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Volumn 6, Issue FEB, 2015, Pages

The environment of regulatory T cell biology: Cytokines, metabolites, and the microbiome

Author keywords

Cytokines; Environment; FOXP3; Immune regulation; Metabolites; Microbiome; Plasticity; Regulatory T cells

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOKINE; POLYSACCHARIDE; PROBIOTIC AGENT; RETINOIC ACID; RETINOL; SHORT CHAIN FATTY ACID; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; VITAMIN D;

EID: 84926614125     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00061     Document Type: Review
Times cited : (126)

References (228)
  • 1
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol (2007) 37:2378-89. doi:10.1002/eji.200737594
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3    Baumann, K.4    Grützkau, A.5    Dong, J.6
  • 2
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 5:e38. doi:10.1371/journal.pbio.0050038
    • (2007) PLoS Biol , vol.5
    • Floess, S.1    Freyer, J.2    Siewert, C.3    Baron, U.4    Olek, S.5    Polansky, J.6
  • 4
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 203:1701-11. doi:10.1084/jem.20060772
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5    Zhu, S.6
  • 5
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med (2006) 203:1693-700. doi:10.1084/jem.20060468
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3    Zaunders, J.4    Sasson, S.5    Landay, A.6
  • 7
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 35:109-22. doi:10.1016/j.immuni.2011.03.029
    • (2011) Immunity , vol.35 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3    Nickerson, D.4    Schmitt, E.G.5    Edwards, B.6
  • 8
  • 9
    • 84923107503 scopus 로고    scopus 로고
    • Control of tissue-localized immune responses by human regulatory T cells
    • Pesenacker AM, Broady R, Levings MK. Control of tissue-localized immune responses by human regulatory T cells. Eur J Immunol (2014). doi:10.1002/eji.201344205
    • (2014) Eur J Immunol
    • Pesenacker, A.M.1    Broady, R.2    Levings, M.K.3
  • 10
    • 35448967862 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
    • Burchill MA, Yang J, Vang KB, Farrar MA. Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunol Lett (2007) 114:1-8. doi:10.1016/j.imlet.2007.08.005
    • (2007) Immunol Lett , vol.114 , pp. 1-8
    • Burchill, M.A.1    Yang, J.2    Vang, K.B.3    Farrar, M.A.4
  • 11
    • 84883772994 scopus 로고    scopus 로고
    • Role of cytokines in thymus-versus peripherally derived-regulatory T cell differentiation and function
    • Goldstein JD, Pérol L, Zaragoza B, Baeyens A, Marodon G, Piaggio E. Role of cytokines in thymus-versus peripherally derived-regulatory T cell differentiation and function. Front Immunol (2013) 4:155. doi:10.3389/fimmu.2013.00155
    • (2013) Front Immunol , vol.4 , pp. 155
    • Goldstein, J.D.1    Pérol, L.2    Zaragoza, B.3    Baeyens, A.4    Marodon, G.5    Piaggio, E.6
  • 12
    • 79954559096 scopus 로고    scopus 로고
    • T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells
    • Cheng G, Yu A, Malek TR. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev (2011) 241:63-76. doi:10.1111/j.1600-065X.2011.01004.x
    • (2011) Immunol Rev , vol.241 , pp. 63-76
    • Cheng, G.1    Yu, A.2    Malek, T.R.3
  • 13
    • 84891090694 scopus 로고    scopus 로고
    • Interleukin-2 and STAT5 in regulatory T cell development and function
    • Mahmud SA, Manlove LS, Farrar MA. Interleukin-2 and STAT5 in regulatory T cell development and function. JAKSTAT (2013) 2:e23154. doi:10.4161/jkst.23154
    • (2013) JAKSTAT , vol.2
    • Mahmud, S.A.1    Manlove, L.S.2    Farrar, M.A.3
  • 14
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor-dependent STAT5 activation is required for the development of Foxp3+ regulatory T Cells
    • Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. IL-2 receptor-dependent STAT5 activation is required for the development of Foxp3+ regulatory T Cells. J Immunol (2007) 178:280-90. doi:10.4049/jimmunol.178.1.280
    • (2007) J Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 15
    • 84912528518 scopus 로고    scopus 로고
    • Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells
    • Marshall D, Sinclair C, Tung S, Seddon B. Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells. J Immunol (2014) 193:5525-33. doi:10.4049/jimmunol.1402144
    • (2014) J Immunol , vol.193 , pp. 5525-5533
    • Marshall, D.1    Sinclair, C.2    Tung, S.3    Seddon, B.4
  • 16
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 6:1142-51. doi:10.1038/ni1263
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 17
    • 47949097840 scopus 로고    scopus 로고
    • A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
    • Bayer AL, Lee JY, De La Barrera A, Surh CD, Malek TR. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol (2008) 181:225-34. doi:10.4049/jimmunol.181.1.225
    • (2008) J Immunol , vol.181 , pp. 225-234
    • Bayer, A.L.1    Lee, J.Y.2    De La Barrera, A.3    Surh, C.D.4    Malek, T.R.5
  • 18
    • 0035554678 scopus 로고    scopus 로고
    • Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
    • Granucci F, Vizzardelli C, Pavelka N, Feau S, Persico M, Virzi E, et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol (2001) 2:882-8. doi:10.1038/ni0901-882
    • (2001) Nat Immunol , vol.2 , pp. 882-888
    • Granucci, F.1    Vizzardelli, C.2    Pavelka, N.3    Feau, S.4    Persico, M.5    Virzi, E.6
  • 19
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    • Watanabe N, Wang YH, Lee HK, Ito T, Wang YH, Cao W, et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature (2005) 436:1181-5. doi:10.1038/nature03886
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.H.2    Lee, H.K.3    Ito, T.4    Wang, Y.H.5    Cao, W.6
  • 20
    • 84893365911 scopus 로고    scopus 로고
    • Thymocyte apoptosis drives the intrathymic generation of regulatory T cells
    • Konkel JE, Jin W, Abbatiello B, Grainger JR, Chen W. Thymocyte apoptosis drives the intrathymic generation of regulatory T cells. Proc Natl Acad Sci U S A (2014) 111:E465-73. doi:10.1073/pnas.1320319111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E465-E473
    • Konkel, J.E.1    Jin, W.2    Abbatiello, B.3    Grainger, J.R.4    Chen, W.5
  • 21
    • 0020451946 scopus 로고
    • Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
    • Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med (1982) 156:1577-86. doi:10.1084/jem.156.6.1565
    • (1982) J Exp Med , vol.156 , pp. 1577-1586
    • Sakaguchi, S.1    Takahashi, T.2    Nishizuka, Y.3
  • 22
    • 84913556128 scopus 로고    scopus 로고
    • Targeting regulatory T cells to improve vaccine immunogenicity in early life
    • Ndure J, Flanagan KL. Targeting regulatory T cells to improve vaccine immunogenicity in early life. Front Microbiol (2014) 5:477. doi:10.3389/fmicb.2014.00477
    • (2014) Front Microbiol , vol.5 , pp. 477
    • Ndure, J.1    Flanagan, K.L.2
  • 23
    • 33947644716 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is essential for TGF-mediated induction of Foxp3+ T regulatory cells
    • Davidson TS, Dipaolo RJ, Andersson J, Shevach EM. Cutting edge: IL-2 is essential for TGF-mediated induction of Foxp3+ T regulatory cells. J Immunol (2007) 178:4022-6. doi:10.4049/jimmunol.178.7.4022
    • (2007) J Immunol , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    Dipaolo, R.J.2    Andersson, J.3    Shevach, E.M.4
  • 24
  • 25
    • 77950343675 scopus 로고    scopus 로고
    • TGF-beta and 'adaptive' Foxp3(+) regulatory T cells
    • Chen W, Konkel JE. TGF-beta and 'adaptive' Foxp3(+) regulatory T cells. J Mol Cell Biol (2010) 2:30-6. doi:10.1093/jmcb/mjp004
    • (2010) J Mol Cell Biol , vol.2 , pp. 30-36
    • Chen, W.1    Konkel, J.E.2
  • 26
    • 84859499803 scopus 로고    scopus 로고
    • Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells
    • Karman J, Jiang JL, Gumlaw N, Zhao H, Campos-Rivera J, Sancho J, et al. Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells. J Biol Chem (2012) 287:11098-107. doi:10.1074/jbc.M111.283705
    • (2012) J Biol Chem , vol.287 , pp. 11098-11107
    • Karman, J.1    Jiang, J.L.2    Gumlaw, N.3    Zhao, H.4    Campos-Rivera, J.5    Sancho, J.6
  • 29
    • 84919628900 scopus 로고    scopus 로고
    • Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region
    • Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, et al. Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. J Immunol (2014) 194:11-124. doi:10.4049/jimmunol.1401145
    • (2014) J Immunol , vol.194 , pp. 11-124
    • Rossetti, M.1    Spreafico, R.2    Saidin, S.3    Chua, C.4    Moshref, M.5    Leong, J.Y.6
  • 30
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    • 83ra41
    • Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med (2011) 3:83ra41. doi:10.1126/scitranslmed.3001809
    • (2011) Sci Transl Med , vol.3
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3    Sieben, C.M.4    Sumstad, D.5    Kadidlo, D.M.6
  • 31
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood (2007) 110:2983-90. doi:10.1182/blood-2007-06-094656
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 32
    • 84855233207 scopus 로고    scopus 로고
    • Suppression assays with human T regulatory cells: a technical guide
    • McMurchy AN, Levings MK. Suppression assays with human T regulatory cells: a technical guide. Eur J Immunol (2012) 42:27-34. doi:10.1002/eji.201141651
    • (2012) Eur J Immunol , vol.42 , pp. 27-34
    • McMurchy, A.N.1    Levings, M.K.2
  • 33
    • 50549098084 scopus 로고    scopus 로고
    • Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
    • Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One (2008) 3:e2705. doi:10.1371/journal.pone.0002705
    • (2008) PLoS One , vol.3
    • Wang, R.1    Wan, Q.2    Kozhaya, L.3    Fujii, H.4    Unutmaz, D.5
  • 34
    • 73249123203 scopus 로고    scopus 로고
    • Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg
    • Stockis J, Colau D, Coulie PG, Lucas S. Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur J Immunol (2009) 39:3315-22. doi:10.1002/eji.200939684
    • (2009) Eur J Immunol , vol.39 , pp. 3315-3322
    • Stockis, J.1    Colau, D.2    Coulie, P.G.3    Lucas, S.4
  • 35
    • 69449085219 scopus 로고    scopus 로고
    • GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells
    • Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 106:13445-50. doi:10.1073/pnas.0901944106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13445-13450
    • Tran, D.Q.1    Andersson, J.2    Wang, R.3    Ramsey, H.4    Unutmaz, D.5    Shevach, E.M.6
  • 36
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med (2002) 196:255-60. doi:10.1084/jem.20020394
    • (2002) J Exp Med , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 37
    • 51049101255 scopus 로고    scopus 로고
    • CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    • Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, et al. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 205:1975-81. doi:10.1084/jem.20080308
    • (2008) J Exp Med , vol.205 , pp. 1975-1981
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3    Davidson, T.S.4    Ramsey, H.5    O'Shea, J.J.6
  • 38
    • 0031945499 scopus 로고    scopus 로고
    • How do monoclonal antibodies induce tolerance?. A role for infectious tolerance?
