Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

EMBO Journal

Volumn 29, Issue 19, 2010, Pages 3408-3420

  Kuperstein, Inna ^a,b,h   Broersen, Kerensa ^a,c   Benilova, Iryna ^a,b,d   Rozenski, Jef ^e   Jonckheere, Wim ^a,c   Debulpaep, Maja ^a,c   Vandersteen, Annelies ^a,c   Segers Nolten, Ine ^f   Van Der Werf, Kees ^f   Subramaniam, Vinod ^f   Braeken, Dries ^d   Callewaert, Geert ^d   Bartic, Carmen ^b,d   D'Hooge, Rudi ^b   Martins, Ivo Cristiano ^a,c,g   Rousseau, Frederic ^a,c   Schymkowitz, Joost ^a,c   De Strooper, Bart ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d IMEC   (Belgium)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^f UNIVERSITY OF TWENTE   (Netherlands)

^g Institute de Medicina Molecular   (Portugal)

^h INSERM U900   (France)

Author keywords

Alzheimer's disease; b amyloid peptides; microelectrode array; neurotoxicity; oligomer

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; OLIGOMER; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); FLUORESCENT DYE; PEPTIDE FRAGMENT; PROTEIN BINDING; THIAZOLE DERIVATIVE; THIOFLAVINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CYTOTOXICITY; LEARNING; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; SYNAPSE; AMYLOID PLAQUE; ANALYSIS OF VARIANCE; ANIMAL; BIOPHYSICS; HUMAN; INFRARED SPECTROSCOPY; KINETICS; METABOLISM; MICROELECTRODE; NERVE CELL; PATCH CLAMP TECHNIQUE; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; BIOPHYSICS; FLUORESCENT DYES; HUMANS; KINETICS; MICE; MICROELECTRODES; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; PROTEIN BINDING; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THIAZOLES;

EID: 77957785420     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.211     Document Type: Article

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