-
1
-
-
33746310315
-
Alzheimer's disease
-
DOI 10.1016/S0140-6736(06)69113-7, PII S0140673606691137
-
Blennow, K., de Leon, M.J. & Zetterberg, H. Alzheimer's disease. Lancet 368, 387-403 (2006). (Pubitemid 44108123)
-
(2006)
Lancet
, vol.368
, Issue.9533
, pp. 387-403
-
-
Blennow, K.1
De Leon, M.J.2
Zetterberg, H.3
-
2
-
-
23844551164
-
Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques
-
DOI 10.1021/bi0508237
-
Miravalle, L. et al. Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques. Biochemistry 44, 10810-10821 (2005). (Pubitemid 41153641)
-
(2005)
Biochemistry
, vol.44
, Issue.32
, pp. 10810-10821
-
-
Miravalle, L.1
Calero, M.2
Takao, M.3
Roher, A.E.4
Ghetti, B.5
Vidal, R.6
-
3
-
-
35148869239
-
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered γ-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
-
Van Vickle, G.D. et al. TgCRND8 amyloid precursor protein transgenic mice exhibit an altered γ-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry 46, 10317-10327 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 10317-10327
-
-
Van Vickle, G.D.1
-
4
-
-
0028973637
-
Amyloid beta-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid
-
DOI 10.1016/0006-8993(95)01163-2
-
Iizuka, T. et al. Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid. Brain Res. 702, 275-278 (1995). (Pubitemid 3011418)
-
(1995)
Brain Research
, vol.702
, Issue.1-2
, pp. 275-278
-
-
Iizuka, T.1
Shoji, M.2
Harigaya, Y.3
Kawarabayashi, T.4
Watanabe, M.5
Kanai, M.6
Hirai, S.7
-
5
-
-
0034747316
-
Correlation between Aßx-40-Aßx-42-and Aßx-43-containing amyloid plaques and cognitive decline
-
Parvathy, S. et al. Correlation between Aßx-40-, Aßx-42-and Aßx-43-containing amyloid plaques and cognitive decline. Arch. Neurol. 58, 2025-2032 (2001).
-
(2001)
Arch. Neurol.
, vol.58
, pp. 2025-2032
-
-
Parvathy, S.1
-
6
-
-
67649488309
-
Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains
-
Welander, H. et al. Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains. J. Neurochem. 110, 697-706 (2009).
-
(2009)
J. Neurochem.
, vol.110
, pp. 697-706
-
-
Welander, H.1
-
7
-
-
77958507752
-
The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: Clinical report and quantification of Aβ in different brain regions
-
Keller, L. et al. The PSEN1 I143T mutation in a Swedish family with Alzheimer's disease: clinical report and quantification of Aβ in different brain regions. Eur. J. Hum. Genet. 18, 1202-1208 (2010).
-
(2010)
Eur. J. Hum. Genet.
, vol.18
, pp. 1202-1208
-
-
Keller, L.1
-
8
-
-
19944430034
-
Longer forms of amyloid β protein: Implications for the mechanism of intramembrane cleavage by γ-secretase
-
DOI 10.1523/JNEUROSCI.1575-04.2005
-
Qi-Takahara, Y. et al. Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase. J. Neurosci. 25, 436-445 (2005). (Pubitemid 40105614)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.2
, pp. 436-445
-
-
Qi-Takahara, Y.1
Morishima-Kawashima, M.2
Tanimura, Yu.3
Dolios, G.4
Hirotani, N.5
Horikoshi, Y.6
Kametani, F.7
Maeda, M.8
Saido, T.C.9
Wang, R.10
Ihara, Y.11
-
9
-
-
70350451482
-
γ-Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of β-carboxyl terminal fragment
-
Takami, M. et al. γ-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of β-carboxyl terminal fragment. J. Neurosci. 29, 13042-13052 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 13042-13052
-
-
Takami, M.1
-
10
-
-
47749093936
-
Enzymatic characteristics of I213T mutant Presenilin-1/γ-secretase in cell models and knock-in mouse brains: FAD-linked mutation impairs γ-site cleavage of APP-CTFβ
-
Shimojo, M. et al. Enzymatic characteristics of I213T mutant Presenilin-1/γ-secretase in cell models and knock-in mouse brains: FAD-linked mutation impairs γ-site cleavage of APP-CTFβ. J. Biol. Chem. 283, 16488-16496 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16488-16496
-
-
Shimojo, M.1
-
11
-
-
0027258525
-
The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
DOI 10.1021/bi00069a001
-
Jarrett, J.T., Berger, E.P. & Lansbury, P.T. Jr. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32, 4693-4697 (1993). (Pubitemid 23162022)