    • Waldmann H, Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu Rev Immunol (1998) 16:619-44. doi:10.1146/annurev.immunol.16.1.619
    • (1998) Annu Rev Immunol , vol.16 , pp. 619-644
    • Waldmann, H.1    Cobbold, S.2
  • 39
    • 78049303465 scopus 로고    scopus 로고
    • Infectious tolerance: therapeutic potential
    • Kendal AR, Waldmann H. Infectious tolerance: therapeutic potential. Curr Opin Immunol (2010) 22:560-5. doi:10.1016/j.coi.2010.08.002
    • (2010) Curr Opin Immunol , vol.22 , pp. 560-565
    • Kendal, A.R.1    Waldmann, H.2
  • 40
    • 80555129271 scopus 로고    scopus 로고
    • Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance
    • Kendal AR, Chen Y, Regateiro FS, Ma J, Adams E, Cobbold SP, et al. Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance. J Exp Med (2011) 208:2043-53. doi:10.1084/jem.20110767
    • (2011) J Exp Med , vol.208 , pp. 2043-2053
    • Kendal, A.R.1    Chen, Y.2    Regateiro, F.S.3    Ma, J.4    Adams, E.5    Cobbold, S.P.6
  • 41
    • 34548208943 scopus 로고    scopus 로고
    • Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    • Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, et al. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 449:361-5. doi:10.1038/nature06110
    • (2007) Nature , vol.449 , pp. 361-365
    • Travis, M.A.1    Reizis, B.2    Melton, A.C.3    Masteller, E.4    Tang, Q.5    Proctor, J.M.6
  • 42
    • 84869094298 scopus 로고    scopus 로고
    • Regulation of TGFbeta in the immune system: an emerging role for integrins and dendritic cells
    • Worthington JJ, Fenton TM, Czajkowska BI, Klementowicz JE, Travis MA. Regulation of TGFbeta in the immune system: an emerging role for integrins and dendritic cells. Immunobiology (2012) 217:1259-65. doi:10.1016/j.imbio.2012.06.009
    • (2012) Immunobiology , vol.217 , pp. 1259-1265
    • Worthington, J.J.1    Fenton, T.M.2    Czajkowska, B.I.3    Klementowicz, J.E.4    Travis, M.A.5
  • 43
    • 84859102273 scopus 로고    scopus 로고
    • Induced regulatory T cells: mechanisms of conversion and suppressive potential
    • Dons EM, Raimondi G, Cooper DK, Thomson AW. Induced regulatory T cells: mechanisms of conversion and suppressive potential. Hum Immunol (2012) 73:328-34. doi:10.1016/j.humimm.2011.12.011
    • (2012) Hum Immunol , vol.73 , pp. 328-334
    • Dons, E.M.1    Raimondi, G.2    Cooper, D.K.3    Thomson, A.W.4
  • 44
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 204:1757-64. doi:10.1084/jem.20070590
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6
  • 45
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 317:256-60. doi:10.1126/science.1145697
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6
  • 46
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 204:1775-85. doi:10.1084/jem.20070602
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 47
    • 70349310093 scopus 로고    scopus 로고
    • De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid
    • Wang J, Huizinga TW, Toes RE. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J Immunol (2009) 183:4119-26. doi:10.4049/jimmunol.0901065
    • (2009) J Immunol , vol.183 , pp. 4119-4126
    • Wang, J.1    Huizinga, T.W.2    Toes, R.E.3
  • 48
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One (2011) 6:e15868. doi:10.1371/journal.pone.0015868
    • (2011) PLoS One , vol.6
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 49
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • Hippen KL, Merkel SC, Schirm DK, Nelson C, Tennis NC, Riley JL, et al. Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant (2011) 11:1148-57. doi:10.1111/j.1600-6143.2011.03558.x
    • (2011) Am J Transplant , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3    Nelson, C.4    Tennis, N.C.5    Riley, J.L.6
  • 50
    • 84910648204 scopus 로고    scopus 로고
    • Superiority of rapamycin over tacrolimus in preserving nonhuman primate treg half-life and phenotype after adoptive transfer
    • Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, et al. Superiority of rapamycin over tacrolimus in preserving nonhuman primate treg half-life and phenotype after adoptive transfer. Am J Transplant (2014) 14:2691-703. doi:10.1111/ajt.12934
    • (2014) Am J Transplant , vol.14 , pp. 2691-2703
    • Singh, K.1    Stempora, L.2    Harvey, R.D.3    Kirk, A.D.4    Larsen, C.P.5    Blazar, B.R.6
  • 51
    • 84883162955 scopus 로고    scopus 로고
    • Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells
    • Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, et al. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nat Immunol (2013) 14:959-65. doi:10.1038/ni.2649
    • (2013) Nat Immunol , vol.14 , pp. 959-965
    • Pierson, W.1    Cauwe, B.2    Policheni, A.3    Schlenner, S.M.4    Franckaert, D.5    Berges, J.6
  • 52
    • 84879601640 scopus 로고    scopus 로고
    • Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
    • Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, et al. Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity (2013) 38:1116-28. doi:10.1016/j.immuni.2013.02.022
    • (2013) Immunity , vol.38 , pp. 1116-1128
    • Tai, X.1    Erman, B.2    Alag, A.3    Mu, J.4    Kimura, M.5    Katz, G.6
  • 54
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 35:337-48. doi:10.1016/j.immuni.2011.08.012
    • (2011) Immunity , vol.35 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 56
    • 84866548843 scopus 로고    scopus 로고
    • Transcription factor Foxp3 and its protein partners form a complex regulatory network
    • Rudra D, Deroos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol (2012) 13:1010-9. doi:10.1038/ni.2402
    • (2012) Nat Immunol , vol.13 , pp. 1010-1019
    • Rudra, D.1    Deroos, P.2    Chaudhry, A.3    Niec, R.E.4    Arvey, A.5    Samstein, R.M.6
  • 57
    • 84876805126 scopus 로고    scopus 로고
    • Cutting edge: memory regulatory T cells require IL-7 and not IL-2 for their maintenance in peripheral tissues
    • Gratz IK, Truong H-A, Yang SH-Y, Maurano MM, Lee K, Abbas AK, et al. Cutting edge: memory regulatory T cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol (2013) 190:4483-7. doi:10.4049/jimmunol.1300212
    • (2013) J Immunol , vol.190 , pp. 4483-4487
    • Gratz, I.K.1    Truong, H.-A.2    Yang, S.H.-Y.3    Maurano, M.M.4    Lee, K.5    Abbas, A.K.6
  • 58
    • 84883773405 scopus 로고    scopus 로고
    • IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels
    • Raynor J, Sholl A, Plas DR, Bouillet P, Chougnet CA, Hildeman DA. IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels. Front Immunol (2013) 4:161. doi:10.3389/fimmu.2013.00161
    • (2013) Front Immunol , vol.4 , pp. 161
    • Raynor, J.1    Sholl, A.2    Plas, D.R.3    Bouillet, P.4    Chougnet, C.A.5    Hildeman, D.A.6
  • 59
    • 33846005781 scopus 로고    scopus 로고
    • IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    • Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood (2007) 109:194-202. doi:10.1182/blood-2006-02-002873
    • (2007) Blood , vol.109 , pp. 194-202
    • Clark, R.A.1    Kupper, T.S.2
  • 60
    • 80051789004 scopus 로고    scopus 로고
    • IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood
    • Xu S, Sun Z, Sun Y, Zhu J, Li X, Zhang X, et al. IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood. Immunol Lett (2011) 140:59-67. doi:10.1016/j.imlet.2011.06.005
    • (2011) Immunol Lett , vol.140 , pp. 59-67
    • Xu, S.1    Sun, Z.2    Sun, Y.3    Zhu, J.4    Li, X.5    Zhang, X.6
  • 61
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 28:687-97. doi:10.1016/j.immuni.2008.03.016
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5    Sgouroudis, E.6
  • 62
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med (2009) 206:751-60. doi:10.1084/jem.20082824
    • (2009) J Exp Med , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6
  • 63
    • 84869791967 scopus 로고    scopus 로고
    • Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways
    • Lee SY, Cho ML, Oh HJ, Ryu JG, Park MJ, Jhun JY, et al. Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways. Immunology (2012) 137:305-16. doi:10.1111/imm.12008
    • (2012) Immunology , vol.137 , pp. 305-316
    • Lee, S.Y.1    Cho, M.L.2    Oh, H.J.3    Ryu, J.G.4    Park, M.J.5    Jhun, J.Y.6
  • 64
    • 84926347527 scopus 로고    scopus 로고
    • Interleukin-2/anti-interleukin-2 immune complex expands regulatory T Cells and reduces angiotensin II-induced aortic stiffening
    • 126365
    • Majeed B, Tawinwung S, Eberson LS, Secomb TW, Larmonier N, Larson DF. Interleukin-2/anti-interleukin-2 immune complex expands regulatory T Cells and reduces angiotensin II-induced aortic stiffening. Int J Hypertens (2014) 2014:126365. doi:10.1155/2014/126365
    • (2014) Int J Hypertens , vol.2014
    • Majeed, B.1    Tawinwung, S.2    Eberson, L.S.3    Secomb, T.W.4    Larmonier, N.5    Larson, D.F.6
