A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models

Journal of Neuroscience

Volumn 34, Issue 19, 2014, Pages 6425-6437

  Kallop, Dara Y ^a   Meilandt, William J ^a   Gogineni, Alvin ^a   Easley Neal, Courtney ^a   Wu, Tiffany ^a   Jubb, Adrian M ^a   Yaylaoglu, Murat ^a   Shamloo, Mehrdad ^b   Tessier Lavigne, Marc ^c   Scearce Levie, Kimberly ^a   Weimer, Robby M ^a  

^a GENENTECH INC   (United States)

^b STANFORD UNIVERSITY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alzheimer's; APP; DR6

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DEATH RECEPTOR; DEATH RECEPTOR 6; MESSENGER RNA; UNCLASSIFIED DRUG;

ACTIVE AVOIDANCE TEST; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARNES MAZE TEST; BEHAVIOR DISORDER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEAR-POTENTIATED STARTLE TEST; FEMALE; GENE DELETION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LOCOMOTION; MALE; MORRIS WATER MAZE TEST; MOUSE; MRNA EXPRESSION ASSAY; NONHUMAN; OPEN FIELD TEST; POLYADENYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPSE DENSITY;

ALZHEIMER'S; APP; DR6;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AVOIDANCE LEARNING; CENTRAL NERVOUS SYSTEM; CONDITIONING, OPERANT; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEAR; GLIOSIS; HUMANS; IN SITU HYBRIDIZATION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEURAL PATHWAYS; PLAQUE, AMYLOID; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 84899851998     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4963-13.2014     Document Type: Article

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