Amyloid β-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length Tau phosphorylation

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20797-20811

  Reifert, Jack ^a   Hartung Cranston, DeeAnn ^a   Feinstein, Stuart C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; CALPAINS; CASPASES; CELLULAR CHANGES; HIPPOCAMPAL CULTURE; HIPPOCAMPAL NEURONS; HYPERPHOSPHORYLATION; IMMUNOBLOTTING; KINASE ACTIVITY; MOLECULAR MECHANISM; NEURONAL CELL; NEURONAL DYSFUNCTION; NEURONAL RESPONSE; SPECIFIC SITES; TWO-DIMENSIONAL GELS;

ANTIBODIES; CELL DEATH; DEGRADATION; GELS; GLYCOPROTEINS; OLIGOMERS; PHOSPHORYLATION;

CELL CULTURE;

AMYLOID BETA PROTEIN; CALPAIN; CASPASE 3; CASPASE 7; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; TAU PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; CASPASE 3; CASPASE 7; CELL DEATH; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS;

RATTUS;

EID: 79957996565     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.234674     Document Type: Article

References (61)

1. Ballatore, C., Lee, V. M., and Trojanowski, J. Q. (2007) Nat. Rev. Neurosci. 8, 663-672
2. Buée, L., and Delacourte, A. (1999) Brain Pathol. 9, 681-693
3. Haass, C., and Selkoe, D. J. (2007) Nat. Rev. Mol. Cell Biol. 8, 101-112
4. Beyreuther, K., Bush, A. I., Dyrks, T., Hilbich, C., König, G., Mönning, U., Multhaup, G., Prior, R., Rumble, B., Schubert, W., et al. (1991) Ann. N.Y. Acad. Sci. 640, 129-139
5. Tanzi, R. E., and Bertram, L. (2005) Cell 120, 545-555
6. Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P., and Ferreira, A. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 6364-6369
7. Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G. Q., and Mucke, L. (2007) Science 316, 750-754
8. Hardy, J. A., and Higgins, G. A. (1992) Science 256, 184-185
9. Selkoe, D. J. (1991) Neuron. 6, 487-498
10. Walsh, D. M., and Selkoe, D. J. (2007) J. Neurochem. 101, 1172-1184
11. Mi, K., and Johnson, G. V. (2006) Curr. Alzheimer Res. 3, 449-463
12. Lai, R. Y., Gertz, H. N., Wischik, D. J., Xuereb, J. H., Mukaetova-Ladinska, E. B., Harrington, C. R., Edwards, P. C., Mena, R., Paykel, E. S., and Brayne, C. (1995) Neurobiol. Aging 16, 433-445
13. Terwel, D., Muyllaert, D., Dewachter, I., Borghgraef, P., Croes, S., Devijver, H., and Van Leuven, F. (2008) Am. J. Pathol. 172, 786-798
14. Hernandez, P., Lee, G., Sjoberg, M., and Maccioni, R. B. (2009) J. Alzheimers Dis. 16, 149-156
15. Drechsel, D. N., Hyman, A. A., Cobb, M. H., and Kirschner, M. W. (1992) Mol. Biol. Cell 3, 1141-1154
16. Jeganathan, S., Hascher, A., Chinnathambi, S., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2008) J. Biol. Chem. 283, 32066-32076
17. Park, S. Y., and Ferreira, A. (2005) J. Neurosci. 25, 5365-5375
18. Amadoro, G., Ciotti, M. T., Costanzi, M., Cestari, V., Calissano, P., and Canu, N. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 2892-2897
19. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Science 300, 486-489
20. Jan, A., Hartley, D. M., and Lashuel, H. A. (2010) Nat. Protoc. 5, 1186-1209
21. Fedoroff, S., and Richardson, A. (2001) Protocols for Neural Cell Culture, 3rd ed., pp. 255-264, Humana Press, Totowa, NJ
22. Rothman, S. (1984) J. Neurosci. 4, 1884-1891
23. Kosik, K. S., Orecchio, L. D., Bakalis, S., and Neve, R. L. (1989) Neuron. 2, 1389-1397
24. Khurana, V., Lu, Y., Steinhilb, M. L., Oldham, S., Shulman, J. M., and Feany, M. B. (2006) Curr. Biol. 16, 230-241
25. Gamblin, T. C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A. L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., Miller, R., Berry, R. W., Binder, L. I., and Cryns, V. L. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 10032-10037
26. Bloom, G. S., Ren, K., and Glabe, C. G. (2005) Biochim. Biophys. Acta 1739, 116-124