  • 65
    • 84864855006 scopus 로고    scopus 로고
    • IL-2/IL-2Ab complexes induce regulatory T cell expansion and protect against proteinuric CKD
    • Polhill T, Zhang GY, Hu M, Sawyer A, Zhou JJ, Saito M, et al. IL-2/IL-2Ab complexes induce regulatory T cell expansion and protect against proteinuric CKD. J Am Soc Nephrol (2012) 23:1303-8. doi:10.1681/ASN.2011111130
    • (2012) J Am Soc Nephrol , vol.23 , pp. 1303-1308
    • Polhill, T.1    Zhang, G.Y.2    Hu, M.3    Sawyer, A.4    Zhou, J.J.5    Saito, M.6
  • 66
    • 84885048272 scopus 로고    scopus 로고
    • IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells
    • Kim MG, Koo TY, Yan JJ, Lee E, Han KH, Jeong JC, et al. IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. J Am Soc Nephrol (2013) 24:1529-36. doi:10.1681/ASN.2012080784
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1529-1536
    • Kim, M.G.1    Koo, T.Y.2    Yan, J.J.3    Lee, E.4    Han, K.H.5    Jeong, J.C.6
  • 67
    • 84891488474 scopus 로고    scopus 로고
    • The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
    • Bayer AL, Pugliese A, Malek TR. The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation. Immunol Res (2013) 57:197-209. doi:10.1007/s12026-013-8452-5
    • (2013) Immunol Res , vol.57 , pp. 197-209
    • Bayer, A.L.1    Pugliese, A.2    Malek, T.R.3
  • 68
    • 84887625676 scopus 로고    scopus 로고
    • Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
    • Hartemann A, Bensimon G, Payan CA, Jacqueminet S, Bourron O, Nicolas N, et al. Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol (2013) 1:295-305. doi:10.1016/S2213-8587(13)70113-X
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 295-305
    • Hartemann, A.1    Bensimon, G.2    Payan, C.A.3    Jacqueminet, S.4    Bourron, O.5    Nicolas, N.6
  • 69
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • ra143-ra79
    • Matsuoka K-I, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med (2013) 5:ra143-79. doi:10.1126/scitranslmed.3005265
    • (2013) Sci Transl Med , vol.5
    • Matsuoka, K.-I.1    Koreth, J.2    Kim, H.T.3    Bascug, G.4    McDonough, S.5    Kawano, Y.6
  • 70
    • 84898940914 scopus 로고    scopus 로고
    • Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity
    • Kennedy-Nasser AA, Ku S, Castillo-Caro P, Hazrat Y, Wu M-F, Liu H, et al. Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin Cancer Res (2014) 20:2215-25. doi:10.1158/1078-0432.CCR-13-3205
    • (2014) Clin Cancer Res , vol.20 , pp. 2215-2225
    • Kennedy-Nasser, A.A.1    Ku, S.2    Castillo-Caro, P.3    Hazrat, Y.4    Wu, M.-F.5    Liu, H.6
  • 71
    • 84857646605 scopus 로고    scopus 로고
    • The role of interleukin-2 during homeostasis and activation of the immune system
    • Boyman O, Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol (2012) 12:180-90. doi:10.1038/nri3156
    • (2012) Nat Rev Immunol , vol.12 , pp. 180-190
    • Boyman, O.1    Sprent, J.2
  • 72
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
    • Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes (2012) 61:2340-8. doi:10.2337/db12-0049
    • (2012) Diabetes , vol.61 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3    Bollyky, J.B.4    Samuels, P.L.5    Goland, R.6
  • 73
    • 84860317093 scopus 로고    scopus 로고
    • Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
    • Garg G, Tyler JR, Yang JHM, Cutler AJ, Downes K, Pekalski M, et al. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol (2012) 188:4644-53. doi:10.4049/jimmunol.1100272
    • (2012) J Immunol , vol.188 , pp. 4644-4653
    • Garg, G.1    Tyler, J.R.2    Yang, J.H.M.3    Cutler, A.J.4    Downes, K.5    Pekalski, M.6
  • 74
    • 84907070734 scopus 로고    scopus 로고
    • Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis
    • Bending D, Pesenacker AM, Ursu S, Wu Q, Lom H, Thirugnanabalan B, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. J Immunol (2014) 193:2699-708. doi:10.4049/jimmunol.1400599
    • (2014) J Immunol , vol.193 , pp. 2699-2708
    • Bending, D.1    Pesenacker, A.M.2    Ursu, S.3    Wu, Q.4    Lom, H.5    Thirugnanabalan, B.6
  • 75
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer (2010) 127:759-67. doi:10.1002/ijc.25429
    • (2010) Int J Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 76
    • 84861175955 scopus 로고    scopus 로고
    • CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
    • Rech AJ, Mick R, Martin S, Recio A, Aqui NA, Powell DJ Jr, et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med (2012) 4:134ra162. doi:10.1126/scitranslmed.3003330
    • (2012) Sci Transl Med , vol.4 , pp. 134ra162
    • Rech, A.J.1    Mick, R.2    Martin, S.3    Recio, A.4    Aqui, N.A.5    Powell, D.J.6
  • 77
    • 84919628870 scopus 로고    scopus 로고
    • In vivo maintenance of human regulatory T cells during CD25 blockade
    • Huss DJ, Mehta DS, Sharma A, You X, Riester KA, Sheridan JP, et al. In vivo maintenance of human regulatory T cells during CD25 blockade. J Immunol (2014) 194:84-92. doi:10.4049/jimmunol.1402140
    • (2014) J Immunol , vol.194 , pp. 84-92
    • Huss, D.J.1    Mehta, D.S.2    Sharma, A.3    You, X.4    Riester, K.A.5    Sheridan, J.P.6
  • 78
    • 84904977285 scopus 로고    scopus 로고
    • The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients
    • Bouvy AP, Klepper M, Kho MM, Boer K, Betjes MG, Weimar W, et al. The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients. Nephrol Dial Transplant (2014) 29:1587-97. doi:10.1093/ndt/gfu079
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 1587-1597
    • Bouvy, A.P.1    Klepper, M.2    Kho, M.M.3    Boer, K.4    Betjes, M.G.5    Weimar, W.6
  • 79
    • 44449104907 scopus 로고    scopus 로고
    • The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33
    • Palmer G, Lipsky BP, Smithgall MD, Meininger D, Siu S, Talabot-Ayer D, et al. The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33. Cytokine (2008) 42:358-64. doi:10.1016/j.cyto.2008.03.008
    • (2008) Cytokine , vol.42 , pp. 358-364
    • Palmer, G.1    Lipsky, B.P.2    Smithgall, M.D.3    Meininger, D.4    Siu, S.5    Talabot-Ayer, D.6
  • 80
    • 84864145383 scopus 로고    scopus 로고
    • Interleukin-33 and the function of innate lymphoid cells
    • Mirchandani AS, Salmond RJ, Liew FY. Interleukin-33 and the function of innate lymphoid cells. Trends Immunol (2012) 33:389-96. doi:10.1016/j.it.2012.04.005
    • (2012) Trends Immunol , vol.33 , pp. 389-396
    • Mirchandani, A.S.1    Salmond, R.J.2    Liew, F.Y.3
  • 82
    • 80555126115 scopus 로고    scopus 로고
    • IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival
    • Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, et al. IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol (2011) 187:4598-610. doi:10.4049/jimmunol.1100519
    • (2011) J Immunol , vol.187 , pp. 4598-4610
    • Turnquist, H.R.1    Zhao, Z.2    Rosborough, B.R.3    Liu, Q.4    Castellaneta, A.5    Isse, K.6
  • 83
    • 84870527455 scopus 로고    scopus 로고
    • Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3(+) regulatory T-cell responses in mice
    • Duan L, Chen J, Zhang H, Yang H, Zhu P, Xiong A, et al. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3(+) regulatory T-cell responses in mice. Mol Med (2012) 18:753-61. doi:10.2119/molmed.2011.00428
    • (2012) Mol Med , vol.18 , pp. 753-761
    • Duan, L.1    Chen, J.2    Zhang, H.3    Yang, H.4    Zhu, P.5    Xiong, A.6
  • 84
    • 84907569702 scopus 로고    scopus 로고
    • IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells
    • Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, et al. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol (2014) 193:4010-20. doi:10.4049/jimmunol.1400481
    • (2014) J Immunol , vol.193 , pp. 4010-4020
    • Matta, B.M.1    Lott, J.M.2    Mathews, L.R.3    Liu, Q.4    Rosborough, B.R.5    Blazar, B.R.6
  • 86
    • 41549160626 scopus 로고    scopus 로고
    • Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    • Izcue A, Hue S, Buonocore S, Arancibia-Cárcamo CV, Ahern PP, Iwakura Y, et al. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 28:559-70. doi:10.1016/j.immuni.2008.02.019
    • (2008) Immunity , vol.28 , pp. 559-570
    • Izcue, A.1    Hue, S.2    Buonocore, S.3    Arancibia-Cárcamo, C.V.4    Ahern, P.P.5    Iwakura, Y.6
  • 87
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on T cells
    • Ahern PP, Schiering C, Buonocore S, McGeachy MJ, Cua DJ, Maloy KJ, et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 33:279-88. doi:10.1016/j.immuni.2010.08.010
    • (2010) Immunity , vol.33 , pp. 279-288
    • Ahern, P.P.1    Schiering, C.2    Buonocore, S.3    McGeachy, M.J.4    Cua, D.J.5    Maloy, K.J.6
  • 88
    • 79958086613 scopus 로고    scopus 로고
    • Interleukin-33 biology with potential insights into human diseases
