Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein

Biochemical and Biophysical Research Communications

Volumn 388, Issue 2, 2009, Pages 450-455

  Park, Sun Ah ^a,d   Shaked, Gideon M ^a   Bredesen, Dale E ^b,c   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Soonchunhyang University   (South Korea)

Author keywords

Amyloid precursor protein; Asp 664 cleavage; C31; Caspase; Cytotoxicity; Jcasp

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA GALACTOSIDASE; C31 PROTEIN; CYTOTOXIC FACTOR; GAMMA SECRETASE INHIBITOR; HETERODIMER; HOMODIMER; JCASP PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ACID; CELL LINE, TUMOR; CYTOTOXINS; GAMMA-AMINOBUTYRIC ACID; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RATS; TRIGLYCERIDES;

EID: 69249212154     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.042     Document Type: Article

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