-
(1993)
Biochemistry
, vol.32
, Issue.18
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
12
-
-
0037422540
-
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
-
Bitan, G. et al. Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc. Natl. Acad. Sci. USA 100, 330-335 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 330-335
-
-
Bitan, G.1
-
13
-
-
21444450394
-
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid β-peptides
-
DOI 10.1074/jbc.M501130200
-
Nakaya, Y. et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid β-peptides. J. Biol. Chem. 280, 19070-19077 (2005). (Pubitemid 41379613)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.19
, pp. 19070-19077
-
-
Nakaya, Y.1
Yamane, T.2
Shiraishi, H.3
Wang, H.-Q.4
Matsubara, E.5
Sato, T.6
Dolios, G.7
Wang, R.8
De Strooper, B.9
Shoji, M.10
Komano, H.11
Yanagisawa, K.12
Ihara, Y.13
Fraser, P.14
St. George-Hyslop, P.15
Nishimura, M.16
-
14
-
-
8644276394
-
A presenilin 1 R278I mutation presenting with language impairment
-
Godbolt, A.K. et al. A presenilin 1 R278I mutation presenting with language impairment. Neurology 63, 1702-1704 (2004). (Pubitemid 39507593)
-
(2004)
Neurology
, vol.63
, Issue.9
, pp. 1702-1704
-
-
Godbolt, A.K.1
Beck, J.A.2
Collinge, J.3
Garrard, P.4
Warren, J.D.5
Fox, N.C.6
Rossor, M.N.7
-
15
-
-
0030779784
-
Skeletal and CNS defects in Presenilin-1-deficient mice
-
Shen, J. et al. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89, 629-639 (1997). (Pubitemid 27511773)
-
(1997)
Cell
, vol.89
, Issue.4
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
16
-
-
17744401440
-
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
-
DOI 10.1038/387288a0
-
Wong, P.C. et al. Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387, 288-292 (1997). (Pubitemid 27220764)
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.S.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van Der Ploeg, L.H.T.9
Sisodia, S.S.10
-
17
-
-
1642561910
-
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
-
DOI 10.1046/j.1432-1033.2003.03936.x
-
Culvenor, J.G. et al. Characterization of presenilin complexes from mouse and human brain using blue native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations. Eur. J. Biochem. 271, 375-385 (2003). (Pubitemid 38130465)
-
(2004)
European Journal of Biochemistry
, vol.271
, Issue.2
, pp. 375-385
-
-
Culvenor, J.G.1
Ilaya, N.T.2
Ryan, M.T.3
Canterford, L.4
Hoke, D.E.5
Williamson, N.A.6
McLean, C.A.7
Masters, C.L.8
Evin, G.9
-
18
-
-
15544380450
-
Transition-state analogue γ-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
-
DOI 10.1021/bi0481702
-
Evin, G. et al. Transition-state analogue γ-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex. Biochemistry 44, 4332-4341 (2005). (Pubitemid 40403974)
-
(2005)
Biochemistry
, vol.44
, Issue.11
, pp. 4332-4341
-
-
Evin, G.1
Canterford, L.D.2
Hoke, D.E.3
Sharples, R.A.4
Culvenor, J.G.5
Masters, C.L.6
-
19
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
DOI 10.1016/S0896-6273(00)80291-3
-
Thinakaran, G. et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190 (1996). (Pubitemid 26251602)
-
(1996)
Neuron
, vol.17
, Issue.1
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
20
-
-
0030811016
-
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo
-
DOI 10.1038/nm0797-756
-
Lee, M.K. et al. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat. Med. 3, 756-760 (1997). (Pubitemid 27298719)
-
(1997)
Nature Medicine
, vol.3
, Issue.7
, pp. 756-760
-
-
Lee, M.K.1
Borchelt, D.R.2
Kim, G.3
Thinakaran, G.4
Slunt, H.H.5
Ratovitski, T.6
Martin, L.J.7
Kittur, A.8
Gandy, S.9
Levey, A.I.10
Jenkins, N.11
Copeland, N.12
Price, D.L.13
Sisodia, S.S.14
-
21
-
-
36849084633
-
Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.4244-07.2007
-
Kaneko, H. et al. Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. J. Neurosci. 27, 13092-13097 (2007). (Pubitemid 350225495)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.48
, pp. 13092-13097
-
-
Kaneko, H.1
Kakita, A.2
