Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 18, 2006, Pages 7130-7135

  Galvan, Veronica ^a   Gorostiza, Olivia F ^a   Banwait, Surita ^a   Ataie, Marina ^a   Logvinova, Anna V ^a   Sitaraman, Sandhya ^c   Carlson, Elaine ^d   Sagi, Sarah A ^b   Chevallier, Nathalie ^b   Jin, Kunin ^a   Greenberg, David A ^a   Bredesen, Dale E ^a,d  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amyloid precursor protein intracytoplasmic domain; amyloid precursor protein c31; Caspase; Memory; Neurodegeneration

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; CASPASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DENTATE GYRUS; ENZYME ACTIVE SITE; GENE MUTATION; MOUSE; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SYNAPSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASPARTIC ACID; ASTROCYTES; BEHAVIOR, ANIMAL; CELL PROLIFERATION; COGNITION DISORDERS; HIPPOCAMPUS; HUMANS; MAZE LEARNING; MICE; MICE, TRANSGENIC; NEURONS; POINT MUTATION; STEM CELLS;

MUS MUSCULUS;

EID: 33646480747     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509695103     Document Type: Article

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