Safety and biomarker effects of solanezumab in patients with Alzheimer's disease

Alzheimer's and Dementia

Volumn 8, Issue 4, 2012, Pages 261-271

  Farlow, Martin ^a   Arnold, Steven E ^b,c   Van Dyck, Christopher H ^d   Aisen, Paul S ^e   Snider, B Joy ^f   Porsteinsson, Anton P ^g   Friedrich, Stuart ^h   Dean, Robert A ^h   Gonzales, Celedon ^h   Sethuraman, Gopalan ^h   Demattos, Ronald B ^h   Mohs, Richard ^h   Paul, Steven M ⁱ   Siemers, Eric R ^h  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^h ELI LILLY AND COMPANY   (United States)

ⁱ WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

amyloid; A monoclonal antibody; Alzheimer's disease; Cerebrospinal fluid immunotherapy; LY2062430; Solanezumab

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; BIOLOGICAL MARKER; C REACTIVE PROTEIN; HIGH SENSITIVITY C REACTIVE PROTEIN; PLACEBO; SOLANEZUMAB; UNCLASSIFIED DRUG;

ADULT; AGED; AGITATION; ALZHEIMER DISEASE; ANXIETY; ARTICLE; BACKACHE; CELL COUNT; CEREBROSPINAL FLUID ANALYSIS; COGNITION; CONFUSION; CONTROLLED STUDY; COUGHING; DEMENTIA; DERMATITIS; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; FALLING; FATIGUE; FEMALE; HERPES ZOSTER; HUMAN; HYPERHIDROSIS; LACERATION; MAJOR CLINICAL STUDY; MALE; MUSCLE SPASM; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY CYST; PANCREATITIS; PEPTIC ULCER BLEEDING; PERIPHERAL EDEMA; PHASE 2 CLINICAL TRIAL; POSTDURAL PUNCTURE HEADACHE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RASH; RHINOPHARYNGITIS; SIDE EFFECT; SINGLE DRUG DOSE; SKIN ULCER; SUBDURAL HEMATOMA; SYNCOPE; THORAX PAIN; TREATMENT DURATION; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIBODIES, MONOCLONAL, HUMANIZED; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS; PSYCHIATRIC STATUS RATING SCALES; PYRIDINES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME;

EID: 84863221661     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2011.09.224     Document Type: Article

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