Kasuga, K.3
Nozaki, H.4
Ishikawa, A.5
Miyashita, A.6
Kuwano, R.7
Ito, G.8
Iwatsubo, T.9
Takahashi, H.10
Nishizawa, M.11
Onodera, O.12
Sisodia, S.S.13
Ikeuchi, T.14
-
22
-
-
0242331600
-
A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
-
DOI 10.1073/pnas.1735338100
-
Schroeter, E.H. et al. A presenilin dimer at the core of the γ-secretase enzyme: insight from parallel analysis of Notch1 and APP proteolysis. Proc. Natl. Acad. Sci. USA 100, 13075-13080 (2003). (Pubitemid 37340028)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.22
, pp. 13075-13080
-
-
Schroeter, E.H.1
Ilagan, Ma.X.G.2
Brunkan, A.L.3
Hecimovic, S.4
Li, Y.-M.5
Xu, M.6
Lewis, H.D.7
Saxena, M.T.8
De Strooper, B.9
Coonrod, A.10
Tomita, T.11
Iwatsubo, T.12
Moore, C.L.13
Goate, A.14
Wolfe, M.S.15
Shearman, M.16
Kopan, R.17
-
23
-
-
3142721151
-
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons
-
DOI 10.1074/jbc.M401891200
-
Hama, E., Shirotani, K., Iwata, N. & Saido, T.C. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons. J. Biol. Chem. 279, 30259-30264 (2004). (Pubitemid 38937952)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.29
, pp. 30259-30264
-
-
Hama, E.1
Shirotani, K.2
Iwata, N.3
Saido, T.C.4
-
24
-
-
33745700370
-
Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
-
Kumar-Singh, S. et al. Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40. Hum. Mutat. 27, 686-695 (2006).
-
(2006)
Hum. Mutat.
, vol.27
, pp. 686-695
-
-
Kumar-Singh, S.1
-
25
-
-
33744952846
-
Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology
-
DOI 10.1074/jbc.M512574200
-
Wang, R., Wang, B., He, W. & Zheng, H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J. Biol. Chem. 281, 15330-15336 (2006). (Pubitemid 43855123)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.22
, pp. 15330-15336
-
-
Wang, R.1
Wang, B.2
He, W.3
Zheng, H.4
-
26
-
-
35348821915
-
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
-
DOI 10.1523/JNEUROSCI.0673-07.2007
-
Maeda, J. et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J. Neurosci. 27, 10957-10968 (2007). (Pubitemid 47574168)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.41
, pp. 10957-10968
-
-
Maeda, J.1
Ji, B.2
Irie, T.3
Tomiyama, T.4
Maruyama, M.5
Okauchi, T.6
Staufenbiel, M.7
Iwata, N.8
Ono, M.9
Saido, T.C.10
Suzuki, K.11
Mori, H.12
Higuchi, M.13
Suhara, T.14
-
27
-
-
0028855851
-
Dominant and differential deposition of distinct β-amyloid peptide species AßN3(pE), in senile plaques
-
Saido, T.C. et al. Dominant and differential deposition of distinct β-amyloid peptide species, AßN3(pE), in senile plaques. Neuron 14, 457-466 (1995).
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
-
28
-
-
53549099647
-
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology
-
Schilling, S. et al. Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology. Nat. Med. 14, 1106-1111 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 1106-1111
-
-
Schilling, S.1
-
29
-
-
67949086707
-
Presenilins are essential for regulating neurotransmitter release
-
Zhang, C. et al. Presenilins are essential for regulating neurotransmitter release. Nature 460, 632-636 (2009).
-
(2009)
Nature
, vol.460
, pp. 632-636
-
-
Zhang, C.1
-
30
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
DOI 10.1038/35014735
-
Russo, C. et al. Presenilin-1 mutations in Alzheimer's disease. Nature 405, 531-532 (2000). (Pubitemid 30367716)
-
(2000)
Nature
, vol.405
, Issue.6786
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
31
-
-
22544482926
-
Aβ42 is essential for parenchymal and vascular amyloid deposition in mice
-
DOI 10.1016/j.neuron.2005.06.030, PII S0896627305005362
-
McGowan, E. et al. Aβ42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191-199 (2005). (Pubitemid 41019251)
-
(2005)
Neuron
, vol.47
, Issue.2
, pp. 191-199
-
-
McGowan, E.1
Pickford, F.2
Kim, J.3
Onstead, L.4
Eriksen, J.5
Yu, C.6
Skipper, L.7
Murphy, M.P.8
Beard, J.9
Das, P.10
Jansen, K.11
DeLucia, M.12
Lin, W.-L.13
Dolios, G.14
Wang, R.15
Eckman, C.B.16
Dickson, D.W.17
Hutton, M.18
Hardy, J.19
Golde, T.20
more..
