In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals

Journal of Neurochemistry

Volumn 74, Issue 1, 2000, Pages 270-279

  Sayre, Lawrence M ^a   Perry, George ^a   Harris, Peggy L R ^a   Liu, Yahua ^a   Schubert, Kathryn A ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Copper; Iron; Neurofibrillary tangles; Reactive oxygen species; Senile plaques

Indexed keywords

COPPER; DEFEROXAMINE; DIAMINOBENZIDINE; IRON; METAL ION; PENTETIC ACID; PEROXIDASE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SENILE PLAQUE;

3,3'-DIAMINOBENZIDINE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CATALYSIS; CHELATING AGENTS; COPPER; DEFEROXAMINE; FEMALE; HUMANS; HYDROGEN PEROXIDE; IRON; IRON CHELATING AGENTS; MALE; MIDDLE AGED; NEUROFIBRILLARY TANGLES; OXIDATION-REDUCTION; PENTETIC ACID; SENILE PLAQUES; TAU PROTEINS;

EID: 0033964859     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0740270.x     Document Type: Article

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