    • Palmer G, Gabay C. Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol (2011) 7:321-9. doi:10.1038/nrrheum.2011.53
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 321-329
    • Palmer, G.1    Gabay, C.2
  • 89
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
    • Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 19:322-8. doi:10.1038/nm.3085
    • (2013) Nat Med , vol.19 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3    Guo, T.B.4    He, D.5    Fang, L.6
  • 91
    • 45349102912 scopus 로고    scopus 로고
    • Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha
    • Wang J, Van Dongen H, Scherer HU, Huizinga TWJ, Toes REM. Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha. Arthritis Rheum (2008) 58:1609-18. doi:10.1002/art.23460
    • (2008) Arthritis Rheum , vol.58 , pp. 1609-1618
    • Wang, J.1    Van Dongen, H.2    Scherer, H.U.3    Huizinga, T.W.J.4    Toes, R.E.M.5
  • 92
    • 84875708261 scopus 로고    scopus 로고
    • TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway
    • Zhang Q, Cui F, Fang L, Hong J, Zheng B, Zhang JZ. TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway. J Mol Cell Biol (2013) 5:85-98. doi:10.1093/jmcb/mjs063
    • (2013) J Mol Cell Biol , vol.5 , pp. 85-98
    • Zhang, Q.1    Cui, F.2    Fang, L.3    Hong, J.4    Zheng, B.5    Zhang, J.Z.6
  • 93
    • 34250864955 scopus 로고    scopus 로고
    • Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    • Chen X, Baumel M, Mannel DN, Howard OM, Oppenheim JJ. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol (2007) 179:154-61. doi:10.4049/jimmunol.179.1.154
    • (2007) J Immunol , vol.179 , pp. 154-161
    • Chen, X.1    Baumel, M.2    Mannel, D.N.3    Howard, O.M.4    Oppenheim, J.J.5
  • 94
    • 84926109500 scopus 로고    scopus 로고
    • TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells
    • Chen X, Oppenheim JJ. TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells. Curr Dir Autoimmun (2010) 11:119-34. doi:10.1159/000289201
    • (2010) Curr Dir Autoimmun , vol.11 , pp. 119-134
    • Chen, X.1    Oppenheim, J.J.2
  • 95
    • 0141750423 scopus 로고    scopus 로고
    • The biology of TNF blockade
    • Suryaprasad AG, Prindiville T. The biology of TNF blockade. Autoimmun Rev (2003) 2:346-57. doi:10.1016/S1568-9972(03)00048-X
    • (2003) Autoimmun Rev , vol.2 , pp. 346-357
    • Suryaprasad, A.G.1    Prindiville, T.2
  • 97
    • 75749129902 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells
    • Ma HL, Napierata L, Stedman N, Benoit S, Collins M, Nickerson-Nutter C, et al. Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. Arthritis Rheum (2010) 62:430-40. doi:10.1002/art.27203
    • (2010) Arthritis Rheum , vol.62 , pp. 430-440
    • Ma, H.L.1    Napierata, L.2    Stedman, N.3    Benoit, S.4    Collins, M.5    Nickerson-Nutter, C.6
  • 98
    • 84897944747 scopus 로고    scopus 로고
    • Lineage stability and phenotypic plasticity of Foxp3(+) regulatory T cells
    • Hori S. Lineage stability and phenotypic plasticity of Foxp3(+) regulatory T cells. Immunol Rev (2014) 259:159-72. doi:10.1111/imr.12175
    • (2014) Immunol Rev , vol.259 , pp. 159-172
    • Hori, S.1
  • 99
    • 84897946867 scopus 로고    scopus 로고
    • Once a Treg, always a Treg?
    • Sawant DV, Vignali DA. Once a Treg, always a Treg? Immunol Rev (2014) 259:173-91. doi:10.1111/imr.12173
    • (2014) Immunol Rev , vol.259 , pp. 173-191
    • Sawant, D.V.1    Vignali, D.A.2
  • 100
    • 84861039642 scopus 로고    scopus 로고
    • Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
    • Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood (2012) 119:4430-40. doi:10.1182/blood-2011-11-392324
    • (2012) Blood , vol.119 , pp. 4430-4440
    • Duhen, T.1    Duhen, R.2    Lanzavecchia, A.3    Sallusto, F.4    Campbell, D.J.5
  • 101
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-
    • Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-. J Immunol (2007) 178:6725-9. doi:10.4049/jimmunol.178.11.6725
    • (2007) J Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 102
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJPM, Smeets RL, Vink PM, Van Rijssen E, Boots AMH, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood (2008) 112:2340-52. doi:10.1182/blood-2008-01-133967
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.P.M.1    Smeets, R.L.2    Vink, P.M.3    Van Rijssen, E.4    Boots, A.M.H.5    Joosten, I.6
  • 103
    • 65549088243 scopus 로고    scopus 로고
    • IL-17-producing human peripheral regulatory T cells retain suppressive function
    • Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood (2009) 113:4240-9. doi:10.1182/blood-2008-10-183251
    • (2009) Blood , vol.113 , pp. 4240-4249
    • Beriou, G.1    Costantino, C.M.2    Ashley, C.W.3    Yang, L.4    Kuchroo, V.K.5    Baecher-Allan, C.6
  • 104
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 326:986-91. doi:10.1126/science.1172702
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 105
    • 64149086421 scopus 로고    scopus 로고
    • IL-1beta and IL-2 convert human Treg into T(H)17 cells
    • Deknuydt F, Bioley G, Valmori D, Ayyoub M. IL-1beta and IL-2 convert human Treg into T(H)17 cells. Clin Immunol (2009) 131:298-307. doi:10.1016/j.clim.2008.12.008
    • (2009) Clin Immunol , vol.131 , pp. 298-307
    • Deknuydt, F.1    Bioley, G.2    Valmori, D.3    Ayyoub, M.4
  • 106
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard GS, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 10:595-602. doi:10.1038/ni.1731
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.S.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 108
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y, Chaudhry A, Kas A, Deroos P, Kim JM, Chu TT, et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 458:351-6. doi:10.1038/nature07674
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    Deroos, P.4    Kim, J.M.5    Chu, T.T.6
  • 109
    • 79958130907 scopus 로고    scopus 로고
    • Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis
    • Feng T, Cao AT, Weaver CT, Elson CO, Cong Y. Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis. Gastroenterology (2011) 140:2031-43. doi:10.1053/j.gastro.2011.03.009
    • (2011) Gastroenterology , vol.140 , pp. 2031-2043
    • Feng, T.1    Cao, A.T.2    Weaver, C.T.3    Elson, C.O.4    Cong, Y.5
  • 110
    • 84866483591 scopus 로고    scopus 로고
    • The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
    • Hall AOHH, Beiting DP, Tato CM, John B, Lombana CG, Pritchard GH, et al. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 37:511-23. doi:10.1016/j.immuni.2012.06.014
    • (2012) Immunity , vol.37 , pp. 511-523
    • Hall, A.O.H.H.1    Beiting, D.P.2    Tato, C.M.3    John, B.4    Lombana, C.G.5    Pritchard, G.H.6
  • 111
    • 84866183753 scopus 로고    scopus 로고
    • IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease
    • Koenecke C, Lee C-W, Thamm K, Föhse L, Schafferus M, Mittrücker H-W, et al. IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol (2012) 189:2890-6. doi:10.4049/jimmunol.1200413
    • (2012) J Immunol , vol.189 , pp. 2890-2896
    • Koenecke, C.1    Lee, C.-W.2    Thamm, K.3    Föhse, L.4    Schafferus, M.5    Mittrücker, H.-W.6
  • 112
    • 84881527926 scopus 로고    scopus 로고
    • CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner
    • Afzali B, Mitchell PJ, Edozie FC, Povoleri GAM, Dowson SE, Demandt L, et al. CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Eur J Immunol (2013) 43:2043-54. doi:10.1002/eji.201243296
    • (2013) Eur J Immunol , vol.43 , pp. 2043-2054
    • Afzali, B.1    Mitchell, P.J.2    Edozie, F.C.3    Povoleri, G.A.M.4    Dowson, S.E.5    Demandt, L.6
  • 113
    • 84874608992 scopus 로고    scopus 로고
    • Control of inflammation by integration of environmental cues by regulatory T cells
    • Chaudhry A, Rudensky AY. Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest (2013) 123:939-44. doi:10.1172/JCI57175
    • (2013) J Clin Invest , vol.123 , pp. 939-944
    • Chaudhry, A.1    Rudensky, A.Y.2
  • 114
    • 84877275454 scopus 로고    scopus 로고
    • CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines
    • Pesenacker AM, Bending D, Ursu S, Wu Q, Nistala K, Wedderburn LR. CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines. Blood (2013) 121:2647-58. doi:10.1182/blood-2012-08-443473
    • (2013) Blood , vol.121 , pp. 2647-2658
    • Pesenacker, A.M.1    Bending, D.2    Ursu, S.3    Wu, Q.4    Nistala, K.5    Wedderburn, L.R.6
  • 115
    • 79958134797 scopus 로고    scopus 로고
    • Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease
    • Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med (2011) 17:673-5. doi:10.1038/nm.2389
    • (2011) Nat Med , vol.17 , pp. 673-675