-
32
-
-
33846435323
-
Aβ40 inhibits amyloid deposition in vivo
-
DOI 10.1523/JNEUROSCI.4849-06.2007
-
Kim, J. et al. Aβ40 inhibits amyloid deposition in vivo. J. Neurosci. 27, 627-633 (2007). (Pubitemid 46143766)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.3
, pp. 627-633
-
-
Kim, J.1
Onstead, L.2
Randle, S.3
Price, R.4
Smithson, L.5
Zwizinski, C.6
Dickson, D.W.7
Golde, T.8
McGowan, E.9
-
33
-
-
77954927651
-
Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity
-
Ono, K., Condron, M. & Teplow, D.B. Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity. J. Biol. Chem. 285, 23186-23197 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 23186-23197
-
-
Ono, K.1
Condron, M.2
Teplow, D.B.3
-
34
-
-
57149145222
-
The ratio of monomeric to aggregated forms of Aβ40 and Aβ42 is an important determinant of amyloid-β aggregation, fibrillogenesis, and toxicity
-
Jan, A. et al. The ratio of monomeric to aggregated forms of Aβ40 and Aβ42 is an important determinant of amyloid-β aggregation, fibrillogenesis, and toxicity. J. Biol. Chem. 283, 28176-28189 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28176-28189
-
-
Jan, A.1
-
35
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
DOI 10.1038/35016111
-
Huppert, S.S. et al. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405, 966-970 (2000). (Pubitemid 30435055)
-
(2000)
Nature
, vol.405
, Issue.6789
, pp. 966-970
-
-
Huppert, S.S.1
Le, A.2
Schroeter, E.H.3
Mumm, J.S.4
Saxena, M.T.5
Milner, L.A.6
Kopan, R.7
-
36
-
-
0037470192
-
Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "γ-secretase"
-
DOI 10.1074/jbc.M209252200
-
Ikeuchi, T. et al. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "γ-secretase". J. Biol. Chem. 278, 7010-7018 (2003). (Pubitemid 36800696)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.9
, pp. 7010-7018
-
-
Ikeuchi, T.1
Dolios, G.2
Kim, S.-H.3
Wang, R.4
Sisodia, S.S.5
-
37
-
-
65549140727
-
γ-Secretase heterogeneity in the Aph1 subunit: Relevance for Alzheimer's disease
-
Serneels, L. et al. γ-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science 324, 639-642 (2009).
-
(2009)
Science
, vol.324
, pp. 639-642
-
-
Serneels, L.1
-
38
-
-
33645105621
-
Presenilin clinical mutations can affect γ-secretase activity by different mechanisms
-
Bentahir, M. et al. Presenilin clinical mutations can affect γ-secretase activity by different mechanisms. J. Neurochem. 96, 732-742 (2006).
-
(2006)
J. Neurochem.
, vol.96
, pp. 732-742
-
-
Bentahir, M.1
-
39
-
-
33645578379
-
Deletion of presenilin 1 hydrophilic loop sequence leads to imparired γ-secretase activity and exacerbated amyloid pathology
-
Deng, Y. et al. Deletion of presenilin 1 hydrophilic loop sequence leads to imparired γ-secretase activity and exacerbated amyloid pathology. J. Neurosci. 26, 3845-3854 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 3845-3854
-
-
Deng, Y.1
-
40
-
-
14244252864
-
Development of a safe oral Aβ vaccine using recombinant adeno-associated virus vector for Alzheimer's disease
-
Hara, H. et al. Development of a safe oral Aβ vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J. Alzheimers Dis. 6, 483-488 (2004). (Pubitemid 40916690)
-
(2004)
Journal of Alzheimer's Disease
, vol.6
, Issue.5
, pp. 483-488
-
-
Hara, H.1
Monsonego, A.2
Yuasa, K.3
Adachi, K.4
Xiao, X.5
Takeda, S.6
Takahashi, K.7
Weiner, H.L.8
Tabira, T.9
-
41
-
-
34347399599
-
Oral vaccination with a viral vector containing Aβ cDNA attenuates age-related Aβ accumulation and memory deficits without causing inflammation in a mouse Alzheimer model
-
DOI 10.1096/fj.06-7685com
-
Mouri, A. et al. Oral vaccination with a viral vector containing Aβ cDNA attenuates age-related Aβ accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J. 21, 2135-2148 (2007). (Pubitemid 47026449)
-
(2007)
FASEB Journal
, vol.21
, Issue.9
, pp. 2135-2148
