Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease

Neurobiology of Aging

Volumn 35, Issue 10, 2014, Pages 2288-2301

  Becerril Ortega, Javier ^a,b   Bordji, Karim ^c   Fréret, Thomas ^c   Rush, Travis ^a,b   Buisson, Alain ^a,b  

^a GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^b UNIV GRENOBLE ALPES   (France)

^c UNIVERSITÉ DE CAEN   (France)

Author keywords

Alzheimer's disease; Amyloid beta; GluN2B; Iron; NMDA; Transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DIZOCILPINE; FERROUS SULFATE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; IRON; LACTATE DEHYDROGENASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NUCLEAR PROTEIN; PROTEIN SC35; REACTIVE OXYGEN METABOLITE; RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; CELL DEATH; CELL VIABILITY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; EXPOSURE; GENETIC TRANSFECTION; HEK293 CELL LINE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; IRON OVERLOAD; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNAPSE; TRANSGENIC MOUSE; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; COGNITION DISORDERS; COMPLICATION; CYTOLOGY; DISEASE MODEL; METABOLISM; NERVE CELL; PSYCHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; IRON OVERLOAD; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS;

EID: 84903818809     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.04.019     Document Type: Article

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