Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP

Journal of Neuroscience

Volumn 26, Issue 52, 2006, Pages 13428-13436

  Saganich, Michael J ^a   Schroeder, Brock E ^b   Galvan, Veronica ^c   Bredesen, Dale E ^c   Koo, Edward H ^b   Heinemann, Stephen F ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

A peptide; Alzheimer's disease; Amyloid; Hippocampus; Learning memory; LTP; Potentiation; Schaffer collateral terminals; Spatial memory; Synaptic plasticity

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE MUTATION; LEARNING; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HUMANS; LEARNING; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; NEURONAL PLASTICITY; PEPTIDE FRAGMENTS; SYNAPTIC TRANSMISSION;

EID: 33845898816     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4180-06.2006     Document Type: Article

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