Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: Correlation with spatial memory deficits

Neuroscience

Volumn 93, Issue 4, 1999, Pages 1409-1420

  Anderson, J J ^a   Holtz, G ^a   Baskin, P P ^a   Wang, R ^b   Mazzarelli, L ^b   Wagner, S L ^a   Menzaghi, F ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

amyloid; Ageing; Amyloid precursor protein; Learning; Memory

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PEPTIDE; PROTEIN ANTIBODY;

AGE; AGED; AGING; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID LEVEL; COGNITION; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LEARNING; MALE; MASS SPECTROMETRY; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SPATIAL MEMORY; TASK PERFORMANCE; WORKING MEMORY;

AGING; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CEREBRAL CORTEX; COGNITION; CONDITIONING (PSYCHOLOGY); ENDOPEPTIDASES; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED F344; RETENTION (PSYCHOLOGY); SOLUBILITY; SPACE PERCEPTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VISUAL ACUITY;

EID: 0032768748     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00244-4     Document Type: Article

References (37)

1. Almkvist O., Basun H., Wagner S.L., Rowe B.A., Wahlund L.-O., Lannfelt L. Cerebrospinal fluid levels of α-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. Archs Neurol. 54:1997;641-644.
2. Barnes C.A. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends Neurosci. 17:1994;13-18.
3. Beeson J.G., Shelton E.R., Chan H.W., Gage F.H. Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain. J. comp. Neurol. 342:1994;69-77.
4. Bowes M., Masliah E., Otero D., Zivin J., Saitoh T. Reduction of neurological damage by a peptide segment of the amyloid β-A4 protein precursor in a rabbit spinal cord ischemia model. Expl Neurol. 129:1994;112-119.
5. Carroll R.T., Lust M.R., Kim K.S., Doyle P.D., Emmerling M.R. An age-related correlation between levels of β-amyloid precursor protein and β-amyloid in human cerebrospinal fluid. Biochem. biophys. Res. Commun. 210:1995;345-349.
6. Clarris H.J., Key B., Beyreuther K., Masters C.L., Small D.H. Expression of the amyloid protein precursor of Alzheimer's disease in the developing olfactory system. Devl Brain Res. 88:1995;87-95.
7. Doyle E., Bruce M.T., Breen K.C., Smith D.C., Anderton B., Regan C.M. Intraventricular infusions of antibodies to amyloid-β-protein precursor impair the acquisition of a passive avoidance response in the rat. Neurosci. Lett. 115:1990;97-102.
8. Eichenbaum H., Stewart C., Morris R.G. Hippocampal representation in place learning. J. Neurosci. 10:1990;3531-3542.
9. Esch F.S., Keim P.S., Beattie E.C., Blacker R.W., Culwell A.K., Oltersdorf T., McClure D., Ward P.J. Cleavage of amyloid β peptide during constitutive processing of its precursor. Science. 248:1990;1122-1124.
10. Fazeli M.S., Breen K., Errington M.L., Bliss T.V.P. Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anesthetized rats. Neurosci. Lett. 169:1994;77-80.
11. Furukawa K., Sopher B.L., Rydel R.E., Begley J.G., Pham D.G., Martin G.M., Fox M., Mattson M.P. Increased activity-regulating and neuroprotective efficacy of α-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J. Neurochem. 67:1996;1882-1896.
12. Geinisman Y., de Toledo-Morrell L., Morrell F. Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats. Proc. natn. Acad. Sci. U.S.A. 83:1986;3027-3031.
13. Glenner G.G., Wong C.W. Alzheimer's disease: an initial report of the purification and characterization of a novel cerebral vascular amyloid protein. Biochem. biophys. Res. Commun. 120:1984;885-890.
14. Higgins G.A., Oyler G.A., Neve R.L., Chen K.S., Gage F.H. Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats. Proc. natn. Acad. Sci. U.S.A. 87:1990;3032-3036.
15. Huber G., Martin J.R., Loffler J., Moreau J.L. Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach. Brain Res. 603:1993;348-352.
