Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Nature Medicine

Volumn 14, Issue 8, 2008, Pages 837-842

  Shankar, Ganesh M ^a   Li, Shaomin ^a   Mehta, Tapan H ^a   Garcia Munoz, Amaya ^b   Shepardson, Nina E ^a   Smith, Imelda ^b   Brett, Francesca M ^c   Farrell, Michael A ^c   Rowan, Michael J ^d   Lemere, Cynthia A ^a   Regan, Ciaran M ^b   Walsh, Dominic M ^b   Sabatini, Bernardo L ^a   Selkoe, Dennis J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c BEAUMONT HOSPITAL   (Ireland)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIBODY; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OLIGOMER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; DENDRITIC SPINE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; DENDRITIC SPINES; DIMERIZATION; HIPPOCAMPUS; HUMANS; LEARNING; MEMORY; MICE; NEURONAL PLASTICITY; NEURONS; RATS; SYNAPSES;

ANIMALIA; RATTUS; RODENTIA;

EID: 49149124343     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1782     Document Type: Article

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