Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurons

Brain Research

Volumn 842, Issue 2, 1999, Pages 311-323

  Harada, Jun ^a   Sugimoto, Masahiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Alzheimer's disease; Apoptosis; Beta amyloid; Caspase; Cortical neuron

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE 3; CASPASE INHIBITOR; LACTATE DEHYDROGENASE; MICROTUBULE ASSOCIATED PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CHROMATIN; CONTROLLED STUDY; IMMUNOREACTIVITY; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; ASTROCYTES; CASPASE 3; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; KINETICS; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 0032876784     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01808-9     Document Type: Article

References (44)

1. Anderson A.J., Pike C.J., Cotman C.W. Differential induction of immediate early gene proteins in cultured neurons by β-amyloid (Aβ): association of c-Jun with Aβ-induced apoptosis. J. Neurochem. 65:1995;1487-1498.
2. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77:1994;817-827.
3. Copani A., Koh J.-Y., Cotman C.W. β-Amyloid increases neuronal susceptibility to injury by glucose deprivation. NeuroReport. 2:1991;763-765.
4. Copani A., Bruno V., Battaglia G., Leanza G., Pellitteri R., Ruso A., Stanzani S., Nicoletti F. Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by β-amyloid peptide. Mol. Pharmacol. 47:1995;890-897.
5. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated Dnase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50.
6. Estus S., Tucker H.M., Rooyen C., Wright S., Brigham E.F., Wogulis M., Rydel R.E. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J. Neurosci. 17:1997;7736-7745.
7. Fernandes-Alnemri T., Takahashi A., Armstrong R., Krebs J., Fritz L., Tomaselli K.J., Wang L., Yu Z., Croce C.M., Salveson G., Earnshaw W.C., Litwack G., Alnemli E.S. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55:1995;6045-6052.
8. Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., Angeretti N. Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35. NeuroReport. 4:1993;523-526.
9. Gervais F.G., Daigen X., Robertson G.S., Vaillancourt J.P., Zhu Y., Huang J., LeBlanc A., Smith D., Rigby M., Shearman M.S., Clarke E.E., Zheng H., Van Der Ploeg L.H.T., Ruffolo S.C., Thornberry N.A., Xanthoudakis S., Zamboni R.J., Roy S., Nicholson D.W. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell. 97:1999;395-406.
10. Harada J., Sugimoto M. Inhibitors of interleukin-1β-converting enzyme family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide in cerebellar granule neurons. Brain Res. 793:1998;231-243.
11. Harada J., Sugimoto M. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons. Jpn. J. Pharmacol. 79:1999;369-378.
12. Hirsch T., Marchetti P., Susin S.A., Dallaporta B., Zamzami N., Marzo I., Geuskens M., Kroemer G. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene. 15:1997;1573-1581.
13. Imaizumi K., Morihara T., Mori Y., Katayama T., Tsuda M., Furuyama T., Wanaka A., Takeda M., Tohyama M. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid β protein. J. Biol. Chem. 274:1999;7975-7981.
14. Ivins K.J., Ivins J.K., Sharp J.P., Cotman C.W. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by β-amyloid. J. Biol. Chem. 274:1999;2107-2112.
15. Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273:1998;9357-9360.
16. Janicke R.U., Ng P., Sprengart M.L., Porter A.G. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J. Biol. Chem. 273:1998;15540-15545.
17. Jordan J., Galindo M.F., Miller R.J. Role of calpain- and interleukin-1β converting enzyme-like proteases in the β-amyloid-induced death of rat hippocampal neurons in culture. J. Neurochem. 68:1997;1612-1621.
18. Kaneko I., Yamada N., Sakuraba Y., Kamenosono M., Tutumi S. Suppression of mitochondrial succinate dehydrogenase, a primary target of β-amyloid, and its derivative racemized at Ser residue. J. Neurochem. 65:1995;2585-2593.
19. Keane R.W., Srinivasan A., Foster L.M., Testa M.-P., Ord T., Nonner D., Wang H.-G., Reed J.C., Bredesen D.E., Kayalar C. Activation of CPP32 during apoptosis of neurons and astrocytes. J. Neurosci. Res. 48:1997;168-180.
20. Koh J.-Y., Yang L.Y., Cotman C.W. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533:1990;315-320.
21. Krajewska M., Wang H.-G., Krajewski S., Zapata J.M., Shabaik A., Gascoyne R., Reed J.C. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease. Cancer Res. 57:1997;1605-1613.
22. Kuida K., Zheng T.S., Na S., Kuan C.-y., Yang D., Karasuyama H., Rakic P., Flavell R.A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 384:1996;368-372.
23. LaFerla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:1995;21-30.
24. Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
25. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7951-7955.
26. Mashina T., Naito M., Noguchi K., Miller D.K., Nicholson D.W., Tsuruo T. Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene. 14:1997;1007-1012.
27. Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R.E. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:1992;376-389.
28. Mattson M.P., Partin J., Bagley J.G. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 807:1998;167-176.
29. Morimoto K., Yoshimi K., Tonohiro T., Yamada N., Oda T., Kaneko I. Co-injection of β-Amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons. Neuroscience. 84:1998;479-487.
30. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., Munday N.A., Raju S.M., Smulson M.E., Yamin T.-T., Yu V.L., Miller D.K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376:1995;37-43.
31. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem Sci. 22:1997;299-306.
32. Nicotera P., Leist M., Manzo L. Neuronal cell death: a demise with different shapes. Trends Pharmacol. Sci. 20:1999;46-51.
33. Perry D.K., Smyth M.J., Stennicke H.R., Salvesen G.S., Duriez P., Poirier G.G., Hannun Y.A. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J. Biol. Chem. 272:1997;18530-18533.
34. Salvesen G.S., Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell. 91:1997;443-446.
35. Sanchez I., Xu C.-J., Juo P., Kakizuka A., Blenis J., Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 22:1999;623-633.
36. Shearman M.S., Ragan C.I., Iversen L.L. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid mediated cell death. Proc. Natl. Acad. Sci. U.S.A. 91:1994;1470-1474.
37. Shimohama S., Tanino H., Fujimoto S. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Biochem. Biophys. Res. Commun. 256:1999;381-384.
38. Uchida Y., Tomonaga M. Neurotrophic action of Alzheimer's disease brain extract is due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons. Brain Res. 481:1989;190-193.
39. Watt J.A., Pike C.J., Walencewicz-Wasserman A.J., Cotman C.W. Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res. 661:1994;147-156.
40. Woo M., Hakem R., Soengas M.S., Duncan G.S., Shahinian A., Kagi D., Hakem A., McCurrach M., Khoo W., Kaufman S.A., Senaldi G., Howard T., Lowe S.W., Mak T.W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12:1998;806-819.
41. Xiang J., Chao D.T., Korsmeyer S.J. BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc. Natl. Acad. Sci. U.S.A. 93:1996;14559-14563.
42. Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Vinters H.V., Frautschy S.A., Cole G.M. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol. 152:1998;379-389.
43. Yankner B.A. Mechanism of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
44. Zheng T.S., Schlosser S.F., Dao T., Hingorani R., Crispe I.N., Boyer J.L., Fflavell R.A. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13618-13623.