16. Kitaguchi N., Takahashi Y., Tokushima Y., Shiojimi S., Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitor activity. Nature. 331:1988;530-532.
17. Lannfelt L., Basun H., Wahlund L.-O., Rowe B.A., Wagner S.L. Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease. Nature Med. 1:1995;829-832.
18. Lin L., LeBlanc C.J., Deacon T.W., Isacson O. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. NeuroReport. 9:1998;547-552.
19. Lindner M.D., Dworetzky S.I., Sampson C., Loy R. Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction. J. Neurosci. 14:1994;2282-2289.
20. Marin S., Baudry M. Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory. Neurobiol. Learn. Mem. 63:1995;1-18.
21. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. natn. Acad. Sci. U.S.A. 82:1985;4245-4249.
22. Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R.E. Evidence for excitoprotective and intra-neuronal calcium-regulating roles for secreted forms of β-amyloid precursor protein. Neuron. 10:1993;243-254.
23. Meziane H., Dodart J.-C., Mathis C., Little S., Clemens J., Paul S.M., Ungerer A. Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice. Proc. natn. Acad. Sci. U.S.A. 95:1998;12683-12688.
24. Morris R.G., Garrud P., Rawlins J.N., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
25. Morrison J.H., Hof P.R. Life and death of neurons in the aging brain. Science. 278:1997;412-419.
26. Motter M., Vigo-Pelfrey C., Kholodenko D., Barbour R., Johnson-Wood K., Galasko D., Chang L., Miller B., Clark C., Green R., Olson D., Southwick P., Wolfert R., Munroe B., Lieberburg I., Seubert P., Schenk D. Reduction of β-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann. Neurol. 38:1995;643-648.
27. Ponte P., Gonzalez-DeWhitt P., Schilling J., Miller J., Hsu D., Greenberg B., Davis K., Wallace W., Lieberburg I., Fuller F.A. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature. 331:1988;525-527.
28. Roch J.-M., Masliah E., Roch-Levecq A.-C., Sundsmo M.P., Otero D.A.C., Veinbergs I., Saitoh T. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor. Proc. natn. Acad. Sci. U.S.A. 91:1994;7450-7454.
29. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher N., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., Schenk D. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature. 359:1992;325-327.
30. Sisodia S.S., Koo E.H., Beyreuther K., Unterbeck A., Price D.L. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science. 248:1990;492-495.
31. Smith-Swintosky V.L., Pettigrew L.C., Craddock S.D., Culwell A.R., Rydel R.E., Mattson M.P. Secreted forms of β-amyloid precursor protein protect against ischemic brain injury. J. Neurochem. 63:1994;781-784.
32. Southwick P.C., Yamagata S.K., Echols C.L., Higson G.J., Neynaber S.A., Parson R.E., Munroe W.A. Assessment of amyloid β protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease. J. Neurochem. 66:1996;259-265.
33. Sutherland R.J., Whishaw I.Q., Kolb B. A behavioral analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat. Behav. Brain Res. 7:1983;133-153.
34. Tanzi R.E., McClatchey A.I., Lamperti E.D., Villa-Komaroff L., Gusella J.F., Neve R.L. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 331:1988;528-530.
35. Van Nostrand W.E., Wagner S.L., Shankle W.R., Farrow J.S., Dick M., Rozemuller J.M., Kuiper M.A., Wolters E.C., Zimmerman J., Cotman C.W., Cunningham D.D. Decreased levels of soluble amyloid β-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc. natn. Acad. Sci. U.S.A. 89:1992;2551-2555.
36. Wallace W., Ahlers S.T., Gotlib J., Bragin V., Sugar J., Gluck R., Shea P.A., Davis K.L., Haroutunian V. Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation. Proc. natn. Acad. Sci. U.S.A. 90:1993;8712-8716.
37. Wallace W.C., Lieberburg I., Schenk D., Vigo-Pelfrey C., Davis K.L., Haroutunian V. Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats. J. Neurosci. 15:1995;4896-4905.