    • Dominguez-Villar, M.1    Baecher-Allan, C.M.2    Hafler, D.A.3
  • 116
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol (2011) 186:3918-26. doi:10.4049/jimmunol.1003099
    • (2011) J Immunol , vol.186 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3    Esensten, J.H.4    Liu, W.5    Hulme, M.A.6
  • 117
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G, Bouladoux N, Wohlfert EA, Hall JA, Chou D, Dos Santos L, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity (2009) 31:772-86. doi:10.1016/j.immuni.2009.10.001
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1    Bouladoux, N.2    Wohlfert, E.A.3    Hall, J.A.4    Chou, D.5    Dos Santos, L.6
  • 118
    • 79955040909 scopus 로고    scopus 로고
    • IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer
    • Kryczek I, Wu K, Zhao E, Wei S, Vatan L, Szeliga W, et al. IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol (2011) 186:4388-95. doi:10.4049/jimmunol.1003251
    • (2011) J Immunol , vol.186 , pp. 4388-4395
    • Kryczek, I.1    Wu, K.2    Zhao, E.3    Wei, S.4    Vatan, L.5    Szeliga, W.6
  • 119
    • 84895855564 scopus 로고    scopus 로고
    • T regulatory cells in childhood arthritis-novel insights
    • Pesenacker AM, Wedderburn LR. T regulatory cells in childhood arthritis-novel insights. Expert Rev Mol Med (2013) 15:e13-13. doi:10.1017/erm.2013.14
    • (2013) Expert Rev Mol Med , vol.15 , pp. e13
    • Pesenacker, A.M.1    Wedderburn, L.R.2
  • 120
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-Hora M, Kodama T, et al. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med (2014) 20:62-8. doi:10.1038/nm.3432
    • (2014) Nat Med , vol.20 , pp. 62-68
    • Komatsu, N.1    Okamoto, K.2    Sawa, S.3    Nakashima, T.4    Oh-Hora, M.5    Kodama, T.6
  • 122
    • 51049123438 scopus 로고    scopus 로고
    • The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation
    • Chen N, Onisko B, Napoli JL. The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation. J Biol Chem (2008) 283:20841-7. doi:10.1074/jbc.M802314200
    • (2008) J Biol Chem , vol.283 , pp. 20841-20847
    • Chen, N.1    Onisko, B.2    Napoli, J.L.3
  • 123
    • 84897553364 scopus 로고    scopus 로고
    • Modulation of T cell and innate immune responses by retinoic Acid
    • Raverdeau M, Mills KH. Modulation of T cell and innate immune responses by retinoic Acid. J Immunol (2014) 192:2953-8. doi:10.4049/jimmunol.1303245
    • (2014) J Immunol , vol.192 , pp. 2953-2958
    • Raverdeau, M.1    Mills, K.H.2
  • 124
    • 51349095960 scopus 로고    scopus 로고
    • Tuning microenvironments: induction of regulatory T cells by dendritic cells
    • Belkaid Y, Oldenhove G. Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity (2008) 29:362-71. doi:10.1016/j.immuni.2008.08.005
    • (2008) Immunity , vol.29 , pp. 362-371
    • Belkaid, Y.1    Oldenhove, G.2
  • 125
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson E, Uronen-Hansson H, Pabst O, Eksteen B, Tian J, Coombes JL, et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med (2008) 205:2139-49. doi:10.1084/jem.20080414
    • (2008) J Exp Med , vol.205 , pp. 2139-2149
    • Jaensson, E.1    Uronen-Hansson, H.2    Pabst, O.3    Eksteen, B.4    Tian, J.5    Coombes, J.L.6
  • 126
    • 84885448793 scopus 로고    scopus 로고
    • Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells
    • Klebanoff CA, Spencer SP, Torabi-Parizi P, Grainger JR, Roychoudhuri R, Ji Y, et al. Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med (2013) 210:1961-76. doi:10.1084/jem.20122508
    • (2013) J Exp Med , vol.210 , pp. 1961-1976
    • Klebanoff, C.A.1    Spencer, S.P.2    Torabi-Parizi, P.3    Grainger, J.R.4    Roychoudhuri, R.5    Ji, Y.6
  • 127
  • 128
    • 84906308941 scopus 로고    scopus 로고
    • Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions
    • Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, et al. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A (2014) 111:E3432-40. doi:10.1073/pnas.1408780111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E3432-E3440
    • Lu, L.1    Lan, Q.2    Li, Z.3    Zhou, X.4    Gu, J.5    Li, Q.6
  • 129
    • 84926407089 scopus 로고    scopus 로고
    • Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2
    • Holder BS, Grant CR, Liberal R, Ma Y, Heneghan MA, Mieli-Vergani G, et al. Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2. J Autoimmun (2014) 53:26-32. doi:10.1016/j.jaut.2014.02.001
    • (2014) J Autoimmun , vol.53 , pp. 26-32
    • Holder, B.S.1    Grant, C.R.2    Liberal, R.3    Ma, Y.4    Heneghan, M.A.5    Mieli-Vergani, G.6
  • 130
    • 84908271093 scopus 로고    scopus 로고
    • All-trans retinoic acid attenuates experimental colitis through inhibition of NF-kappaB signaling
    • Hong K, Zhang Y, Guo Y, Xie J, Wang J, He X, et al. All-trans retinoic acid attenuates experimental colitis through inhibition of NF-kappaB signaling. Immunol Lett (2014) 162:34-40. doi:10.1016/j.imlet.2014.06.011
    • (2014) Immunol Lett , vol.162 , pp. 34-40
    • Hong, K.1    Zhang, Y.2    Guo, Y.3    Xie, J.4    Wang, J.5    He, X.6
  • 131
    • 84901477903 scopus 로고    scopus 로고
    • Oral administration of all-trans retinoic acid suppresses experimental periodontitis by modulating the Th17/Treg imbalance
    • Wang L, Wang J, Jin Y, Gao H, Lin X. Oral administration of all-trans retinoic acid suppresses experimental periodontitis by modulating the Th17/Treg imbalance. J Periodontol (2014) 85:740-50. doi:10.1902/jop.2013.130132
    • (2014) J Periodontol , vol.85 , pp. 740-750
    • Wang, L.1    Wang, J.2    Jin, Y.3    Gao, H.4    Lin, X.5
  • 132
    • 77949873898 scopus 로고    scopus 로고
    • Vitamin D controls T cell antigen receptor signaling and activation of human T cells
    • von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol (2010) 11:344-9. doi:10.1038/ni.1851
    • (2010) Nat Immunol , vol.11 , pp. 344-349
    • von Essen, M.R.1    Kongsbak, M.2    Schjerling, P.3    Olgaard, K.4    Odum, N.5    Geisler, C.6
  • 133
    • 80052387833 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    • Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, et al. 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 31:3653-69. doi:10.1128/MCB.05020-11
    • (2011) Mol Cell Biol , vol.31 , pp. 3653-3669
    • Joshi, S.1    Pantalena, L.C.2    Liu, X.K.3    Gaffen, S.L.4    Liu, H.5    Rohowsky-Kochan, C.6
  • 134
    • 84867202982 scopus 로고    scopus 로고
    • The role of 1alpha,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells
    • Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabrysova L, et al. The role of 1alpha,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol (2012) 42:2697-708. doi:10.1002/eji.201242370
    • (2012) Eur J Immunol , vol.42 , pp. 2697-2708
    • Urry, Z.1    Chambers, E.S.2    Xystrakis, E.3    Dimeloe, S.4    Richards, D.F.5    Gabrysova, L.6
  • 135
    • 84926621134 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from Type 1 diabetes patients
    • Van Belle TL, Vanherwegen AS, Feyaerts D, De Clercq P, Verstuyf A, Korf H, et al. 1,25-dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from Type 1 diabetes patients. PLoS One (2014) 9:e109194. doi:10.1371/journal.pone.0109194
    • (2014) PLoS One , vol.9
    • Van Belle, T.L.1    Vanherwegen, A.S.2    Feyaerts, D.3    De Clercq, P.4    Verstuyf, A.5    Korf, H.6
  • 136
    • 84904865500 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D3 in combination with transforming growth factor-beta increases the frequency of Foxp3(+) regulatory T cells through preferential expansion and usage of interleukin-2
    • Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, et al. 1alpha,25-dihydroxyvitamin D3 in combination with transforming growth factor-beta increases the frequency of Foxp3(+) regulatory T cells through preferential expansion and usage of interleukin-2. Immunology (2014) 143:52-60. doi:10.1111/imm.12289
    • (2014) Immunology , vol.143 , pp. 52-60
    • Chambers, E.S.1    Suwannasaen, D.2    Mann, E.H.3    Urry, Z.4    Richards, D.F.5    Lertmemongkolchai, G.6
  • 137
    • 84902137423 scopus 로고    scopus 로고
    • Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1alpha, 25-dihydroxyvitamin D3
    • Urry ZL, Richards DF, Black C, Morales M, Carnes J, Hawrylowicz CM, et al. Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1alpha, 25-dihydroxyvitamin D3. BMC Immunol (2014) 15:21. doi:10.1186/1471-2172-15-21
    • (2014) BMC Immunol , vol.15 , pp. 21
    • Urry, Z.L.1    Richards, D.F.2    Black, C.3    Morales, M.4    Carnes, J.5    Hawrylowicz, C.M.6
  • 138
    • 84902206179 scopus 로고    scopus 로고
    • Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity
    • Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, et al. Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol (2014) 75:739-58. doi:10.1002/ana.24165
