-
1
-
-
0026597063
-
Alzheimer’s disease: the amyloid cascade hypothesis
-
COI: 1:CAS:528:DyaK38Xitlarurg%3D, PID: 1566067
-
Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science 1992;256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
2
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
COI: 1:CAS:528:DyaL2MXktlGltr0%3D, PID: 3159021
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 1985;82:4245-4249.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
3
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
COI: 1:CAS:528:DyaL28XksVSnt74%3D, PID: 2424016
-
Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A 1986;83:4044-4048.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
4
-
-
0023109592
-
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
COI: 1:CAS:528:DyaL2sXhtlaru7o%3D, PID: 2949367
-
Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987;235:880-884.
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
-
5
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity
-
COI: 1:CAS:528:DyaK1MXotFKmu7k%3D, PID: 10591213
-
Yan R, Bienkowski MJ, Shuck ME, et al. Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity. Nature 1999;402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
-
6
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
COI: 1:CAS:528:DyaK1MXisFGqt7g%3D, PID: 10206644
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999;398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
7
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
-
COI: 1:CAS:528:DC%2BD1MXhs1Sht7jE, PID: 20009055
-
Green RC, Schneider LS, Amato DA, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009;302:2557-2264.
-
(2009)
JAMA
, vol.302
, pp. 2264-2557
-
-
Green, R.C.1
Schneider, L.S.2
Amato, D.A.3
-
8
-
-
84880712325
-
A phase 3 trial of semagacestat for treatment of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3sXhtF2nur7L, PID: 23883379
-
Doody RS, Raman R, Farlow M, et al. A phase 3 trial of semagacestat for treatment of Alzheimer’s disease. N Engl J Med 2013;369:341-350.
-
(2013)
N Engl J Med
, vol.369
, pp. 341-350
-
-
Doody, R.S.1
Raman, R.2
Farlow, M.3
-
9
-
-
84892748542
-
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2cXhs1Ggt70%3D, PID: 24450890
-
Doody RS, Thomas RG, Farlow M, et al. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease. N Engl J Med 2014;370:311-321.
-
(2014)
N Engl J Med
, vol.370
, pp. 311-321
-
-
Doody, R.S.1
Thomas, R.G.2
Farlow, M.3
-
10
-
-
84892695519
-
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2cXhs1Ggt7o%3D, PID: 24450891
-
Salloway S, Sperling R, Fox NC, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med 2014;370:322-333.
-
(2014)
N Engl J Med
, vol.370
, pp. 322-333
-
-
Salloway, S.1
Sperling, R.2
Fox, N.C.3
-
11
-
-
84884852756
-
Metallostasis in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC38XhslymtrnN, PID: 23142767
-
Ayton S, Lei P, Bush AI. Metallostasis in Alzheimer’s disease. Free Radic Biol Med 2013;62:76-89.
-
(2013)
Free Radic Biol Med
, vol.62
, pp. 76-89
-
-
Ayton, S.1
Lei, P.2
Bush, A.I.3
-
12
-
-
84907597179
-
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
-
COI: 1:CAS:528:DC%2BC2cXhsVWlu77K, PID: 24853080
-
Karran E, Hardy J. A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease. Ann Neurol 2014;76:185-205.
-
(2014)
Ann Neurol
, vol.76
, pp. 185-205
-
-
Karran, E.1
Hardy, J.2
-
13
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
COI: 1:CAS:528:DyaK1MXks1Khsbc%3D, PID: 10408445
-
Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
14
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD3sXksVOjs7c%3D, PID: 12765607
-
Hock C, Konietzko U, Streffer JR, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer’s disease. Neuron 2003;38:547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
-
15
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial
-
COI: 1:CAS:528:DC%2BD1cXoslWkt74%3D, PID: 18640458
-
Holmes C, Boche D, Wilkinson D, et al. Long-term effects of Abeta42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 2008;372:216-223.
-
(2008)
Lancet.
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
-
16
-
-
64549152492
-
Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders
-
COI: 1:CAS:528:DC%2BD1MXlt1Ois78%3D, PID: 19355849
-
Vellas B, Black R, Thal LJ, et al. Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr Alzheimer Res 2009;6:144-151.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 144-151
-
-
Vellas, B.1
Black, R.2
Thal, L.J.3
-
17
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
-
COI: 1:CAS:528:DC%2BD1MXhsFait7rN, PID: 19923550
-
Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73:2061-2070.
-
(2009)
Neurology
, vol.73
, pp. 2061-2070
-
-
Salloway, S.1
Sperling, R.2
Gilman, S.3
-
18
-
-
77949300796
-
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
-
COI: 1:CAS:528:DC%2BC3cXltF2kt7Y%3D, PID: 20189881
-
Rinne JO, Brooks DJ, Rossor MN, et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010;9:363-372.
-
(2010)
Lancet Neurol
, vol.9
, pp. 363-372
-
-
Rinne, J.O.1
Brooks, D.J.2
Rossor, M.N.3
-
19
-
-
84855780598
-
Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta
-
COI: 1:CAS:528:DC%2BC38XntlKgug%3D%3D, PID: 21955818
-
Bohrmann B, Baumann K, Benz J, et al. Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta. J Alzheimers Dis 2012;28:49-69.
-
(2012)
J Alzheimers Dis
, vol.28
, pp. 49-69
-
-
Bohrmann, B.1
Baumann, K.2
Benz, J.3
-
20
-
-
84863221661
-
Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC38XosVKhtb8%3D, PID: 22672770
-
Farlow M, Arnold SE, van Dyck CH, et al. Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease. Alzheimers Dement 2012;8:261-271.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 261-271
-
-
Farlow, M.1
Arnold, S.E.2
van Dyck, C.H.3
-
21
-
-
49449101906
-
Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
-
PID: 18695053
-
Fleisher AS, Raman R, Siemers ER, et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol 2008;65:1031-1038.
-
(2008)
Arch Neurol
, vol.65
, pp. 1031-1038
-
-
Fleisher, A.S.1
Raman, R.2
Siemers, E.R.3
-
22
-
-
34547539177
-
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
-
COI: 1:CAS:528:DC%2BD2sXnt1Oiu7c%3D, PID: 17556541
-
Zhang Y-W, Wang R, Liu Q, Zhang H, Liao F-F, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci USA 2007;104:10613-10618.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10613-10618
-
-
Zhang, Y.-W.1
Wang, R.2
Liu, Q.3
Zhang, H.4
Liao, F.-F.5
Xu, H.6
-
23
-
-
43249122280
-
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer’s disease: a randomised phase II trial
-
COI: 1:CAS:528:DC%2BD1cXntlSjtL8%3D, PID: 18450517
-
Wilcock GK, Black SE, Hendrix SB, et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer’s disease: a randomised phase II trial. Lancet Neurol 2008;7:483-493.
-
(2008)
Lancet Neurol
, vol.7
, pp. 483-493
-
-
Wilcock, G.K.1
Black, S.E.2
Hendrix, S.B.3
-
24
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease
-
COI: 1:CAS:528:DyaK3MXhsFyhu7k%3D, PID: 1671712
-
Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 1991;349:704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
-
25
-
-
0030293676
-
Familial Alzheimer’s disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
COI: 1:CAS:528:DyaK28XnsVCrtL0%3D, PID: 8938131
-
Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alzheimer’s disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996;17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
26
-
-
57149145222
-
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity
-
COI: 1:CAS:528:DC%2BD1cXht1ans7zP, PID: 18694930
-
Jan A, Gokce O, Luthi-Carter R, Lashuel HA. The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. J Biol Chem 2008;283:28176-28189.
-
(2008)
J Biol Chem
, vol.283
, pp. 28176-28189
-
-
Jan, A.1
Gokce, O.2
Luthi-Carter, R.3
Lashuel, H.A.4
-
27
-
-
77957785420
-
Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
-
COI: 1:CAS:528:DC%2BC3cXhtFSmsbzP, PID: 20818335
-
Kuperstein I, Broersen K, Benilova I, et al. Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J 2010;29:3408-3420.
-
(2010)
EMBO J
, vol.29
, pp. 3408-3420
-
-
Kuperstein, I.1
Broersen, K.2
Benilova, I.3
-
28
-
-
53549099647
-
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer’s disease-like pathology
-
COI: 1:CAS:528:DC%2BD1cXht1Slu7zL, PID: 18836460
-
Schilling S, Zeitschel U, Hoffmann T, et al. Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer’s disease-like pathology. Nat Med 2008;14:1106-1111.
-
(2008)
Nat Med
, vol.14
, pp. 1106-1111
-
-
Schilling, S.1
Zeitschel, U.2
Hoffmann, T.3
-
29
-
-
84860519322
-
N-Terminal pyroglutamate formation of Abeta38 and Abeta40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation
-
COI: 1:CAS:528:DC%2BC38XhtVGltrvE, PID: 22375951
-
Schlenzig D, Ronicke R, Cynis H, et al. N-Terminal pyroglutamate formation of Abeta38 and Abeta40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. J Neurochem 2012;121:774-784.
-
(2012)
J Neurochem
, vol.121
, pp. 774-784
-
-
Schlenzig, D.1
Ronicke, R.2
Cynis, H.3
-
30
-
-
84862816040
-
Passive immunization against pyroglutamate-3 amyloid-beta reduces plaque burden in Alzheimer-like transgenic mice: a pilot study
-
COI: 1:CAS:528:DC%2BC38XlvVOls74%3D, PID: 22343072
-
Frost JL, Liu B, Kleinschmidt M, Schilling S, Demuth HU, Lemere CA. Passive immunization against pyroglutamate-3 amyloid-beta reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegener Dis 2012;10:265-270.
-
(2012)
Neurodegener Dis
, vol.10
, pp. 265-270
-
-
Frost, J.L.1
Liu, B.2
Kleinschmidt, M.3
Schilling, S.4
Demuth, H.U.5
Lemere, C.A.6
-
31
-
-
80052578595
-
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Abeta is induced by pyroglutamate-Abeta formation
-
COI: 1:CAS:528:DC%2BC3MXhtFOhtrzI, PID: 21900558
-
Alexandru A, Jagla W, Graubner S, et al. Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Abeta is induced by pyroglutamate-Abeta formation. J Neurosci 2011;31:12790-12801.
-
(2011)
J Neurosci
, vol.31
, pp. 12790-12801
-
-
Alexandru, A.1
Jagla, W.2
Graubner, S.3
-
32
-
-
79960819248
-
Potent amyloidogenicity and pathogenicity of Aβ43
-
COI: 1:CAS:528:DC%2BC3MXotlClsLs%3D, PID: 21725313
-
Saito T, Suemoto T, Brouwers N, et al. Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci 2011;14:1023-1032.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1023-1032
-
-
Saito, T.1
Suemoto, T.2
Brouwers, N.3
-
33
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics
-
COI: 1:CAS:528:DC%2BC3MXhtVelsL3L, PID: 21852788
-
Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 2011;10:698-712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
34
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
PID: 16541076
-
Lesné S, Koh MT, Kotilinek LA, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006;440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.A.3
-
35
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
COI: 1:CAS:528:DC%2BD38XivVOntL8%3D, PID: 11932745
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002;416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
36
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
COI: 1:CAS:528:DC%2BD2MXhtFWmsw%3D%3D, PID: 15608634
-
Cleary JP, Walsh DM, Hofmeister JJ, et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 2005;8:79-84.
-
(2005)
Nat Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
-
37
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory
-
COI: 1:CAS:528:DC%2BD1cXptlKltb0%3D, PID: 18568035
-
Shankar GM, Li S, Mehta TH, et al. Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat Med 2008;14:837-842.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
-
38
-
-
84903208566
-
Secreted amyloid beta-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity
-
COI: 1:CAS:528:DC%2BC2cXotFOhsL4%3D, PID: 24840308
-
Welzel AT, Maggio JE, Shankar GM, et al. Secreted amyloid beta-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry 2014;53:3908-3921.
