
Chin, J.1
Palop, J.J.2
Yu, G.Q.3
Kojima, N.4
Masliah, E.5
Mucke, L.6
-
10
-
-
27144489060
-
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease
-
Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 25:9694 -9703.
-
(2005)
J Neurosci
, vol.25
, pp. 9694-9703
-
-
Chin, J.1
Palop, J.J.2
Puoliväli, J.3
Massaro, C.4
Bien-Ly, N.5
Gerstein, H.6
Scearce-Levie, K.7
Masliah, E.8
Mucke, L.9
-
11
-
-
0036582717
-
Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice
-
Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F (2002) Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci 22:3445-3453.
-
(2002)
J Neurosci
, vol.22
, pp. 3445-3453
-
-
Dewachter, I.1
Reversé, D.2
Caluwaerts, N.3
Ris, L.4
Kuipéri, C.5
Van den Haute, C.6
Spittaels, K.7
Umans, L.8
Serneels, L.9
Thiry, E.10
Moechars, D.11
Mercken, M.12
Godaux, E.13
Van Leuven, F.14
-
12
-
-
0023691166
-
A new one-trial test for neurobiological studies of memory in rats. 1. Behavioral data
-
Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1. Behavioral data. Behav Brain Res 31:47-59.
-
(1988)
Behav Brain Res
, vol.31
, pp. 47-59
-
-
Ennaceur, A.1
Delacour, J.2
-
13
-
-
0035399822
-
Agerelated impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
-
Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR (2001) Agerelated impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J Neurosci 21:4691- 4698.
-
(2001)
J Neurosci
, vol.21
, pp. 4691-4698
-
-
Fitzjohn, S.M.1
Morton, R.A.2
Kuenzi, F.3
Rosahl, T.W.4
Shearman, M.5
Lewis, H.6
Smith, D.7
Reynolds, D.S.8
Davies, C.H.9
Collingridge, G.L.10
Seabrook, G.R.11
-
14
-
-
33646480747
-
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664
-
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE (2006) Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A 103:7130 -7135.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7130-7135
-
-
Galvan, V.1
Gorostiza, O.F.2
Banwait, S.3
Ataie, M.4
Logvinova, A.V.5
Sitaraman, S.6
Carlson, E.7
Sagi, S.A.8
Chevallier, N.9
Jin, K.10
Greenberg, D.A.11
Bredesen, D.E.12
-
15
-
-
43849090364
-
Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664
-
Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE (2008) Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res 191:246 -255.
-
(2008)
Behav Brain Res
, vol.191
, pp. 246-255
-
-
Galvan, V.1
Zhang, J.2
Gorostiza, O.F.3
Banwait, S.4
Huang, W.5
Ataie, M.6
Tang, H.7
Bredesen, D.E.8
-
16
-
-
0028985574
-
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527.
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527.
-
-
-
-
17
-
-
0035909901
-
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
-
Gao Y, Pimplikar SW (2001) The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A 98:14979-14984.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14979-14984
-
-
Gao, Y.1
Pimplikar, S.W.2
-
18
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Ab peptide formation
-
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Ab peptide formation. Cell 97:395-406.
-
(1999)
Cell
, vol.97
, pp. 395-406
-
-
Gervais, F.G.1
Xu, D.2
Robertson, G.S.3
Vaillancourt, J.P.4
Zhu, Y.5
Huang, J.6
LeBlanc, A.7
Smith, D.8
Rigby, M.9
Shearman, M.S.10
Clarke, E.E.11
Zheng, H.12
Van Der Ploeg, L.H.13
Ruffolo, S.C.14
Thornberry, N.A.15
Xanthoudakis, S.16
Zamboni, R.J.17
Roy, S.18
Nicholson, D.W.19
-
19
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A 96:3228 -3233.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.C.8
Nicoll, R.A.9
Mucke, L.10
-
20
-
-
33645520634
-
Earlyonset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
-
Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE (2006) Earlyonset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 103:5161-5166.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5161-5166
-
-
Jacobsen, J.S.1
Wu, C.C.2
Redwine, J.M.3
Comery, T.A.4
Arias, R.5
Bowlby, M.6
Martone, R.7
Morrison, J.H.8
Pangalos, M.N.9
Reinhart, P.H.10
Bloom, F.E.11
-
21
-
-
0031020909
-
42 deposition in a transgenic mouse model of Alzheimer disease
-
42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci U S A 94:1550 -1555.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
Hu, K.4
Gordon, G.5
Barbour, R.6
Khan, K.7
Gordon, M.8
Tan, H.9
Games, D.10
Lieberburg, I.11
Schenk, D.12
Seubert, P.13
McConlogue, L.14
-
22
-
-
50349083093
-
-
Knobloch M, Mansuy IM (2008) Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 37:73- 82. Kobayashi DT, Chen KS (2005) Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease. Genes Brain Behav 4:173-196.