    • (2014) Ann Neurol , vol.75 , pp. 739-758
    • Breuer, J.1    Schwab, N.2    Schneider-Hohendorf, T.3    Marziniak, M.4    Mohan, H.5    Bhatia, U.6
  • 139
    • 33744826596 scopus 로고    scopus 로고
    • Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease
    • Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol (2006) 92:60-4. doi:10.1016/j.pbiomolbio.2006.02.020
    • (2006) Prog Biophys Mol Biol , vol.92 , pp. 60-64
    • Cantorna, M.T.1
  • 140
    • 84875221558 scopus 로고    scopus 로고
    • The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude
    • Dobson R, Giovannoni G, Ramagopalan S. The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude. J Neurol Neurosurg Psychiatry (2013) 84:427-32. doi:10.1136/jnnp-2012-303934
    • (2013) J Neurol Neurosurg Psychiatry , vol.84 , pp. 427-432
    • Dobson, R.1    Giovannoni, G.2    Ramagopalan, S.3
  • 141
    • 84890560881 scopus 로고    scopus 로고
    • Review article: vitamin D and inflammatory bowel diseases
    • Mouli VP, Ananthakrishnan AN. Review article: vitamin D and inflammatory bowel diseases. Aliment Pharmacol Ther (2014) 39:125-36. doi:10.1111/apt.12553
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 125-136
    • Mouli, V.P.1    Ananthakrishnan, A.N.2
  • 142
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature (2008) 453:65-71. doi:10.1038/nature06880
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1    Basso, A.S.2    Iglesias, A.H.3    Korn, T.4    Farez, M.F.5    Bettelli, E.6
  • 143
    • 77955859470 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    • Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol (2010) 11:846-53. doi:10.1038/ni.1915
    • (2010) Nat Immunol , vol.11 , pp. 846-853
    • Gandhi, R.1    Kumar, D.2    Burns, E.J.3    Nadeau, M.4    Dake, B.5    Laroni, A.6
  • 144
    • 84893938271 scopus 로고    scopus 로고
    • Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo
    • Duarte JH, Di Meglio P, Hirota K, Ahlfors H, Stockinger B. Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS One (2013) 8:e79819. doi:10.1371/journal.pone.0079819
    • (2013) PLoS One , vol.8
    • Duarte, J.H.1    Di Meglio, P.2    Hirota, K.3    Ahlfors, H.4    Stockinger, B.5
  • 145
    • 70149101645 scopus 로고    scopus 로고
    • IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
    • Baban B, Chandler PR, Sharma MD, Pihkala J, Koni PA, Munn DH, et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol (2009) 183:2475-83. doi:10.4049/jimmunol.0900986
    • (2009) J Immunol , vol.183 , pp. 2475-2483
    • Baban, B.1    Chandler, P.R.2    Sharma, M.D.3    Pihkala, J.4    Koni, P.A.5    Munn, D.H.6
  • 146
    • 78650673114 scopus 로고    scopus 로고
    • IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis
    • Yan Y, Zhang GX, Gran B, Fallarino F, Yu S, Li H, et al. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol (2010) 185:5953-61. doi:10.4049/jimmunol.1001628
    • (2010) J Immunol , vol.185 , pp. 5953-5961
    • Yan, Y.1    Zhang, G.X.2    Gran, B.3    Fallarino, F.4    Yu, S.5    Li, H.6
  • 147
    • 84888027907 scopus 로고    scopus 로고
    • IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells
    • Curran TA, Jalili RB, Farrokhi A, Ghahary A. IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells. Immunobiology (2014) 219:17-24. doi:10.1016/j.imbio.2013.06.008
    • (2014) Immunobiology , vol.219 , pp. 17-24
    • Curran, T.A.1    Jalili, R.B.2    Farrokhi, A.3    Ghahary, A.4
  • 148
    • 84874690840 scopus 로고    scopus 로고
    • Possible role of the 'IDO-AhR axis' in maternal-foetal tolerance
    • Hao K, Zhou Q, Chen W, Jia W, Zheng J, Kang J, et al. Possible role of the 'IDO-AhR axis' in maternal-foetal tolerance. Cell Biol Int (2013) 37:105-8. doi:10.1002/cbin.10023
    • (2013) Cell Biol Int , vol.37 , pp. 105-108
    • Hao, K.1    Zhou, Q.2    Chen, W.3    Jia, W.4    Zheng, J.5    Kang, J.6
  • 149
    • 1542287265 scopus 로고    scopus 로고
    • Regulatory T cells mediate maternal tolerance to the fetus
    • Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol (2004) 5:266-71. doi:10.1038/ni1037
    • (2004) Nat Immunol , vol.5 , pp. 266-271
    • Aluvihare, V.R.1    Kallikourdis, M.2    Betz, A.G.3
  • 150
    • 84896825131 scopus 로고    scopus 로고
    • Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production
    • Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, et al. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One (2014) 9:e87877. doi:10.1371/journal.pone.0087877
    • (2014) PLoS One , vol.9
    • Lowe, M.M.1    Mold, J.E.2    Kanwar, B.3    Huang, Y.4    Louie, A.5    Pollastri, M.P.6
  • 151
    • 84896775261 scopus 로고    scopus 로고
    • Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice
    • Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, et al. Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice. Neuropharmacology (2014) 81:237-43. doi:10.1016/j.neuropharm.2014.02.011
    • (2014) Neuropharmacology , vol.81 , pp. 237-243
    • Fazio, F.1    Zappulla, C.2    Notartomaso, S.3    Busceti, C.4    Bessede, A.5    Scarselli, P.6
  • 152
    • 84879326975 scopus 로고    scopus 로고
    • Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells
    • Rouse M, Singh NP, Nagarkatti PS, Nagarkatti M. Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells. Br J Pharmacol (2013) 169:1305-21. doi:10.1111/bph.12205
    • (2013) Br J Pharmacol , vol.169 , pp. 1305-1321
    • Rouse, M.1    Singh, N.P.2    Nagarkatti, P.S.3    Nagarkatti, M.4
  • 153
    • 84912107546 scopus 로고    scopus 로고
    • 3, 3'-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance
    • Liu Y, She W, Wang F, Li J, Wang J, Jiang W. 3, 3'-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. Int Immunopharmacol (2014) 23:489-98. doi:10.1016/j.intimp.2014.09.024
    • (2014) Int Immunopharmacol , vol.23 , pp. 489-498
    • Liu, Y.1    She, W.2    Wang, F.3    Li, J.4    Wang, J.5    Jiang, W.6
  • 154
    • 84896776715 scopus 로고    scopus 로고
    • Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease
    • Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One (2014) 9:e88726. doi:10.1371/journal.pone.0088726
    • (2014) PLoS One , vol.9
    • Punj, S.1    Kopparapu, P.2    Jang, H.S.3    Phillips, J.L.4    Pennington, J.5    Rohlman, D.6
  • 155
    • 84896542936 scopus 로고    scopus 로고
    • Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
    • Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev (2014) 13:668-77. doi:10.1016/j.autrev.2013.12.004
    • (2014) Autoimmun Rev , vol.13 , pp. 668-677
    • Noack, M.1    Miossec, P.2
  • 156
    • 41949083203 scopus 로고    scopus 로고
    • Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade
    • Yegutkin GG. Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophys Acta (2008) 1783:673-94. doi:10.1016/j.bbamcr.2008.01.024
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 673-694
    • Yegutkin, G.G.1
  • 157
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther (2006) 112:358-404. doi:10.1016/j.pharmthera.2005.04.013
    • (2006) Pharmacol Ther , vol.112 , pp. 358-404
    • Bours, M.J.1    Swennen, E.L.2    Di Virgilio, F.3    Cronstein, B.N.4    Dagnelie, P.C.5
  • 158
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 204:1257-65. doi:10.1084/jem.20062512
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6
  • 159
    • 84903936227 scopus 로고    scopus 로고
    • Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells
    • Schuler PJ, Saze Z, Hong CS, Muller L, Gillespie DG, Cheng D, et al. Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells. Clin Exp Immunol (2014) 177:531-43. doi:10.1111/cei.12354
    • (2014) Clin Exp Immunol , vol.177 , pp. 531-543
    • Schuler, P.J.1    Saze, Z.2    Hong, C.S.3    Muller, L.4    Gillespie, D.G.5    Cheng, D.6
  • 160
    • 0036102125 scopus 로고    scopus 로고
    • CD39 is the dominant Langerhans cell associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness
    • Mizumoto N, Kumamoto T, Robson SC, Sevigny J, Matsue H, Enjyoji K, et al. CD39 is the dominant Langerhans cell associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 8:358-65. doi:10.1038/nm0402-358
    • (2002) Nat Med , vol.8 , pp. 358-365
    • Mizumoto, N.1    Kumamoto, T.2    Robson, S.C.3    Sevigny, J.4    Matsue, H.5    Enjyoji, K.6
  • 161
    • 25844523991 scopus 로고    scopus 로고
    • Cell-surface enzymes in control of leukocyte trafficking
    • Salmi M, Jalkanen S. Cell-surface enzymes in control of leukocyte trafficking. Nat Rev Immunol (2005) 5:760-71. doi:10.1038/nri1705
    • (2005) Nat Rev Immunol , vol.5 , pp. 760-771
    • Salmi, M.1    Jalkanen, S.2
  • 162
    • 57649131049 scopus 로고    scopus 로고
    • Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine
    • Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, et al. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem (2008) 283:28480-6. doi:10.1074/jbc.M800039200
    • (2008) J Biol Chem , vol.283 , pp. 28480-28486
    • Corriden, R.1    Chen, Y.2    Inoue, Y.3    Beldi, G.4    Robson, S.C.5    Insel, P.A.6
  • 163
    • 84908340275 scopus 로고    scopus 로고
    • A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation
    • Wang Y, Begum-Haque S, Telesford KM, Ochoa-Reparaz J, Christy M, Kasper EJ, et al. A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation. Gut Microbes (2014) 5:552-61. doi:10.4161/gmic.29797
    • (2014) Gut Microbes , vol.5 , pp. 552-561
    • Wang, Y.1    Begum-Haque, S.2    Telesford, K.M.3    Ochoa-Reparaz, J.4    Christy, M.5    Kasper, E.J.6
  • 164
    • 0034327277 scopus 로고    scopus 로고
    • Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function
    • Narravula S, Lennon PF, Mueller BU, Colgan SP. Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J Immunol (2000) 165:5262-8. doi:10.4049/jimmunol.165.9.5262
    • (2000) J Immunol , vol.165 , pp. 5262-5268
    • Narravula, S.1    Lennon, P.F.2    Mueller, B.U.3    Colgan, S.P.4
  • 165
    • 84871299189 scopus 로고    scopus 로고
    • The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
    • Ohta A, Kini R, Ohta A, Subramanian M, Madasu M, Sitkovsky M. The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway. Front Immunol (2012) 3:190. doi:10.3389/fimmu.2012.00190
    • (2012) Front Immunol , vol.3 , pp. 190
    • Ohta, A.1    Kini, R.2    Ohta, A.3    Subramanian, M.4    Madasu, M.5    Sitkovsky, M.6
  • 166
    • 34250376423 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    • Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med (2007) 204:1303-10. doi:10.1084/jem.20062129
    • (2007) J Exp Med , vol.204 , pp. 1303-1310
    • Bopp, T.1    Becker, C.2    Klein, M.3    Klein-Hessling, S.4    Palmetshofer, A.5    Serfling, E.6
  • 167
    • 64249083235 scopus 로고    scopus 로고
    • Inhibition of cAMP degradation improves regulatory T cell-mediated suppression
    • Bopp T, Dehzad N, Reuter S, Klein M, Ullrich N, Stassen M, et al. Inhibition of cAMP degradation improves regulatory T cell-mediated suppression. J Immunol (2009) 182:4017-24. doi:10.4049/jimmunol.0803310
    • (2009) J Immunol , vol.182 , pp. 4017-4024
    • Bopp, T.1    Dehzad, N.2    Reuter, S.3    Klein, M.4    Ullrich, N.5    Stassen, M.6
  • 168
    • 84856574460 scopus 로고    scopus 로고
    • Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells
    • Klein M, Vaeth M, Scheel T, Grabbe S, Baumgrass R, Berberich-Siebelt F, et al. Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells. J Immunol (2012) 188:1091-7. doi:10.4049/jimmunol.1102045
    • (2012) J Immunol , vol.188 , pp. 1091-1097
    • Klein, M.1    Vaeth, M.2    Scheel, T.3    Grabbe, S.4    Baumgrass, R.5    Berberich-Siebelt, F.6
  • 169
    • 77957019251 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation
    • Fassbender M, Gerlitzki B, Ullrich N, Lupp C, Klein M, Radsak MP, et al. Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell Immunol (2010) 265:91-6. doi:10.1016/j.cellimm.2010.07.007
    • (2010) Cell Immunol , vol.265 , pp. 91-96
    • Fassbender, M.1    Gerlitzki, B.2    Ullrich, N.3    Lupp, C.4    Klein, M.5    Radsak, M.P.6
  • 170
    • 84862143798 scopus 로고    scopus 로고
    • Cyclic AMP underpins suppression by regulatory T cells
    • Bodor J, Bopp T, Vaeth M, Klein M, Serfling E, Hunig T, et al. Cyclic AMP underpins suppression by regulatory T cells. Eur J Immunol (2012) 42:1375-84. doi:10.1002/eji.201141578
    • (2012) Eur J Immunol , vol.42 , pp. 1375-1384
    • Bodor, J.1    Bopp, T.2    Vaeth, M.3    Klein, M.4    Serfling, E.5    Hunig, T.6
  • 171
    • 77951983618 scopus 로고    scopus 로고
    • cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression
    • Liao H, Hyman MC, Baek AE, Fukase K, Pinsky DJ. cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem (2010) 285:14791-805. doi:10.1074/jbc.M110.116905
    • (2010) J Biol Chem , vol.285 , pp. 14791-14805
    • Liao, H.1    Hyman, M.C.2    Baek, A.E.3    Fukase, K.4    Pinsky, D.J.5
  • 172
    • 84884344914 scopus 로고    scopus 로고
    • Cyclic AMP suppresses TGF-beta-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK
    • Cao J, Zhang X, Wang Q, Wang X, Jin J, Zhu T, et al. Cyclic AMP suppresses TGF-beta-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK. Cell Immunol (2013) 285:42-8. doi:10.1016/j.cellimm.2013.08.006
    • (2013) Cell Immunol , vol.285 , pp. 42-48
    • Cao, J.1    Zhang, X.2    Wang, Q.3    Wang, X.4    Jin, J.5    Zhu, T.6
  • 173
    • 70449707793 scopus 로고    scopus 로고
    • Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide
    • Pozo D, Anderson P, Gonzalez-Rey E. Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide. J Immunol (2009) 183:4346-59. doi:10.4049/jimmunol.0900400
    • (2009) J Immunol , vol.183 , pp. 4346-4359
    • Pozo, D.1    Anderson, P.2    Gonzalez-Rey, E.3
  • 174
    • 80051856839 scopus 로고    scopus 로고
    • The human gut microbiome: ecology and recent evolutionary changes
    • Walter J, Ley R. The human gut microbiome: ecology and recent evolutionary changes. Annu Rev Microbiol (2011) 65:411-29. doi:10.1146/annurev-micro-090110-102830
    • (2011) Annu Rev Microbiol , vol.65 , pp. 411-429
    • Walter, J.1    Ley, R.2
  • 175
    • 80054020840 scopus 로고    scopus 로고
    • Peripheral education of the immune system by colonic commensal microbiota
    • Lathrop SK, Bloom SM, Rao SM, Nutsch K, Lio CW, Santacruz N, et al. Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 478:250-4. doi:10.1038/nature10434
    • (2011) Nature , vol.478 , pp. 250-254
    • Lathrop, S.K.1    Bloom, S.M.2    Rao, S.M.3    Nutsch, K.4    Lio, C.W.5    Santacruz, N.6
  • 176
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2011) 331:337-41. doi:10.1126/science.1198469
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 177
    • 79956315886 scopus 로고    scopus 로고
    • Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    • Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity (2011) 34:794-806. doi:10.1016/j.immuni.2011.03.021
    • (2011) Immunity , vol.34 , pp. 794-806
    • Geuking, M.B.1    Cahenzli, J.2    Lawson, M.A.3    Ng, D.C.4    Slack, E.5    Hapfelmeier, S.6
  • 178
    • 84926650614 scopus 로고    scopus 로고
    • Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-beta and MyD88
    • 279736
    • Maria A, English KA, Gorham JD. Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-beta and MyD88. J Immunol Res (2014) 2014:279736. doi:10.1155/2014/279736
    • (2014) J Immunol Res , vol.2014
    • Maria, A.1    English, K.A.2    Gorham, J.D.3
  • 180
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia N, Campbell C, Fan X, Dikiy S, Van Der Veeken J, Deroos P, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature (2013) 504:451-5. doi:10.1038/nature12726
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3    Dikiy, S.4    Van Der Veeken, J.5    Deroos, P.6
  • 181
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature (2013) 504:446-50. doi:10.1038/nature12721
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3    Endo, T.A.4    Nakato, G.5    Takahashi, D.6
  • 182
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 341:569-73. doi:10.1126/science.1241165
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3    Michaud, M.4    Gallini, C.A.5    Bohlooly, Y.M.6
  • 183
    • 77955913743 scopus 로고    scopus 로고
    • A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
    • Ochoa-Reparaz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, et al. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol (2010) 3:487-95. doi:10.1038/mi.2010.29
    • (2010) Mucosal Immunol , vol.3 , pp. 487-495
    • Ochoa-Reparaz, J.1    Mielcarz, D.W.2    Wang, Y.3    Begum-Haque, S.4    Dasgupta, S.5    Kasper, D.L.6
  • 184
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 107:12204-9. doi:10.1073/pnas.0909122107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 186
    • 84868629743 scopus 로고    scopus 로고
    • Genomic insights into syntrophy: the paradigm for anaerobic metabolic cooperation
    • Sieber JR, McInerney MJ, Gunsalus RP. Genomic insights into syntrophy: the paradigm for anaerobic metabolic cooperation. Annu Rev Microbiol (2012) 66:429-52. doi:10.1146/annurev-micro-090110-102844
    • (2012) Annu Rev Microbiol , vol.66 , pp. 429-452
    • Sieber, J.R.1    McInerney, M.J.2    Gunsalus, R.P.3
  • 187
    • 0018718884 scopus 로고
    • The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine
    • Cummings JH, Hill MJ, Bone ES, Branch WJ, Jenkins DJ. The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine. Am J Clin Nutr (1979) 32:2094-101.