-
(2014)
Biochemistry
, vol.53
, pp. 3908-3921
-
-
Welzel, A.T.1
Maggio, J.E.2
Shankar, G.M.3
-
39
-
-
84939893377
-
Anti-Abeta antibody target engagement: a response to Siemers et al
-
PID: 25120193
-
Watt AD, Crespi GA, Down RA, et al. Anti-Abeta antibody target engagement: a response to Siemers et al. Acta Neuropathol 2014;128:611-614.
-
(2014)
Acta Neuropathol
, vol.128
, pp. 611-614
-
-
Watt, A.D.1
Crespi, G.A.2
Down, R.A.3
-
40
-
-
79952135798
-
AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure
-
COI: 1:CAS:528:DC%2BC3MXisVajur0%3D, PID: 21204788
-
Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure. Biochem J 2011;434:503-512.
-
(2011)
Biochem J
, vol.434
, pp. 503-512
-
-
Thornton, C.1
Bright, N.J.2
Sastre, M.3
Muckett, P.J.4
Carling, D.5
-
41
-
-
77956587739
-
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
-
COI: 1:CAS:528:DC%2BC3cXhtF2qsLnK, PID: 20826658
-
Zempel H, Thies E, Mandelkow E, Mandelkow E-M. Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci 2010;30:11938-11950.
-
(2010)
J Neurosci
, vol.30
, pp. 11938-11950
-
-
Zempel, H.1
Thies, E.2
Mandelkow, E.3
Mandelkow, E.-M.4
-
42
-
-
0028986916
-
beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
-
COI: 1:CAS:528:DyaK2MXlt1aiu78%3D, PID: 7718249
-
Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995;14:879-888.
-
(1995)
Neuron
, vol.14
, pp. 879-888
-
-
Busciglio, J.1
Lorenzo, A.2
Yeh, J.3
Yankner, B.A.4
-
43
-
-
33751218015
-
Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid
-
COI: 1:CAS:528:DC%2BD28Xht1GksbvK, PID: 17101697
-
King ME, Kan H-M, Baas PW, Erisir A, Glabe CG, Bloom GS. Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid. J Cell Biol 2006;175:541-546.
-
(2006)
J Cell Biol
, vol.175
, pp. 541-546
-
-
King, M.E.1
Kan, H.-M.2
Baas, P.W.3
Erisir, A.4
Glabe, C.G.5
Bloom, G.S.6
-
44
-
-
79957996565
-
Amyloid {beta}-mediated cell death of cultured hippocampal neurons reveals extensive tau fragmentation without increased full-length tau phosphorylation
-
COI: 1:CAS:528:DC%2BC3MXmvFCgurg%3D, PID: 21482827
-
Reifert J, Hartung-Cranston D, Feinstein SC. Amyloid {beta}-mediated cell death of cultured hippocampal neurons reveals extensive tau fragmentation without increased full-length tau phosphorylation. J Biol Chem 2011;286:20797-20811.
-
(2011)
J Biol Chem
, vol.286
, pp. 20797-20811
-
-
Reifert, J.1
Hartung-Cranston, D.2
Feinstein, S.C.3
-
45
-
-
84863638361
-
The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: Implications for Alzheimer therapeutics
-
COI: 1:CAS:528:DC%2BC38XhtVGlsb%2FN, PID: 22787030
-
Ayton S, Lei P. The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: Implications for Alzheimer therapeutics. J Neurosci 2012;32:9454-9456.
-
(2012)
J Neurosci
, vol.32
, pp. 9454-9456
-
-
Ayton, S.1
Lei, P.2
-
46
-
-
84863238028
-
Inhibition of the NFAT pathway alleviates amyloid Beta neurotoxicity in a mouse model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC38XjslKjur8%3D, PID: 22378890
-
Hudry E, Wu HY, Arbel-Ornath M, et al. Inhibition of the NFAT pathway alleviates amyloid Beta neurotoxicity in a mouse model of Alzheimer’s disease. J Neurosci 2012;32:3176-3192.
-
(2012)
J Neurosci
, vol.32
, pp. 3176-3192
-
-
Hudry, E.1
Wu, H.Y.2
Arbel-Ornath, M.3
-
47
-
-
77957345679
-
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model
-
COI: 1:CAS:528:DC%2BC3cXhsVSqu7fM, PID: 20802182
-
Hurtado DE, Molina-Porcel L, Iba M, et al. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol 2010;177:1977-1988.
-
(2010)
Am J Pathol
, vol.177
, pp. 1977-1988
-
-
Hurtado, D.E.1
Molina-Porcel, L.2
Iba, M.3
-
48
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
COI: 1:CAS:528:DC%2BD3MXmsVeru7Y%3D, PID: 11520987
-
Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001;293:1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
-
49
-
-
40449098952
-
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice
-
COI: 1:CAS:528:DC%2BD1cXktVKgsrk%3D, PID: 18258852
-
Terwel D, Muyllaert D, Dewachter I, et al. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. Am J Pathol 2008;172:786-798.
-
(2008)
Am J Pathol
, vol.172
, pp. 786-798
-
-
Terwel, D.1
Muyllaert, D.2
Dewachter, I.3
-
50
-
-
51449096696
-
Abeta inhibits the proteasome and enhances amyloid and tau accumulation
-
COI: 1:CAS:528:DC%2BD1cXhtFCksLzN, PID: 17544172
-
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging 2008;29:1607-1618.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1607-1618
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
LaFerla, F.M.5
-
51
-
-
34547464672
-
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice
-
COI: 1:CAS:528:DC%2BD2sXhtVOqtL%2FJ, PID: 17472708
-
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem 2007;102:1053-1063.
-
(2007)
J Neurochem
, vol.102
, pp. 1053-1063
-
-
Oddo, S.1
Caccamo, A.2
Cheng, D.3
Jouleh, B.4
Torp, R.5
LaFerla, F.M.6
-
52
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
PID: 11520988
-
Götz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 2001;293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
53
-
-
31844439888
-
Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
-
COI: 1:CAS:528:DC%2BD28XitFCjs7k%3D, PID: 16385556
-
Ma QL, Lim GP, Harris-White ME, et al. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res 2006;83:374-384.
-
(2006)
J Neurosci Res
, vol.83
, pp. 374-384
-
-
Ma, Q.L.1
Lim, G.P.2
Harris-White, M.E.3
-
54
-
-
67649363905
-
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD1MXotFKgtL8%3D, PID: 19553436
-
Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer’s disease. J Neurosci 2009;29:7957-7965.
-
(2009)
J Neurosci
, vol.29
, pp. 7957-7965
-
-
Wilcock, D.M.1
Gharkholonarehe, N.2
Van Nostrand, W.E.3
Davis, J.4
Vitek, M.P.5
Colton, C.A.6
-
55
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
COI: 1:CAS:528:DC%2BD2cXmvFOisLk%3D, PID: 15294141
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004;43:321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
56
-
-
0942265972
-
Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression
-
COI: 1:CAS:528:DC%2BD2cXhtVaisLg%3D, PID: 14720205
-
Liu T, Perry G, Chan HW, et al. Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. J Neurochem 2004;88:554-563.
-
(2004)
J Neurochem
, vol.88
, pp. 554-563
-
-
Liu, T.1
Perry, G.2
Chan, H.W.3
-
57
-
-
0037197836
-
Tau is essential to beta -amyloid-induced neurotoxicity
-
COI: 1:CAS:528:DC%2BD38XjslWnt74%3D, PID: 11959919
-
Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A. Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A 2002;99:6364-6369.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
58
-
-
77957737750
-
Tau reduction prevents A{beta}-induced defects in axonal transport
-
COI: 1:CAS:528:DC%2BC3cXht1CgtrfN, PID: 20829454
-
Vossel KA, Zhang K, Brodbeck J, et al. Tau reduction prevents A{beta}-induced defects in axonal transport. Science 2010;330:198.
-
(2010)
Science
, vol.330
, pp. 198
-
-
Vossel, K.A.1
Zhang, K.2
Brodbeck, J.3
-
59
-
-
79551510136
-
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation
-
COI: 1:CAS:528:DC%2BC3MXhvFGkurs%3D, PID: 21289177
-
Shipton OA, Leitz JR, Dworzak J, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci 2011;31:1688-1692.
-
(2011)
J Neurosci
, vol.31
, pp. 1688-1692
-
-
Shipton, O.A.1
Leitz, J.R.2
Dworzak, J.3
-
60
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model
-
COI: 1:CAS:528:DC%2BD2sXkvVWrtrw%3D, PID: 17478722
-
Roberson ED, Scearce-Levie K, Palop JJ, et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Science 2007;316:750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
-
61
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models
-
COI: 1:CAS:528:DC%2BC3cXpvFKrtr4%3D, PID: 20655099
-
Ittner LM, Ke YD, Delerue F, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell 2010;142:387-397.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
-
62
-
-
78651506630
-
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3MXht1arsrk%3D, PID: 21228179
-
Roberson ED, Halabisky B, Yoo JW, et al. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J Neurosci 2011;31:700-711.
-
(2011)
J Neurosci
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
-
63
-
-
77953808475
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3cXnvVOmsb8%3D, PID: 20434528
-
Dawson HN, Cantillana V, Jansen M, et al. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer’s disease. Neuroscience 2010;169:516-531.
-
(2010)
Neuroscience
, vol.169
, pp. 516-531
-
-
Dawson, H.N.1
Cantillana, V.2
Jansen, M.3
-
64
-
-
84856708923
-
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
-
COI: 1:CAS:528:DC%2BC38XhtlOlsbg%3D, PID: 22286308
-
Lei P, Ayton S, Finkelstein DI, et al. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 2012;18:291-295.
-
(2012)
Nat Med
, vol.18
, pp. 291-295
-
-
Lei, P.1
Ayton, S.2
Finkelstein, D.I.3
-
65
-
-
84901036309
-
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging
-
COI: 1:CAS:528:DC%2BC2cXovFGgu7c%3D, PID: 24849348
-
Ma QL, Zuo X, Yang F, et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci 2014;34:7124-7136.
-
(2014)
J Neurosci
, vol.34
, pp. 7124-7136
-
-
Ma, Q.L.1
Zuo, X.2
Yang, F.3
-
66
-
-
84906922815
-
Motor and cognitive deficits in aged tau knockout mice in two background strains
-
PID: 25124182
-
Lei P, Ayton S, Moon S, et al. Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener 2014;9:29.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 29
-
-
Lei, P.1
Ayton, S.2
Moon, S.3
-
67
-
-
84875250937
-
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study
-
COI: 1:CAS:528:DC%2BC3sXksFejsrw%3D, PID: 23477989
-
Villemagne VL, Burnham S, Bourgeat P, et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurol 2013;12:357-367.
-
(2013)
Lancet Neurol
, vol.12
, pp. 357-367
-
-
Villemagne, V.L.1
Burnham, S.2
Bourgeat, P.3
-
68
-
-
76849091134
-
Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
-
COI: 1:CAS:528:DC%2BC3cXhs1Ogt78%3D, PID: 20140000
-
Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol 2010;6:108-119.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 108-119
-
-
Lemere, C.A.1
Masliah, E.2
-
69
-
-
0034733705
-
Evidence that the beta-amyloid plaques of Alzheimer’s disease represent the redox-silencing and entombment of abeta by zinc
-
COI: 1:CAS:528:DC%2BD3cXkslahs7o%3D, PID: 10801774
-
Cuajungco MP, Goldstein LE, Nunomura A, et al. Evidence that the beta-amyloid plaques of Alzheimer’s disease represent the redox-silencing and entombment of abeta by zinc. J Biol Chem 2000;275:19439-19442.
