Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the β-amyloid precursor protein

Journal of Neurochemistry

Volumn 66, Issue 5, 1996, Pages 2034-2040

  Fraser, S P ^a   Suh, Y H ^b   Chong, Y H ^b,c   Djamgoz, M B A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Seoul National University   (South Korea)

^c Ewha Womans University School of Medicine   (South Korea)

Author keywords

Alzheimer's disease; C terminal fragment (CT105); Ca2+ influx; Internal injection; Ion channel formation; Toxicity; Two electrode voltage clamp; Xenopus oocytes; Amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; PROTEIN PRECURSOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; ION CURRENT; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; XENOPUS;

EID: 0029923244     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66052034.x     Document Type: Article

References (48)

1. Arispe N., Pollard H. B., and Rojas E. (1993a) Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [(AβP-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. USA 90, 10573-10577.
2. Arispe N., Rojas E., and Pollard H. B. (1993b) Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: blockade by trimethamine and aluminium. Proc. Natl. Acad. Sci. USA 90, 567-571.
3. Bhakdi S. and Tranum-Jensen J. (1987) Damage to mammalian cells by proteins that form transmembrane pores. Rev. Physiol. Biochem. Pharmacol. 107, 147-210.
4. Chong Y. H., Jung J. M., Choi W., Park C. H., Choi K. S., and Suh Y.-H. (1994) Bacterial expression, purification of full length and carboxyl terminal fragments of Alzheimer precursor protein and their proteolytic processing by thrombin. Life Sci. 54, 1259-1268.
5. Dascal N., Landau E. M., and Lass Y. (1984) Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3′,5′-cyclic monophosphate. J. Physiol. (Lond.) 352, 551-574.
6. Drake L., Korchev Y , Bashford L., Djamgoz M. B. A., Wakelin D., Ashall F., and Bundy D. (1994) The major secreted product of the whipworm, Trichuris, is a pore-forming protein. Proc. R. Soc Lond. [Biol ] 257, 255-261.
7. Dyrks T., Weidemann A., Multhaup G., Salbaum J. M., Lemaire H.-G., Kang J., Müller-Hill B., Masters C. L., and Beyreuther K. (1988) Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor protein of Alzheimer's disease. EMBO J. 7, 949-957.
8. Dyrks T., Dyrks E., Hartmann T., Masters C., and Beyreuther K. (1992) Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J. Biol. Chem. 267, 18210-18217.
9. Einstein G., Buranosky R., and Crain B. J. (1994) Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques. J. Neurosci. 14, 5077-5088.
10. Esch F. S., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., McClure D., and Ward P. J (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248, 1122-1124.
11. Estus S., Golde T. E., Kunishita T., Blades D., Lowery D., Eisen M., Ustak M., Qu X. M., Tabira T., Greenberg B. D., and Younkin S. G. (1992) Potentially amyloidogenic carboxyl-terminal derivatives of the amyloid protein precursor. Science 255, 726-728.
12. + channels. Science 264, 276-279.
13. Fraser S. P. and Djamgoz M. B. A. (1992) Xenopus oocytes: endogenous electrophysiological characteristics, in Current Aspects of the Neurosciences, Vol. 4 (Osborne N., ed), pp. 267-315. Macmillan Press, London.
14. Fraser S. P., Moon C., and Djamgoz M. B. A. (1993) Electrophysiology of Xenopus oocytes: an expression system in molecular neurobiology, in Electrophysiology, a Practical Approach (Wallis D. I., ed), pp. 65-86. Oxford University Press, Oxford.
15. Fraser S. P., Suh Y.-H., Chong Y. H., and Djamgoz M. B. A. (1995) The C-terminal fragment of the Alzheimer's disease β-amyloid precursor protein is a potent inducer of membrane currents in Xenopus oocytes. (Abstr.) J. Physiol. (Lond.) 489, 66P.
16. Fukuchi K.-I., Kamino K., Deeb S. S., Furlong C. E., Sundstrom J. A., Smith A. C., and Martin G. M. (1992) Expression of a carboxy-terminal region of the β-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity Mol. Brain Res. 16, 37-46.
17. Fukuchi K.-I., Soper B., and Martin G. M. (1993) Neurotoxicity of β-amyloid. Nature 361, 122.
18. Furukawa K., Abe Y., and Akaike N. (1994) Amyloid β protein-induced irreversible currents in rat cortical neurones. Neuroreport 5, 2016-2018.
19. Gearing M., Wilson R. W., Unger E. R., Shelton E. R., Chan H. W., Masters C L., Beyreuther K., and Mirra S. S. (1993) Amyloid precursor protein (APP) in the striatum in Alzheimer's disease: an immunohistochemical study. J. Neuropathol. Exp. Neurol. 52, 22-30.