-
-
Mouri, A.1
Noda, Y.2
Hara, H.3
Mizoguchi, H.4
Tabira, T.5
Nabeshima, T.6
-
42
-
-
0035228637
-
Senile plaques in an aged Western Lowland gorilla
-
DOI 10.1538/expanim.50.77
-
Kimura, N. et al. Senile plaques in an aged Western Lowland Gorilla. Exp. Anim. 50, 77-81 (2001). (Pubitemid 33620372)
-
(2001)
Experimental Animals
, vol.50
, Issue.1
, pp. 77-81
-
-
Kimura, N.1
Nakamura, S.2
Goto, N.3
Narushima, E.4
Hara, I.5
Shichiri, S.6
Saitou, K.7
Nose, M.8
Hayashi, T.9
Kawamura, S.10
Yoshikawa, Y.11
-
43
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
DOI 10.1073/pnas.94.24.13287
-
Sturchler-Pierrat, C. et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. USA 94, 13287-13292 (1997). (Pubitemid 27518514)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.24
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.-H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
44
-
-
33745808762
-
Neprilysin-sensitive synapse-associated amyloid-β peptide oligomers impair neuronal plasticity and cognitive function
-
DOI 10.1074/jbc.M601372200
-
Huang, S.-M. et al. Neprilysin-sensitive synapse-associated amyloid-β peptide oligomers impair neuronal plasticity and cognitive function. J. Biol. Chem. 281, 17941-17951 (2006). (Pubitemid 44035593)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.26
, pp. 17941-17951
-
-
Huang, S.-M.1
Mouri, A.2
Kokubo, H.3
Nakajima, R.4
Suemoto, T.5
Higuchi, M.6
Staufenbiel, M.7
Noda, Y.8
Yamaguchi, H.9
Nabeshima, T.10
Saido, T.C.11
Iwata, N.12
-
45
-
-
0030003538
-
Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
-
DOI 10.1073/pnas.93.4.1683
-
Kopan, R., Schroeter, E.H., Weintraub, H. & Nye, J.S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 93, 1683-1688 (1996). (Pubitemid 26075185)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.4
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
46
-
-
9144266913
-
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain
-
DOI 10.1523/JNEUROSCI.4792-03.2004
-
Iwata, N. et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-β peptide in mouse brain. J. Neurosci. 24, 991-998 (2004). (Pubitemid 38146610)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.4
, pp. 991-998
-
-
Iwata, N.1
Mizukami, H.2
Shirotani, K.3
Takaki, Y.4
Muramatsu, S.-I.5
Lu, B.6
Gerard, N.P.7
Gerard, C.8
Ozawa, K.9
Saido, T.C.10
-
47
-
-
0028169925
-
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
-
Iwatsubo, T. et al. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13, 45-53 (1994).
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
-
48
-
-
0032893154
-
Appearance of sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimer in the cortex during aging
-
Enya, M. et al. Appearance of sodium dodecylsulfate-stable amyloid β-protein (Aβ) dimer in the cortex during aging. Am. J. Pathol. 154, 271-279 (1999). (Pubitemid 29031634)
-
(1999)
American Journal of Pathology
, vol.154
, Issue.1
, pp. 271-279
-
-
Enya, M.1
Morishima-Kawashima, M.2
Yoshimura, M.3
Shinkai, Y.4
Kusui, K.5
Khan, K.6
Games, D.7
Schenk, D.8
Sugihara, S.9
Yamaguchi, H.10
Ihara, Y.11
-
49
-
-
77954215576
-
An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies
-
Ryan, D.A., Narrow, W.C., Federoff, H.J. & Bowers, W.J. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J. Neurosci. Res. 190, 171-179 (2010).
-
(2010)
J. Neurosci. Res.
, vol.190
, pp. 171-179
-
-
Ryan, D.A.1
Narrow, W.C.2
Federoff, H.J.3
Bowers, W.J.4
-
50
-
-
0035479323
-
Systemic genetic study of Alzheimer disease in Latin America: Mutation frequencies of the amyloid β precursor protein and presenilin gene in Colombia
-
Arango, D. et al. Systemic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid β precursor protein and presenilin gene in Colombia. Am. J. Med. Genet. 103, 138-143 (2001).
-
(2001)
Am. J. Med. Genet.
, vol.103
, pp. 138-143
-
-
Arango, D.1
|