27. Nicholson, A. M., and Ferreira, A. (2009) J. Neurosci. 29, 4640-4651
28. Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., and Selkoe, D. J. (2008) Nat. Med. 14, 837-842
29. Ono, K., Condron, M. M., and Teplow, D. B. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 14745-14750
30. Cheng, G., Yu, Z., Zhou, D., and Mattson, M. P. (2002) Exp. Neurol. 175, 407-414
31. Townsend, M., Mehta, T., and Selkoe, D. J. (2007) J. Biol. Chem. 282, 33305-33312
32. Song, L., De Sarno, P., and Jope, R. S. (2002) J. Biol. Chem. 277, 44701-44708
33. Rankin, C. A., Sun, Q., and Gamblin, T. C. (2007) Mol. Neurodegener. 2, 12
34. Cohen, P., and Frame, S. (2001) Nat. Rev. Mol. Cell Biol. 2, 769-776
35. Hamdane, M., Sambo, A. V., Delobel, P., Bégard, S., Violleau, A., Delacourte, A., Bertrand, P., Benavides, J., and Buée, L. (2003) J. Biol. Chem. 278, 34026-34034
36. Town, T., Zolton, J., Shaffner, R., Schnell, B., Crescentini, R., Wu, Y., Zeng, J., DelleDonne, A., Obregon, D., Tan, J., and Mullan, M. (2002) J. Neurosci. Res. 69, 362-372
37. Patrick, G. N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., and Tsai, L. H. (1999) Nature 402, 615-622
38. Lee, M. S., Kwon, Y. T., Li, M., Peng, J., Friedlander, R. M., and Tsai, L. H. (2000) Nature 405, 360-364
39. Glantz, S. B., Cianci, C. D., Iyer, R., Pradhan, D., Wang, K. K., and Morrow, J. S. (2007) Biochemistry 46, 502-513
40. Nath, R., Raser, K. J., Stafford, D., Hajimohammadreza, I., Posner, A., Allen, H., Talanian, R. V., Yuen, P., Gilbertsen, R. B., and Wang, K. K. (1996) Biochem. J. 319, 683-690
41. Byun, Y., Chen, F., Chang, R., Trivedi, M., Green, K. J., and Cryns, V. L. (2001) Cell Death Differ. 8, 443-450
42. Shimohama, S., Tanino, H., and Fujimoto, S. (1999) Biochem. Biophys. Res. Commun. 256, 381-384
43. Tsuji, T., Shimohama, S., Kimura, J., and Shimizu, K. (1998) Neurosci. Lett. 248, 109-112
44. Deleted in proof
45. Garg, S., Timm, T., Mandelkow, E. M., Mandelkow, E., and Wang, Y. (2011) Neurobiol. Aging 32, 1-14
46. Johnson, G. V., and Stoothoff, W. H. (2004) J. Cell Sci. 117, 5721-5729
47. Sudo, H., and Baas, P. W. (2010) J. Neurosci. 30, 7215-7226
48. Janke, C., Holzer, M., Klose, J., and Arendt, T. (1996) FEBS Lett. 379, 222-226
49. Sergeant, N., David, J. P., Goedert, M., Jakes, R., Vermersch, P., Buée, L., Lefranc, D., Wattez, A., and Delacourte, A. (1997) J. Neurochem. 69, 834-844
50. Adamec, E., Mohan, P., Vonsattel, J. P., and Nixon, R. A. (2002) Acta Neuropathol. 104, 92-104
51. Cribbs, D. H., Poon, W. W., Rissman, R. A., and Blurton-Jones, M. (2004) Am. J. Pathol. 165, 353-355
52. Augustinack, J. C., Schneider, A., Mandelkow, E. M., and Hyman, B. T. (2002) Acta Neuropathol. 103, 26-35
53. Biernat, J., Gustke, N., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1993) Neuron 11, 153-163
54. Forman, M. S., Trojanowski, J. Q., and Lee, V. M. (2004) Nat. Med. 10, 1055-1063
55. Ghosal, K., Vogt, D. L., Liang, M., Shen, Y., Lamb, B. T., and Pimplikar, S. W. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 18367-18372
56. Nikolaev, A., McLaughlin, T., O'Leary, D. D., and Tessier-Lavigne, M. (2009) Nature 457, 981-989
57. Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen, M., Gazova, Z., Mandelkow, E., and Mandelkow, E. M. (2006) J. Biol. Chem. 281, 1205-1214
58. Bunker, J. M., Wilson, L., Jordan, M. A., and Feinstein, S. C. (2004) Mol. Biol. Cell 15, 2720-2728
59. Feinstein, S. C., and Wilson, L. (2005) Biochim. Biophys. Acta 1739, 268-279
60. Rosenberg, K. J., Ross, J. L., Feinstein, H. E., Feinstein, S. C., and Israelachvili, J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 7445-7450
61. Makrides, V., Shen, T. E., Bhatia, R., Smith, B. L., Thimm, J., Lal, R. and Feinstein, S. C. (2003) J. Biol. Chem. 278, 33298-33304