Aβ 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

Brain

Volumn 125, Issue 9, 2002, Pages 2036-2043

  Wei, Wanli ^a   Norton, Darrell D ^a   Wang, Xiantao ^a   Kusiak, John W ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Caspase; JNK; p3 peptide

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [17-42]; AMYLOID PRECURSOR PROTEIN; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 9; GAMMA SECRETASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (17 42); AMYLOID BETA-PROTEIN (17-42); CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL LYSATE; CONTROLLED STUDY; DOWN SYNDROME; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NERVE CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; CELL CULTURE; CHEMISTRY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

AMYLOID BETA-PROTEIN; APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PEPTIDE FRAGMENTS; TUMOR CELLS, CULTURED;

EID: 0036707528     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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