The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Aβ and acts as a cognitive enhancer

European Journal of Neuroscience

Volumn 19, Issue 7, 2004, Pages 1933-1938

  Mileusnic, R ^a   Lancashire, C L ^a   Rose, S R R ^a  

^a OPEN UNIVERSITY   (United Kingdom)

Author keywords

APP; Memory rescue; Neuroprotection; RER; RERMS

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ARGINYLGLUTAMYLARGININE; CELL MEMBRANE PROTEIN; CENTRAL STIMULANT AGENT; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AMNESIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CHICK EMBRYO; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; NERVE CELL MEMBRANE; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE; PERIKARYON; PRIORITY JOURNAL; SECOND MESSENGER; TASK PERFORMANCE;

AMNESIA; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; AVOIDANCE LEARNING; BINDING SITES; BINDING, COMPETITIVE; BIOTINYLATION; BLOTTING, WESTERN; CELL COUNT; CELL MEMBRANE; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; MEMORY DISORDERS; NOOTROPIC AGENTS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHOSPHOPYRUVATE HYDRATASE; PROSENCEPHALON;

EID: 1842633450     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2004.03276.x     Document Type: Article

References (33)

1. Bradford, M.M. (1976) A rapid and sensitive method for the quantification of micrograms of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
2. Burnette, W.N. (1981) 'Western blotting' electrophoretic transfer of proteins from sodium dodecyl sulphate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem., 112, 198-203.
3. Coulson, E.R., Paliga, K., Beyreuther, K. & Masters, C.L. (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem. Int., 36, 175-184.
4. Davis, J.L., Masouka, D.T., Gerbrant, L.K. & Cherkin, A. (1979) Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol. Behav., 22, 177-184.
5. Doyle, E., Bruce, M.T., Breen, K.C., Smith, D.C., Anderton, B. & Regan, C.M. (1990) Intraventricular infusions of antibodies to amyloid-β-protein precursor impair acquisition of a passive avoidance response in the rat. Neurosci. Lett., 115, 97-102.
6. Goodman, Y. & Mattson, M.P. (1994) Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury. Exp. Neural., 128, 1-12.
7. + channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity. Brain Res., 706, 328-332.
8. Hardy, J. & Selkoe, D. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 297, 353-356.
9. Huber, G., Bailly, Y., Martin, J.R., Mariani, J. & Brugg, B. (1997) Synaptic β-amyloid precursor proteins increase with learning capacity in rats. Neurosci., 80, 313-320.
10. Huber, G., Martin, J.R., Löfler, J. & Moreau, J.L. (1993) Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach. Brain Res., 603, 348-352.
11. Ishida, A., Furukva, K., Keller, J.N. & Mattson, M.P. (1997) Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. Neuroreport, 8, 2133-2137.
12. Jin, L.W., Ninomiya, H., Roch, J.M., Schubert, D., Masliah, E., Otero, D.A. & Saitoh, T. (1994) Peptides containing the RERMS sequence of amyloid β/A4 protein precursor bind cell surface and promote neurite extension. J. Neurosci., 14, 5461-5470.
13. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
14. Li, H.L., Roch, J.M., Sundsmo, M., Otero, D., Sisodia, S., Thomas, R. & Saitoh, T. (1997) Defective neurite extension is caused by a mutation in Amyloid β/ A4 protein precursor found in familial Alzheimer's disease. J. Neurobiol., 32, 469-480.
15. Lössner, B. & Rose, S.P.R. (1983) Passive avoidance training increases fucokinase activity in right forebrain base of day-old chicks. J. Neurochem., 41, 1357-1363.
16. Mattson, M.P. (1994) Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium response to glutamate in cultured embryonic hippocampal neurons. J. Neurobiol., 25, 439-450.
17. 2+ homeostasis in Alzheimer's disease. TINS, 16, 409-414.
18. Mattson, M.P., Cheng, B., Culwell, A., Esch, F., Lieberburg, I. & Rydel, R.E. (1993b) Evidence for excitoprotective and intra-neuronal calcium regulating roles for secreted forms of β-amyloid precursor protein. Neuron, 10, 243-254.
19. Mileusnic, R., Lancashire, C.L., Johnston, A.N.B. & Rose, S. (2000) APP is required during an early phase of memory formation. Eur. J. Neurosci., 12, 4487-4495.
20. Milner, A.J., Dallerac, G.M., Cummings, D.M., Rose, S.P.R., Mileusnic, R. & Murphy, K.P.S.J. (2003) Restorative properties of an APP-derived peptide on the induction of hippocampal LTP in beta-amyloid treated brain slices. British Neurosci. Assoc. Abstr., 17, P38.03.
21. Mucke, L., Masliah, E., Johnson, W.B., Ruppe, M.D., Alford, M., Rocenstein, E.M., Forss-Petter, S., Pietrapaolo, M., Mallory, M. & Abraham, C.R. (1994) Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice. Brain Res., 666, 151-167.
22. Ninomiya, H., Roch, J.M., Sundsmo, M.P., Otero, D.A.C. & Saitoh, T. (1993) Amino acid sequence RERMS represents the active domain of amyloid β/A4 protein precursor that promotes fibroblast growth. J. Cell Biol., 121, 879-886.
23. Roch, J.M., Masliah, E., Roch-Levecq, A.C., Sundsmo, M.P., Otero, D.A., Veinbergs, I. & Saitoh, T. (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor. Proceedings Natl Acad. Sci. USA, 91, 7450-7454.
24. Rose, S.P.R. (2000) God's organism? The chick as a model system for memory studies. Learn. Memory, 7, 1-17.
25. Saitoh, T., Sundsmo, M., Roch, J.M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T. & Schenk, D.B. (1989) Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts. Cell, 58, 615-622.
26. Schubert, D., Jin, L.W., Saitoh, T. & Cole, G. (1989) The regulation of amyloid β-protein precursor secretion and its modulatory role in cell adhesion. Neuron, 3, 689-694.
27. Selkoe, D.J. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci., 17, 489-517.
28. Sokal, R.R. & Rohlf, F.J. (1981) Biometry: the Principles and Practice of Statistics in Biological Research 2nd Edn. W.H. Freeman, New York.
29. Solomonia, R.O., Morgan, K., McCabe, B.J., Jackson, A.P. & Horn, G. (2003) Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long-term memory. Eur. J. Neurosci., 17, 1073-1081.
30. Storey, E., Beyreuther, K. & Masters, C.L. (1996) Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture colocalise with adhesion patch components. Brain Res., 735, 217-231.
31. Teather, L.A., Magnusson, J.E., Chow, C.M. & Wurtman, R.J. (2002) Environmental conditions influence hippocampus-dependent behaviours and brain levels of amyloid precursor protein in rat. Eur. J. Neurosci., 16, 2405-2415.
32. Turner, P.R., O'Connor, K., Tate, W.P. & Abraham, W.C. (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog. Neurobiol., 70, 1-32.
33. Yamamoto, K., Miyoshi, T., Yae, T., Kawashima, K., Araki, H., Hanada, K., Otero, D.A.C., Roch, J.M. & Saitoh, T. (1994) The survival of rat cerebral cortical neurons in the presence of trophic APP peptides. J. Neurobiol., 25, 585-594.