Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

Aging Cell

Volumn 11, Issue 6, 2012, Pages 1084-1093

  Matrone, Carmela ^a,b   Luvisetto, Siro ^a   La Rosa, Luca R ^a   Tamayev, Robert ^c   Pignataro, Annabella ^a,d   Canu, Nadia ^a,e   Yang, Li ^f   Barbagallo, Alessia P M ^c   Biundo, Fabrizio ^c   Lombino, Franco ^c   Zheng, Hui ^f   Ammassari Teule, Martine ^a,d   D'Adamio, Luciano ^c  

^a CNR   (Italy)

^b AARHUS UNIVERSITY   (Denmark)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Behavior; Cholinergic system; Dendritic spines; TrkA receptor; YENTPY domain

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROTEIN TYROSINE KINASE A; TYROSINE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC ACTIVITY; COGNITION; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; MALE; MOUSE; NEUROMUSCULAR FUNCTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

AGING; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; COGNITION; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GLYCINE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MOTOR ENDPLATE; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; SYNAPSES; TYROSINE;

MUS;

EID: 84869164516     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12009     Document Type: Article

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