    • (1979) Am J Clin Nutr , vol.32 , pp. 2094-2101
    • Cummings, J.H.1    Hill, M.J.2    Bone, E.S.3    Branch, W.J.4    Jenkins, D.J.5
  • 188
    • 84908608590 scopus 로고    scopus 로고
    • The gut microbiota, bacterial metabolites and colorectal cancer
    • Louis P, Hold GL, Flint HJ. The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol (2014) 12:661-72. doi:10.1038/nrmicro3344
    • (2014) Nat Rev Microbiol , vol.12 , pp. 661-672
    • Louis, P.1    Hold, G.L.2    Flint, H.J.3
  • 190
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut (1987) 28:1221-7. doi:10.1136/gut.28.10.1221
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 191
    • 77957263331 scopus 로고    scopus 로고
    • Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation
    • Sleeth ML, Thompson EL, Ford HE, Zac-Varghese SE, Frost G. Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. Nutr Res Rev (2010) 23:135-45. doi:10.1017/S0954422410000089
    • (2010) Nutr Res Rev , vol.23 , pp. 135-145
    • Sleeth, M.L.1    Thompson, E.L.2    Ford, H.E.3    Zac-Varghese, S.E.4    Frost, G.5
  • 192
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity (2014) 40:128-39. doi:10.1016/j.immuni.2013.12.007
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1    Gurav, A.2    Sivaprakasam, S.3    Brady, E.4    Padia, R.5    Shi, H.6
  • 193
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature (2008) 453:620-5. doi:10.1038/nature07008
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 194
    • 79956311926 scopus 로고    scopus 로고
    • The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, et al. The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 332:974-7. doi:10.1126/science.1206095
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6
  • 195
    • 84904694854 scopus 로고    scopus 로고
    • An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling
    • Wang Y, Telesford KM, Ochoa-Reparaz J, Haque-Begum S, Christy M, Kasper EJ, et al. An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling. Nat Commun (2014) 5:4432. doi:10.1038/ncomms5432
    • (2014) Nat Commun , vol.5 , pp. 4432
    • Wang, Y.1    Telesford, K.M.2    Ochoa-Reparaz, J.3    Haque-Begum, S.4    Christy, M.5    Kasper, E.J.6
  • 196
    • 20044387585 scopus 로고    scopus 로고
    • Extensive DNA inversions in the B. fragilis genome control variable gene expression
    • Cerdeno-Tarraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, et al. Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science (2005) 307:1463-5. doi:10.1126/science.1107008
    • (2005) Science , vol.307 , pp. 1463-1465
    • Cerdeno-Tarraga, A.M.1    Patrick, S.2    Crossman, L.C.3    Blakely, G.4    Abratt, V.5    Lennard, N.6
  • 197
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 122:107-18. doi:10.1016/j.cell.2005.05.007
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 199
    • 84898647980 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
    • Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, Reinecker HC, Kasper DL. Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe (2014) 15:413-23. doi:10.1016/j.chom.2014.03.006
    • (2014) Cell Host Microbe , vol.15 , pp. 413-423
    • Dasgupta, S.1    Erturk-Hasdemir, D.2    Ochoa-Reparaz, J.3    Reinecker, H.C.4    Kasper, D.L.5
  • 200
    • 51249111466 scopus 로고    scopus 로고
    • The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
    • Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunol (2008) 125(2):145-53. doi:10.1111/j.1365-2567.2008.02939.x
    • (2008) Immunol , vol.125 , Issue.2 , pp. 145-153
    • Himmel, M.E.1    Hardenberg, G.2    Piccirillo, C.A.3    Steiner, T.S.4    Levings, M.K.5
  • 201
    • 33646487278 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells
    • Liu H, Komai-Koma M, Xu D, Liew FY. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 103:7048-53. doi:10.1073/pnas.0601554103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7048-7053
    • Liu, H.1    Komai-Koma, M.2    Xu, D.3    Liew, F.Y.4
  • 203
    • 77954503874 scopus 로고    scopus 로고
    • Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands
    • Oberg HH, Ly TT, Ussat S, Meyer T, Kabelitz D, Wesch D. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol (2010) 184:4733-40. doi:10.4049/jimmunol.0804279
    • (2010) J Immunol , vol.184 , pp. 4733-4740
    • Oberg, H.H.1    Ly, T.T.2    Ussat, S.3    Meyer, T.4    Kabelitz, D.5    Wesch, D.6
  • 204
    • 80052677833 scopus 로고    scopus 로고
    • TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function
    • Nyirenda MH, Sanvito L, Darlington PJ, O'brien K, Zhang GX, Constantinescu CS, et al. TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol (2011) 187:2278-90. doi:10.4049/jimmunol.1003715
    • (2011) J Immunol , vol.187 , pp. 2278-2290
    • Nyirenda, M.H.1    Sanvito, L.2    Darlington, P.J.3    O'brien, K.4    Zhang, G.X.5    Constantinescu, C.S.6
  • 205
    • 76649140863 scopus 로고    scopus 로고
    • Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
    • Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A (2010) 107:2159-64. doi:10.1073/pnas.0904055107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2159-2164
    • Kwon, H.K.1    Lee, C.G.2    So, J.S.3    Chae, C.S.4    Hwang, J.S.5    Sahoo, A.6
  • 207
    • 20444503737 scopus 로고    scopus 로고
    • Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    • Smits HH, Engering A, Van Der Kleij D, De Jong EC, Schipper K, Van Capel TM, et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol (2005) 115:1260-7. doi:10.1016/j.jaci.2005.03.036
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1260-1267
    • Smits, H.H.1    Engering, A.2    Van Der Kleij, D.3    De Jong, E.C.4    Schipper, K.5    Van Capel, T.M.6
  • 208
    • 84861125677 scopus 로고    scopus 로고
    • Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression
    • Lopez P, Gonzalez-Rodriguez I, Sanchez B, Ruas-Madiedo P, Suarez A, Margolles A, et al. Interaction of Bifidobacterium bifidum LMG13195 with HT29 cells influences regulatory-T-cell-associated chemokine receptor expression. Appl Environ Microbiol (2012) 78:2850-7. doi:10.1128/AEM.07581-11
    • (2012) Appl Environ Microbiol , vol.78 , pp. 2850-2857
    • Lopez, P.1    Gonzalez-Rodriguez, I.2    Sanchez, B.3    Ruas-Madiedo, P.4    Suarez, A.5    Margolles, A.6
  • 209
    • 84898943285 scopus 로고    scopus 로고
    • The immunomodulatory effect of probiotics beyond atopy: an update
    • Vitaliti G, Pavone P, Guglielmo F, Spataro G, Falsaperla R. The immunomodulatory effect of probiotics beyond atopy: an update. J Asthma (2014) 51:320-32. doi:10.3109/02770903.2013.862259
    • (2014) J Asthma , vol.51 , pp. 320-332
    • Vitaliti, G.1    Pavone, P.2    Guglielmo, F.3    Spataro, G.4    Falsaperla, R.5
  • 210
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood (2006) 108:1571-9. doi:10.1182/blood-2006-02-004747
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3    Porcheray, F.4    Kim, H.5    Litsa, D.6
  • 211
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 9:632-40. doi:10.1038/ni.1607
    • (2008) Nat Immunol , vol.9 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 212
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-to convert naive CD4+CD25-cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-to convert naive CD4+CD25-cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol (2007) 178:2018-27. doi:10.4049/jimmunol.178.4.2018
    • (2007) J Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 213
    • 79956085895 scopus 로고    scopus 로고
    • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    • Liao W, Lin J-X, Wang L, Li P, Leonard WJ. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 12:551-9. doi:10.1038/ni.2030
    • (2011) Nat Immunol , vol.12 , pp. 551-559
    • Liao, W.1    Lin, J.-X.2    Wang, L.3    Li, P.4    Leonard, W.J.5
  • 214
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei K-J, Li L, Marinos N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 198:1875-86. doi:10.1084/jem.20030152
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.-J.4    Li, L.5    Marinos, N.6
  • 215
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells
    • Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J Clin Invest (2003) 112:1437-43. doi:10.1172/JCI200319441
    • (2003) J Clin Invest , vol.112 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3    Benard, A.4    Van Landeghen, M.5    Buckner, J.H.6
  • 216
    • 36549005035 scopus 로고    scopus 로고
    • Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25-T cells
    • Amarnath S, Dong L, Li J, Wu Y, Chen W. Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25-T cells. Retrovirology (2007) 4:57-57. doi:10.1186/1742-4690-4-57
    • (2007) Retrovirology , vol.4 , pp. 57-57
    • Amarnath, S.1    Dong, L.2    Li, J.3    Wu, Y.4    Chen, W.5
  • 217
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio CW, Hsieh CS. A two-step process for thymic regulatory T cell development. Immunity (2008) 28:100-11. doi:10.1016/j.immuni.2007.11.021
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 218
    • 40049087686 scopus 로고    scopus 로고
    • STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25-effector T cells
    • Passerini L, Allan SE, Battaglia M, Di Nunzio S, Alstad AN, Levings MK, et al. STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25-effector T cells. Int Immunol (2008) 20:421-31. doi:10.1093/intimm/dxn002
    • (2008) Int Immunol , vol.20 , pp. 421-431
    • Passerini, L.1    Allan, S.E.2    Battaglia, M.3    Di Nunzio, S.4    Alstad, A.N.5    Levings, M.K.6
  • 219
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, et al. Stability of the regulatory T cell lineage in vivo. Science (2010) 329:1667-71. doi:10.1126/science.1191996
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1    Niec, R.E.2    Josefowicz, S.3    Li, L.4    Darce, J.5    Mathis, D.6
  • 220
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 13:423-31. doi:10.1038/nm1564
    • (2007) Nat Med , vol.13 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3    Bettelli, E.4    Awasthi, A.5    Petersen, T.R.6
  • 221
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    • Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 9:1347-55. doi:10.1038/ni.1677
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3    Galileos, G.4    Gao, W.5    Sobel, R.A.6
  • 222
    • 84863010992 scopus 로고    scopus 로고
    • STAT6-dependent regulation of Th9 development
    • Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol (2012) 188:968-75. doi:10.4049/jimmunol.1102840
    • (2012) J Immunol , vol.188 , pp. 968-975
    • Goswami, R.1    Jabeen, R.2    Yagi, R.3    Pham, D.4    Zhu, J.5    Goenka, S.6
  • 223
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441:235-8. doi:10.1038/nature04753
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 224
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 24:179-89. doi:10.1016/j.immuni.2006.01.001
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 225
    • 84862695017 scopus 로고    scopus 로고
    • Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
    • Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol (2012) 181:8-18. doi:10.1016/j.ajpath.2012.03.044
    • (2012) Am J Pathol , vol.181 , pp. 8-18
    • Maddur, M.S.1    Miossec, P.2    Kaveri, S.V.3    Bayry, J.4
  • 226
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9:641-9. doi:10.1038/ni.1610
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 227
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol (2008) 9:650-7. doi:10.1038/ni.1613
    • (2008) Nat Immunol , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupe, P.5    Barillot, E.6
  • 228
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
    • Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature (2008) 454:350-2. doi:10.1038/nature07021
    • (2008) Nature , vol.454 , pp. 350-352
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3    Hastings, W.D.4    Bettelli, E.5    Oukka, M.6


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