-
(2000)
J Biol Chem
, vol.275
, pp. 19439-19442
-
-
Cuajungco, M.P.1
Goldstein, L.E.2
Nunomura, A.3
-
70
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease
-
COI: 1:STN:280:DyaK1MvhvFarsA%3D%3D, PID: 10487842
-
Lue LF, Kuo YM, Roher AE, et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer’s disease. Am J Pathol 1999;155:853-862.
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
-
71
-
-
0027980901
-
Rapid induction of Alzheimer A beta amyloid formation by zinc
-
COI: 1:CAS:528:DyaK2cXmsFaqs7k%3D, PID: 8073293
-
Bush AI, Pettingell WH, Multhaup G, et al. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1994;265:1464-1467.
-
(1994)
Science
, vol.265
, pp. 1464-1467
-
-
Bush, A.I.1
Pettingell, W.H.2
Multhaup, G.3
-
72
-
-
0036592524
-
Amyloid-beta: redox-metal chelator and antioxidant
-
COI: 1:CAS:528:DC%2BD38XmtFWisbk%3D, PID: 12226539
-
Atwood CS, Robinson SR, Smith MA. Amyloid-beta: redox-metal chelator and antioxidant. J Alzheimers Dis 2002;4:203-214.
-
(2002)
J Alzheimers Dis
, vol.4
, pp. 203-214
-
-
Atwood, C.S.1
Robinson, S.R.2
Smith, M.A.3
-
73
-
-
0030804608
-
Increased amount of zinc in the hippocampus and amygdala of Alzheimer’s diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
-
COI: 1:CAS:528:DyaK2sXms1eqsr8%3D, PID: 9334939
-
Danscher G, Jensen KB, Frederickson CJ, et al. Increased amount of zinc in the hippocampus and amygdala of Alzheimer’s diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material. J Neurosci Methods 1997;76:53-59.
-
(1997)
J Neurosci Methods
, vol.76
, pp. 53-59
-
-
Danscher, G.1
Jensen, K.B.2
Frederickson, C.J.3
-
74
-
-
0037086888
-
Determination of cadmium and zinc in Alzheimer’s brain tissue using inductively coupled plasma mass spectrometry
-
COI: 1:CAS:528:DC%2BD38XhsFWgsbg%3D, PID: 11867068
-
Panayi AE, Spyrou NM, Iversen BS, White MA, Part P. Determination of cadmium and zinc in Alzheimer’s brain tissue using inductively coupled plasma mass spectrometry. J Neurol Sci 2002;195:1-10.
-
(2002)
J Neurol Sci
, vol.195
, pp. 1-10
-
-
Panayi, A.E.1
Spyrou, N.M.2
Iversen, B.S.3
White, M.A.4
Part, P.5
-
75
-
-
0029063462
-
Elemental imbalances in the olfactory pathway in Alzheimer’s disease
-
COI: 1:STN:280:DyaK287nt1Gqsg%3D%3D, PID: 8586977
-
Samudralwar DL, Diprete CC, Ni BF, Ehmann WD, Markesbery WR. Elemental imbalances in the olfactory pathway in Alzheimer’s disease. J Neurol Sci 1995;130:139-145.
-
(1995)
J Neurol Sci
, vol.130
, pp. 139-145
-
-
Samudralwar, D.L.1
Diprete, C.C.2
Ni, B.F.3
Ehmann, W.D.4
Markesbery, W.R.5
-
76
-
-
0030297178
-
Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress
-
COI: 1:CAS:528:DyaK2sXisFOrtA%3D%3D, PID: 8981312
-
Deibel MA, Ehmann WD, Markesbery WR. Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress. J Neurol Sci 1996;143:137-142.
-
(1996)
J Neurol Sci
, vol.143
, pp. 137-142
-
-
Deibel, M.A.1
Ehmann, W.D.2
Markesbery, W.R.3
-
77
-
-
33746800368
-
Elevated cortical zinc in Alzheimer disease
-
COI: 1:CAS:528:DC%2BD28XlvFylu7g%3D, PID: 16832080
-
Religa D, Strozyk D, Cherny RA, et al. Elevated cortical zinc in Alzheimer disease. Neurology 2006;67:69-75.
-
(2006)
Neurology
, vol.67
, pp. 69-75
-
-
Religa, D.1
Strozyk, D.2
Cherny, R.A.3
-
78
-
-
79955650486
-
Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3MXjvVKjtLY%3D, PID: 21187585
-
Schrag M, Crofton A, Zabel M, et al. Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer’s disease. J Alzheimers Dis 2011;24:137-149.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 137-149
-
-
Schrag, M.1
Crofton, A.2
Zabel, M.3
-
79
-
-
0033986037
-
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer’s diseased brains
-
COI: 1:CAS:528:DC%2BD3cXhtVOrt7s%3D, PID: 10678753
-
Suh SW, Jensen KB, Jensen MS, et al. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer’s diseased brains. Brain Res 2000;852:274-278.
-
(2000)
Brain Res
, vol.852
, pp. 274-278
-
-
Suh, S.W.1
Jensen, K.B.2
Jensen, M.S.3
-
80
-
-
23744431884
-
Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques
-
COI: 1:CAS:528:DC%2BD2MXmt1Wgu7c%3D, PID: 15981003
-
Stoltenberg M, Bruhn M, Sondergaard C, et al. Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques. Histochem Cell Biol 2005;123:605-611.
-
(2005)
Histochem Cell Biol
, vol.123
, pp. 605-611
-
-
Stoltenberg, M.1
Bruhn, M.2
Sondergaard, C.3
-
81
-
-
33745004381
-
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD28XlvF2nsLc%3D, PID: 16325427
-
Miller LM, Wang Q, Telivala TP, Smith RJ, Lanzirotti A, Miklossy J. Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer’s disease. J Struct Biol 2006;155:30-37.
-
(2006)
J Struct Biol
, vol.155
, pp. 30-37
-
-
Miller, L.M.1
Wang, Q.2
Telivala, T.P.3
Smith, R.J.4
Lanzirotti, A.5
Miklossy, J.6
-
82
-
-
0032507975
-
Copper, iron and zinc in Alzheimer’s disease senile plaques
-
COI: 1:CAS:528:DyaK1cXjsVentbo%3D, PID: 9667777
-
Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR. Copper, iron and zinc in Alzheimer’s disease senile plaques. J Neurol Sci 1998;158:47-52.
-
(1998)
J Neurol Sci
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
83
-
-
0027220686
-
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer’s disease
-
COI: 1:CAS:528:DyaK3sXlslyltbc%3D, PID: 8344894
-
Bush AI, Multhaup G, Moir RD, et al. A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer’s disease. J Biol Chem 1993;268:16109-16112.
-
(1993)
J Biol Chem
, vol.268
, pp. 16109-16112
-
-
Bush, A.I.1
Multhaup, G.2
Moir, R.D.3
-
84
-
-
0037188530
-
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
-
COI: 1:CAS:528:DC%2BD38XktlCrs7Y%3D, PID: 12032347
-
Lee JY, Cole TB, Palmiter RD, Suh SW, Koh JY. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc Natl Acad Sci U S A 2002;99:7705-7710.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 7705-7710
-
-
Lee, J.Y.1
Cole, T.B.2
Palmiter, R.D.3
Suh, S.W.4
Koh, J.Y.5
-
85
-
-
76149093866
-
Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease?
-
COI: 1:CAS:528:DC%2BC3cXitV2jtb0%3D, PID: 20130173
-
Adlard PA, Parncutt JM, Finkelstein DI, Bush AI. Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease? J Neurosci 2010;30:1631-1636.
-
(2010)
J Neurosci
, vol.30
, pp. 1631-1636
-
-
Adlard, P.A.1
Parncutt, J.M.2
Finkelstein, D.I.3
Bush, A.I.4
-
86
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease
-
COI: 1:CAS:528:DyaK1MXjslChsLY%3D, PID: 10097139
-
Lammich S, Kojro E, Postina R, et al. Constitutive and regulated alpha-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A 1999;96:3922-3927.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
-
87
-
-
27644482219
-
In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
-
COI: 1:CAS:528:DC%2BD2MXht1SltLvP, PID: 16262694
-
Hoke DE, Tan JL, Ilaya NT, et al. In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc. FEBS J 2005;272:5544-5557.
-
(2005)
FEBS J
, vol.272
, pp. 5544-5557
-
-
Hoke, D.E.1
Tan, J.L.2
Ilaya, N.T.3
-
88
-
-
79953167471
-
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity
-
COI: 1:CAS:528:DC%2BC3MXjtFOitb0%3D, PID: 21239495
-
Greenough MA, Volitaskis I, Li Q-X, et al. Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity. J Biol Chem 2011;286:9776-9786.
-
(2011)
J Biol Chem
, vol.286
, pp. 9776-9786
-
-
Greenough, M.A.1
Volitaskis, I.2
Li, Q.-X.3
-
89
-
-
0028180196
-
Modulation of A beta adhesiveness and secretase site cleavage by zinc
-
COI: 1:CAS:528:DyaK2cXltVGrsbY%3D, PID: 8163520
-
Bush AI, Pettingell WH, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. J Biol Chem 1994;269:12152-12158.
-
(1994)
J Biol Chem
, vol.269
, pp. 12152-12158
-
-
Bush, A.I.1
Pettingell, W.H.2
Paradis, M.D.3
Tanzi, R.E.4
-
90
-
-
59449101792
-
Restored degradation of the Alzheimer’s amyloid-beta peptide by targeting amyloid formation
-
COI: 1:CAS:528:DC%2BD1MXivFels70%3D, PID: 19141082
-
Crouch PJ, Tew DJ, Du T, et al. Restored degradation of the Alzheimer’s amyloid-beta peptide by targeting amyloid formation. J Neurochem 2009;108:1198-1207.
-
(2009)
J Neurochem
, vol.108
, pp. 1198-1207
-
-
Crouch, P.J.1
Tew, D.J.2
Du, T.3
-
91
-
-
67349208449
-
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells
-
COI: 1:CAS:528:DC%2BD1MXntVGrtrs%3D, PID: 19111579
-
Boom A, Authelet M, Dedecker R, et al. Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. Biochim Biophys Acta 2009;1793:1058-1067.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1058-1067
-
-
Boom, A.1
Authelet, M.2
Dedecker, R.3
-
92
-
-
71749113077
-
Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322
-
COI: 1:CAS:528:DC%2BD1MXhsFWitLbK, PID: 19826005
-
Mo Z-Y, Zhu Y-Z, Zhu H-L, Fan J-B, Chen J, Liang Y. Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322. J Biol Chem 2009;284:34648-34657.
-
(2009)
J Biol Chem
, vol.284
, pp. 34648-34657
-
-
Mo, Z.-Y.1
Zhu, Y.-Z.2
Zhu, H.-L.3
Fan, J.-B.4
Chen, J.5
Liang, Y.6
-
93
-
-
84923060369
-
Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation
-
COI: 1:CAS:528:DC%2BC2cXht1agsLzN, PID: 25066125
-
Huang Y, Wu Z, Cao Y, Lang M, Lu B, Zhou B. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Rep 2014;8:831-842.
-
(2014)
Cell Rep
, vol.8
, pp. 831-842
-
-
Huang, Y.1
Wu, Z.2
Cao, Y.3
Lang, M.4
Lu, B.5
Zhou, B.6
-
94
-
-
14844299775
-
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
-
COI: 1:CAS:528:DC%2BD2MXitleiu7w%3D, PID: 15715661
-
An W-L, Bjorkdahl C, Liu R, Cowburn RF, Winblad B, Pei J-J. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. J Neurochem 2005;92:1104-1115.
