In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

FEBS Journal

Volumn 272, Issue 21, 2005, Pages 5544-5557

  Hoke, David E ^a,b   Tan, Jiang Li ^a   Ilaya, Nancy T ^a   Culvenor, Janetta G ^a   Smith, Stephanie J ^a   White, Anthony R ^a   Masters, Colin L ^a   Evin, Geneviève M ^a,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Alzheimer's disease; Amyloid beta; Amyloid precursor protein; Gamma secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DIMETHYL SULFOXIDE; GAMMA SECRETASE; PRESENILIN 1; ZINC;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CORRELATION ANALYSIS; ENZYME ACTIVITY; IN VITRO STUDY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, GEL; COS CELLS; DIMETHYL SULFOXIDE; ENDOPEPTIDASES; ESCHERICHIA COLI; GENE EXPRESSION; GUINEA PIGS; MEMBRANE PROTEINS; MEMBRANES; MOLECULAR WEIGHT; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY; ZINC;

BACTERIA (MICROORGANISMS);

EID: 27644482219     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04950.x     Document Type: Article

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