Caspase cleavage of the amyloid precursor protein modulates amyloid β-protein toxicity

Journal of Neurochemistry

Volumn 87, Issue 3, 2003, Pages 733-741

  Lu, Daniel C ^a   Soriano, Salvador ^a   Bredesen, Dale E ^b   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Alzheimer's disease; Amyloid protein; Amyloid protein precursor; Apoptosis; C31.; Caspase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CASPASE; CASPASE 8; CASPASE 9; COMPLEMENT COMPONENT C3A;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; DNA CLEAVAGE; ENZYME ACTIVATION; HISTOPATHOLOGY; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RAT; SENILE PLAQUE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; CASPASES; CATALYTIC DOMAIN; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSFECTION;

ANIMALIA;

EID: 0142179222     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02059.x     Document Type: Article

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