-
Knobloch M, Mansuy IM (2008) Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 37:73- 82. Kobayashi DT, Chen KS (2005) Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease. Genes Brain Behav 4:173-196.
-
-
-
-
23
-
-
33645038471
-
A specific amyloid-β protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-β protein assembly in the brain impairs memory. Nature 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
24
-
-
0034107524
-
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
-
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE (2000) A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor. Nat Med 6:397- 404.
-
(2000)
Nat Med
, vol.6
, pp. 397-404
-
-
Lu, D.C.1
Rabizadeh, S.2
Chandra, S.3
Shayya, R.F.4
Ellerby, L.M.5
Ye, X.6
Salvesen, G.S.7
Koo, E.H.8
Bredesen, D.E.9
-
25
-
-
0035900875
-
β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations
-
McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL (2001) β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. Mol Brain Res 97:103-113.
-
(2001)
Mol Brain Res
, vol.97
, pp. 103-113
-
-
McPhie, D.L.1
Golde, T.2
Eckman, C.B.3
Yager, D.4
Brant, J.B.5
Neve, R.L.6
-
26
-
-
44949184540
-
Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease
-
Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L (2008) Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci 28:5007-5017.
-
(2008)
J Neurosci
, vol.28
, pp. 5007-5017
-
-
Meilandt, W.J.1
Yu, G.Q.2
Chin, J.3
Roberson, E.D.4
Palop, J.J.5
Wu, T.6
Scearce-Levie, K.7
Mucke, L.8
-
27
-
-
60849097262
-
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβ oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
-
Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβ oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci 29:1977-1986.
-
(2009)
J Neurosci
, vol.29
, pp. 1977-1986
-
-
Meilandt, W.J.1
Cisse, M.2
Ho, K.3
Wu, T.4
Esposito, L.A.5
Scearce-Levie, K.6
Cheng, I.H.7
Yu, G.Q.8
Mucke, L.9
-
28
-
-
0033525520
-
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
-
Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F (1999) Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 274:6483- 6492.
-
(1999)
J Biol Chem
, vol.274
, pp. 6483-6492
-
-
Moechars, D.1
Dewachter, I.2
Lorent, K.3
Reversé, D.4
Baekelandt, V.5
Naidu, A.6
Tesseur, I.7
Spittaels, K.8
Haute, C.V.9
Checler, F.10
Godaux, E.11
Cordell, B.12
Van Leuven, F.13
-
30
-
-
0028968005
-
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein
-
Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E (1995) Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. J Exp Med 181:1551-1556.
-
(1995)
J Exp Med
, vol.181
, pp. 1551-1556
-
-
Mucke, L.1
Abraham, C.R.2
Ruppe, M.D.3
Rockenstein, E.M.4
Toggas, S.M.5
Mallory, M.6
Alford, M.7
Masliah, E.8
-
31
-
-
0034213718
-
1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20:4050-4058.
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
32
-
-
48349085043
-
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
-
Müller T, Meyer HE, Egensperger R, Marcus K (2008) The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol 85:393-406.
-
(2008)
Prog Neurobiol
, vol.85
, pp. 393-406
-
-
Müller, T.1
Meyer, H.E.2
Egensperger, R.3
Marcus, K.4
-
33
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457:981-989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.3
Tessier-Lavigne, M.4
-
34
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
35
-
-
9644254315
-
Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease
-
Ognibene E, Middei S, Daniele S, Adriani W, Ghirardi O, Caprioli A, Laviola G (2005) Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease. Behav Brain Res 156:225-232.
-
(2005)
Behav Brain Res
, vol.156
, pp. 225-232
-
-
Ognibene, E.1
Middei, S.2
Daniele, S.3
Adriani, W.4
Ghirardi, O.5
Caprioli, A.6
Laviola, G.7
-
36
-
-
65249091454
-
Epilepsy and cognitive impairments in Alzheimer's disease
-
Palop JJ, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer's disease. Arch Neurol 66:435-440.
-
(2009)
Arch Neurol
, vol.66
, pp. 435-440
-
-
Palop, J.J.1
Mucke, L.2
-
37
-
-
0042924399
-
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
-
Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A 100:9572-9577.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9572-9577
-
-
Palop, J.J.1
Jones, B.2
Kekonius, L.3
Chin, J.4
Yu, G.Q.5
Raber, J.6
Masliah, E.7
Mucke, L.8
-
38
-
-
27144530643
-
Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice
-
Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J Neurosci 25:9686-9693.