-
(2005)
J Neurochem
, vol.92
, pp. 1104-1115
-
-
An, W.-L.1
Bjorkdahl, C.2
Liu, R.3
Cowburn, R.F.4
Winblad, B.5
Pei, J.-J.6
-
95
-
-
29344460850
-
P70 S6 kinase mediates tau phosphorylation and synthesis
-
COI: 1:CAS:528:DC%2BD28XkslGl, PID: 16364302
-
Pei J-J, An W-L, Zhou X-W, et al. P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Lett 2006;580:107-114.
-
(2006)
FEBS Lett
, vol.580
, pp. 107-114
-
-
Pei, J.-J.1
An, W.-L.2
Zhou, X.-W.3
-
97
-
-
84893774898
-
Nigral iron elevation is an invariable feature of Parkinson’s disease and is a sufficient cause of neurodegeneration
-
Ayton S, Lei P. Nigral iron elevation is an invariable feature of Parkinson’s disease and is a sufficient cause of neurodegeneration. Biomed Research Int 2014;2014:581256.
-
(2014)
Biomed Research Int
, vol.2014
, pp. 581256
-
-
Ayton, S.1
Lei, P.2
-
98
-
-
84903870684
-
Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
-
PID: 25011704
-
Ayton S, Lei P, Adlard PA, et al. Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease. Mol Neurodegener 2014;9:27.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 27
-
-
Ayton, S.1
Lei, P.2
Adlard, P.A.3
-
99
-
-
84938039523
-
Alzheimer’s disease; a clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis
-
COI: 1:STN:280:DyaG2c%2FjtVCmuw%3D%3D
-
Goodman L. Alzheimer’s disease; a clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis. J Nerv Mental Dis 1953;118:97-130.
-
(1953)
J Nerv Mental Dis
, vol.118
, pp. 97-130
-
-
Goodman, L.1
-
100
-
-
0026513756
-
A histochemical study of iron, transferrin, and ferritin in Alzheimer’s diseased brains
-
COI: 1:CAS:528:DyaK38Xht1Kitrc%3D, PID: 1613823
-
Connor JR, Menzies SL, St Martin SM, Mufson EJ. A histochemical study of iron, transferrin, and ferritin in Alzheimer’s diseased brains. J Neurosci Res 1992;31:75-83.
-
(1992)
J Neurosci Res
, vol.31
, pp. 75-83
-
-
Connor, J.R.1
Menzies, S.L.2
St Martin, S.M.3
Mufson, E.J.4
-
101
-
-
0026590705
-
Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer’s disease
-
COI: 1:CAS:528:DyaK38XhvFajsLY%3D, PID: 1573683
-
Connor JR, Snyder BS, Beard JL, Fine RE, Mufson EJ. Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer’s disease. J Neurosci Res 1992;31:327-335.
-
(1992)
J Neurosci Res
, vol.31
, pp. 327-335
-
-
Connor, J.R.1
Snyder, B.S.2
Beard, J.L.3
Fine, R.E.4
Mufson, E.J.5
-
102
-
-
23944491628
-
In situ characterization and mapping of iron compounds in Alzheimer’s disease tissue
-
COI: 1:CAS:528:DC%2BD2MXoslCnt7Y%3D, PID: 16131727
-
Collingwood JF, Mikhaylova A, Davidson M, et al. In situ characterization and mapping of iron compounds in Alzheimer’s disease tissue. J Alzheimers Dis 2005;7:267-272.
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 267-272
-
-
Collingwood, J.F.1
Mikhaylova, A.2
Davidson, M.3
-
103
-
-
79955658817
-
Detecting amyloid-beta plaques in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3MXntlygu74%3D, PID: 21279620
-
Baltes C, Princz-Kranz F, Rudin M, Mueggler T. Detecting amyloid-beta plaques in Alzheimer’s disease. Methods Mol Biol 2011;711:511-533.
-
(2011)
Methods Mol Biol
, vol.711
, pp. 511-533
-
-
Baltes, C.1
Princz-Kranz, F.2
Rudin, M.3
Mueggler, T.4
-
104
-
-
66149090377
-
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer’s disease and APP/PS1 transgenic mice
-
PID: 19388095
-
Meadowcroft MD, Connor JR, Smith MB, Yang QX. MRI and histological analysis of beta-amyloid plaques in both human Alzheimer’s disease and APP/PS1 transgenic mice. J Magn Reson Imaging 2009;29:997-1007.
-
(2009)
J Magn Reson Imaging
, vol.29
, pp. 997-1007
-
-
Meadowcroft, M.D.1
Connor, J.R.2
Smith, M.B.3
Yang, Q.X.4
-
105
-
-
47849086918
-
Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer’s plaque core material
-
COI: 1:CAS:528:DC%2BD1cXmvFGltrw%3D, PID: 18560134
-
Collingwood JF, Chong RK, Kasama T, et al. Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer’s plaque core material. J Alzheimers Dis 2008;14:235-245.
-
(2008)
J Alzheimers Dis
, vol.14
, pp. 235-245
-
-
Collingwood, J.F.1
Chong, R.K.2
Kasama, T.3
-
106
-
-
77956647381
-
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3cXhtFyitb%2FJ, PID: 20817278
-
Duce JA, Tsatsanis A, Cater MA, et al. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer’s disease. Cell 2010;142:857-867.
-
(2010)
Cell
, vol.142
, pp. 857-867
-
-
Duce, J.A.1
Tsatsanis, A.2
Cater, M.A.3
-
107
-
-
0029166601
-
Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer’s disease
-
COI: 1:CAS:528:DyaK2MXnsVClsrk%3D, PID: 15374228
-
Andrasi E, Farkas E, Scheibler H, Reffy A, Bezur L. Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer’s disease. Arch Gerontol Geriatr 1995;21:89-97.
-
(1995)
Arch Gerontol Geriatr
, vol.21
, pp. 89-97
-
-
Andrasi, E.1
Farkas, E.2
Scheibler, H.3
Reffy, A.4
Bezur, L.5
-
108
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
COI: 1:CAS:528:DyaK2sXlvVWjsLo%3D, PID: 9275217
-
Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A 1997;94:9866-9868.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
109
-
-
84897365963
-
A delicate balance: Iron metabolism and diseases of the brain
-
PID: 23874300
-
Hare D, Ayton S, Bush A, Lei P. A delicate balance: Iron metabolism and diseases of the brain. Front Aging Neurosci 2013;5:34.
-
(2013)
Front Aging Neurosci
, vol.5
, pp. 34
-
-
Hare, D.1
Ayton, S.2
Bush, A.3
Lei, P.4
-
111
-
-
0028981159
-
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death
-
COI: 1:CAS:528:DyaK2MXnvFChurs%3D, PID: 7666206
-
Mark RJ, Hensley K, Butterfield DA, Mattson MP. Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. J Neurosci 1995;15:6239-6249.
-
(1995)
J Neurosci
, vol.15
, pp. 6239-6249
-
-
Mark, R.J.1
Hensley, K.2
Butterfield, D.A.3
Mattson, M.P.4
-
112
-
-
0032587938
-
Effect of oxidation on Ca2+ -ATPase activity and membrane lipids in lens epithelial microsomes
-
COI: 1:CAS:528:DyaK1MXkvVKqsbk%3D, PID: 10443934
-
Ahuja RP, Borchman D, Dean WL, et al. Effect of oxidation on Ca2+ -ATPase activity and membrane lipids in lens epithelial microsomes. Free Radic Biol Med 1999;27:177-185.
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 177-185
-
-
Ahuja, R.P.1
Borchman, D.2
Dean, W.L.3
-
113
-
-
0032171640
-
Oxidative damage to sarcoplasmic reticulum Ca2 + -ATPase AT submicromolar iron concentrations: evidence for metal-catalyzed oxidation
-
COI: 1:CAS:528:DyaK1cXlslKgtrg%3D, PID: 9741592
-
Moreau VH, Castilho RF, Ferreira ST, Carvalho-Alves PC. Oxidative damage to sarcoplasmic reticulum Ca2 + -ATPase AT submicromolar iron concentrations: evidence for metal-catalyzed oxidation. Free Radic Biol Med 1998;25:554-560.
-
(1998)
Free Radic Biol Med
, vol.25
, pp. 554-560
-
-
Moreau, V.H.1
Castilho, R.F.2
Ferreira, S.T.3
Carvalho-Alves, P.C.4
-
114
-
-
0030831615
-
Iron-induced inhibition of Na+, K(+)-ATPase and Na+/Ca2+ exchanger in synaptosomes: protection by the pyridoindole stobadine
-
COI: 1:CAS:528:DyaK2sXntVGhtro%3D, PID: 9357020
-
Kaplan P, Matejovicova M, Mezesova V. Iron-induced inhibition of Na+, K(+)-ATPase and Na+/Ca2+ exchanger in synaptosomes: protection by the pyridoindole stobadine. Neurochem Res 1997;22:1523-1529.
-
(1997)
Neurochem Res
, vol.22
, pp. 1523-1529
-
-
Kaplan, P.1
Matejovicova, M.2
Mezesova, V.3
-
115
-
-
70450209180
-
Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger
-
COI: 1:CAS:528:DC%2BD1MXhtl2iu7fF, PID: 19715555
-
Gnana-Prakasam JP, Thangaraju M, Liu K, et al. Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Biochem J 2009;424:243-252.
-
(2009)
Biochem J
, vol.424
, pp. 243-252
-
-
Gnana-Prakasam, J.P.1
Thangaraju, M.2
Liu, K.3
-
116
-
-
63349089476
-
Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons
-
COI: 1:CAS:528:DC%2BD1MXitVOqs7Y%3D, PID: 19135430
-
Yu J, Guo Y, Sun M, Li B, Zhang Y, Li C. Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons. Brain Res 2009;1257:102-107.
-
(2009)
Brain Res
, vol.1257
, pp. 102-107
-
-
Yu, J.1
Guo, Y.2
Sun, M.3
Li, B.4
Zhang, Y.5
Li, C.6
-
117
-
-
79955957835
-
HFE polymorphisms affect cellular glutamate regulation
-
COI: 1:CAS:528:DC%2BC3MXmsVGiu7Y%3D, PID: 19560233
-
Mitchell RM, Lee SY, Simmons Z, Connor JR. HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging 2011;32:1114-1123.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1114-1123
-
-
Mitchell, R.M.1
Lee, S.Y.2
Simmons, Z.3
Connor, J.R.4
-
118
-
-
0031768026
-
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
-
COI: 1:CAS:528:DyaK1cXnsFChtr8%3D, PID: 9818940
-
Pedersen WA, Fu W, Keller JN, et al. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol 1998;44:819-824.
-
(1998)
Ann Neurol
, vol.44
, pp. 819-824
-
-
Pedersen, W.A.1
Fu, W.2
Keller, J.N.3
-
119
-
-
0034063728
-
A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal
-
COI: 1:CAS:528:DC%2BD3cXitVegtr8%3D, PID: 10737598
-
Pedersen WA, Chan SL, Mattson MP. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J Neurochem 2000;74:1426-1433.
-
(2000)
J Neurochem
, vol.74
, pp. 1426-1433
-
-
Pedersen, W.A.1
Chan, S.L.2
Mattson, M.P.3
-
120
-
-
0030754962
-
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
-
COI: 1:CAS:528:DyaK2sXls1Olur8%3D, PID: 9276486
-
Keller JN, Mark RJ, Bruce AJ, et al. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience 1997;80:685-696.
-
(1997)
Neuroscience
, vol.80
, pp. 685-696
-
-
Keller, J.N.1
Mark, R.J.2
Bruce, A.J.3
-
121
-
-
0242664242
-
Expression of Na+, K+-ATPase in Pichia pastoris: analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling
-
COI: 1:CAS:528:DC%2BD3sXosl2itbc%3D, PID: 12949069
-
Strugatsky D, Gottschalk KE, Goldshleger R, Bibi E, Karlish SJ. Expression of Na+, K+-ATPase in Pichia pastoris: analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling. J Biol Chem 2003;278:46064–46073.
