Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration

Neuron

Volumn 51, Issue 1, 2006, Pages 29-42

  Salehi, Ahmad ^a   Delcroix, Jean Dominique ^a   Belichenko, Pavel V ^a   Zhan, Ke ^a   Wu, Chengbiao ^a   Valletta, Janice S ^a   Takimoto Kimura, Ryoko ^a   Kleschevnikov, Alexander M ^a   Sambamurti, Kumar ^b   Chung, Peter P ^b   Xia, Weiming ^c   Villar, Angela ^d   Campbell, William A ^c   Kulnane, Laura Shapiro ^e   Nixon, Ralph A ^f   Lamb, Bruce T ^e   Epstein, Charles J ^d   Stokin, Gorazd B ^g   Goldstein, Lawrence S B ^g   Mobley, William C ^a,h  

^a STANFORD UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HUMDISEASE; MOLNEURO

Indexed keywords

AMYLOID PRECURSOR PROTEIN; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC NERVE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOWN SYNDROME; ENDOSOME; MALE; MOUSE; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROGRADE NERVE FIBER TRANSPORT; TRISOMY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONAL TRANSPORT; BASAL NUCLEUS OF MEYNERT; CHOLINERGIC FIBERS; DISEASE MODELS, ANIMAL; DOWN SYNDROME; ENDOSOMES; FEMALE; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE GROWTH FACTOR; PROTEIN TRANSPORT; SENILE PLAQUES; UP-REGULATION;

EID: 33745512851     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2006.05.022     Document Type: Article

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