-
(2005)
J Neurosci
, vol.25
, pp. 9686-9693
-
-
Palop, J.J.1
Chin, J.2
Bien-Ly, N.3
Massaro, C.4
Yeung, B.Z.5
Yu, G.Q.6
Mucke, L.7
-
39
-
-
34548264782
-
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
-
Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L (2007) Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55:697-711.
-
(2007)
Neuron
, vol.55
, pp. 697-711
-
-
Palop, J.J.1
Chin, J.2
Roberson, E.D.3
Wang, J.4
Thwin, M.T.5
Bien-Ly, N.6
Yoo, J.7
Ho, K.O.8
Yu, G.Q.9
Kreitzer, A.10
Finkbeiner, S.11
Noebels, J.L.12
Mucke, L.13
-
40
-
-
69249212154
-
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein
-
Park SA, Shaked GM, Bredesen DE, Koo EH (2009) Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun 388:450-455.
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 450-455
-
-
Park, S.A.1
Shaked, G.M.2
Bredesen, D.E.3
Koo, E.H.4
-
41
-
-
33750731675
-
100 years and counting: Prospects for defeating Alzheimer's disease
-
Roberson ED, Mucke L (2006) 100 years and counting: prospects for defeating Alzheimer's disease. Science 314:781-784.
-
(2006)
Science
, vol.314
, pp. 781-784
-
-
Roberson, E.D.1
Mucke, L.2
-
42
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316:750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
43
-
-
0028875687
-
Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of transgenic mice andhumanswith Alzheimer's disease
-
Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L (1995) Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of transgenic mice andhumanswith Alzheimer's disease. J Biol Chem 270:28257-28267.
-
(1995)
J Biol Chem
, vol.270
, pp. 28257-28267
-
-
Rockenstein, E.M.1
McConlogue, L.2
Tan, H.3
Power, M.4
Masliah, E.5
Mucke, L.6
-
44
-
-
33847214486
-
Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
-
Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E (2007) Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci 27:1981-1991.
-
(2007)
J Neurosci
, vol.27
, pp. 1981-1991
-
-
Rockenstein, E.1
Torrance, M.2
Adame, A.3
Mante, M.4
Bar-on, P.5
Rose, J.B.6
Crews, L.7
Masliah, E.8
-
45
-
-
33845898816
-
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP
-
Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF (2006) Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci 26:13428-13436.
-
(2006)
J Neurosci
, vol.26
, pp. 13428-13436
-
-
Saganich, M.J.1
Schroeder, B.E.2
Galvan, V.3
Bredesen, D.E.4
Koo, E.H.5
Heinemann, S.F.6
-
46
-
-
44549087765
-
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
-
Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192:106 -113.
-
(2008)
Behav Brain Res
, vol.192
, pp. 106-113
-
-
Selkoe, D.J.1
-
47
-
-
33845661843
-
Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)
-
Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH (2006) Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). FASEB J 20:1254-1256.
-
(2006)
FASEB J
, vol.20
, pp. 1254-1256
-
-
Shaked, G.M.1
Kummer, M.P.2
Lu, D.C.3
Galvan, V.4
Bredesen, D.E.5
Koo, E.H.6
-
48
-
-
53849106834
-
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
-
Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60:247-257.
-
(2008)
Neuron
, vol.60
, pp. 247-257
-
-
Sun, B.1
Zhou, Y.2
Halabisky, B.3
Lo, I.4
Cho, S.H.5
Mueller-Steiner, S.6
Devidze, N.7
Wang, X.8
Grubb, A.9
Gan, L.10
-
49
-
-
0030872413
-
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
-
Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ (1997) Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol 56:933-944.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 933-944
-
-
Sze, C.I.1
Troncoso, J.C.2
Kawas, C.3
Mouton, P.4
Price, D.L.5
Martin, L.J.6
-
50
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
51
-
-
34248190279
-
Aβ oligomers: A decade of discovery
-
Walsh DM, Selkoe DJ (2007) Aβ oligomers: a decade of discovery. J Neurochem 101:1172-1184.
-
(2007)
J Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
52
-
-
0033605252
-
Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
-
Weidemann A, Paliga K, Dürrwang U, Reinhard FB, Schuckert O, Evin G, Masters CL (1999) Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J Biol Chem 274:5823-5829.
-
(1999)
J Biol Chem
, vol.274
, pp. 5823-5829
-
-
Weidemann, A.1
Paliga, K.2
Dürrwang, U.3
Reinhard, F.B.4
Schuckert, O.5
Evin, G.6
Masters, C.L.7
-
53
-
-
70350324313
-
Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience
-
Zhang J, Gorostiza O, Tang H, Bredesen DE, Galvan V (2009) Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res 206:202-207.
-
(2009)
Behav Brain Res
, vol.206
, pp. 202-207
-
-
Zhang, J.1
Gorostiza, O.2
Tang, H.3
Bredesen, D.E.4
Galvan, V.5
|