-
(2003)
J Biol Chem
, vol.278
, pp. 46064-46073
-
-
Strugatsky, D.1
Gottschalk, K.E.2
Goldshleger, R.3
Bibi, E.4
Karlish, S.J.5
-
122
-
-
79953898190
-
Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity
-
COI: 1:CAS:528:DC%2BC3MXksVKmtbw%3D, PID: 21296883
-
Munoz P, Humeres A, Elgueta C, Kirkwood A, Hidalgo C, Nunez MT. Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J Biol Chem 2011;286:13382-13392.
-
(2011)
J Biol Chem
, vol.286
, pp. 13382-13392
-
-
Munoz, P.1
Humeres, A.2
Elgueta, C.3
Kirkwood, A.4
Hidalgo, C.5
Nunez, M.T.6
-
123
-
-
44849112514
-
Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia
-
COI: 1:CAS:528:DC%2BD1cXntFyrt74%3D, PID: 18384166
-
Jiang X, Mu D, Biran V, et al. Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia. Ann Neurol 2008;63:632-641.
-
(2008)
Ann Neurol
, vol.63
, pp. 632-641
-
-
Jiang, X.1
Mu, D.2
Biran, V.3
-
124
-
-
0036789052
-
Blockade by ferrous iron of Ca2+ influx through N-methyl-D-aspartate receptor channels in immature cultured rat cortical neurons
-
COI: 1:CAS:528:DC%2BD38XnvVGgsL8%3D, PID: 12358723
-
Nakamichi N, Ohno H, Nakamura Y, Hirai T, Kuramoto N, Yoneda Y. Blockade by ferrous iron of Ca2+ influx through N-methyl-D-aspartate receptor channels in immature cultured rat cortical neurons. J Neurochem 2002;83:1-11.
-
(2002)
J Neurochem
, vol.83
, pp. 1-11
-
-
Nakamichi, N.1
Ohno, H.2
Nakamura, Y.3
Hirai, T.4
Kuramoto, N.5
Yoneda, Y.6
-
125
-
-
79953003310
-
Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction
-
COI: 1:CAS:528:DC%2BC3MXhsFGltbc%3D, PID: 21147774
-
Shinkyo R, Guengerich FP. Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction. J Biol Chem 2011;286:4632-4643.
-
(2011)
J Biol Chem
, vol.286
, pp. 4632-4643
-
-
Shinkyo, R.1
Guengerich, F.P.2
-
126
-
-
77955668811
-
Hepatic iron loading in mice increases cholesterol biosynthesis
-
COI: 1:CAS:528:DC%2BC3cXhtV2ju7vK, PID: 20683946
-
Graham RM, Chua AC, Carter KW, et al. Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology 2010;52:462-471.
-
(2010)
Hepatology
, vol.52
, pp. 462-471
-
-
Graham, R.M.1
Chua, A.C.2
Carter, K.W.3
-
127
-
-
15744362815
-
Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in THP-1 mononuclear phagocytes
-
COI: 1:CAS:528:DC%2BD2MXis1Gqsr4%3D, PID: 15798950
-
Kraml PJ, Klein RL, Huang Y, Nareika A, Lopes-Virella MF. Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in THP-1 mononuclear phagocytes. Metabolism 2005;54:453-459.
-
(2005)
Metabolism
, vol.54
, pp. 453-459
-
-
Kraml, P.J.1
Klein, R.L.2
Huang, Y.3
Nareika, A.4
Lopes-Virella, M.F.5
-
128
-
-
80051793186
-
Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events
-
Francis N, Wong SH, Hampson P, et al. Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events. Biochim Biophys Acta 2011;1813:1822-1826.
-
(1813)
Biochim Biophys Acta
, vol.2011
, pp. 1822-1826
-
-
Francis, N.1
Wong, S.H.2
Hampson, P.3
-
129
-
-
26044457923
-
Iron-mediated free-radical formation of signaling lipids in a model system
-
COI: 1:CAS:528:DC%2BD2MXhtVGrsLjO, PID: 16105667
-
Yurkova I, Kisel M, Arnhold J, Shadyro O. Iron-mediated free-radical formation of signaling lipids in a model system. Chem Phys Lipids 2005;137:29-37.
-
(2005)
Chem Phys Lipids
, vol.137
, pp. 29-37
-
-
Yurkova, I.1
Kisel, M.2
Arnhold, J.3
Shadyro, O.4
-
130
-
-
80053993322
-
Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children
-
COI: 1:CAS:528:DC%2BC3MXht1ylsrjM, PID: 21587279
-
Yehuda S, Rabinovitz-Shenkar S, Carasso RL. Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children. Eur J Clin Nutr 2011;65:1167-1169.
-
(2011)
Eur J Clin Nutr
, vol.65
, pp. 1167-1169
-
-
Yehuda, S.1
Rabinovitz-Shenkar, S.2
Carasso, R.L.3
-
131
-
-
69549116305
-
Maternal iron deficiency alters essential fatty acid and eicosanoid metabolism and increases locomotion in adult guinea pig offspring
-
COI: 1:CAS:528:DC%2BD1MXhtlWrt7nJ, PID: 19640965
-
LeBlanc CP, Fiset S, Surette ME, Turgeon O’Brien H, Rioux FM. Maternal iron deficiency alters essential fatty acid and eicosanoid metabolism and increases locomotion in adult guinea pig offspring. J Nutr 2009;139:1653-1659.
-
(2009)
J Nutr
, vol.139
, pp. 1653-1659
-
-
LeBlanc, C.P.1
Fiset, S.2
Surette, M.E.3
Turgeon O’Brien, H.4
Rioux, F.M.5
-
132
-
-
0142093015
-
Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats
-
COI: 1:CAS:528:DC%2BD3sXntlKitLc%3D, PID: 12895262
-
Brown KE, Dennery PA, Ridnour LA, et al. Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver Int 2003;23:232-242.
-
(2003)
Liver Int
, vol.23
, pp. 232-242
-
-
Brown, K.E.1
Dennery, P.A.2
Ridnour, L.A.3
-
133
-
-
0019805510
-
Effects of ferrous chloride and iron dextran on lipid peroxidation in vivo in vitamin E and selenium adequate and deficient rats
-
COI: 1:CAS:528:DyaL3MXmtF2is7g%3D, PID: 7288501
-
Dougherty JJ, Croft WA, Hoekstra WG. Effects of ferrous chloride and iron dextran on lipid peroxidation in vivo in vitamin E and selenium adequate and deficient rats. J Nutr 1981;111:1784-1796.
-
(1981)
J Nutr
, vol.111
, pp. 1784-1796
-
-
Dougherty, J.J.1
Croft, W.A.2
Hoekstra, W.G.3
-
134
-
-
33646259713
-
Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice
-
COI: 1:CAS:528:DC%2BD28XlsVOgtLw%3D, PID: 16649999
-
Isaac G, Fredriksson A, Danielsson R, Eriksson P, Bergquist J. Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice. FEBS J 2006;273:2232-2243.
-
(2006)
FEBS J
, vol.273
, pp. 2232-2243
-
-
Isaac, G.1
Fredriksson, A.2
Danielsson, R.3
Eriksson, P.4
Bergquist, J.5
-
135
-
-
0023954581
-
Effect of excess dietary iron on lipid composition of calf liver, heart, and skeletal muscle
-
COI: 1:CAS:528:DyaL1cXitVelsLw%3D, PID: 3379174
-
Jenkins KJ, Kramer JK. Effect of excess dietary iron on lipid composition of calf liver, heart, and skeletal muscle. J Dairy Sci 1988;71:435-441.
-
(1988)
J Dairy Sci
, vol.71
, pp. 435-441
-
-
Jenkins, K.J.1
Kramer, J.K.2
-
136
-
-
1842504355
-
Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders
-
COI: 1:CAS:528:DC%2BD2cXjvVOnu7o%3D, PID: 15105254
-
Mattson MP. Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders. Ann N Y Acad Sci 2004;1012:37-50.
-
(2004)
Ann N Y Acad Sci
, vol.1012
, pp. 37-50
-
-
Mattson, M.P.1
-
137
-
-
84861541814
-
Ferroptosis: an iron-dependent form of nonapoptotic cell death
-
COI: 1:CAS:528:DC%2BC38XnslSntrw%3D, PID: 22632970
-
Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149:1060-1072.
-
(2012)
Cell
, vol.149
, pp. 1060-1072
-
-
Dixon, S.J.1
Lemberg, K.M.2
Lamprecht, M.R.3
-
138
-
-
34250372956
-
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels
-
PID: 17568748
-
Yagoda N, von Rechenberg M, Zaganjor E, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007;447:864-868.
-
(2007)
Nature
, vol.447
, pp. 864-868
-
-
Yagoda, N.1
von Rechenberg, M.2
Zaganjor, E.3
-
139
-
-
40849085503
-
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells
-
COI: 1:CAS:528:DC%2BD1cXjs1Klsrs%3D, PID: 18355723
-
Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol 2008;15:234-245.
-
(2008)
Chem Biol
, vol.15
, pp. 234-245
-
-
Yang, W.S.1
Stockwell, B.R.2
-
140
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer’s amyloid precursor protein transcript
-
COI: 1:CAS:528:DC%2BD38Xosl2ks70%3D, PID: 12198135
-
Rogers JT, Randall JD, Cahill CM, et al. An iron-responsive element type II in the 5′-untranslated region of the Alzheimer’s amyloid precursor protein transcript. J Biol Chem 2002;277:45518-45528.
-
(2002)
J Biol Chem
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
-
141
-
-
84880137264
-
Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity
-
COI: 1:CAS:528:DC%2BC3sXptV2ktro%3D, PID: 23685131
-
Li X, Liu Y, Zheng Q, et al. Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity. Neurosci Lett 2013;548:90-94.
-
(2013)
Neurosci Lett
, vol.548
, pp. 90-94
-
-
Li, X.1
Liu, Y.2
Zheng, Q.3
-
142
-
-
84903818809
-
Iron overload accelerates neuronal amyloid-beta production and cognitive impairment in transgenic mice model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2cXoslCms70%3D, PID: 24863668
-
Becerril-Ortega J, Bordji K, Freret T, Rush T, Buisson A. Iron overload accelerates neuronal amyloid-beta production and cognitive impairment in transgenic mice model of Alzheimer’s disease. Neurobiol Aging 2014;35:2288-2301.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 2288-2301
-
-
Becerril-Ortega, J.1
Bordji, K.2
Freret, T.3
Rush, T.4
Buisson, A.5
-
143
-
-
0027327488
-
Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide
-
COI: 1:CAS:528:DyaK3sXmsVeisL4%3D, PID: 8360682
-
Mantyh PW, Ghilardi JR, Rogers S, et al. Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J Neurochem 1993;61:1171-1174.
-
(1993)
J Neurochem
, vol.61
, pp. 1171-1174
-
-
Mantyh, P.W.1
Ghilardi, J.R.2
Rogers, S.3
-
144
-
-
12144282992
-
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer’s Abeta peptides
-
COI: 1:CAS:528:DC%2BD2cXhtVejurjI, PID: 15578276
-
Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer’s Abeta peptides. J Biol Inorg Chem 2004;9:954-960.
-
(2004)
J Biol Inorg Chem
, vol.9
, pp. 954-960
-
-
Huang, X.1
Atwood, C.S.2
Moir, R.D.3
Hartshorn, M.A.4
Tanzi, R.E.5
Bush, A.I.6
-
145
-
-
0028871735
-
The role of iron in beta amyloid toxicity
-
COI: 1:CAS:528:DyaK2MXptlenu7c%3D, PID: 7488167
-
Schubert D, Chevion M. The role of iron in beta amyloid toxicity. Biochem Biophys Res Commun 1995;216:702-707.
