Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

Molecular Neurodegeneration

Volumn 3, Issue 1, 2008, Pages

  Giliberto, Luca ^a,d   Zhou, Dawang ^a   Weldon, Richard ^a   Tamagno, Elena ^b   De Luca, Pasquale ^c   Tabaton, Massimo ^d   D'Adamio, Luciano ^a,e  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c Grande Ospedale Metropolitano   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MUS; MUS MUSCULUS;

EID: 52049112089     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-3-12     Document Type: Article

References (29)

1. The amyloid precursor protein: beyond amyloid. H Zheng EH Koo, Mol Neurodegener 2006/08/26 2006 1 5 16930452 10.1186/1750-1326-1-5
2. Deciphering the genetic basis of Alzheimer's disease. DJ Selkoe MB Podlisny, Annu Rev Genomics Hum Genet 2002 3 67 99 10.1146/annurev.genom.3. 022502.103022 12142353
3. Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. B Passer L Pellegrini C Russo RM Siegel MJ Lenardo G Schettini M Bachmann M Tabaton L D'Adamio, J Alzheimers Dis 2000 2 3-4 289 301 12214090
4. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. MA Leissring MP Murphy TR Mead Y Akbari MC Sugarman M Jannatipour B Anliker U Muller P Saftig B De Strooper MS Wolfe TE Golde FM LaFerla, Proc Natl Acad Sci U S A 2002/03/28 2002 99 7 4697 4702 11917117 10.1073/pnas.072033799
5. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. X Cao TC Sudhof, Science 2001 293 5527 115 120 10.1126/science.1058783 11441186
6. Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas MD Rand RJ Lake, Science 1999/04/30 1999 284 5415 770 776 10.1126/science.284.5415.770 10221902
7. Presenilins: molecular switches between proteolysis and signal transduction. W Annaert B De Strooper, Trends Neurosci 1999/09/11 1999 22 10 439 443 10.1016/S0166-2236(99)01455-1 10481190
8. Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain. JC Wiley EA Smith MP Hudson WC Ladiges M Bothwell, J Biol Chem 2007/09/15 2007 282 46 33313 33325 10.1074/jbc.M706024200 17855370
9. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. SH Baek KA Ohgi DW Rose EH Koo CK Glass MG Rosenfeld, Cell 2002/08/02 2002 110 1 55 67 10.1016/S0092-8674(02)00809-7 12150997
10. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. R Pardossi-Piquard A Petit T Kawarai C Sunyach C Alves da Costa B Vincent S Ring L D'Adamio J Shen U Muller P St George Hyslop F Checler, Neuron 2005 46 4 541 554 10.1016/j.neuron.2005.04.008 15944124
11. Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. KA Ryan SW Pimplikar, J Cell Biol 2005/10/19 2005 171 2 327 335 16230462 10.1083/jcb.200505078
12. C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. HS Kim EM Kim JP Lee CH Park S Kim JH Seo KA Chang E Yu SJ Jeong YH Chong YH Suh, Faseb J 2003/08/19 2003 17 13 1951 1953 12923068
13. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. YW Zhang R Wang Q Liu H Zhang FF Liao H Xu, Proc Natl Acad Sci U S A 2007/06/09 2007 104 25 10613 10618 17556541 10.1073/pnas.0703903104
14. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Q Liu CV Zerbinatti J Zhang HS Hoe B Wang SL Cole J Herz L Muglia G Bu, Neuron 2007/10/09 2007 56 1 66 78 10.1016/j.neuron.2007.08.008 17920016
15. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. RC von Rotz BM Kohli J Bosset M Meier T Suzuki RM Nitsch U Konietzko, J Cell Sci 2004 117 Pt 19 4435 4448 10.1242/jcs.01323 15331662
16. Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo. KW Ahn Y Joo Y Choi M Kim SH Lee SH Cha YH Suh HS Kim, J Neurosci Res 2008/04/29 2008 86 11 2476 2487 10.1002/jnr.21690 18438935
17. Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). T Muller CG Concannon MW Ward CM Walsh AL Tirniceriu F Tribl D Kogel JH Prehn R Egensperger, Mol Biol Cell 2007 18 1 201 210 17093061 10.1091/mbc.E06-04-0283
18. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. SS Hebert L Serneels A Tolia K Craessaerts C Derks MA Filippov U Muller B De Strooper, EMBO Rep 2006/05/27 2006 7 7 739 745 16729020 10.1038/sj.embor.7400704
19. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. E Waldron S Isbert A Kern S Jaeger AM Martin SS Hebert C Behl S Weggen B De Strooper CU Pietrzik, Exp Cell Res 2008/06/19 2008 314 13 2419 2433 10.1016/j.yexcr.2008.05.003 18559276
20. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. T Ozaki Y Li H Kikuchi T Tomita T Iwatsubo A Nakagawara, Biochem Biophys Res Commun 2006 351 1 57 63 10.1016/j.bbrc.2006.09. 162 17054906
21. The gamma/epsilon-Secretase-Derived APP Intracellular Domain Fragments Regulate p53. F Checler C Sunyach R Pardossi-Piquard J Sevalle B Vincent T Kawarai N Girardot P St George-Hyslop CA da Costa, Curr Alzheimer Res 2007 4 4 423 426 10.2174/156720507781788945 17908046
22. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). MH Scheinfeld R Roncarati P Vito PA Lopez M Abdallah L D'Adamio, J Biol Chem 2002 277 5 3767 3775 10.1074/jbc.M108357200 11724784
23. A new mathematical model for relative quantification in real-time RT-PCR. MW Pfaffl, Nucleic Acids Res 2001/05/09 2001 29 9 e45 11328886 10.1093/nar/29.9.e45
24. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. T Abel PV Nguyen M Barad TA Deuel ER Kandel R Bourtchouladze, Cell 1997/03/07 1997 88 5 615 626 10.1016/S0092-8674(00)81904- 2 9054501
25. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. P Cupers I Orlans K Craessaerts W Annaert B De Strooper, J Neurochem 2001 78 5 1168 1178 10.1046/j.1471-4159.2001.00516.x 11553691
26. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. C Yu SH Kim T Ikeuchi H Xu L Gasparini R Wang SS Sisodia, J Biol Chem 2001/10/05 2001 276 47 43756 43760 10.1074/jbc.C100410200 11583985
27. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. Y Gu H Misonou T Sato N Dohmae K Takio Y Ihara, J Biol Chem 2001/08/03 2001 276 38 35235 35238 10.1074/jbc.C100357200 11483588
28. Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. G Minopoli M Stante F Napolitano F Telese L Aloia M De Felice R Di Lauro R Pacelli A Brunetti N Zambrano T Russo, J Biol Chem 2006/11/24 2007 282 2 831 835 10.1074/jbc.C600276200 17121854
29. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. X Cao TC Sudhof, J Biol Chem 2004/03/27 2004 279 23 24601 24611 10.1074/jbc.M402248200 15044485