Redox-active iron mediates amyloid-β toxicity

Free Radical Biology and Medicine

Volumn 30, Issue 4, 2001, Pages 447-450

  Rottkamp, Catherine A ^a   Raina, Arun K ^a   Zhu, Xiongwei ^a   Gaier, Elizabeth ^a   Bush, Ashley I ^b   Atwood, Craig S ^a   Chevion, Mordechai ^c   Perry, George ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Alzheimer disease; Amyloid ; Free radicals; Iron; Neurotoxicity; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; DEFEROXAMINE; IRON; IRON CHELATING AGENT;

ARTICLE; ATTENUATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NEUROPATHOLOGY; NEUROTOXICITY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REACTION ANALYSIS;

AMYLOID BETA-PROTEIN; ANTIOXIDANTS; CELL DEATH; DEFEROXAMINE; HUMANS; IRON; NEUROBLASTOMA; NEURONS; OXIDATIVE STRESS; TUMOR CELLS, CULTURED;

EID: 0035865905     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00494-9     Document Type: Article

References (26)

1. Aβ associated neuropil changes: Correlation with neuronal loss and dementia
2. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
3. Neurotrophic and neurotoxic effects of amyloid-β protein: Reversal by tachykinin neuropeptides
4. Aggregation related toxicity of synthetic β-amyloid protein in hippocampal cultures
5. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
6. Amyloid β-protein and genetics of Alzheimer's disease
7. Vitamin E protects nerve cells from amyloid-β protein toxicity
8. Advanced Maillard reaction end products are associated with Alzheimer disease pathology
9. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
10. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
11. Neuronal oxidative stress precedes amyloid-β deposition in Down's syndrome
12. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
13. Mechanisms of neurotoxicity associated with amyloid-β deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: A critical appraisal
14. Amyloid beta peptides do not form peptide-derived free radicals spontaneously but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides
15. Dramatic aggregation of Alzheimer A by Cu(II) is induced by conditions representing physiological acidosis
16. Characterization of copper interactions with Alzheimer Aβ peptides: Identification of an attomolar affinity copper binding site on amyloid beta 1-42
17. Promotion of transition metal-induced reactive oxygen species formation by β-amyloid
18. The A peptide of Alzheimer disease directly produces hydrogen peroxide through metal ion reduction
19. Cu(II) potentiation of Alzheimer Aβ neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
20. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
21. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
22. The role of iron in beta-amyloid toxicity
23. Copper, iron and zinc in Alzheimer disease plaques
24. Abnormal localization of iron regulatory protein in Alzheimer's disease
25. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
26. Intramuscular desferrioxamine in patients with Alzheimer disease