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 702-707
-
-
Schubert, D.1
Chevion, M.2
-
146
-
-
79952996094
-
Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation
-
COI: 1:CAS:528:DC%2BC3MXhsFGlsbc%3D, PID: 21147772
-
Liu B, Moloney A, Meehan S, et al. Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. J Biol Chem 2011;286:4248-4256.
-
(2011)
J Biol Chem
, vol.286
, pp. 4248-4256
-
-
Liu, B.1
Moloney, A.2
Meehan, S.3
-
147
-
-
0035865905
-
Redox-active iron mediates amyloid-beta toxicity
-
COI: 1:CAS:528:DC%2BD3MXhtFegtr4%3D, PID: 11182300
-
Rottkamp CA, Raina AK, Zhu XW, et al. Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med 2001;30:447-450.
-
(2001)
Free Radic Biol Med
, vol.30
, pp. 447-450
-
-
Rottkamp, C.A.1
Raina, A.K.2
Zhu, X.W.3
-
148
-
-
64049096553
-
Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer’s disease
-
PID: 19519625
-
Rival T, Page RM, Chandraratna DS, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer’s disease. Eur J Neurosci 2009;29:1335-1347.
-
(2009)
Eur J Neurosci
, vol.29
, pp. 1335-1347
-
-
Rival, T.1
Page, R.M.2
Chandraratna, D.S.3
-
149
-
-
0038647463
-
Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity
-
COI: 1:CAS:528:DC%2BD3sXltFeluro%3D, PID: 12807431
-
Kuperstein F, Yavin E. Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity. J Neurochem 2003;86:114-125.
-
(2003)
J Neurochem
, vol.86
, pp. 114-125
-
-
Kuperstein, F.1
Yavin, E.2
-
150
-
-
0027414336
-
Differences in microtubule binding and self-association abilities of bovine brain tau isoforms
-
PID: 8463318
-
García de Ancos J, Correas I, Avila J. Differences in microtubule binding and self-association abilities of bovine brain tau isoforms. J Biol Chem 1993;268:7976-7982.
-
(1993)
J Biol Chem
, vol.268
, pp. 7976-7982
-
-
García de Ancos, J.1
Correas, I.2
Avila, J.3
-
151
-
-
0029145757
-
Isolation of a phosphorylated soluble tau fraction from Alzheimer’s disease brain
-
COI: 1:CAS:528:DyaK2MXnslWjtrs%3D, PID: 8544900
-
Ledesma MD, Avila J, Correas I. Isolation of a phosphorylated soluble tau fraction from Alzheimer’s disease brain. Neurobiol Aging 1995;16:515-522.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 515-522
-
-
Ledesma, M.D.1
Avila, J.2
Correas, I.3
-
152
-
-
0036724204
-
Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD38XmvVertLk%3D, PID: 12358761
-
Yamamoto A, Shin R-W, Hasegawa K, et al. Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer’s disease. J Neurochem 2002;82:1137-1147.
-
(2002)
J Neurochem
, vol.82
, pp. 1137-1147
-
-
Yamamoto, A.1
Shin, R.-W.2
Hasegawa, K.3
-
153
-
-
12844250694
-
Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3
-
COI: 1:CAS:528:DC%2BD2MXkt1arsw%3D%3D, PID: 15665406
-
Lovell MA, Xiong S, Xie C, Davies PL, Markesbery WR. Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. J Alzheimers Dis 2004;6:659-671.
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 659-671
-
-
Lovell, M.A.1
Xiong, S.2
Xie, C.3
Davies, P.L.4
Markesbery, W.R.5
-
154
-
-
33747429095
-
Dietary and genetically-induced oxidative stress alter tau phosphorylation: influence of folate and apolipoprotein E deficiency
-
COI: 1:CAS:528:DC%2BD28XotFKgsrY%3D, PID: 16917148
-
Chan A, Shea TB. Dietary and genetically-induced oxidative stress alter tau phosphorylation: influence of folate and apolipoprotein E deficiency. J Alzheimers Dis 2006;9:399-405.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 399-405
-
-
Chan, A.1
Shea, T.B.2
-
155
-
-
34748821202
-
Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase
-
COI: 1:CAS:528:DC%2BD2sXhtVGrs7bP, PID: 17886035
-
Huang X, Dai J, Huang C, Zhang Q, Bhanot O, Pelle E. Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase. Free Radic Res 2007;41:1135-1142.
-
(2007)
Free Radic Res
, vol.41
, pp. 1135-1142
-
-
Huang, X.1
Dai, J.2
Huang, C.3
Zhang, Q.4
Bhanot, O.5
Pelle, E.6
-
156
-
-
33745835031
-
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
-
PID: 16629179
-
Muñoz P, Zavala G, Castillo K, Aguirre P, Hidalgo C, Nuñez MT. Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells. Biol Res 2006;39:189-190.
-
(2006)
Biol Res
, vol.39
, pp. 189-190
-
-
Muñoz, P.1
Zavala, G.2
Castillo, K.3
Aguirre, P.4
Hidalgo, C.5
Nuñez, M.T.6
-
157
-
-
0023899370
-
Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer’s disease brains with Alz 50 and Tau-1
-
COI: 1:CAS:528:DyaL1cXkt1WitLk%3D, PID: 3131334
-
Ksiezak-Reding H, Binder LI, Yen S-HC. Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer’s disease brains with Alz 50 and Tau-1. J Biol Chem 1988;263:7948-7953.
-
(1988)
J Biol Chem
, vol.263
, pp. 7948-7953
-
-
Ksiezak-Reding, H.1
Binder, L.I.2
Yen, S.-H.C.3
-
158
-
-
0028095224
-
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
-
COI: 1:CAS:528:DyaK2cXlslKktbY%3D, PID: 8076698
-
Khatoon S, Grundke-Iqbal I, Iqbal K. Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 1994;351:80-84.
-
(1994)
FEBS Lett
, vol.351
, pp. 80-84
-
-
Khatoon, S.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
159
-
-
0037712872
-
Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study
-
COI: 1:CAS:528:DC%2BD3sXis1eisbY%3D, PID: 12677447
-
Zhukareva V, Sundarraj S, Mann D, et al. Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta Neuropathol 2003;105:469-476.
-
(2003)
Acta Neuropathol
, vol.105
, pp. 469-476
-
-
Zhukareva, V.1
Sundarraj, S.2
Mann, D.3
-
160
-
-
70349230790
-
Phosphorylation of soluble tau differs in Pick’s disease and Alzheimer’s disease brains
-
COI: 1:CAS:528:DC%2BD1MXhtFelsLrK, PID: 19693433
-
van Eersel J, Bi M, Ke YD, et al. Phosphorylation of soluble tau differs in Pick’s disease and Alzheimer’s disease brains. J Neural Transm 2009;116:1243-1251.
-
(2009)
J Neural Transm
, vol.116
, pp. 1243-1251
-
-
van Eersel, J.1
Bi, M.2
Ke, Y.D.3
-
161
-
-
84903720548
-
sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin
-
COI: 1:CAS:528:DC%2BC2cXht1ems7zP, PID: 24867889
-
McCarthy RC, Park YH, Kosman DJ. sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 2014;15:809-815.
-
(2014)
EMBO Rep
, vol.15
, pp. 809-815
-
-
McCarthy, R.C.1
Park, Y.H.2
Kosman, D.J.3
-
162
-
-
84896844669
-
Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron
-
COI: 1:CAS:528:DC%2BC2cXksVWgu78%3D, PID: 24509156
-
Ayton S, Zhang M, Roberts BR, et al. Ceruloplasmin and beta-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron. Free Radic Biol Med 2014;69:331-337.
-
(2014)
Free Radic Biol Med
, vol.69
, pp. 331-337
-
-
Ayton, S.1
Zhang, M.2
Roberts, B.R.3
-
163
-
-
34547782810
-
Copper and iron disorders of the brain
-
COI: 1:CAS:528:DC%2BD2sXptFKnuro%3D, PID: 17367269
-
Madsen E, Gitlin JD. Copper and iron disorders of the brain. Annu Rev Neurosci 2007;30:317-337.
-
(2007)
Annu Rev Neurosci
, vol.30
, pp. 317-337
-
-
Madsen, E.1
Gitlin, J.D.2
-
164
-
-
1642308134
-
Neurodegenerative diseases and oxidative stress
-
COI: 1:CAS:528:DC%2BD2cXit12nsL4%3D, PID: 15031734
-
Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004;3:205-214.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 205-214
-
-
Barnham, K.J.1
Masters, C.L.2
Bush, A.I.3
-
165
-
-
0242290357
-
Neurotoxic, redox-competent Alzheimer’s beta-amyloid is released from lipid membrane by methionine oxidation
-
COI: 1:CAS:528:DC%2BD3sXosFSkt7g%3D, PID: 12925530
-
Barnham KJ, Ciccotosto GD, Tickler AK, et al. Neurotoxic, redox-competent Alzheimer’s beta-amyloid is released from lipid membrane by methionine oxidation. J Biol Chem 2003;278:42959-42965.
-
(2003)
J Biol Chem
, vol.278
, pp. 42959-42965
-
-
Barnham, K.J.1
Ciccotosto, G.D.2
Tickler, A.K.3
-
166
-
-
24644475272
-
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase
-
COI: 1:CAS:528:DC%2BD2MXhtVSjs7%2FM, PID: 16127459
-
Puglielli L, Friedlich AL, Setchell KDR, et al. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest 2005;115:2556-2563.
-
(2005)
J Clin Invest
, vol.115
, pp. 2556-2563
-
-
Puglielli, L.1
Friedlich, A.L.2
Setchell, K.D.R.3
-
167
-
-
77951571462
-
Copper metallochaperones
-
COI: 1:CAS:528:DC%2BC3cXpslSht74%3D, PID: 20205585
-
Robinson NJ, Winge DR. Copper metallochaperones. Annu Rev Biochem 2010;79:537-562.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 537-562
-
-
Robinson, N.J.1
Winge, D.R.2
-
168
-
-
84878398613
-
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
-
COI: 1:CAS:528:DC%2BC3sXosFKitL8%3D, PID: 23424051
-
Ayton S, Lei P, Duce JA, et al. Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease. Ann Neurol 2013;73:554-559.
-
(2013)
Ann Neurol
, vol.73
, pp. 554-559
-
-
Ayton, S.1
Lei, P.2
Duce, J.A.3
-
169
-
-
84907148276
-
A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe under physiologically relevant conditions
-
Wong BX, Ayton S, Lam LQ, et al. A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe under physiologically relevant conditions. Biochim Biophys Acta 2014;1840:3299-3310.
-
(1840)
Biochim Biophys Acta
, vol.2014
, pp. 3299-3310
-
-
Wong, B.X.1
Ayton, S.2
Lam, L.Q.3
-
170
-
-
0028903259
-
Aceruloplasminemia: molecular characterization of this disorder of iron metabolism
-
COI: 1:CAS:528:DyaK2MXksl2ku7w%3D, PID: 7708681
-
Harris ZL, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RT, Gitlin JD. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci U S A 1995;92:2539-2543.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 2539-2543
-
-
Harris, Z.L.1
Takahashi, Y.2
Miyajima, H.3
Serizawa, M.4
MacGillivray, R.T.5
Gitlin, J.D.6
-
171
-
-
33846912266
-
Amyloid-beta peptide forms monomeric complexes with Cu(II) and Zn(II) prior to aggregation
-
COI: 1:CAS:528:DC%2BD2sXht1Gntbs%3D, PID: 17195250
-
Talmard C, Guilloreau L, Coppel Y, Mazarguil H, Faller P. Amyloid-beta peptide forms monomeric complexes with Cu(II) and Zn(II) prior to aggregation. Chembiochem 2007;8:163-165.