20. Golde T. E., Estus S., Younkin L. H., Selkoe D. J., and Younkin S. G. (1992) Processing of the amyloid protein precursor to potentially amyloidogenic carboxyl-terminal derivatives. Science 255, 728-730.
21. Grundke-Iqbal I., Iqbal K., George L., Tung Y.-C. Kim K. S., and Wisniewski H. M. (1989) Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 86, 2853-2857.
22. Haass C., Koo E. H., Mellon A., Hung A. Y., and Selkoe D. (1992a) Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
23. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. J. (1992b) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325
24. Hartmann H., Eckert A., and Muller W. E. (1994) Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity. Biochem. Biophys. Res. Commun. 200, 1185-1192.
25. Hayashi Y., Kashiwagi K., and Yoshikawa K. (1992) Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA transfected glioma cells. Biochem. Biophys. Res. Commun. 187, 1249-1255.
26. Howland D. S., Savage M. J., Huntress F. A., Wallace R. E., Schwartz D. A., Loh T., Melloni R. H , Degennaro L. J., Greenberg B. D., Siman R., Swanson M. E., and Scott R. W. (1995) Mutant and native human β-amyloid precursor proteins in transgenic mouse brain. Neurobiol. Aging 16, 685-699.
27. Joachim C. L., Morris J. H., and Selkoe D. J. (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am. J. Pathol. 135, 309-319.
28. Kametani F., Tanaka K., Tokuda T., and Ikeda S.-I. (1994) Secretory cleavage site of Alzheimer amyloid precursor protein is heterogeneous in Down's syndrome brain. FEBS Lett. 351, 165-167.
29. Maruyama K., Terakado K., Usami M., and Yoshikawa K. (1990) Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature 347, 566-569.
30. Matsumoto A. (1994) Altered processing characteristics of β amyloid-containing peptides in cytosol and media of familial Alzheimer's disease cells. Biochim. Biophys. Acta 1225, 304-310.
31. 2+ homeostasis in Alzheimer's disease. Trends Neurosci. 16, 409-414.
32. Miledi R. and Parker I. (1984) Chloride currents induced by injection of calcium into Xenopus oocytes. J. Physiol. (Lond.) 357, 173-183.
33. Neve R. L., Kammesheidt A., and Hohmann C. F. (1992) Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neurotoxicity in vivo. Proc. Natl. Acad. Sci. USA 89, 3448-3452.
34. 100 transgenic mice. Soc. Neurosci. Abstr. 20, 601.
35. Selkoe D. J. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
36. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., and Schenk D. (1992) Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325-327.
37. Simmons M. A. and Schneider C. R. (1993) Amyloid β-peptides act directly on single neurons. Neurosci. Lett. 150, 133-136.
38. Tamaoka A., Kalaria R. N., Lieberburg I., and Selkoe D. J. (1992) Identification of a stable fragment of the Alzheimer amyloid precursor containing the β-protein in brain microvessels. Proc. Natl. Acad. Sci. USA 89, 1345-1349.
39. 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurones in culture. J. Neurochem. 62, 372-375.
40. Whitson J. S., Selkoe D. J., and Cotman C. W. (1989) Amyloid β protein enhances survival of hippocampal neurons in vitro. Science 243, 1488-1490.
41. Whitson J. S., Glabe C. G., Shintani E., Abcar A., and Cotman C. W. (1990) β-Amyloid protein promotes neuritic branching in hippocampal cultures Neurosci. Lett. 110, 319-324.
42. Wolf D., Quon D., Wang Y., and Cordell B. (1990) Identification and characterization of C-terminal fragments of the amyloid β-amyloid precursor produced in cell culture. EMBO J. 9, 2079-2084.
43. Yang X.-C. and Sachs F. (1990) Characterization of stretch-activated ion channels in Xenopus oocytes. J. Physiol. (Lond.) 431, 103-122.
44. Yankner B. A., Dawes L. R., Fisher S., Villa-Komaroff L., Oster-Granite M. L., and Neve R. L. (1989) Neurotoxicity of a fragment of the amyloid precursor protein associated with Alzheimer's disease. Science 245, 417-420.
45. Yankner B. A., Duffy L. K., and Kirscher D. A. (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282.
46. Yoshikawa K., Aizawa T., and Hayashi Y. (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67.
47. Young J. D., Peterson C. G. B., Venge P., and Conn Z. A. (1986) Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature 321, 613-616.
48. Zubenko G. S., Wusylko M., Cohen B. M., Baller F., and Teply I. (1987) Family study of platelet membrane fluidity in Alzheimer's disease. Science 238, 539-542.