In situ characterization and mapping of iron compounds in Alzheimer's disease tissue

Journal of Alzheimer's Disease

Volumn 7, Issue 4, 2005, Pages 267-272

  Collingwood, J F ^a   Mikhaylova, A ^b   Davidson, M ^b   Batich, C ^b   Streit, W J ^c   Terry, J ^d   Dobson, J ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Alzheimer's disease; Ferritin; Iron; Magnetite; Neurodegeneration; X ray

Indexed keywords

FERRITIN; IRON; MAGNETITE;

ALZHEIMER DISEASE; ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FRONTAL LOBE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IN SITU HYBRIDIZATION; IRON METABOLISM; IRON OVERLOAD; NEUROPATHOLOGY; PRIORITY JOURNAL; TISSUE SECTION;

EID: 23944491628     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2005-7401     Document Type: Article

References (24)

1. Y. Ke and Z. Qian, Iron misregulation in the brain: a primary cause of neurodegenerative disorders, The Lancet Neurol 2 (2003), 246-253.
2. L. Goodman, Alzheimer's disease - a clinicopathologic analysis of 23 cases with a theory on pathogenesis, J. Nerv. Ment. Dis. 118 (1953), 97-130.
3. G. Bishop et al., Iron: a pathological mediator of Alzheimer disease, Dev. Neurosci. 24 (2002), 184-187.
4. P.M. Harrison and P. Arosio, The ferritins: molecular properties, iron storage function and cellular regulation, Biochim Biophys Acta 1275 (1996), 161-203.
5. C.M. Morris, J.M. Candy, A.E. Oakley, C.A. Bloxham and J.A. Edwardson, Histochemical distribution of non-haem iron in the human brain, Acta. Anat. (Basel) 144 (1992), 235-257.
6. M.A. Smith, P.L.R. Harris, L.M. Sayre and G. Perry, Iron accumulation in Alzheimer disease is a source of redox-generated free radicals, Proc. Natl. Acad. Sci. USA 94 (1997), 9866-9868.
7. L.M. Sayre, G. Perry, P.L.R. Harris, Y.H. Liu, K.H. Schubert and M.A. Smith, In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals, J. Neurochem 74 (2000), 270-279.
8. J.L. Kirschvink, A. Kobayashi-Kirschvink and B.J. Woodford, Magnetite biomineralization in the human brain, Proc. Natl. Acad. Sci. USA 89 (1992), 7683-7687.
9. P.P. Schultheiss-Grassi, R. Wessiken and J. Dobson, TEM observation of biogenic magnetite extracted from the human hippocampus, Biochim. Biophys. Acta 1426 (1999), 212-216.
10. D. Hautot, Q.A. Pankhurst, N. Khan and J. Dobson, Preliminary evaluation of nanoscale biogenic magnetite and Alzheimer's disease, Proc. Royal Soc. Lon. B: Biol. Lett. 270 (2003), S62-S64.
11. C. Quintana, M. Lancin, C. Marhic, M. Ṕerez, J. Avila and J.L. Carrascosa, Preliminary high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brain in patients with neurodegenerative PSP and Alzheimer diseases, Cell. & Molec. Biol. 46 (2000), 807-820.
12. C. Quintana, J.M. Cowley and C. Marhic, Electron diffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin, J Struct Biol 147 (2004), 166-178.
13. J. Dobson, Nanoscale biogenic iron oxides and neurodegenerative disease, FEBS Lett 496 (2001), 1-5.
14. J. Dobson, Magnetic iron compounds in neurological disorders, Ann. NY Acad. Sci. 1012 (2004), 183-192.
15. K. Honda, G. Casadesus, R. Petersen, G. Perry and M.A. Smith, Oxidative stress and redox-active iron in Alzheimer's disease, Ann. NY Acad. Sci. 1012 (2004), 179-182.
16. J.R. Burdo and J.R. Conner, Brain iron uptake and homeostatic mechanisms: an overview, Biometals 16 (2003), 63-75.
17. L. Zecca, M.B. Youdim, P. Riederer, J.R. Connor and R.R. Crichton, Iron, brain ageing and neurodegenerative disorders, Nat. Rev. Neurosci. 5 (2004), 863-873.
18. G. Casadesus, M.A. Smith, X. Zhu, G. Aliev, A.D. Cash, K. Honda, R.B. Petersen and G. Perry, Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species, J Alzheimer's Dis 6 (2004), 165-169.
19. S. Yoshida, A. Ektessabi and S. Fujisawa, XANES spectroscopy of a single neuron from a patient with Parkinson's disease, J. Synchrotron Rad 8 (2001), 998-1000.
20. M. Newville, P. Livins, Y. Yacoby, E.A. Stern and J.J. Rehr, Near-edge x-ray-absorption fine structure of Pb: A comparison of theory and experiment, Phys. Rev. B. 47 (1993), 14126-14131.
21. M. Wilke, F. Farges, P. Petit, G.E. Brown and F. Martin, Oxidation state and coordination of Fe in minerals: An Fe K-XANES spectroscopic study, American Mineralogist 86 (2001), 714-730.
22. A. Bush, Copper, zinc, and the metallobiology of Alzheimer disease, Alz. Dis Assoc. Disord. 17 (2003), 147-150.
23. G. Bartzokis, T.A. Tishler, I.S. Shin, P.H. Lu and J.L. Cummings, Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases, Ann. NY Acad Sci. 1012 (2004), 224-236.
24. D.R. Richardson, Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions, Ann. NY Acad. Sci. 1012 (2004), 326-341.