-
(2007)
Chembiochem
, vol.8
, pp. 163-165
-
-
Talmard, C.1
Guilloreau, L.2
Coppel, Y.3
Mazarguil, H.4
Faller, P.5
-
172
-
-
0032557425
-
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis
-
COI: 1:CAS:528:DyaK1cXjsVerur4%3D, PID: 9582309
-
Atwood CS, Moir RD, Huang X, et al. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem 1998;273:12817-12826.
-
(1998)
J Biol Chem
, vol.273
, pp. 12817-12826
-
-
Atwood, C.S.1
Moir, R.D.2
Huang, X.3
-
173
-
-
30044432558
-
Molecular modeling of the inhibitory mechanism of copper(II) on aggregation of amyloid beta-peptide
-
COI: 1:CAS:528:DC%2BD28XosFWgsQ%3D%3D
-
Jiao Y, Han DX, Yang P. Molecular modeling of the inhibitory mechanism of copper(II) on aggregation of amyloid beta-peptide. Sci China Ser B 2005;48:580-590.
-
(2005)
Sci China Ser B
, vol.48
, pp. 580-590
-
-
Jiao, Y.1
Han, D.X.2
Yang, P.3
-
174
-
-
34547443431
-
Mechanism of copper(II) inhibiting Alzheimer’s amyloid beta-peptide from aggregation: a molecular dynamics investigation
-
COI: 1:CAS:528:DC%2BD2sXmtlGgt70%3D, PID: 17564430
-
Jiao Y, Yang P. Mechanism of copper(II) inhibiting Alzheimer’s amyloid beta-peptide from aggregation: a molecular dynamics investigation. J Phys Chem B 2007;111:7646-7655.
-
(2007)
J Phys Chem B
, vol.111
, pp. 7646-7655
-
-
Jiao, Y.1
Yang, P.2
-
175
-
-
69949167074
-
Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators
-
PID: 19619132
-
Tõugu V, Karafin A, Zovo K, et al. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. J Neurochem 2009;110:1784-1795.
-
(2009)
J Neurochem
, vol.110
, pp. 1784-1795
-
-
Tõugu, V.1
Karafin, A.2
Zovo, K.3
-
176
-
-
57649130599
-
Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents
-
Wu W-h, Lei P, Liu Q, et al. Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents. J Biol Chem 2008;283:31657-31664.
-
(2008)
J Biol Chem
, vol.283
, pp. 31657-31664
-
-
W-h, W.1
Lei, P.2
Liu, Q.3
-
177
-
-
75649136954
-
Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity
-
COI: 1:CAS:528:DC%2BD1MXhs1SqtLrP, PID: 19937895
-
Perrone L, Mothes E, Vignes M, et al. Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity. Chembiochem 2010;11:110-118.
-
(2010)
Chembiochem
, vol.11
, pp. 110-118
-
-
Perrone, L.1
Mothes, E.2
Vignes, M.3
-
178
-
-
18344414746
-
The A beta peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction
-
COI: 1:CAS:528:DyaK1MXjtlWqs7g%3D, PID: 10386999
-
Huang X, Atwood CS, Hartshorn MA, et al. The A beta peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 1999;38:7609-7616.
-
(1999)
Biochemistry
, vol.38
, pp. 7609-7616
-
-
Huang, X.1
Atwood, C.S.2
Hartshorn, M.A.3
-
179
-
-
0033601338
-
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
-
COI: 1:CAS:528:DC%2BD3cXpsFSi, PID: 10601271
-
Huang X, Cuajungco MP, Atwood CS, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999;274:37111-37116.
-
(1999)
J Biol Chem
, vol.274
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
-
180
-
-
34547914869
-
Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological relevance
-
COI: 1:CAS:528:DC%2BD2sXnslOnu7g%3D, PID: 17636872
-
Jiang D, Men L, Wang J, et al. Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological relevance. Biochemistry 2007;46:9270-9282.
-
(2007)
Biochemistry
, vol.46
, pp. 9270-9282
-
-
Jiang, D.1
Men, L.2
Wang, J.3
-
181
-
-
0043172479
-
The glutamatergic system and Alzheimer’s disease: therapeutic implications
-
COI: 1:CAS:528:DC%2BD3sXmslSht7w%3D, PID: 12828500
-
Butterfield DA, Pocernich CB. The glutamatergic system and Alzheimer’s disease: therapeutic implications. CNS Drugs 2003;17:641-652.
-
(2003)
CNS Drugs
, vol.17
, pp. 641-652
-
-
Butterfield, D.A.1
Pocernich, C.B.2
-
182
-
-
0027269660
-
Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer’s disease: investigative and therapeutic perspectives
-
COI: 1:CAS:528:DyaK3sXktVKjsrY%3D, PID: 8473885
-
Francis PT, Sims NR, Procter AW, Bowen DM. Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer’s disease: investigative and therapeutic perspectives. J Neurochem 1993;60:1589-1604.
-
(1993)
J Neurochem
, vol.60
, pp. 1589-1604
-
-
Francis, P.T.1
Sims, N.R.2
Procter, A.W.3
Bowen, D.M.4
-
183
-
-
0042890397
-
Methods for studying synaptosomal copper release
-
COI: 1:CAS:528:DC%2BD3sXms1yqsrs%3D, PID: 12948559
-
Hopt A, Korte S, Fink H, et al. Methods for studying synaptosomal copper release. J Neurosci Methods 2003;128:159-172.
-
(2003)
J Neurosci Methods
, vol.128
, pp. 159-172
-
-
Hopt, A.1
Korte, S.2
Fink, H.3
-
184
-
-
0023748491
-
Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper
-
COI: 1:CAS:528:DyaL1cXmtVyrurk%3D, PID: 3187909
-
Hartter DE, Barnea A. Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper. Synapse 1988;2:412-415.
-
(1988)
Synapse
, vol.2
, pp. 412-415
-
-
Hartter, D.E.1
Barnea, A.2
-
185
-
-
12144257164
-
NMDA receptor activation mediates copper homeostasis in hippocampal neurons
-
COI: 1:CAS:528:DC%2BD2MXhtVWrs74%3D, PID: 15634787
-
Schlief ML, Craig AM, Gitlin JD. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci 2005;25:239-246.
-
(2005)
J Neurosci
, vol.25
, pp. 239-246
-
-
Schlief, M.L.1
Craig, A.M.2
Gitlin, J.D.3
-
186
-
-
33749534285
-
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity
-
COI: 1:CAS:528:DC%2BD28XhtVygsrjO, PID: 17003121
-
Schlief ML, West T, Craig AM, Holtzman DM, Gitlin JD. Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proc Natl Acad Sci U S A 2006;103:14919-14924.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14919-14924
-
-
Schlief, M.L.1
West, T.2
Craig, A.M.3
Holtzman, D.M.4
Gitlin, J.D.5
-
187
-
-
53749090208
-
Structural characterization of binding of Cu(II) to tau protein
-
COI: 1:CAS:528:DC%2BD1cXhtFeltL7M, PID: 18803399
-
Soragni A, Zambelli B, Mukrasch MD, et al. Structural characterization of binding of Cu(II) to tau protein. Biochemistry 2008;47:10841-10851.
-
(2008)
Biochemistry
, vol.47
, pp. 10841-10851
-
-
Soragni, A.1
Zambelli, B.2
Mukrasch, M.D.3
-
188
-
-
27744565566
-
Binding of copper (II) ion to an Alzheimer’s tau peptide as revealed by MALDI-TOF MS, CD, and NMR
-
COI: 1:CAS:528:DC%2BD2MXhtVert7zO, PID: 15986501
-
Ma QF, Li YM, Du JT, et al. Binding of copper (II) ion to an Alzheimer’s tau peptide as revealed by MALDI-TOF MS, CD, and NMR. Biopolymers 2005;79:74-85.
-
(2005)
Biopolymers
, vol.79
, pp. 74-85
-
-
Ma, Q.F.1
Li, Y.M.2
Du, J.T.3
-
189
-
-
33645407628
-
Copper binding properties of a tau peptide associated with Alzheimer’s disease studied by CD, NMR, and MALDI-TOF MS
-
COI: 1:CAS:528:DC%2BD28XjtFWqs7o%3D, PID: 16225961
-
Ma Q, Li Y, Du J, et al. Copper binding properties of a tau peptide associated with Alzheimer’s disease studied by CD, NMR, and MALDI-TOF MS. Peptides 2006;27:841-89.
-
(2006)
Peptides
, vol.27
, pp. 841-889
-
-
Ma, Q.1
Li, Y.2
Du, J.3
-
190
-
-
35348982797
-
Copper (II) modulates in vitro aggregation of a tau peptide
-
COI: 1:CAS:528:DC%2BD2sXht1aht7bO, PID: 17919778
-
Zhou LX, Du JT, Zeng ZY, et al. Copper (II) modulates in vitro aggregation of a tau peptide. Peptides 2007;28:2229-2234.
-
(2007)
Peptides
, vol.28
, pp. 2229-2234
-
-
Zhou, L.X.1
Du, J.T.2
Zeng, Z.Y.3
-
191
-
-
34248586955
-
Hydrogen peroxide can be generated by tau in the presence of Cu(II)
-
COI: 1:CAS:528:DC%2BD2sXlsFKgu7k%3D, PID: 17498655
-
Su XY, Wu WH, Huang ZP, et al. Hydrogen peroxide can be generated by tau in the presence of Cu(II). Biochem Biophys Res Commun 2007;358:661-665.
-
(2007)
Biochem Biophys Res Commun
, vol.358
, pp. 661-665
-
-
Su, X.Y.1
Wu, W.H.2
Huang, Z.P.3
-
192
-
-
0033964859
-
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals
-
COI: 1:CAS:528:DC%2BD3cXlt12k, PID: 10617129
-
Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals. J Neurochem 2000;74:270-279.
-
(2000)
J Neurochem
, vol.74
, pp. 270-279
-
-
Sayre, L.M.1
Perry, G.2
Harris, P.L.3
Liu, Y.4
Schubert, K.A.5
Smith, M.A.6
-
193
-
-
61349110122
-
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
-
COI: 1:CAS:528:DC%2BD1MXjsFWgsbo%3D, PID: 19183260
-
Kitazawa M, Cheng D, Laferla FM. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem 2009;108:1550-1560.
-
(2009)
J Neurochem
, vol.108
, pp. 1550-1560
-
-
Kitazawa, M.1
Cheng, D.2
Laferla, F.M.3
-
194
-
-
58849090893
-
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
-
COI: 1:CAS:528:DC%2BD1MXhtVels7Y%3D, PID: 19122148
-
Crouch PJ, Hung LW, Adlard PA, et al. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A 2009;106:381-386.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 381-386
-
-
Crouch, P.J.1
Hung, L.W.2
Adlard, P.A.3
-
195
-
-
0033781375
-
Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals
-
Tateishi J. Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals. Neuropathology 2000;20(Suppl.):S20–S24.
-
(2000)
Neuropathology
, vol.20
, pp. 20-24
-
-
Tateishi, J.1
-
196
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice
-
COI: 1:CAS:528:DC%2BD3MXkvFSksbw%3D, PID: 11430801
-
Cherny RA, Atwood CS, Xilinas ME, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice. Neuron 2001;30:665-676.
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
197
-
-
2942750367
-
Clioquinol, a drug for Alzheimer’s disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes
-
PID: 15206857
-
Di Vaira M, Bazzicalupi C, Orioli P, Messori L, Bruni B, Zatta P. Clioquinol, a drug for Alzheimer’s disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes. Inorg Chem 2004;43:3795-3797.
