Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

Biochemistry

Volumn 53, Issue 24, 2014, Pages 3908-3921

  Welzel, Alfred T ^a   Maggio, John E ^b,c   Shankar, Ganesh M ^b   Walker, Donald E ^d   Ostaszewski, Beth L ^b   Li, Shaomin ^b   Klyubin, Igor ^e   Rowan, Michael J ^e   Seubert, Peter ^d   Walsh, Dominic M ^a,b   Selkoe, Dennis J ^b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d ELAN PHARMACEUTICALS   (United States)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; GLYCOPROTEINS; MASS SPECTROMETRY; SODIUM DODECYL SULFATE;

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; CELL CULTURE MODELS; CHINESE HAMSTER OVARY CELLS; DELETERIOUS EFFECTS; LONG-TERM POTENTIATIONS; MONOMERIC FRAGMENTS; SYNAPTIC PLASTICITY;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CYANOGEN BROMIDE; DODECYL SULFATE SODIUM; HOMODIMER; MONOMER; OLIGOMER;

ADULT; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; CATION EXCHANGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMUNOPRECIPITATION; ISOELECTRIC FOCUSING; LIGAND BINDING; LONG TERM POTENTIATION; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; MOLECULAR WEIGHT; NERVE CELL PLASTICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SYNAPSE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA, CONDITIONED; HUMANS; LONG-TERM POTENTIATION; MALE; MICE; NEURONAL PLASTICITY; PEPTIDE FRAGMENTS; RATS; SYNAPSES;

EID: 84903208566     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5003053     Document Type: Article

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