CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

EMBO Journal

Volumn 18, Issue 7, 1999, Pages 1783-1792

  Felkai, S ^b   Ewbank, J J ^a,b   Lemieux, J ^b   Labbe J C ^b   Brown, G G ^b   Hekimi, S ^b  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Aging; Caenorhabditis elegans; Growth control; Mitochondria

Indexed keywords

GREEN FLUORESCENT PROTEIN; PROTEIN;

AGING; ARTICLE; BEHAVIOR; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL RESPIRATION; DEVELOPMENTAL GENETICS; GENE MUTATION; MITOCHONDRION; NEMATODE; NONHUMAN; PRIORITY JOURNAL; SOMATIC CELL;

CAENORHABDITIS ELEGANS; INVERTEBRATA; NEMATODA;

EID: 0033118981     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.7.1783     Document Type: Article

References (27)

1. Andersson, S.G. et al. (1998) The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature, 396, 133-140.
2. Avery, L. (1993) The genetics of feeding in Caenorhabditis elegans. Genetics, 133, 897-917.
3. Bolanowski, M.A., Russell, R.L. and Jacobson, L.A. (1981) Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters. Mech. Ageing Dev., 15, 279-295.
4. Brown, G.G. and Beattie, D.S. (1977) Role of coenzyme Q in the mitochondrial respiratory chain. Reconstitution of activity in coenzyme Q deficient mutants of yeast. Biochemistry, 16, 4449-4454.
5. Croll, N.A., Smith, J.M. and Zuckerman, B.M. (1977) The aging process of the nematode Caenorhabditis elegans in bacterial and axenic culture. Exp. Aging Res., 3, 175-189.
6. Ewbank, J.J., Barnes, T.M. Lakowski, B., Lussier, M., Bussey, H. and Hekimi, S. (1997) Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science, 275, 980-983.
7. Felton, J., Michaelis, S. and Wright, A.J. (1980) Mutations in two unlinked genes are required to produce asparagine auxotrophy in Escherichia coli. J. Bacterial., 142, 221-228.
8. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
9. Hagen, T.M., Yowe, D.L., Bartholomew, J.C., Wehr, C.M., Do, K.L., Park, J.Y. and Ames, B.N. (1997) Mitochondrial decay in hepatocytes from old rats: membrane potential decline, heterogeneity and oxidants increase. Proc. Natl Acad. Sci. USA, 94, 3064-3069.
10. Harman, D. (1972) The biologic clock: the mitochondria? J. Am. Geriatr. Soc., 20, 145-147.
11. Hekimi, S., Lakowski, B., Barnes, T. and Ewbank, J. (1998) Molecular genetics of life span in C.elegans: how much does it teach us? Trends Genet., 14, 14-20.
12. Ishii, N., Fujii, M., Hartman, P.S., Tsuda, M., Yasuda, K., Senoomatsuda, N., Yanase, S., Ayusawa, D. and Suzuki, K. (1998) A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature, 394, 694-697.
13. Johnson, L.V., Walsh, M.L., Bockus, B.J. and Chen, L.B. (1981) Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J. Cell Biol., 88, 526-535.
14. Jonassen, T., Marbois, B.N., Kim, L., Chin, A., Xia, Y.R., Lusis, A.J. and Clarke, C.F. (1996) Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome. Arch. Biochem. Biophys., 330, 285-289.
15. Jonassen, T., Proft, M., Randez-Gil, F., Schultz, J.R., Marbois, B.N., Entian, K.D. and Clarke, C.F. (1998) Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J. Biol. Chem., 273, 3351-3357.
16. Labbé, J.-C., Hekimi, S. and Rokeach, L. (1999) The levels of the RoRNP-associated Y RNA are dependent upon of ROP-1. the C. elegans Ro60 protein. Genetics, 151, 143-150.
17. Lakowski, B. and Hekimi, S. (1996) Determination of life-span in Caenorhabditis elegans by four clock genes. Science, 272, 1010-1013.
18. Lakowski, B. and Hekimi, S. (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA, 95, 13091-13096.
19. Linnane, A.W., Marzuki, S., Ozawa, T. and Tanaka, M. (1989) Mitochondrial DNA mutations as contributor to ageing and degenerative diseases. Lancet, 1, 642-645.
20. Marbois, B.N. and Clarke, C.F. (1996) The COQ7 gene encodes a protein in S. cerevisiae necessary for ubiquinone biosynthesis. J. Biol. Chem., 271, 2995-3004.
21. Mello, C. and Fire, A. (1995) DNA transformation. Methods Cell Biol., 48, 451-482.
22. Mello, C.C., Kramer, J.M., Stinchcomb, D. and Ambros, V. (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J., 10, 3959-3970.
23. Miquel, J. (1998) An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications. Exp. Gerontol., 33, 113-126.
24. Murfitt, R.R., Vogel, K. and Sanadi, D.R. (1976) Characterization of the mitochondria of the free-living nematode, C. elegans. Camp. Biochem. Physiol. B, 53, 423-430.
25. Poyton, R.O. and McEwen, J.E. (1996) Crosstalk between nuclear and mitochondrial genomes. Annu. Rev. Biochem., 65, 563-607.
26. Shigenaga, M.K., Hagen, T.M. and Ames, B.N. (1994) Oxidative damage and mitochondrial decay in aging. Proc. Natl Acad. Sci. USA, 91, 10771-10778.
27. Wong, A., Boutis, P. and Hekimi, S. (1995) Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics, 139, 1247-1259.