Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques

Histochemistry and Cell Biology

Volumn 123, Issue 6, 2005, Pages 605-611

  Stoltenberg, M ^a   Bruhn, M ^a   Sondergaard C ^a   Doering, P ^a   West, M J ^a   Larsen, A ^a   Troncoso, J C ^b   Danscher, G ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autometallography (AMG); Beta amyloid; Histochemistry; Ultrastructure; Zinc

Indexed keywords

GLUTARALDEHYDE; SILVER; SODIUM SULFIDE; SULFUR; ZINC ION;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOMETALLOGRAPHY; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; DYSTROPHY; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN TISSUE; IMMERSION; MALE; MOUSE; NEURITE; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; STAINING; STEREOLOGY; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CRYSTALLOGRAPHY; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; NANOTECHNOLOGY; PRESENILIN-1; SENILE PLAQUES; ZINC;

EID: 23744431884     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-005-0787-0     Document Type: Article

References (31)

1. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945
2. Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion J-P (2004) Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol Dis 15:47-60
3. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
4. Bush AI (2003) The metallobiology of Alzheimer's disease. Trends Neurosci 26:207-214
5. Bush AI, Pettingell WH, Multhaup G, Paradis Md, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE (1994a) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265:1464-1467
6. Bush AI, Pettingell WH Jr, Paradis MD, Tanzi RE (1994b) Modulation of A beta adhesiveness and secretase site cleavage by zinc. J Biol Chem 269:12152-12158
7. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30:665-676
8. Danscher G (1981) Histochemical demonstration of heavy metals. A revised version of the sulphide silver method suitable for both light and electronmicroscopy. Histochemistry 71:1-16
9. Danscher G, Haug FM, Fredens K (1973) Effects of didethyldithiocarbamate (DEDTC) on sulphide silver stained boutons. Reversible blocking of Timm's sulphide silver stain for "heavy" metals in DEDTC treated rats (light microscopy). Exp Brain Res 16:521-532
10. Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, Juhl S, Stoltenberg M, Ravid R (1997a) Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections form autopsy material. J Neurosci Meth 76:53-59
11. Danscher G, Juhl S, Stoltenberg M, Krunderup B, Schrøder H (1997b) Autometallographic silver amplification of zinc sulphide crystal lattices in zinc enriched synaptic and secretory vesicles. J Histochem Cytochem 45:1503-1510
12. AMG: histochemical in situ capturing of zinc ions in catalytic zinc-sulphur nanocrystals. J Histochem Cytochem 52:1619-1625
13. Frederickson CJ, Kasarskis EJ, Ringo D, Frederickson RE (1987) A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain. J Neurosci Meth 20:91-103
14. Friedlich AL, Lee JY, van Groen T, Cherny RA, Volitakis I, Cole TB, PalmiterRD, Koh JY, Bush AI (2004) Neuronal zinc exchange with the blood vessels wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci 24:3453-3459
15. Howell GA, Welch MG, Frederickson CJ (1984) Stimulation induced uptake and release of zinc in hippocampal slices. Nature 308:736-738
16. Jaarsma D, Korf J (1990) A novel non-perfusion Timm method for human brain tissue. J Neurosci Meth 35:125-131
17. Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum of Alzheimer's disease. Am J Pathol 135:309-319
18. Koh JY, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272:1013-1061
19. Kurt MA, Davies DC, Kidd M, Duff K, Rolph SC, Jennings KH, Hewlett DR (2001) Neurodegenerative changes associated with β-amyloid deposition in the brains of mice carrying mutant amyloid precursor pretein and mutant presenilin-1 transgenes. Exp Neurol 171:59-71
20. Lee JY, Mook-Jung I, Koh JY (1999). Histochemical reactive zinc in plaques of the Swedish mutant β-amyloid precursor protein transgenic mice. J Neurosci 19:RC10:1-5
21. Liu ST, Howlett G, Barrow CJ (1999) Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease. Biochemistry 38:9373-9378
22. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486
23. Pérez-Clausell J, Danscher G (1986) Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide. Brain Res 362:358-361
24. Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, Davis S, Beyreuther K, Tanzi RE, Masters CL (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting a beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 60:1685-1691
25. Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y (2002) Amyloid cored plaques in PS1/APP transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Arch 441:358-367
26. Slomianka L (1992) Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat. Neuroscience 48:325-352
27. Smart TG, Constanti A (1983) Pre- and postsynaptic effects of zinc on in vitro prepyriform neurons. Neurosci Lett 40:205-211
28. Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, Danscher G, Frederickson CJ (2000) Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 852:274-278
29. Takeda A (2001) Zinc homeostasis and functions of zinc in the brain. Biometals 14:343-351
30. Weiss JH, Hartley DM, Koh JY, Choi DW (1993) AMPA receptor activation potentiates zinc neurotoxicity. Neuron 10:43-49
31. Zalewski PD, Forbes IJ, Betts WH (1993) Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p- toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochem J 296:403-408