-
(2004)
Inorg Chem
, vol.43
, pp. 3795-3797
-
-
Di Vaira, M.1
Bazzicalupi, C.2
Orioli, P.3
Messori, L.4
Bruni, B.5
Zatta, P.6
-
198
-
-
10644280708
-
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2cXhtVCktbjK
-
Treiber C, Simons A, Strauss M, et al. Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer’s disease. Biol Chem 2004;279:51958-51964.
-
(2004)
Biol Chem
, vol.279
, pp. 51958-51964
-
-
Treiber, C.1
Simons, A.2
Strauss, M.3
-
199
-
-
18144374793
-
Metal ion-dependent effects of Clioquinol on the fibril growth of an amyloid {beta} peptide
-
COI: 1:CAS:528:DC%2BD2MXjtleitL0%3D, PID: 15718230
-
Raman B, Ban T, Yamaguchi K-i, et al. Metal ion-dependent effects of Clioquinol on the fibril growth of an amyloid {beta} peptide. J Biol Chem 2005;280:16157-16162.
-
(2005)
J Biol Chem
, vol.280
, pp. 16157-16162
-
-
Raman, B.1
Ban, T.2
Yamaguchi, K.-I.3
-
200
-
-
34249097722
-
Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice
-
COI: 1:CAS:528:DC%2BD2sXlvFantr0%3D, PID: 17434477
-
Priel T, Aricha-Tamir B, Sekler I. Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice. Eur J Pharmacol 2007;565:232-239.
-
(2007)
Eur J Pharmacol
, vol.565
, pp. 232-239
-
-
Priel, T.1
Aricha-Tamir, B.2
Sekler, I.3
-
201
-
-
69249144876
-
Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol’s anticancer activity
-
COI: 1:CAS:528:DC%2BD1MXhtVGju7zI, PID: 19530227
-
Barrea RA, Chen D, Irving TC, Dou QP. Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol’s anticancer activity. J Cell Biochem 2009;108:96-105.
-
(2009)
J Cell Biochem
, vol.108
, pp. 96-105
-
-
Barrea, R.A.1
Chen, D.2
Irving, T.C.3
Dou, Q.P.4
-
202
-
-
0242288463
-
Clioquinol effects on tissue chelatable zinc in mice
-
COI: 1:CAS:528:DC%2BD3sXotVars78%3D
-
Nitzan YB, Sekler I, Frederickson CJ, et al. Clioquinol effects on tissue chelatable zinc in mice. J Mol Med (Berl) 2003;81:637-644.
-
(2003)
J Mol Med (Berl)
, vol.81
, pp. 637-644
-
-
Nitzan, Y.B.1
Sekler, I.2
Frederickson, C.J.3
-
203
-
-
46149107512
-
Rapid restoration of cognition in Alzheimer’s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
-
COI: 1:CAS:528:DC%2BD1cXoslyjur0%3D, PID: 18614028
-
Adlard PA, Cherny RA, Finkelstein DI, et al. Rapid restoration of cognition in Alzheimer’s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 2008;59:43-55.
-
(2008)
Neuron
, vol.59
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
-
204
-
-
78650480388
-
The metal chelating and chaperoning effects of clioquinol: insights from yeast studies
-
COI: 1:CAS:528:DC%2BC3cXhtlOhtrzE, PID: 21504115
-
Li C, Wang J, Zhou B. The metal chelating and chaperoning effects of clioquinol: insights from yeast studies. J Alzheimers Dis 2010;21:1249-1262.
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 1249-1262
-
-
Li, C.1
Wang, J.2
Zhou, B.3
-
205
-
-
79954628520
-
Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore
-
COI: 1:CAS:528:DC%2BC3MXkvVGltL8%3D, PID: 21220021
-
Park MH, Lee SJ, Byun HR, et al. Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore. Neurobiol Dis 2011;42:242-251.
-
(2011)
Neurobiol Dis
, vol.42
, pp. 242-251
-
-
Park, M.H.1
Lee, S.J.2
Byun, H.R.3
-
206
-
-
80052684579
-
The Alzheimer’s therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity
-
COI: 1:CAS:528:DC%2BC3MXhtlyiurvK, PID: 21797865
-
Crouch PJ, Savva MS, Hung LW, et al. The Alzheimer’s therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem 2011;119:220-230.
-
(2011)
J Neurochem
, vol.119
, pp. 220-230
-
-
Crouch, P.J.1
Savva, M.S.2
Hung, L.W.3
-
207
-
-
3342880690
-
A role for heme in Alzheimer’s disease: heme binds amyloid beta and has altered metabolism
-
COI: 1:CAS:528:DC%2BD2cXmsVCmtbg%3D, PID: 15263070
-
Atamna H, Frey WH. A role for heme in Alzheimer’s disease: heme binds amyloid beta and has altered metabolism. Proc Natl Acad Sci U S A 2004;101:11153-11158.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11153-11158
-
-
Atamna, H.1
Frey, W.H.2
-
208
-
-
33845922640
-
Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells
-
COI: 1:CAS:528:DC%2BD28XhtFKgtbnI, PID: 16973622
-
Choi SM, Choi KO, Park YK, Cho H, Yang EG, Park H. Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells. J Biol Chem 2006;281:34056-34063.
-
(2006)
J Biol Chem
, vol.281
, pp. 34056-34063
-
-
Choi, S.M.1
Choi, K.O.2
Park, Y.K.3
Cho, H.4
Yang, E.G.5
Park, H.6
-
209
-
-
0033118981
-
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
-
COI: 1:CAS:528:DyaK1MXivVyksr4%3D, PID: 10202142
-
Felkai S, Ewbank JJ, Lemieux J, Labbe JC, Brown GG, Hekimi S. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J 1999;18:1783-1792.
-
(1999)
EMBO J
, vol.18
, pp. 1783-1792
-
-
Felkai, S.1
Ewbank, J.J.2
Lemieux, J.3
Labbe, J.C.4
Brown, G.G.5
Hekimi, S.6
-
210
-
-
0242684415
-
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease
-
COI: 1:CAS:528:DC%2BD3sXivFWkurg%3D, PID: 12670420
-
Kaur D, Yantiri F, Rajagopalan S, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease. Neuron 2003;37:899-909.
-
(2003)
Neuron
, vol.37
, pp. 899-909
-
-
Kaur, D.1
Yantiri, F.2
Rajagopalan, S.3
-
211
-
-
70349142176
-
Clioquinol and other hydroxyquinoline derivatives inhibit Abeta(1-42) oligomer assembly
-
COI: 1:CAS:528:DC%2BD1MXhtFGkurfP, PID: 19664688
-
LeVine H, 3rd, Ding Q, Walker JA, Voss RS, Augelli-Szafran CE. Clioquinol and other hydroxyquinoline derivatives inhibit Abeta(1-42) oligomer assembly. Neurosci Lett 2009;465:99-103.
-
(2009)
Neurosci Lett
, vol.465
, pp. 99-103
-
-
LeVine, H.1
Ding, Q.2
Walker, J.A.3
Voss, R.S.4
Augelli-Szafran, C.E.5
-
212
-
-
70350597464
-
Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited
-
COI: 1:CAS:528:DC%2BD1MXhtFKktb%2FJ, PID: 19817493
-
Mancino AM, Hindo SS, Kochi A, Lim MH. Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited. Inorg Chem 2009;48:9596-9598.
-
(2009)
Inorg Chem
, vol.48
, pp. 9596-9598
-
-
Mancino, A.M.1
Hindo, S.S.2
Kochi, A.3
Lim, M.H.4
-
213
-
-
79956122555
-
In vitro modelling of Alzheimer’s disease: degeneration and cell death induced by viral delivery of amyloid and tau
-
COI: 1:CAS:528:DC%2BC3MXmsFagt7k%3D, PID: 21295028
-
Stoppelkamp S, Bell HS, Palacios-Filardo J, Shewan DA, Riedel G, Platt B. In vitro modelling of Alzheimer’s disease: degeneration and cell death induced by viral delivery of amyloid and tau. Exp Neurol 2011;229:226-237.
-
(2011)
Exp Neurol
, vol.229
, pp. 226-237
-
-
Stoppelkamp, S.1
Bell, H.S.2
Palacios-Filardo, J.3
Shewan, D.A.4
Riedel, G.5
Platt, B.6
-
214
-
-
67849106894
-
Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD1MXmvVOhs7w%3D, PID: 19363260
-
Grossi C, Francese S, Casini A, et al. Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis 2009;17:423-440.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 423-440
-
-
Grossi, C.1
Francese, S.2
Casini, A.3
-
215
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
-
PID: 14676042
-
Ritchie CW, Bush AI, Mackinnon A, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003;60:1685-1691.
-
(2003)
Arch Neurol
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
-
216
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer’s disease: a phase IIa, double-blind, randomised, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BD1cXhtFWmsL3F, PID: 18672400
-
Lannfelt L, Blennow K, Zetterberg H, et al. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer’s disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2008;7:779-786.
-
(2008)
Lancet Neurol
, vol.7
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
-
217
-
-
77954344206
-
PBT2 rapidly improves cognition in Alzheimer’s Disease: additional phase II analyses
-
COI: 1:CAS:528:DC%2BC3cXmsFWjs7Y%3D, PID: 20164561
-
Faux NG, Ritchie CW, Gunn AP, et al. PBT2 rapidly improves cognition in Alzheimer’s Disease: additional phase II analyses. J Alzheimers Dis 2010;20:509-516.
-
(2010)
J Alzheimers Dis
, vol.20
, pp. 509-516
-
-
Faux, N.G.1
Ritchie, C.W.2
Gunn, A.P.3
-
218
-
-
84885372632
-
PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse model of Huntington’s disease
-
PID: 25063332
-
Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM. PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse model of Huntington’s disease. J Huntingtons Dis 2012;1:211-219.
-
(2012)
J Huntingtons Dis
, vol.1
, pp. 211-219
-
-
Cherny, R.A.1
Ayton, S.2
Finkelstein, D.I.3
Bush, A.I.4
McColl, G.5
Massa, S.M.6
-
219
-
-
41949115990
-
Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
-
COI: 1:CAS:528:DC%2BD1cXhvFelur0%3D, PID: 18086681
-
Donnelly PS, Caragounis A, Du T, et al. Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide. J Biol Chem 2008;283:4568-4577.
-
(2008)
J Biol Chem
, vol.283
, pp. 4568-4577
-
-
Donnelly, P.S.1
Caragounis, A.2
Du, T.3
-
220
-
-
84861728900
-
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease
-
COI: 1:CAS:528:DC%2BC38XlsFOjsbs%3D, PID: 22473957
-
Hung LW, Villemagne VL, Cheng L, et al. The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease. J Exp Med 2012;209:837-854.
-
(2012)
J Exp Med
, vol.209
, pp. 837-854
-
-
Hung, L.W.1
Villemagne, V.L.2
Cheng, L.3
-
221
-
-
0025726462
-
Intramuscular desferrioxamine in patients with Alzheimer’s disease
-
COI: 1:STN:280:DyaK3M3jt1aruw%3D%3D, PID: 1674295
-
Crapper McLachlan DR, Dalton AJ, Kruck TP, et al. Intramuscular desferrioxamine in patients with Alzheimer’s disease. Lancet 1991;337:1304-1308.
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crapper McLachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.3
-
222
-
-
84897930725
-
Targeting chelatable iron as a therapeutic modality in Parkinson’s disease
-
COI: 1:CAS:528:DC%2BC2cXpvVWmurk%3D, PID: 24251381
-
Devos D, Moreau C, Devedjian JC, et al. Targeting chelatable iron as a therapeutic modality in Parkinson’s disease. Antioxid Redox Signal 2014;21:195-210.
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 195-210
-
-
Devos, D.1
Moreau, C.2
Devedjian, J.C.3
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